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Poly(ADP-ribosyl)ation of Apoptosis Antagonizing Transcription Factor Involved in Hydroquinone-Induced DNA Damage Response 被引量:6
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作者 ling xiao xuan liu jia xian +5 位作者 yun lin du yu jun chen shao qian chen jia long tang huan wen liu lin hua 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2016年第1期80-84,共5页
The molecular mechanism of DNA damage induced by hydroquinone (HQ) remains unclear. Poly(ADP-ribose) polymerase-1 (PARP-1) usually works as a DNA damage sensor, and hence, it is possible that PARP-1 is involved ... The molecular mechanism of DNA damage induced by hydroquinone (HQ) remains unclear. Poly(ADP-ribose) polymerase-1 (PARP-1) usually works as a DNA damage sensor, and hence, it is possible that PARP-1 is involved in the DNA damage response induced by HQ. In TK6 cells treated with HQ, PARP activity as well as the expression of apoptosis antagonizing transcription factor (AATF), PARP-1, and phosphorylated H2AX (v-H2AX) were maximum at 0.5 h, 6 h, 3 h, and 3 h, respectively. To explore the detailed mechanisms underlying the prompt DNA repair reaction, the above indicators were investigated in PARP-l-silenced cells. PARP activity and expression of AATF and PARP-1 decreased to 36%, 32%, and 33%, respectively, in the cells; however, y-H2AX expression increased to 265%. Co-immunoprecipitation (co-IP) assays were employed to determine whether PARP-1 and AATF formed protein complexes. The interaction between these proteins together with the results from IP assays and confocal microscopy indicated that poly(ADP-ribosyl)ation {PARylation) regulated AATF expression, in conclusion, PARP-1 was involved in the DNA damage repair induced by HQ via increasing the accumulation of AATF through PARylation. 展开更多
关键词 PARP DNA DDR Figure ADP-ribosyl)ation of Apoptosis Antagonizing Transcription Factor Involved in Hydroquinone-Induced DNA Damage Response
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LncRNA LUCAT1 Activation Mediated by theDown-regulation of DNMT1 Is Involved inCell Apoptosis Induced by PM2.5 被引量:2
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作者 LING Xiao Xuan ZHANG Hai Qiao +6 位作者 liu jia xian liu Zhi Dong PENG jian Ming ZHANG Xiao Qing SHAO Jun Li CHEN Zhen Fa liu Lin Hua 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2018年第8期608-612,共5页
Particulate matter (PM), which is a great environmental concern, has been classified as a Group 1 human carcinogen by the International Agency for Research on Cancer (IARC);.Epidemiological and experimental studie... Particulate matter (PM), which is a great environmental concern, has been classified as a Group 1 human carcinogen by the International Agency for Research on Cancer (IARC);.Epidemiological and experimental studies have indicated that chronic exposure to PM, especially PM;(particles with an aerodynamic diameter less than 展开更多
关键词 PBS RNA LncRNA LUCAT1 Activation Mediated by the Down-regulation of DNMT1 Is Involved in Cell Apoptosis Induced by PM Figure
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一起由诺如病毒GⅠ.5型引起胃肠炎聚集性疫情的分子流行病学分析 被引量:2
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作者 许少坚 任燕 +10 位作者 陈宏标 赖晓玲 张海龙 罗经伟 满云翔 郝夏琼 李锦宗 刘佳娴 全德甫 曹赫 林启辉 《热带医学杂志》 CAS 2019年第12期1575-1577,共3页
目的对2018年深圳市龙华区发生的一起由诺如病毒GⅠ.5型引起的胃肠炎聚集性疫情进行分子流行病分析。方法对诺如病毒GⅠ组核酸阳性的样本进行聚合酶-衣壳区序列测定,同源性和系统进化分析。结果成功获得3份样本的聚合酶-衣壳区序列,样... 目的对2018年深圳市龙华区发生的一起由诺如病毒GⅠ.5型引起的胃肠炎聚集性疫情进行分子流行病分析。方法对诺如病毒GⅠ组核酸阳性的样本进行聚合酶-衣壳区序列测定,同源性和系统进化分析。结果成功获得3份样本的聚合酶-衣壳区序列,样本编号分别为18JB00186、18JB00187和18JB00190,长度552 bp,核苷酸和氨基酸的同源性为100%,与2018年成都分离株MK121731.1同源性最高,相似度(Per.Ident)99.07%。衣壳区的系统发生树构建分析结果显示,它们属于GⅠ.5进化分支,与2013年济南、2014年上海和2018年成都的部分分离株同属于一个进化分支,为GⅠ.5.1分支。聚合酶区的系统发生树构建分析结果显示,它们属于GⅠ.P4进化分支。结论应进一步加强辖区诺如病毒不同型别监测,持续关注不常见型别进化情况。 展开更多
关键词 诺如病毒 聚集性疫情 系统进化
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