The work is dedicated to develop a one-step eco-friendly method to prepare antibacterial polyethylene terephthalate(PET).We report a one-step eco-friendly method to manufacture antibacterial PET via on-line amination ...The work is dedicated to develop a one-step eco-friendly method to prepare antibacterial polyethylene terephthalate(PET).We report a one-step eco-friendly method to manufacture antibacterial PET via on-line amination reaction by melt coextrusion.Beside evenly mixing of poly(hexamethylene guanidine)(PHMG)and PET in the melt coextrusion procedure,the amination reaction also occurred between PHMG and PET under high temperature(230-270℃).The antibacterial ability of composite PET showed obvious PHMG concentration dependence,and antibacterial activity reached more than 99%when PHMG content was 2.5 wt%.Moreover,LIVE/DEAD fluorescence test further confirmed that the composite PET could kill bacteria quickly and efiectively(within 30 min);while negligible cytotoxicity was observed to HSF and HUVEC cells.Onestep eco-friendly fabrication of composite antibacterial PET was accomplished by on-line melt coextrusion.The composite antibacterial PET has potential use in multiple fields to combat with pathogenic including textiles,packaging materials,decoration materials and biomedical devices,etc.展开更多
Hollow silica nanospheres with radical pore on the surfaces were prepared using the assemblies of valine amphiphilic small molecule and benzene as double-templates through sol-gel method in tetramethylammonium hydroxi...Hollow silica nanospheres with radical pore on the surfaces were prepared using the assemblies of valine amphiphilic small molecule and benzene as double-templates through sol-gel method in tetramethylammonium hydroxide(25wt%)solution at the stirring rate of 1000 rpm.There are a lot of vertical pores on the surfaces of the hollow spheres after removing the templates in Muffle furnace at 550℃for 5 h.The sample was characterized using field-emission scanning electron microscopy,transmission electron microscopy,Brunauer-Emmett-Teller(BET),X-ray diffraction,etc.The diameter,the vertical pore size of the nanospheres and the BET surface areas are 30-100 nm,4.2 nm,and 570.5 m2/g,respectively.Because the high porosity and specific surface area,this kind of hollow sphere is the excellent antimicrobial carrier.The antibacterial activities of the silica nanospheres were evaluated by using a bacterial growth inhibitory assay.The experimental results show that the silica hollow spheres loaded with Ag+have a good bactericidal effect.展开更多
Fibrous biomaterials are widely used in the design and fabrication of antibacterial wound dressings.Two strategies are used to make anti-infective dressings:antibacterial and probiotic therapies,which have potential b...Fibrous biomaterials are widely used in the design and fabrication of antibacterial wound dressings.Two strategies are used to make anti-infective dressings:antibacterial and probiotic therapies,which have potential biotoxicity and other side-effects.Herein,we report a new strategy for fabricating wound dressings to combat infection.Poly(4-methyl-1-pentene)(PMP) fabric can remove bacteria from infectious wounds through dressing changes based on its efficient bacterial adhesion.The maximum adhered count of S.aureus and E.coli on the PMP fabric was 1.63 × 106CFU/cm~2 and 4.77 × 105CFU/cm~2,respectively.In addition,the PMP fabric could inhibit the twitching motility of bacteria,which is beneficial for inhibiting infection.The ability of the PMP fabric to accelerate wound healing was demonstrated in vivo in a rat wound model.After treatment with the PMP fabric dressing,pathogenic bacteria in the wound were removed through dressing change;therefore,the wound exhibited better healing speed than when the commercial dressing was used.The low bacterial concentration effectively stimulated the expression of growth factors and suppressed wound inflammation,thereby accelerating wound healing.PMP fabric has three advantages:(1) it has been approved for use in clinical treatment by the Food and Drug Administration;(2) no antibacterial agent or probiotics were used;(3) the fabric could be manufactured through an industrial production process.These results indicate that the new strategy can be used in the design of new-generation wound dressings for antibacterial applications.展开更多
基金Funded by the National Natural Science Foundation of China(No.51703169)Key Program of Science and Technology of Jieyang City(No.2019016)Key Research and Development Program of Shandong Province of China(No.2019JZZY010338)。
文摘The work is dedicated to develop a one-step eco-friendly method to prepare antibacterial polyethylene terephthalate(PET).We report a one-step eco-friendly method to manufacture antibacterial PET via on-line amination reaction by melt coextrusion.Beside evenly mixing of poly(hexamethylene guanidine)(PHMG)and PET in the melt coextrusion procedure,the amination reaction also occurred between PHMG and PET under high temperature(230-270℃).The antibacterial ability of composite PET showed obvious PHMG concentration dependence,and antibacterial activity reached more than 99%when PHMG content was 2.5 wt%.Moreover,LIVE/DEAD fluorescence test further confirmed that the composite PET could kill bacteria quickly and efiectively(within 30 min);while negligible cytotoxicity was observed to HSF and HUVEC cells.Onestep eco-friendly fabrication of composite antibacterial PET was accomplished by on-line melt coextrusion.The composite antibacterial PET has potential use in multiple fields to combat with pathogenic including textiles,packaging materials,decoration materials and biomedical devices,etc.
基金Funded by the Opening Funding of the Provincial and Ministerial Joint Construction of the State Key Laboratory of New Textile Materials and Advanced Processing Technology(No.FZ2020003)the National Natural Science Foundation of China(Nos.51603155 and 51703169)。
文摘Hollow silica nanospheres with radical pore on the surfaces were prepared using the assemblies of valine amphiphilic small molecule and benzene as double-templates through sol-gel method in tetramethylammonium hydroxide(25wt%)solution at the stirring rate of 1000 rpm.There are a lot of vertical pores on the surfaces of the hollow spheres after removing the templates in Muffle furnace at 550℃for 5 h.The sample was characterized using field-emission scanning electron microscopy,transmission electron microscopy,Brunauer-Emmett-Teller(BET),X-ray diffraction,etc.The diameter,the vertical pore size of the nanospheres and the BET surface areas are 30-100 nm,4.2 nm,and 570.5 m2/g,respectively.Because the high porosity and specific surface area,this kind of hollow sphere is the excellent antimicrobial carrier.The antibacterial activities of the silica nanospheres were evaluated by using a bacterial growth inhibitory assay.The experimental results show that the silica hollow spheres loaded with Ag+have a good bactericidal effect.
基金supported by the National Natural Science Foundation of China (Grant No.51703169)。
文摘Fibrous biomaterials are widely used in the design and fabrication of antibacterial wound dressings.Two strategies are used to make anti-infective dressings:antibacterial and probiotic therapies,which have potential biotoxicity and other side-effects.Herein,we report a new strategy for fabricating wound dressings to combat infection.Poly(4-methyl-1-pentene)(PMP) fabric can remove bacteria from infectious wounds through dressing changes based on its efficient bacterial adhesion.The maximum adhered count of S.aureus and E.coli on the PMP fabric was 1.63 × 106CFU/cm~2 and 4.77 × 105CFU/cm~2,respectively.In addition,the PMP fabric could inhibit the twitching motility of bacteria,which is beneficial for inhibiting infection.The ability of the PMP fabric to accelerate wound healing was demonstrated in vivo in a rat wound model.After treatment with the PMP fabric dressing,pathogenic bacteria in the wound were removed through dressing change;therefore,the wound exhibited better healing speed than when the commercial dressing was used.The low bacterial concentration effectively stimulated the expression of growth factors and suppressed wound inflammation,thereby accelerating wound healing.PMP fabric has three advantages:(1) it has been approved for use in clinical treatment by the Food and Drug Administration;(2) no antibacterial agent or probiotics were used;(3) the fabric could be manufactured through an industrial production process.These results indicate that the new strategy can be used in the design of new-generation wound dressings for antibacterial applications.
