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阿拉善地块晚古生代构造演化新模式:来自岩浆岩和沉积岩的记录
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作者 邱瑞照 李廷栋 肖庆辉 《矿产勘查》 2024年第1期1-12,共12页
本文根据阿拉善地块岩浆岩和沉积岩的记录分析,结合造山带岩石圈演化,提出阿拉善地块随着古亚洲洋在晚志留世末闭合,发生弧-陆或陆-陆碰撞、以及与相邻地块的碰撞,使陆壳得到广泛加厚;晚古生代时期以伸展为特征,早石炭世造山带岩石圈初... 本文根据阿拉善地块岩浆岩和沉积岩的记录分析,结合造山带岩石圈演化,提出阿拉善地块随着古亚洲洋在晚志留世末闭合,发生弧-陆或陆-陆碰撞、以及与相邻地块的碰撞,使陆壳得到广泛加厚;晚古生代时期以伸展为特征,早石炭世造山带岩石圈初始垮塌,致使阿拉善地块北部珠斯楞—杭乌拉带由泥盆纪相对稳定的被动陆缘,转为活动陆缘,并形成一套前弧碎屑岩-火山岩沉积;晚石炭世乌力吉—宗乃山—沙拉扎山带岩石圈初始垮塌、诺尔公—红古玉林带造山带岩石圈初始垮塌,由此构成阿拉善地块岩石圈部分垮塌,使中南部广泛区域沉降,形成一套后弧环境的海相碳酸盐-碎屑岩沉积岩石组合,并伴随同时期的辉长岩等基性岩体侵入;二叠纪造山带岩石圈完全垮塌,大规模软流圈上涌物质和热,使俯冲的洋壳物质、加厚下地壳混合物质、交代岩石圈地幔衍生新生物质等被加热熔融,形成高(超)钾岩浆储库。早二叠世,因侧向强迫重力翻转或受塔里木早二叠世地幔柱活动的触发,导致高(超)钾质岩浆沿珠斯楞、乌力吉、诺尔公陆壳中的岩石圈不连续挤出,以气球膨胀式短时、快速侵位,形成以珠斯楞、乌力吉、诺尔公为代表的二叠纪巨量花岗岩带,该时期也应该是阿拉善地块最重要的大规模成矿时期。阿拉善地块是华北克拉通的组成部分,至今在其南部依然保留着大于200 km厚的岩石圈。阿拉善地块在早古生代时期汇聚,伴随古亚洲洋、祁连洋的形成、演化与消亡及与华北地块相互作用,使阿拉善地块被“破坏”;晚古生代时期伸展,伴随造山带岩石圈垮塌被“肢解”,总体上属于西部“华北克拉通破坏”范畴,显生宙以来的构造-岩浆事件,是西部“华北克拉通破坏”的响应。 展开更多
关键词 晚古生代 造山带岩石圈垮塌 构造演化新模式 阿拉善地块 内蒙古
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某铁路企业职工肥胖相关性高血压情况分析
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作者 李廷栋 颉亚辉 +7 位作者 吕珍 王国瑞 杨少华 马鸿婧 马婧 刘晓峰 王少华 吴建军 《中国初级卫生保健》 2024年第2期58-60,69,共4页
目的:分析2020年某铁路企业职工肥胖相关性高血压的流行特征,探讨血清胆固醇水平对肥胖相关性高血压的诊断价值。方法:2020年1—12月,选取某铁路企业参与体检的在职职工62707人,分析其血清胆固醇水平与肥胖相关性高血压发生情况和相关性... 目的:分析2020年某铁路企业职工肥胖相关性高血压的流行特征,探讨血清胆固醇水平对肥胖相关性高血压的诊断价值。方法:2020年1—12月,选取某铁路企业参与体检的在职职工62707人,分析其血清胆固醇水平与肥胖相关性高血压发生情况和相关性,预测血清胆固醇各指标对肥胖相关性高血压的诊断价值。结果:铁路职工中,胆固醇异常率为4.68%,异常率与年龄和身体质量指数呈正相关;高血压患病率为22.56%,其中肥胖相关性高血压患病率为11.73%,患病率与年龄和身体质量指数增长呈正相关;低密度脂蛋白与收缩压和舒张压均呈弱正相关,高密度脂蛋白与收缩压和舒张压均呈弱负相关;结论:年龄与胆固醇异常和高血压患病密切相关,但血清胆固醇对肥胖相关性高血压的预测价值有限。 展开更多
关键词 血清胆固醇 肥胖相关性高血压 预测价值
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益肾蠲痹丸干预相关通路介导细胞焦亡对膝骨性关节炎大鼠的影响 被引量:2
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作者 马富海 李廷栋 +4 位作者 赵庆 唐晓栋 陈国栋 李昭成 白登彦 《中国骨质疏松杂志》 CAS CSCD 北大核心 2023年第8期1114-1120,共7页
目的探讨益肾蠲痹丸干预NLRP3/NF-κB/Caspase-1信号通路对膝骨性关节炎(knee osteoarthritis,KOA)大鼠的保护作用,并分析其对细胞焦亡相关蛋白的影响。方法随机将90只SPF级SD大鼠分为空白组、模型组、阳性对照组和益肾蠲痹丸低、中、... 目的探讨益肾蠲痹丸干预NLRP3/NF-κB/Caspase-1信号通路对膝骨性关节炎(knee osteoarthritis,KOA)大鼠的保护作用,并分析其对细胞焦亡相关蛋白的影响。方法随机将90只SPF级SD大鼠分为空白组、模型组、阳性对照组和益肾蠲痹丸低、中、高剂量组,每组15只。空白组不做处理,其他组制备KOA大鼠模型后进行干预治疗。比较6组大鼠干预前后膝关节直径及足趾容积情况;ELISA法检测血清中IL-1β、IL-18及血管内皮生长因子(vascular endothelial growth factor,VEGF)含量变化;HE染色观察关节软骨组织病理学改变情况;TUNEL法检测细胞凋亡情况;免疫组化法分析Caspase-1相关蛋白表达;Western blot及qRT-PCR法检测NLRP3/NF-κB/Caspase-1相关蛋白及mRNA表达水平。结果KOA造模后,与空白组比较,模型组大鼠膝关节直径与足趾容积明显增大,血清中IL-1β、IL-18及VEGF含量明显升高,软骨组织细胞排列紊乱,出现炎性浸润,细胞凋亡程度增高,NLRP3/NF-κB/Caspase-1相关蛋白及mRNA表达水平明显升高(P均<0.05);与模型组比较,阳性对照组及益肾蠲痹丸治疗组大鼠膝关节直径与足趾容积明显减轻,血清中IL-1β、IL-18及VEGF含量下降,软骨组织细胞炎性浸润改善,细胞凋亡程度减轻,NLRP3/NF-κB/Caspase-1相关蛋白及mRNA表达水平明显下降(P均<0.05),其中益肾蠲痹丸高剂量组显著优于益肾蠲痹丸低剂量组(P<0.01)。结论益肾蠲痹丸能够改善KOA大鼠关节软骨组织损伤,降低炎症因子表达和细胞凋亡程度,其机制可能与调控NLRP3/NF-κB/Caspase-1信号通路减轻细胞焦亡有关。 展开更多
关键词 膝骨性关节炎 益肾蠲痹丸 细胞焦亡 NLRP3/NF-κB/Caspase-1 炎症因子
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职工体检中主要血脂指标对糖尿病患者的早期诊断和预测价值
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作者 马婧 李廷栋 +5 位作者 杨少华 冯渤曦 马鸿婧 刘晓峰 王少华 吴建军 《西北民族大学学报(自然科学版)》 2024年第2期61-67,共7页
目的:探讨非高密度脂蛋白胆固醇(non-HDL-C)、空腹血清甘油三酯葡萄糖乘积指数(TyG)和血浆致动脉粥样硬化指数(AIP)对糖尿病前期的诊断和预测价值.方法:收集了2020年某铁路企业58030名在职职工的健康数据,采用非条件Logistic回归模型分... 目的:探讨非高密度脂蛋白胆固醇(non-HDL-C)、空腹血清甘油三酯葡萄糖乘积指数(TyG)和血浆致动脉粥样硬化指数(AIP)对糖尿病前期的诊断和预测价值.方法:收集了2020年某铁路企业58030名在职职工的健康数据,采用非条件Logistic回归模型分析non-HDL-C、TyG、AIP与糖尿病前期的关系,并绘制ROC曲线评估这些指标的预测能力.结果:2020年该企业58030名职工糖尿病前期患病率为6.3%.相关性分析发现随着non-HDL-C(r=0.095,P<0.05)、TyG(r=0.211,P<0.05)和AIP(r=0.113,P<0.05)的增加,糖尿病前期患病率逐渐升高.二元Logistic回归分析显示,non-HDL-C(OR=1.472,95%CI=1.423~1.523)、TyG(OR=3.929,95%CI=3.723~4.145)和AIP(OR=4.324,95%CI=3.897~4.797)均为糖尿病前期患病的影响因素.ROC曲线分析进一步证明了non-HDL-C、TyG和AIP对糖尿病前期的预测作用.结论:non-HDL-C、TyG和AIP在筛查中有助于早期预警诊断潜在的糖尿病患者. 展开更多
关键词 铁路职工 非高密度脂蛋白胆固醇 血清甘油三酯葡萄糖乘积指数 血浆致动脉硬化指数
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The Late Carboniferous–Early Permian Ocean-Continent Transition in the West Junggar,Central Asian Orogenic Belt: Constraints from Columnar Jointed Rhyolite 被引量:11
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作者 XU Shenglin CHEN Xuanhua +7 位作者 li tingdong SHI Jianjie DING Weicui li Bing HUANG Penghui ZHANG Yiping ZHANG Yaoyao MA Feizhou 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2019年第2期265-282,共18页
The West Junggar of the western Central Asian Orogenic Belt is one of the typical regions in the term of ocean subduction, contraction and continental growth in the Late Paleozoic. However, it is still controversial o... The West Junggar of the western Central Asian Orogenic Belt is one of the typical regions in the term of ocean subduction, contraction and continental growth in the Late Paleozoic. However, it is still controversial on the exact time of ocean-continent transition so far. This study investigates rhyolites with columnar joint in the West Junggar for the first time.Based on zircon U-Pb dating, we determined that the ages of the newly-discovered rhyolites are between 303.6 and 294.5 Ma, belonging to Late Carboniferous–Early Permian, which is the oldest rhyolite with columnar joint preserved in the world at present. Geochemical results show that the characteristics of the major element compositions include a high content of SiO_2(75.78–79.20 wt%) and a moderate content of Al_2O_3(12.21–13.19 wt%). The total alkali content(K_2O +Na_2O) is 6.14–8.05 wt%, among which K_2O is 2.09–4.72 wt% and the rate of K_2O/Na_2O is 0.38–3.05. Over-based minerals such as Ne, Lc, and Ac do not appear. The contents of TiO_2(0.09–0.24 wt%), CaO(0.15–0.99 wt%) and MgO(0.06–0.18 wt%) are low. A/CNK=0.91–1.68, A/NK=1.06–1.76, and as such, these are associated with the quasi-aluminum-weak peraluminous high potassium calc-alkaline and some calc-alkaline magma series. These rhyolites show a significant negative Eu anomaly with relative enrichment of LREE and LILE(Rb, Ba, Th, U, K) and depletion of Sr, HREE and HFSE(Nb, Ta, Ti, P). These rhyolites also have the characteristics of an A2-type granite, similar to the Miaoergou batholith,which indicates they both were affected by post-orogenic extension. Combining petrological, zircon U-Pb dating and geochemical characteristics of the rhyolites, we conclude that the specific time of ocean-continent transition of the West Junggar is the Late Carboniferous–Early Permian. 展开更多
关键词 RHYOLITE columnar joint zircon U-Pb dating geochemistry ocean-continent TRANSITION West JUNGGAR
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Lithospheric Evolution and Geodynamic Process of the Qinghai-Tibet Plateau: An Inspiration from the Yadong-Golmud-Ejin Geoscience Transect 被引量:8
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作者 li tingdong GAO Rui WU Gongjian 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 1999年第2期173-180,共8页
Abstract The Tibet Geoscience Transect (Yadong-Golmud-Ejin) has revealed the basic structures, tectonic evolution and geodynamic process of the lithosphere of the Qinghai-Tibet plateau. The evidence of northward thrus... Abstract The Tibet Geoscience Transect (Yadong-Golmud-Ejin) has revealed the basic structures, tectonic evolution and geodynamic process of the lithosphere of the Qinghai-Tibet plateau. The evidence of northward thrusting of the Indian plate beneath the Himalayans on the southern margin and to southward compression of the Alxa block on the northern margin has been found. They were the driving forces causing the plateau uplift. The plateau is a continent resulting from amalgamation of eight terranes. These terranes are separated by sutures or large-scale faults, and different terranes have different lateral inhomogeneities and multi-layered lithospheric structures. At depths of about 20–30 km of the crust in the interior of the plateau there commonly exists a low-velocity layer. It is an uncoupled layer of the tectonic stress; above the layer, the upper crustal slices were thrust and overlapped each other and the rocks underwent brittle deformation, thus leading to shortening and thickening of the upper crust. Below the layer, the lateral change of the structure of the lower crust varies most greatly and ductile deformation occurs. The lower crust velocity of southern Tibet shows the reversed feature; whereas the lower crust velocity of northern Tibet increases and displays strong gradient variation and the character of the double Moho. On the whole, the Moho of the plateau is greatly undulatory. Although the crust of the Qinghai-Tibet Plateau has a great thickness, the lithosphere does not thicken markedly. The plateau is in a state of bi-directional compression. The unstable change of the Moho, the interaction between the crust and mantle and between the lithosphere and asthenosphere caused by the sinking of the lithospheric mantle and the strike slip and extension of the crust are the major dynamic factors for maintaining the present height and scope of the Qinghai-Tibet Plateau. 展开更多
关键词 Qinghai-Tibet Plateau LITHOSPHERE geotransect continental dynamics
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Two-episode Tectono-thermal Events of the Heyuan Fault in Late Cretaceous and Oligocene and their Tectonic Implications, Southernmost South China Block 被引量:5
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作者 WANG Qiangmao li Hailong +4 位作者 li tingdong DING Xiaozhong ZHEN Junwei ZHANG Min FAN Yanxia 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2022年第2期447-459,共13页
The Heyuan Fault, is one of the main NE-trending faults in the southernmost South China Block and is close to the northernmost South China Sea to the south. The fault features multi-stage deformation and controlled th... The Heyuan Fault, is one of the main NE-trending faults in the southernmost South China Block and is close to the northernmost South China Sea to the south. The fault features multi-stage deformation and controlled the formation of late Cretaceous to Cenozoic basins. Based on detailed field investigations and comprehensive geochronological research, including zircon U-Pb, Rb-Sr isochron, zircon U-Th-He dating, two episodic tectono-thermal events are recognized. The first occurred during ~79 Ma to 66 Ma, which is characterized by large-scale quartz-fluid emplacement. The other occurred at ~34 Ma, which features the eruption of a set of basalts. The two events show a changing on material source from siliceous hydrotherm to basalt magma, supporting obvious lithospheric thinning of the southernmost South China Block, which shed light on the geological evolution and the interaction mechanisms between the SCB and the northern South China Sea since the Late Cretaceous. 展开更多
关键词 tectono-thermal events Heyuan Fault Heyuan Basin Guangdong Province South China Block South China Sea
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The Discovery of the 2.35Ga Crystalline Basement in the Southwest of the Yangtze Block and its Geological Significance 被引量:5
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作者 ZHANG Heng GAO linzhi +3 位作者 ZHANG Chuanheng DING Xiaozhong li tingdong liU Yanxue 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2018年第6期2460-2461,共2页
Objective Archean and Paleoproterozoic rock units crop out in the northern and southwestern portions of the Yangtze Block in the South China Craton. Archean crystalline basement outcrops are restricted to the northern... Objective Archean and Paleoproterozoic rock units crop out in the northern and southwestern portions of the Yangtze Block in the South China Craton. Archean crystalline basement outcrops are restricted to the northern part of the Yangtze Block and are represented by the Kongling Complex.The protoliths of the TTG gneisses at Kongling were emplaced at 3.3–2.7 Ga(Gao et al., 2011). In the southwestern 展开更多
关键词 PB SHRIMP GA
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Tomographic Imaging of the India-Asia Plate Collisional Tectonics and Mantle Upwelling Beneath Western Tibet 被引量:3
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作者 ZHENG Hongwei li tingdong +3 位作者 HE Rizheng YANG Hui NIU Xiao ZOU Changqiao 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2020年第4期1159-1166,共8页
To better understand the lithosphere mantle collision tectonics between the India plate and Asia plate, we determine three dimensional P wave velocity structure beneath western Tibet using 27,439 arrival times from 2,... To better understand the lithosphere mantle collision tectonics between the India plate and Asia plate, we determine three dimensional P wave velocity structure beneath western Tibet using 27,439 arrival times from 2,174 teleseismic events recorded by 182 stations of Hi-CLIMB Project and 16 stations in the north of Hi-CLMB. Our tomographic images show the velocity structure significantly difference beneath northern and southern Qiangtang, which can further prove that the Longmu Co-Shuanghu ophiolitic belt is a significant tectonic boundary fault zone. There are two prominent high velocity anomalies and two prominent low velocity anomalies in our images. One obvious high velocity anomalies subduct beneath the Tibet at the long distance near 34°N, whereas it is broke off by an obvious low velocity anomaly under the IYS. We interpret them as northward subducting Indian lithosphere mantle and the low velocity anomanly under IYS likely reflects mantle material upwelling triggered by tearing of the northward subduction Indian lithosphere. The other prominent high velocity anomaly was imaged at a depth from 50 km to 200 km horizontal and up to the northern Qiangtang with its southern edge extending to about 34°N through Hoh Xil block. We infer it as the southward subducting Asia lithosphere mantle. The other widely low velocity anomaly beneath the Qiangtang block lies in the gap between the frontier of India plate and Asia plate, where is the channel of mantle material upwelling. 展开更多
关键词 seismic tomography southward subduction of Asia lithosphere mantle northward subduction of Tibet lithosphere mantle Longmu Co-Shuanghu tectonic boundary zone
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Lithofacies Characters and Significance of the Submarine Fan of the Liufengguan Group in Qinling 被引量:2
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作者 ZHENG Ning li tingdong +3 位作者 YOU Guoqing ZHANG Shuanhou CUI Jiantang CHENG Muwei 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2012年第1期174-188,共15页
Field investigation and laboratory research on flysch of the Liufengguan Group in Qinling indicate the following: (1) Sandstone of the Liufengguan Group is categorized as feldspathic lithic graywacke with a minor a... Field investigation and laboratory research on flysch of the Liufengguan Group in Qinling indicate the following: (1) Sandstone of the Liufengguan Group is categorized as feldspathic lithic graywacke with a minor amount of lithic graywacke in the QFR triangular diagram. Grain size〈0.3 mm. Bedding plane structures such as groove casts and suspected flute casts can be found at the bottom of the sandstone. It is inferred that currents may have come from the southeast during deposition. Bedding structures such as ripple marks, graded bedding, parallel bedding, small-scale cross bedding, climbing bedding, suspected convolute bedding, microlamination and sliding structures have also been observed, which are of indicative significance. It is thought that the Liufengguan Group has the sedimentary characteristics of bedding, bedding plane structures and lithologicai assemblages of deep-sea low-density turbidity current deposits. The vertical succession of the Bouma sequence in the inner fan subfacies zone is generally incomplete: the assemblage of Ta and Tabc is commonly seen; the succession of the middle fan subfacies zone is relatively complete; and divisions Te and Tb are common in the outer fan subfacies zone. (2) The flysh of the Liufengguan Group is a sequence of deep-sea argillaceous-arenaceous submarine fan deposits, in which the authors recognize the inner, middle and outer fan subfacies and also nine types of lithofacies: normal graded sandstone (A1), medium- to thick-bedded, fine-grained sandstone (A2), medium- to thick-bedded and massive siltstone (A3), thin-bedded, fine-grained sandstone and mudstone (B1), irregular interbeds of thinbedded, fine-grained sandstone and siltstone (B2), thin-bedded, fine-grained sandstone (C1), very thin-bedded, fine-grained sandstone (D1), olistostromes (El) anddeep-sea mudstone (F). The inner fan consists of four microfacies: natural levee (A1), water channel (A2, A3) and olistostrome (El); in the middle fan there also occur four microfacies, i.e., branch channel (B1), branch channel (B2), interdistributary bay (D1) and olistostrome. The outer fan is made up of the branch channel (C1) and sheet sand (D1) microfacies, which alternate vertically with sediments of deep-sea plain subfacies (F). There occur fining- and thinning-upward channel deposits in the outer-fan subfacies zone of the submarine fan of the Liufengguan Group observed in this study. The quartz content of the graywacke of the deposits is all higher than 40% and may reach as high as 60%. Therefore, on the basis of the aforementioned features, this flysh should be formed in a passive continental-margin tectonic environment. 展开更多
关键词 Liufengguan Group flysh lithofacies low-density turbidity current submarine fan
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P-wave Velocity Structure of Crustal and Upper Mantle beneath South China and its Tectonic Implications
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作者 ZHENG Hongwei li tingdong +6 位作者 HE Rizheng YU Haiying YANG Hui WEN Yanlin WANG Peng liU Fang SUN Dongjun 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2022年第2期621-630,共10页
The 3D P-wave velocity structure beneath the South China Block was determined by applying arrival times from 269 teleseismic events recorded by 240 seismic stations within the study region. Our tomographic results rev... The 3D P-wave velocity structure beneath the South China Block was determined by applying arrival times from 269 teleseismic events recorded by 240 seismic stations within the study region. Our tomographic results reveal the deep structural characteristics of major tectonic units and ore concentration areas. There are distinct high velocity anomalies beneath the ancient Yangtze and Cathaysia blocks, with the lithosphere of the Cathaysia Block being thinner than the Yangtze Block;the Jiangnan orogenic belt, located in the combined zone of two blocks, is a high and low velocity anomaly conversion zone;the famous metallogenic belts of Edongnan, the Youjiang Basin and the Cathaysia Block are obviously low velocity areas with different metallogenic mechanisms. The deep ore-forming material source in the Edongnan metallogenic belt is different from that of the Cathaysia Block. The low velocity anomaly under the Cathaysia Block related to mineralization results from the upwelling of mantle material, caused by the joint action of the Paleo-Tethys tectonic domain, the Paleo-Pacific tectonic domain and the Hainan mantle plume migration and erosion, which has been occurring from northeast to southwest since 80 Ma. The low-temperature mineralization mechanism of Youjiang Basin should be considered not only in terms of the influence of the Emeishan mantle plume in the west and the Paleo-Tethys tectonic domain in the south, but also in the context of the influence of the upwelling of asthenospheric material from the PaleoPacific tectonic domain in the east. 展开更多
关键词 MINERALIZATION tomographic images lithosphere structure Youjiang Basin South China
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皮质酮对Erastin诱导黑色素瘤细胞铁死亡的促进作用 被引量:2
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作者 甘雨灵 梁鹏 +5 位作者 李廷栋 刘利兵 梁福东 齐江华 李儒家 潘东升 《现代肿瘤医学》 CAS 北大核心 2023年第5期818-821,共4页
目的:探讨皮质酮(corticosterone)对铁死亡激活剂Erastin诱导黑色素瘤细胞铁死亡的影响。方法:单独或联合使用10μmol/L的二甲基亚砜(dimethyl sulfoxide, DMSO)、Erastin、皮质酮处理B16-F10细胞。采用MTT法检测细胞活性,透射电子显微... 目的:探讨皮质酮(corticosterone)对铁死亡激活剂Erastin诱导黑色素瘤细胞铁死亡的影响。方法:单独或联合使用10μmol/L的二甲基亚砜(dimethyl sulfoxide, DMSO)、Erastin、皮质酮处理B16-F10细胞。采用MTT法检测细胞活性,透射电子显微镜观察细胞形态的改变,分别用铁离子比色法、谷胱甘肽(glutathione reduced, GSH)、丙二醛(malondialdehyde, MDA)试剂盒检测细胞内铁离子、GSH和MDA的含量,通过荧光探针DCFH-DA检测细胞内活性氧(reactive oxygen species, ROS)水平。结果:与对照组比较,Erastin组、皮质酮组和Erastin+皮质酮组的细胞活性在处理48、72 h后显著下降(P<0.05)。电镜结果发现Erastin组、皮质酮组、Erastin+皮质酮组发生线粒体缩小,结构紧密,嵴减少或消失,Erastin+皮质酮组甚至出现线粒体肿胀、空泡变。Erastin组、皮质酮组和Erastin+皮质酮组细胞内铁、MDA、ROS含量较对照组显著升高(P<0.05),而Erastin组和Erastin+皮质酮组细胞中GSH水平明显低于对照组(P<0.05),上述变化Erastin+皮质酮组比Erastin组更为明显。结论:皮质酮可促进Erastin诱导黑色素瘤细胞铁死亡。 展开更多
关键词 皮质酮 Erastin 铁死亡 黑色素瘤
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肢体隔离热灌注化疗治疗肢端恶性黑色素瘤预后的多因素分析 被引量:1
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作者 李廷栋 尹晓慧 +9 位作者 徐文红 付来华 甘雨灵 刘利兵 梁福东 齐江华 梁鹏 李晶 宋建民 潘东升 《中国医药科学》 2023年第13期4-8,16,共6页
目的探讨影响肢端恶性黑色素瘤进行肢体隔离热灌注化疗预后的相关因素。方法回顾性分析2006年11月至2017年10月甘肃省肿瘤医院骨与软组肿瘤科行手术切取病灶经病理证实并应用顺铂行肢体隔离热灌注化疗的肢端恶性黑色素瘤患者41例的临床... 目的探讨影响肢端恶性黑色素瘤进行肢体隔离热灌注化疗预后的相关因素。方法回顾性分析2006年11月至2017年10月甘肃省肿瘤医院骨与软组肿瘤科行手术切取病灶经病理证实并应用顺铂行肢体隔离热灌注化疗的肢端恶性黑色素瘤患者41例的临床资料,包括年龄、性别、身高、原发灶部位、溃疡、Breslow厚度、Clark分级、淋巴结转移情况及病理分期等相关因素。采用R 4.2.2软件对数据进行统计学分析。采用LASSO回归和逐步双向单因素Cox回归筛选变量,分别将热灌注化疗剂量、身高、病理TNM分期、切缘、有丝分裂指数[总生存期(OS)];热灌注化疗剂量,身高,病理TNM分期,有丝分裂指数[无进展生存期(PFS)]纳入多因素后续多因素Cox回归,筛选独立预后因素,并以森林图展示。通过Kaplan-Meier生存曲线,展示患者术后累计生存率,通过Log-Rank检验比较高、低热灌注化疗剂量对患者生存率的影响。结果基于41例肢体隔离热灌注化疗治疗恶性黑色素瘤患者的临床资料进行LASSO回归,分别将以下变量纳入模型:热灌注化疗剂量、身高、病理TNM分期、远处转移、切缘、有丝分裂指数(OS、PFS)。进一步逐步双向单因素Cox回归及因素Cox回归分析表明:热灌注化疗剂量、身高、病理TNM分期是OS的独立预后因素(P<0.05);热灌注化疗剂量和病理TNM分期是PFS的独立预后因素(P<0.05)。高剂量热灌注化疗可以提高术后患者生存率,晚期恶性黑色素瘤患者术后生存率较低。结论本研究对肢端恶性黑色素瘤患者行肢体隔离热灌注化疗的生存情况进行多因素分析提示:顺铂高剂量区域热灌注化疗能够显著提高患肢术后生存率。肢体隔离热灌注化疗剂量、身高、病理分期是OS独立预后因素,肢体隔离热灌注化疗剂量、病理分期为PFS独立预后因素。 展开更多
关键词 肢端黑色素瘤 肢体隔离热灌注 预后 多因素分析
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基于数据分析CDKN2A基因在软组织肉瘤中的表达和意义
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作者 齐江华 秦三利 +5 位作者 梁福东 刘利兵 潘东升 甘雨灵 李廷栋 梁鹏 《甘肃医药》 2023年第3期224-227,共4页
目的:分析挖掘CDKN2A基因与软组织肉瘤之间的关系。方法:利用GEPIA数据库、UALCAN数据库及String数据库中的数据资料,分析比较CDKN2A基因在软组织肉瘤中的表达及与临床生存期及相关上下游蛋白的关系。结果:CDKN2A基因在软组织肉瘤组织... 目的:分析挖掘CDKN2A基因与软组织肉瘤之间的关系。方法:利用GEPIA数据库、UALCAN数据库及String数据库中的数据资料,分析比较CDKN2A基因在软组织肉瘤中的表达及与临床生存期及相关上下游蛋白的关系。结果:CDKN2A基因在软组织肉瘤组织中高度表达,但其表达与临床预后无统计学差异,仅仅表现出相关性趋势。与CDKN2A基因关系紧密的上下游基因蛋白有11个,相互作用关系较为复杂。结论:CDKN2A基因表达与软组织肉瘤高度相关,并且在软组织肉瘤中参与多条细胞信号通路,所起的作用非常复杂,可作为研究软组织肉瘤病因及治疗的切入点。 展开更多
关键词 CDKN2A基因 软组织肉瘤 GEPIA数据库 UALCAN数据库 String数据库
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扬子板块西南部古元古代岩浆及变质事件——兼论扬子板块对Nuna超大陆事件的响应 被引量:17
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作者 张恒 高林志 +6 位作者 张传恒 丁孝忠 李廷栋 宋彪 刘昊岗 龚成强 张继彪 《地质通报》 CAS CSCD 北大核心 2019年第11期1777-1789,共13页
寻找扬子板块西南地区古老结晶基底一直是众多地质学者追寻的目标,其涉及扬子板块在Nuna超大陆重建中的位置和演化过程,也是前寒武纪研究的重要课题。继在扬子板块西南部中国云南石屏撮科村首次报道2.35Ga花岗片麻岩结晶基底后,又在撮科... 寻找扬子板块西南地区古老结晶基底一直是众多地质学者追寻的目标,其涉及扬子板块在Nuna超大陆重建中的位置和演化过程,也是前寒武纪研究的重要课题。继在扬子板块西南部中国云南石屏撮科村首次报道2.35Ga花岗片麻岩结晶基底后,又在撮科村-高家坡一带3个花岗岩样品中分别获得了2347.3±4.9Ma、2324.3±8.6Ma和2329.4±5.9Ma的SHRIMP锆石U-Pb年龄,进一步确认扬子板块西南部中国境内存在2.32~2.35Ga的岩浆事件,其应为Nuna超大陆汇聚期Arrowsmith造山事件在扬子板块的响应。另在1件糜棱岩化花岗闪长岩样品中获得了1909.8±5.7Ma和1843.1±7.6Ma两组年龄,在扬子板块西南部中国境内首次发现1.90Ga和1.84Ga的构造或变质事件。结合前人研究成果,确定扬子板块西南部存在2.91~2.84Ga,2.36~2.32Ga,2.28~2.19Ga的岩浆事件,以及1.97~1.95Ga,1.90Ga,1.84~1.83Ga的变质事件,为确定扬子板块在Nuna超大陆重建中的位置提供了更多证据。 展开更多
关键词 扬子板块 Nuna超大陆 滇中地区 结晶基底
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兰渝铁路特长隧道空气质量调查分析
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作者 郭强 李廷栋 +1 位作者 刘健生 马婧 《铁路节能环保与安全卫生》 2023年第1期56-60,共5页
了解兰渝铁路特长隧道内空气质量状况,以预防可能对隧道内养护人员产生健康威胁的有害因素。在铁路运营且避开隧道内机械通风开放时间,采用直读式仪器对12条特长隧道内物理因素(温度、湿度、气压、风速、噪声)、化学因素(CO、CO_(2)、O_... 了解兰渝铁路特长隧道内空气质量状况,以预防可能对隧道内养护人员产生健康威胁的有害因素。在铁路运营且避开隧道内机械通风开放时间,采用直读式仪器对12条特长隧道内物理因素(温度、湿度、气压、风速、噪声)、化学因素(CO、CO_(2)、O_(3)、NOX、SO_(2)、粉尘)及可吸入颗粒物(PM_(2.5)、PM_(10))浓度进行测量并与国家相关标准比较。结果表明,兰渝铁路特长隧道内气象条件良好,无高气温、高气压和超标噪声的影响;化学污染物(CO、CO_(2)、O_(3)、NOx、SO_(2)、粉尘)和可吸入颗粒物的浓度基本不超标。此次监测结果说明目前隧道内有害因素未对隧道内相关工作人员健康产生影响。 展开更多
关键词 铁路 特长隧道 空气质量 污染物
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西准噶尔地区洋陆转换时代:来自锆石U-Pb定年与Lu-Hf同位素的约束 被引量:8
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作者 徐盛林 陈宣华 +4 位作者 李廷栋 丁伟翠 史建杰 李冰 马飞宙 《中国地质》 CAS CSCD 北大核心 2019年第5期1061-1078,共18页
中亚造山带西部的西准噶尔地区是古生代洋陆构造转换最显著的地区之一,但是关于该地区洋陆转换的具体时间和地壳演化至今仍存在诸多争议。本文以西准噶尔地区的庙尔沟岩体及其西北侧新发现的柱状节理流纹岩为研究对象,通过锆石U-Pb定年... 中亚造山带西部的西准噶尔地区是古生代洋陆构造转换最显著的地区之一,但是关于该地区洋陆转换的具体时间和地壳演化至今仍存在诸多争议。本文以西准噶尔地区的庙尔沟岩体及其西北侧新发现的柱状节理流纹岩为研究对象,通过锆石U-Pb定年的方法,判断庙尔沟岩体的年龄为302.8~308.8 Ma,柱状节理流纹岩的年龄为303.6~294.5 Ma。锆石Lu-Hf同位素测试结果显示,庙尔沟岩体和柱状节理流纹岩都具有相似的高176Hf/177Hf值和高正εHf(t)值,具有亏损地幔的源区属性,可能来源于下地壳底部残余洋壳或火山岛弧等新生地壳发生部分熔融。结合区域地质资料和前人研究成果,将西准噶尔地区由大洋俯冲向陆内环境转变的时间限定为晚石炭—早二叠世,其基底可能是以新元古代晚期—晚古生代形成的年轻洋壳和岛弧为主,不存在古老的结晶基底。 展开更多
关键词 西准噶尔 洋陆转换 庙尔沟岩体 柱状节理流纹岩 锆石U-PB定年 锆石Lu-Hf同位素 深地勘查工程
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桂北地区丹洲群碎屑锆石LA-ICP-MS U-Pb年龄和Hf同位素特征及其地质意义 被引量:8
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作者 寇彩化 刘燕学 +2 位作者 李廷栋 黄河 张恒 《地质通报》 CAS CSCD 北大核心 2017年第8期1393-1406,共14页
桂北丹洲群顶部拱洞组粉砂岩的碎屑锆石的阴极发光图像和Th/U(0.2~2.4)值显示,它们均为岩浆成因的锆石。锆石^(206)Pb/^(238)Pb年龄分布在730~769Ma和771~850Ma之间,这些锆石的Hf同位素成分范围较大,ε_(Hf)(t)值和二阶段Hf模式年龄(T_(... 桂北丹洲群顶部拱洞组粉砂岩的碎屑锆石的阴极发光图像和Th/U(0.2~2.4)值显示,它们均为岩浆成因的锆石。锆石^(206)Pb/^(238)Pb年龄分布在730~769Ma和771~850Ma之间,这些锆石的Hf同位素成分范围较大,ε_(Hf)(t)值和二阶段Hf模式年龄(T_(DM2))分别为-18.4~11.4和1020~2812Ma。此外,样品中还有一些年龄较老的锆石颗粒,^(207)Pb/^(206)Pb年龄为1910~3140Ma,ε_(Hf)(t)值和二阶段Hf模式年龄(T_(DM2))分别为-13.6~3.4和2740~3635Ma。结合前人的研究推测,桂北丹洲群拱洞组沉积年龄小于等于706±10Ma,物源主要由扬子板块新元古代岩浆岩组成,也有少量太古宙岩浆岩的加入。推测中国华南地区存在对应于Rodinia超大陆聚合相关的格林威尔运动的响应。根据已测锆石的ε_(Hf)(t)值和Hf二阶段模式年龄推断,研究区地壳生长主要经历3个阶段:(1)3.64~3.25Ga,初生地壳出现在3.64Ga;(2)2.98~2.37Ga;(3)2.19~1.28Ga,地壳生长的主要时期。 展开更多
关键词 桂北丹洲群 碎屑锆石LA-ICP-MSU-Pb定年 HF同位素 RODINIA超大陆 地壳生长
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江南造山带西段桂北四堡地区830 Ma辉长岩锆石SIMS U-Pb年代学和岩石地球化学特征及其岩石成因研究 被引量:7
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作者 寇彩化 刘燕学 +4 位作者 李江 李廷栋 丁孝忠 刘勇 靳胜凯 《地学前缘》 EI CAS CSCD 北大核心 2022年第2期218-233,共16页
本次研究对象为江南造山带西段桂北四堡地区新元古代辉长岩,主要由斜长石和单斜辉石组成,含有少量的橄榄石和钛铁氧化物,表明在岩浆演化过程中发生了斜长石和单斜辉石以及少量橄榄石的分离结晶作用。辉长岩锆石SIMS U-Pb谐和年龄为(830&... 本次研究对象为江南造山带西段桂北四堡地区新元古代辉长岩,主要由斜长石和单斜辉石组成,含有少量的橄榄石和钛铁氧化物,表明在岩浆演化过程中发生了斜长石和单斜辉石以及少量橄榄石的分离结晶作用。辉长岩锆石SIMS U-Pb谐和年龄为(830±7)Ma,指示其侵位年龄约为830 Ma。全岩具有低SiO_(2)含量(48.46%~53.99%)、高MgO含量(9.27%~25.22%)、Mg^(#)值较高(62~79)的特征。辉长岩为钙碱性系列岩石,其稀土元素球粒陨石标准化和微量元素原始地幔标准化与典型的弧岩浆相似,具有相对富集轻稀土元素((La/Yb)_(N)=2.2~3.7,(La/Sm)_(N)=2.5~2.9)和大离子亲石元素,明显的高场强元素(Nb、Ta和Ti)亏损的特征,还具有较高的Th/Nb比值(0.7~0.8)和低Nb/La比值(0.4~0.6)。辉长岩具有负的ε_(Nd)(t)值(-6.3~-3.0)和正的ε_(Hf)(t)值(8.0~12.1),指示其源区为亏损地幔,但有富集组分加入。结合区域地质特征,推测辉长岩形成于活动大陆边缘俯冲构造背景,起源于受沉积物流体交代了的楔地幔。 展开更多
关键词 江南造山带西段 新元古代基性岩 锆石SIMS U-Pb年龄 岩石成因 构造背景
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西准噶尔地区最晚期岩浆侵入活动--来自早二叠世-早三叠世接特布调岩体的证据 被引量:6
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作者 徐盛林 陈宣华 +4 位作者 李廷栋 丁伟翠 李冰 张垚垚 马飞宙 《地质学报》 EI CAS CSCD 北大核心 2020年第4期1067-1090,共24页
西准噶尔地区晚古生代构造运动复杂,岩浆侵入活动强烈,地壳生长显著,处在洋陆构造转换的关键时期。接特布调岩体位于连接西准噶尔地区、天山造山带和准噶尔盆地的重要位置,岩石类型以碱长花岗岩、二长花岗岩和花岗闪长岩为主。碱长花岗... 西准噶尔地区晚古生代构造运动复杂,岩浆侵入活动强烈,地壳生长显著,处在洋陆构造转换的关键时期。接特布调岩体位于连接西准噶尔地区、天山造山带和准噶尔盆地的重要位置,岩石类型以碱长花岗岩、二长花岗岩和花岗闪长岩为主。碱长花岗岩矿物组成以碱性长石(55%~60%)、斜长石(15%~20%)和石英(23%~25%)为主,几乎不含暗色矿物,岩石内部无暗色微粒包体;二长花岗岩和花岗闪长岩矿物组成以斜长石(30%~40%和~16%)、碱性长石(30%~40%和~50%)和石英(20%~25%和~18%)为主,含少量黑云母和角闪石,内部存在不同数量和规模的暗色微粒包体。通过高精度锆石U-Pb定年,将接特布调岩体的成岩年龄限定为287~250 Ma,岩体内早三叠世(250.4Ma)二长花岗岩是迄今为止在整个西准噶尔地区发现的最年轻的侵入岩,该期花岗岩的就位标志着西准噶尔地区深成岩浆侵入活动的终结。接特布调岩体整体具有高硅(SiO2=67.04%~77.01%)、富碱(K2O=3.45%~4.63%,Na2O=3.62%~4.18%),贫钙(CaO=0.45%~0.3.05%)、贫镁(MgO=0.16%~1.51%)、低铁(Fe2O3=0.99%~4.40%)的特征,属于高钾钙碱性系列,准铝质-弱过铝质(A/CNK=0.93~1.03)。球粒陨石标准化稀土元素配分图具有明显的右倾海鸥型特征,富集轻稀土元素和Rb、Th、K元素,亏损重稀土元素和Eu、Ba、Nb、Sr、P、Ti元素。碱长花岗岩具有比A性花岗岩低的岩浆结晶温度,属于高分异的I型花岗岩,来源于新生地壳部分熔融;二长花岗岩和花岗闪长岩整体具有较高的岩浆结晶温度,属于壳幔混源的I型花岗岩。接特布调地区在早二叠-早三叠世处于高温、低压、地壳减薄的后造山伸展的陆内演化阶段。 展开更多
关键词 接特布调岩体 地球化学 U-PB年代学 LU-HF同位素 I型花岗岩 后造山 西准噶尔
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