Dental stem cells(DSCs)have attracted significant interest as autologous stem cells since they are easily accessible and give a minimal immune response.These properties and their ability to both maintain self-renewal ...Dental stem cells(DSCs)have attracted significant interest as autologous stem cells since they are easily accessible and give a minimal immune response.These properties and their ability to both maintain self-renewal and undergo multi-lineage differentiation establish them as key players in regenerative medicine.While many regulatory factors determine the differentiation trajectory of DSCs,prior research has predominantly been based on genetic,epigenetic,and molecular aspects.Recent evidence suggests that DSC differentiation can also be influenced by autophagy,a highly conserved cellular process responsible for maintaining cellular and tissue homeostasis under various stress conditions.This comprehensive review endeavors to elucidate the intricate regulatory mechanism and relationship between autophagy and DSC differentiation.To achieve this goal,we dissect the intricacies of autophagy and its mechanisms.Subsequently,we elucidate its pivotal roles in impacting DSC differentiation,including osteo/odontogenic,neurogenic,and angiogenic trajectories.Furthermore,we reveal the regulatory factors that govern autophagy in DSC lineage commitment,including scaffold materials,pharmaceutical cues,and the extrinsic milieu.The implications of this review are far-reaching,underpinning the potential to wield autophagy as a regulatory tool to expedite DSC-directed differentiation and thereby promote the application of DSCs within the realm of regenerative medicine.展开更多
Dear Editor,We are writing this letter to report two unusual cases of femtosecond laser-assisted cataract surgery(FLACS)in two ICL-implanted patients with significant different vault.FLACS has been confirmed by accumu...Dear Editor,We are writing this letter to report two unusual cases of femtosecond laser-assisted cataract surgery(FLACS)in two ICL-implanted patients with significant different vault.FLACS has been confirmed by accumulating evidence to improve the safety and precision of surgery from common cases to complicated cases in treating cataracts[1-3].Implantable collamer lens(ICL)implantation possesses a good performance in its predictability,reversibility,and the rapid visual recovery.展开更多
BACKGROUND Complicated crown-root fracture is considered a severe dental trauma and is unlikely to heal without treatment.Usually,dentists have to remove the loose coronal fragment of the fractured tooth and treat the...BACKGROUND Complicated crown-root fracture is considered a severe dental trauma and is unlikely to heal without treatment.Usually,dentists have to remove the loose coronal fragment of the fractured tooth and treat the remaining part with multidisciplinary approaches.However,we observed spontaneous healing of fracture in two pediatric cases with a history of complicated crown-root fractures over 4 years ago.CASE SUMMARY In case 1,a 12-year-old boy complained of pain at tooth 11 following an accidental fall 1 d ago.Clinical examination showed a crack line on the crown of tooth 11.Cone beam computed tomography(CBCT)images of tooth 11 showed signs of hard tissue deposition between the fractured fragments.The patient recalled that tooth 11 had struck the floor 1 year ago without seeking any other treatment.In case 2,a 10-year-old girl fell down 1 d ago and wanted to have her teeth examined.Clinical examination showed a fracture line on the crown of tooth 21.CBCT images of tooth 21 also showed signs of hard tissue deposition between the fractured fragments.She also had a history of dental trauma 1 year ago and her tooth 11 received dental treatment by another dentist.According to her periapical radiograph at that time,tooth 21 was fractured 1 year ago and the fracture was overlooked by her dentist.Both of these two cases showed spontaneous healing of complicated crown-root fractures.After over 4 years of follow-up,both fractured teeth showed no signs of abnormality.CONCLUSION These findings may provide new insights and perspectives on the management and treatment of crown-root fractures in children.展开更多
Dear Editor,We present the reported case of toric implantable collamer lens(ICL)implantation for correcting pseudophakic anisometropia after unilateral traumatic cataract surgery 10 years ago.After cataract surgery,th...Dear Editor,We present the reported case of toric implantable collamer lens(ICL)implantation for correcting pseudophakic anisometropia after unilateral traumatic cataract surgery 10 years ago.After cataract surgery,the normal pattern of eye development is broken.展开更多
基金funded by grants from the National Natural Science Foundation of China(Nos.81771095,82071235)Key R&D Program of Shaanxi Province(2017SF-103,2021KWZ-26,2023-JC-ZD-56)State Key Laboratory of Military Stomatology(2020ZA01).
文摘Dental stem cells(DSCs)have attracted significant interest as autologous stem cells since they are easily accessible and give a minimal immune response.These properties and their ability to both maintain self-renewal and undergo multi-lineage differentiation establish them as key players in regenerative medicine.While many regulatory factors determine the differentiation trajectory of DSCs,prior research has predominantly been based on genetic,epigenetic,and molecular aspects.Recent evidence suggests that DSC differentiation can also be influenced by autophagy,a highly conserved cellular process responsible for maintaining cellular and tissue homeostasis under various stress conditions.This comprehensive review endeavors to elucidate the intricate regulatory mechanism and relationship between autophagy and DSC differentiation.To achieve this goal,we dissect the intricacies of autophagy and its mechanisms.Subsequently,we elucidate its pivotal roles in impacting DSC differentiation,including osteo/odontogenic,neurogenic,and angiogenic trajectories.Furthermore,we reveal the regulatory factors that govern autophagy in DSC lineage commitment,including scaffold materials,pharmaceutical cues,and the extrinsic milieu.The implications of this review are far-reaching,underpinning the potential to wield autophagy as a regulatory tool to expedite DSC-directed differentiation and thereby promote the application of DSCs within the realm of regenerative medicine.
基金Supported by Key Research and Development Program of Shaanxi Province(No.2020SF-271,No.2017SF-273)。
文摘Dear Editor,We are writing this letter to report two unusual cases of femtosecond laser-assisted cataract surgery(FLACS)in two ICL-implanted patients with significant different vault.FLACS has been confirmed by accumulating evidence to improve the safety and precision of surgery from common cases to complicated cases in treating cataracts[1-3].Implantable collamer lens(ICL)implantation possesses a good performance in its predictability,reversibility,and the rapid visual recovery.
基金Supported by National Natural Science Foundation of China,No.81771095Shaanxi Provincial Key R&D Program,China,No.2021KWZ-26State Key Laboratory of Military Stomatology,No.2020ZA01。
文摘BACKGROUND Complicated crown-root fracture is considered a severe dental trauma and is unlikely to heal without treatment.Usually,dentists have to remove the loose coronal fragment of the fractured tooth and treat the remaining part with multidisciplinary approaches.However,we observed spontaneous healing of fracture in two pediatric cases with a history of complicated crown-root fractures over 4 years ago.CASE SUMMARY In case 1,a 12-year-old boy complained of pain at tooth 11 following an accidental fall 1 d ago.Clinical examination showed a crack line on the crown of tooth 11.Cone beam computed tomography(CBCT)images of tooth 11 showed signs of hard tissue deposition between the fractured fragments.The patient recalled that tooth 11 had struck the floor 1 year ago without seeking any other treatment.In case 2,a 10-year-old girl fell down 1 d ago and wanted to have her teeth examined.Clinical examination showed a fracture line on the crown of tooth 21.CBCT images of tooth 21 also showed signs of hard tissue deposition between the fractured fragments.She also had a history of dental trauma 1 year ago and her tooth 11 received dental treatment by another dentist.According to her periapical radiograph at that time,tooth 21 was fractured 1 year ago and the fracture was overlooked by her dentist.Both of these two cases showed spontaneous healing of complicated crown-root fractures.After over 4 years of follow-up,both fractured teeth showed no signs of abnormality.CONCLUSION These findings may provide new insights and perspectives on the management and treatment of crown-root fractures in children.
文摘Dear Editor,We present the reported case of toric implantable collamer lens(ICL)implantation for correcting pseudophakic anisometropia after unilateral traumatic cataract surgery 10 years ago.After cataract surgery,the normal pattern of eye development is broken.
