Biphasic calcium phosphate (BCP) consisting of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) was successfully synthesized by new hydrothermal route using β-TCP as precursor. The X-ray diffraction analysis ...Biphasic calcium phosphate (BCP) consisting of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) was successfully synthesized by new hydrothermal route using β-TCP as precursor. The X-ray diffraction analysis of as-synthesized powder indicated that β-TCP had been transformed into HA phase and amount of HA formed gradually increased with prolonged time. The results revealed that the recent technique may be able to control the composition of the obtained BCP which would influence the bioresorbability. Porous body of BCP was prepared by impregnation of polymeric sponge template with the slurry of the powder followed by sintering. The X-ray diffraction of porous product revealed that the composition of β-TCP increased after sintering indicating that HA had been decomposed. Porous BCP obtained from the recent technique possessed both macro and micropores structure which are useful for rapid tissue formation. Besides, the recent porous fabrication technique yielded porous BCP which preserved the sponge template morphology, enabling it to fabricate porous material with controlled pores structure.展开更多
Even though a lot of research has been carried out concerning the preparation of carbonate apatite (CHA), they were related to CHA in the form of powder. In the present study, macroporous CHA bone substitutes were pre...Even though a lot of research has been carried out concerning the preparation of carbonate apatite (CHA), they were related to CHA in the form of powder. In the present study, macroporous CHA bone substitutes were prepared through composition-transformation of gypsum and Ca-hydroxide. Here, we investigated the effect of added Ca-hydroxide to gypsum, carbonation periods, and hydrothermal temperatures for phosphatization to understand the basic principle of composition-transformation of gypsum added Ca-hydroxide to fabricate CHA bone substitutes. The specimens were characterized in terms of chemical and physical properties, such as extent of transformation of macroporous gypsum added Ca-hydroxide into CHA body, type and content of carbonate, and crystal morphology. It was observed that the transformation was faster with higher hydrothermal temperature. However, higher hydrothermal temperature caused de-carbonation phenomena which resulted in the lack of carbonate ions of the product. Moreover, the higher the percentage of Ca-hydroxide added to gypsum, caused the complete transformation of gypsum into CHA to be slower. These findings have been applied to the standard fabrication procedure of carbonate apatite, which in turn will allow scaling up process, and will be provided for biomedical purposes for the Indonesian community.展开更多
文摘Biphasic calcium phosphate (BCP) consisting of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) was successfully synthesized by new hydrothermal route using β-TCP as precursor. The X-ray diffraction analysis of as-synthesized powder indicated that β-TCP had been transformed into HA phase and amount of HA formed gradually increased with prolonged time. The results revealed that the recent technique may be able to control the composition of the obtained BCP which would influence the bioresorbability. Porous body of BCP was prepared by impregnation of polymeric sponge template with the slurry of the powder followed by sintering. The X-ray diffraction of porous product revealed that the composition of β-TCP increased after sintering indicating that HA had been decomposed. Porous BCP obtained from the recent technique possessed both macro and micropores structure which are useful for rapid tissue formation. Besides, the recent porous fabrication technique yielded porous BCP which preserved the sponge template morphology, enabling it to fabricate porous material with controlled pores structure.
文摘Even though a lot of research has been carried out concerning the preparation of carbonate apatite (CHA), they were related to CHA in the form of powder. In the present study, macroporous CHA bone substitutes were prepared through composition-transformation of gypsum and Ca-hydroxide. Here, we investigated the effect of added Ca-hydroxide to gypsum, carbonation periods, and hydrothermal temperatures for phosphatization to understand the basic principle of composition-transformation of gypsum added Ca-hydroxide to fabricate CHA bone substitutes. The specimens were characterized in terms of chemical and physical properties, such as extent of transformation of macroporous gypsum added Ca-hydroxide into CHA body, type and content of carbonate, and crystal morphology. It was observed that the transformation was faster with higher hydrothermal temperature. However, higher hydrothermal temperature caused de-carbonation phenomena which resulted in the lack of carbonate ions of the product. Moreover, the higher the percentage of Ca-hydroxide added to gypsum, caused the complete transformation of gypsum into CHA to be slower. These findings have been applied to the standard fabrication procedure of carbonate apatite, which in turn will allow scaling up process, and will be provided for biomedical purposes for the Indonesian community.
