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Association between Polymorphisms in Telomere-Associated Protein Genes and the Cholinesterase Activity of Omethoate-Exposed Workers
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作者 FAN Ya Hui li xin ling +5 位作者 liU Xiao Hua GUO Zhi Feng YAN Meng Qing DUAN Xiao Ran MIAO Wen Bin WANG Wei 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2022年第5期448-452,共5页
Organophosphorus pesticides(OPs)are extensively used for their high efficiency,broad spectrum,and low residue.However,the health hazards caused by long-term,low-dose exposure to OPs are easily ignored.Omethoate is a l... Organophosphorus pesticides(OPs)are extensively used for their high efficiency,broad spectrum,and low residue.However,the health hazards caused by long-term,low-dose exposure to OPs are easily ignored.Omethoate is a large class of OPs that is widely used in China.The inhibition of the cholinesterase(ChE)activity is the main toxicity mechanism of OPs,and such an activity is used as a biomarker of exposure to OPs. 展开更多
关键词 PESTICIDES China. RESIDUE
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Benchmark Dose Assessment for Coke Oven Emissions-Induced Mitochondrial DNA Copy Number Damage Effects
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作者 YAN Zhao Fan GU Zhi Guang +8 位作者 FAN Ya Hui li xin ling NIU Ze Ming DUAN Xiao Ran Mallah Ali Manthar ZHANG Qiao YANG Yong li YAO Wu WANG Wei 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2023年第6期490-500,共11页
Objective The study aimed to estimate the benchmark dose(BMD)of coke oven emissions(COEs)exposure based on mitochondrial damage with the mitochondrial DNA copy number(mtDNAcn)as a biomarker.Methods A total of 782 subj... Objective The study aimed to estimate the benchmark dose(BMD)of coke oven emissions(COEs)exposure based on mitochondrial damage with the mitochondrial DNA copy number(mtDNAcn)as a biomarker.Methods A total of 782 subjects were recruited,including 238 controls and 544 exposed workers.The mtDNAcn of peripheral leukocytes was detected through the real-time fluorescence-based quantitative polymerase chain reaction.Three BMD approaches were used to calculate the BMD of COEs exposure based on the mitochondrial damage and its 95%confidence lower limit(BMDL).Results The mtDNAcn of the exposure group was lower than that of the control group(0.60±0.29 vs.1.03±0.31;P<0.001).A dose-response relationship was shown between the mtDNAcn damage and COEs.Using the Benchmark Dose Software,the occupational exposure limits(OELs)for COEs exposure in males was 0.00190 mg/m^(3).The OELs for COEs exposure using the BBMD were 0.00170 mg/m^(3)for the total population,0.00158 mg/m^(3)for males,and 0.00174 mg/m^(3)for females.In possible risk obtained from animal studies(PROAST),the OELs of the total population,males,and females were 0.00184,0.00178,and 0.00192 mg/m^(3),respectively.Conclusion Based on our conservative estimate,the BMDL of mitochondrial damage caused by COEs is0.002 mg/m^(3).This value will provide a benchmark for determining possible OELs. 展开更多
关键词 Coke oven emissions Mitochondrial DNA copy number Benchmark dose Occupational exposure limits
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补肾活血中药对子宫内膜异位症模型大鼠子宫内膜DNA甲基化的影响 被引量:2
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作者 李新玲 张晋峰 翟红莉 《山西中医》 2018年第5期55-56,60,共3页
目的:观察补肾活血法对子宫内膜异位症(EMs)模型大鼠子宫内膜DNA甲基化的影响。方法:取80只造模成功EMs模型大鼠随机分为治疗组、对照组,另取40只大鼠结扎一侧子宫作为空白组。治疗组予补肾活血免煎颗粒,对照组和空白组予生理盐水,灌胃1... 目的:观察补肾活血法对子宫内膜异位症(EMs)模型大鼠子宫内膜DNA甲基化的影响。方法:取80只造模成功EMs模型大鼠随机分为治疗组、对照组,另取40只大鼠结扎一侧子宫作为空白组。治疗组予补肾活血免煎颗粒,对照组和空白组予生理盐水,灌胃12周后雌雄2:1合笼,各组妊娠大鼠于妊娠第6天尾静脉采血后处死。测定EMs模型大鼠血清E2、P水平,检测子宫内膜HOAX10蛋白表达,检测子宫内膜HOAX10基因DNA甲基化。结果:治疗组EMs模型大鼠E2、P含量与对照组比较明显增高(P<0.05)。治疗组HOXA10分泌期呈强阳性(3+)表达,与对照组比较有统计学意义(P<0.05)。治疗组治疗后HOXA10甲基化率明显降低,与对照组比较有统计学意义(P<0.05)。结论:补肾活血中药可降低EMs模型大鼠HOXA10异常甲基化率,增加HOXA10蛋白表达。 展开更多
关键词 子宫内膜异位症 DNA甲基化 补肾活血 HOXA10 实验研究
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