目的基于网状Meta分析系统评价中药注射液辅助治疗血管性痴呆的效果。方法计算机检索PubMed、Web of Science、Cochrane Library、中国知网(CNKI)、万方数据库(Wanfang)、中国生物医学文献数据库(CBM)、维普数据库(VIP)等数据库中有关...目的基于网状Meta分析系统评价中药注射液辅助治疗血管性痴呆的效果。方法计算机检索PubMed、Web of Science、Cochrane Library、中国知网(CNKI)、万方数据库(Wanfang)、中国生物医学文献数据库(CBM)、维普数据库(VIP)等数据库中有关中药注射液辅助治疗血管性痴呆的临床随机对照试验(RCT),检索时限为各数据库建库到2021年12月。用Cochrane偏倚风险评估工具对所纳入的研究进行质量评价,应用Stata16.0软件进行Meta网状分析。结果最终纳入46个RCTs,涉及6种中药注射液。网状Meta分析结果显示:(1)改善总有效率方面:中药注射液疗效排序依次为西医常规治疗联合复方丹参注射液>醒脑静注射液>舒血宁注射液>银杏达莫注射液>疏血通注射液>丹红注射液>西医常规治疗;(2)在MMSE评分方面:中药注射液疗效排序依次为西医常规治疗联合复方丹参注射液>醒脑静注射液>银杏达莫注射液>舒血宁注射液>丹红注射液>疏血通注射液>西医常规治疗;(3)在ADL评分方面:中药注射液疗效排序依次为西医常规治疗联合疏血通注射液>醒脑静注射液>复方丹参注射液>银杏达莫注射液>舒血宁注射液>丹红注射液>西医常规治疗。结论中药注射液辅助西医治疗对血管性痴呆的治疗均显示出优势。其中复方丹参注射液在有效率、MMSE评分改善方面,疏血通注射液在ADL评分改善方面,称为最佳选择的可能性最大。展开更多
Based on the data of field outcrops,drilling cores,casting thin sections,well logging interpretation,oil/gas shows during drilling,and oil/gas testing results,and combined with modern salt-lake sediments in the Qingha...Based on the data of field outcrops,drilling cores,casting thin sections,well logging interpretation,oil/gas shows during drilling,and oil/gas testing results,and combined with modern salt-lake sediments in the Qinghai Lake,the Neogene saline lake beach-bars in southwestern Qaidam Basin are studied from the perspective of sedimentary characteristics,development patterns,sand control factors,and hydrocarbon accumulation characteristics.Beach-bar sand bodies are widely developed in the Neogene saline lake basin,and they are lithologically fine sandstone and siltstone,with wavy bedding,low-angle cross bedding,and lenticular-vein bedding.In view of spatial-temporal distribution,the beach-bar sand bodies are stacked in multiple stages vertically,migratory laterally,and extensive and continuous in NW-SE trending pattern in the plane.The stacking area of the Neogene beach-bar sandstone is predicted to be 3000 km^(2).The water salinity affects the sedimentation rate and offshore distance of beach-bar sandstone,and the debris input from the source area affects the scale and enrichment of beach-bar sandstone.The ancient landform controls the morphology and stacking style of beach-bar sandstone,and the northwest monsoon driving effect controls the long-axis extension direction of beach-bar sandstone.The beach-bars have a reservoir-forming feature of“one reservoir in one sand body”,with thick beach-bar sand bodies controlling the effective reservoir distribution and oil-source faults controlling the oil/gas migration and accumulation direction.Three favorable exploration target zones in Zhahaquan,Yingdong-eastern Wunan and Huatugou areas are proposed based on the analysis of reservoir-forming elements.展开更多
文摘目的基于网状Meta分析系统评价中药注射液辅助治疗血管性痴呆的效果。方法计算机检索PubMed、Web of Science、Cochrane Library、中国知网(CNKI)、万方数据库(Wanfang)、中国生物医学文献数据库(CBM)、维普数据库(VIP)等数据库中有关中药注射液辅助治疗血管性痴呆的临床随机对照试验(RCT),检索时限为各数据库建库到2021年12月。用Cochrane偏倚风险评估工具对所纳入的研究进行质量评价,应用Stata16.0软件进行Meta网状分析。结果最终纳入46个RCTs,涉及6种中药注射液。网状Meta分析结果显示:(1)改善总有效率方面:中药注射液疗效排序依次为西医常规治疗联合复方丹参注射液>醒脑静注射液>舒血宁注射液>银杏达莫注射液>疏血通注射液>丹红注射液>西医常规治疗;(2)在MMSE评分方面:中药注射液疗效排序依次为西医常规治疗联合复方丹参注射液>醒脑静注射液>银杏达莫注射液>舒血宁注射液>丹红注射液>疏血通注射液>西医常规治疗;(3)在ADL评分方面:中药注射液疗效排序依次为西医常规治疗联合疏血通注射液>醒脑静注射液>复方丹参注射液>银杏达莫注射液>舒血宁注射液>丹红注射液>西医常规治疗。结论中药注射液辅助西医治疗对血管性痴呆的治疗均显示出优势。其中复方丹参注射液在有效率、MMSE评分改善方面,疏血通注射液在ADL评分改善方面,称为最佳选择的可能性最大。
基金Supported by the PetroChina Science and Technology Project (2021DJ0402,2021DJ0202)。
文摘Based on the data of field outcrops,drilling cores,casting thin sections,well logging interpretation,oil/gas shows during drilling,and oil/gas testing results,and combined with modern salt-lake sediments in the Qinghai Lake,the Neogene saline lake beach-bars in southwestern Qaidam Basin are studied from the perspective of sedimentary characteristics,development patterns,sand control factors,and hydrocarbon accumulation characteristics.Beach-bar sand bodies are widely developed in the Neogene saline lake basin,and they are lithologically fine sandstone and siltstone,with wavy bedding,low-angle cross bedding,and lenticular-vein bedding.In view of spatial-temporal distribution,the beach-bar sand bodies are stacked in multiple stages vertically,migratory laterally,and extensive and continuous in NW-SE trending pattern in the plane.The stacking area of the Neogene beach-bar sandstone is predicted to be 3000 km^(2).The water salinity affects the sedimentation rate and offshore distance of beach-bar sandstone,and the debris input from the source area affects the scale and enrichment of beach-bar sandstone.The ancient landform controls the morphology and stacking style of beach-bar sandstone,and the northwest monsoon driving effect controls the long-axis extension direction of beach-bar sandstone.The beach-bars have a reservoir-forming feature of“one reservoir in one sand body”,with thick beach-bar sand bodies controlling the effective reservoir distribution and oil-source faults controlling the oil/gas migration and accumulation direction.Three favorable exploration target zones in Zhahaquan,Yingdong-eastern Wunan and Huatugou areas are proposed based on the analysis of reservoir-forming elements.
