目的采用meta分析咀嚼功能与认知能力下降风险的关系。方法检索PubMed、Embase、The Cochrane Library、Web of Science、CINAHL、中国知识资源综合数据库、万方医学网、维普资讯中文期刊服务平台、中国生物医学文献服务系统等数据库中...目的采用meta分析咀嚼功能与认知能力下降风险的关系。方法检索PubMed、Embase、The Cochrane Library、Web of Science、CINAHL、中国知识资源综合数据库、万方医学网、维普资讯中文期刊服务平台、中国生物医学文献服务系统等数据库中咀嚼功能与认知能力下降风险相关性的文献。使用StataSE15.0软件进行meta分析。结果最终纳入11项研究,包括8项横断面研究和3项病例对照研究,共66108例参与者。咀嚼功能与认知能力下降或痴呆的发生风险存在相关性(优势比=0.52,95%可信区间0.22~0.82)。样本量小于或等于1000例,以及不同研究地区、发表年份、研究类型中咀嚼功能与认知能力下降或痴呆风险均存在相关性。结论咀嚼功能与认知能力存在相关性,良好的咀嚼功能是认知能力下降的保护因素。应继续进行大样本纵向研究,以进一步阐明可能的因果关系。展开更多
BACKGROUND:Remimazolam is a novel ultra-short-acting sedative,but its safety and adverse events(AEs)in high-risk patients in the intensive care unit(ICU)setting remain unknown.METHODS:This was a single-center,retrospe...BACKGROUND:Remimazolam is a novel ultra-short-acting sedative,but its safety and adverse events(AEs)in high-risk patients in the intensive care unit(ICU)setting remain unknown.METHODS:This was a single-center,retrospective study that compared remimazolam to propofol and midazolam in patients undergoing upper gastrointestinal endoscopy.The primary outcome was the incidence of treatment-related AEs.The secondary outcomes were the time to extubation,the length of ICU stay,and the average cost of sedative per case.RESULTS:Of the 88 patients analyzed,47 were treated with remimazolam(mean dose,7.90±4.84mg),and 41 were treated with propofol(21.19±17.98 mg)or midazolam(3.08±2.17 mg).There was no statistically significant difference in the average duration of the endoscopic procedure(35.89±13.37 min vs.44.51±21.68 min,P=0.133)or the time to extubation(15.00±9.75 h vs.20.59±18.71 h,P=0.211)in the remimazolam group(group I)compared to the propofol or midazolam group(group II).ICU stays(5.40±2.93 d vs.4.63±3.31 d,P=0.072)and treatment-related AEs(48.61%vs.51.38%,P=0.056)were similar between groups.The average cost of sedative per case was significantly lower in the group I than in the group II(RMB 16.07±10.58 yuan vs.RMB 24.37±15.46 yuan,P=0.016).CONCLUSION:Remimazolam-based sedation was noninferior to the classic sedatives and had lower average cost per case,indicating that it may be used as a promising sedative for high-risk patients during endoscopic procedures in the ICU setting.展开更多
Software-Defined Networking(SDN)adapts logically-centralized control by decoupling control plane from data plane and provides the efficient use of network resources.However,due to the limitation of traditional routing...Software-Defined Networking(SDN)adapts logically-centralized control by decoupling control plane from data plane and provides the efficient use of network resources.However,due to the limitation of traditional routing strategies relying on manual configuration,SDN may suffer from link congestion and inefficient bandwidth allocation among flows,which could degrade network performance significantly.In this paper,we propose EARS,an intelligence-driven experiential network architecture for automatic routing.EARS adapts deep reinforcement learning(DRL)to simulate the human methods of learning experiential knowledge,employs the closed-loop network control mechanism incorporating with network monitoring technologies to realize the interaction with network environment.The proposed EARS can learn to make better control decision from its own experience by interacting with network environment and optimize the network intelligently by adjusting services and resources offered based on network requirements and environmental conditions.Under the network architecture,we design the network utility function with throughput and delay awareness,differentiate flows based on their size characteristics,and design a DDPGbased automatic routing algorithm as DRL decision brain to find the near-optimal paths for mice and elephant flows.To validate the network architecture,we implement it on a real network environment.Extensive simulation results show that EARS significantly improve the network throughput and reduces the average packet delay in comparison with baseline schemes(e.g.OSPF,ECMP).展开更多
AIM:To evaluate a novel biosensor-based microarray(BBM) assay for detecting rs12979860 and rs8099917 genotypes.METHODS:Four probes specific for rs8099917C/T or rs12979860G/T detection and three sets of quality control...AIM:To evaluate a novel biosensor-based microarray(BBM) assay for detecting rs12979860 and rs8099917 genotypes.METHODS:Four probes specific for rs8099917C/T or rs12979860G/T detection and three sets of quality control probes were designed,constructed and arrayed on an optical biosensor to develop a microarray assay.Two sets of primers were used in a one tube polymerase chain reaction(PCR) system to amplify two target fragments simultaneously.The biosensor microarray contained probes that had been sequenced to confirm that they included the rs8099917C/T or rs12979860G/T alleles of interest and could serve as the specific assay standards.In addition to rehybridization of four probes of known sequence,a total of 40 clinical samples collected from hepatitis C seropositive patients were also tested.The target fragments of all 40 samples were amplified in a 50 μL PCR system.Ten μL of each amplicon was tested by BBM assay,and another 40 μL was used for sequencing.The agreement of the results obtained by the two methods was tested statistically using the kappa coefficient.The sensitivity of the BBM assay was evaluated using serial dilutions of ten clinical blood samples containing 10 3-10 4 white cells/μL.RESULTS:As shown by polyacrylamide gel electrophoresis,two target segments of the interleukin 28Bassociated polymorphisms(SNPs) were successfully amplified in the one-tube PCR system.The lengths of the two amplified fragments were consistent with the known length of the target sequences,137 and 159 bps.After hybridization of the PCR amplicons with the probes located on the BBM array,the signals of each allele of both the rs8099917 SNPs and rs12979860 SNPs were observed simultaneously and were clearly visible by the unaided eye.The signals were distinct from each other,could be interpreted visually,and accurately recorded using an ordinary digital camera.To evaluate the specificity of the assay,both the plasmids and clinical samples were applied to the microarray.First,30 PCR amplicons of the various SNP alleles were hybridized on the BBM microarray.Full agreement between plasmids and the BBM assay was observed,with 30/30 correct matches(100%).The kappa value for the BBM assay with plasmids was 1.00(P < 0.05).For the 40 clinical blood samples,the BBM assay hybridization and direct sequencing results were compared for each amplicon.For patient blood samples,agreement was 28/28 for rs8099917T/T,9/11 for rs8099917T/G,1/1 for rs8099917G/G,24/24 for rs12979860C/C,11/14 for rs12979860C/T,and 2/2 for rs12979860T/T.Only five clinical samples of amplicon assay and direct sequencing results were discordant and heterozygotes:2/11 rs8099917T/G and 3/14 rs12979860C/T.The agreement of outcomes between BBM assay and direct sequencing for the detection of rs8099917 and rs12979860 was 95% and 92.5%,respectively;and the corresponding kappa values were 0.88 and 0.85(A kappa value > 0.75 was defined as substantial agreement).The BBM assay and sequencing had similar specificities for detection and identification of the two SNPs and their alleles.The sensitivity evaluation showed that the BBM assay could detect and identify SNP sequences present in blood samples containing as few as 10 2 white blood cells/μL.CONCLUSION:This biosensor microarray assay was highly specific,sensitive,rapid and easy to perform.It is compatible with clinical practice for detection of rs8099917 and rs12979860.展开更多
The 3D orthogonal woven basalt fiber reinforced polyimide (PI) composites were fabricated and characterized in this study. The PI film was firstly prepared to determine PI processing parameters. Fourier transform infr...The 3D orthogonal woven basalt fiber reinforced polyimide (PI) composites were fabricated and characterized in this study. The PI film was firstly prepared to determine PI processing parameters. Fourier transform infrared (FTIR) analysis showed that 300°C was the suitable imidization temperature. Thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC) results showed relatively good thermal properties of the PI film. In the fabrication of composites, the multi-step impregnation method was applied. The bending properties of 3 mm-thick composite showed increasing trend in all and the second-time impregnated composite had much higher value than the first-time impregnated composite. Moreover, the bending fracture mode photos showed obvious creases except for the first-time impregnated materials, which agreed well with the bending property values. The dielectric constants for the composites were complex because they had not regular value following the mixing rule of the composites, which was mainly due to the interfacial polarization and other effects in the fabrication processing.展开更多
We studied relations between natural seedling reproduction and above ground environment in a longleaf pine ecosystem. Forty-eight 0.05 ha circular plots were sampled under single-tree selection, group-tree selection a...We studied relations between natural seedling reproduction and above ground environment in a longleaf pine ecosystem. Forty-eight 0.05 ha circular plots were sampled under single-tree selection, group-tree selection and control stands in three main longleaf pine areas in south Alabama, USA. We measured six above-ground environment factors, viz. canopy closure, stand density, basal area, average tree height, understory cover and PAR under canopy. We employed forward, back-ward and stepwise selection regression to produce one model. Three main variables：canopy closure, stand density and basal area, were left in the model; light, PAR and understory cover were not incorporated into the model at the 0.10 significance level. Basal area was a positive pa-rameter, while canopy closure and stand density were negative parame-ters. Canopy closure was the main parameter in the model. The model proved to be meaningful, and has potential to provide useful guidance for future work.展开更多
Reproductive health（RH） education and services of female migrants in China have become an important health issue.This research aimed to investigate the RH knowledge and utilization among married female migrants,and ...Reproductive health（RH） education and services of female migrants in China have become an important health issue.This research aimed to investigate the RH knowledge and utilization among married female migrants,and to explore the influencing factors from the perspectives of population and sociology.We conducted a cross-section survey in Shenzhen and Wuhan,China,using the purposive sampling method.A total of 1021 rural-to-urban married migrants were recruited,with 997 valid survey results obtained.A face-to-face structured questionnaire survey was used,with primary focus on knowledge of fertility,contraception,family planning policy and sexual transmitted diseases/acquired immunodeficiency syndrome（STD/AIDs）,and RH service utilization.The results showed that the RH service utilization（38.0%） was at a low level in married migrants and the accessibility of RH service was poor.Females who migrated to（OR=0.32） Wuhan obtained fewer RH consultations than those in Shenzhen.The workers with high school education received additional RH consultations and checkup services than those with other background education,apart from the white collar workers who received extra RH consultations and checkup services than the blue collar workers（P〈0.05）.We can draw a conclusion that the utilization of RH services in married female migrants remains at a low level in China.RH service utilization can be improved via the relevant health departments by enhancing the responsibility of maternal and health care in the community health service center.展开更多
Firstly,the behavior of marine science and technology talents,such as scientific research,innovation,agglomeration and flow behavior,was analyzed,and then the problems in the training of marine science and technology ...Firstly,the behavior of marine science and technology talents,such as scientific research,innovation,agglomeration and flow behavior,was analyzed,and then the problems in the training of marine science and technology talents were discussed.Finally,the training ways of marine science and technology talents were proposed.展开更多
文摘目的采用meta分析咀嚼功能与认知能力下降风险的关系。方法检索PubMed、Embase、The Cochrane Library、Web of Science、CINAHL、中国知识资源综合数据库、万方医学网、维普资讯中文期刊服务平台、中国生物医学文献服务系统等数据库中咀嚼功能与认知能力下降风险相关性的文献。使用StataSE15.0软件进行meta分析。结果最终纳入11项研究,包括8项横断面研究和3项病例对照研究,共66108例参与者。咀嚼功能与认知能力下降或痴呆的发生风险存在相关性(优势比=0.52,95%可信区间0.22~0.82)。样本量小于或等于1000例,以及不同研究地区、发表年份、研究类型中咀嚼功能与认知能力下降或痴呆风险均存在相关性。结论咀嚼功能与认知能力存在相关性,良好的咀嚼功能是认知能力下降的保护因素。应继续进行大样本纵向研究,以进一步阐明可能的因果关系。
基金supported by China International Medical Foundation(Z-2017-24-2028-33)。
文摘BACKGROUND:Remimazolam is a novel ultra-short-acting sedative,but its safety and adverse events(AEs)in high-risk patients in the intensive care unit(ICU)setting remain unknown.METHODS:This was a single-center,retrospective study that compared remimazolam to propofol and midazolam in patients undergoing upper gastrointestinal endoscopy.The primary outcome was the incidence of treatment-related AEs.The secondary outcomes were the time to extubation,the length of ICU stay,and the average cost of sedative per case.RESULTS:Of the 88 patients analyzed,47 were treated with remimazolam(mean dose,7.90±4.84mg),and 41 were treated with propofol(21.19±17.98 mg)or midazolam(3.08±2.17 mg).There was no statistically significant difference in the average duration of the endoscopic procedure(35.89±13.37 min vs.44.51±21.68 min,P=0.133)or the time to extubation(15.00±9.75 h vs.20.59±18.71 h,P=0.211)in the remimazolam group(group I)compared to the propofol or midazolam group(group II).ICU stays(5.40±2.93 d vs.4.63±3.31 d,P=0.072)and treatment-related AEs(48.61%vs.51.38%,P=0.056)were similar between groups.The average cost of sedative per case was significantly lower in the group I than in the group II(RMB 16.07±10.58 yuan vs.RMB 24.37±15.46 yuan,P=0.016).CONCLUSION:Remimazolam-based sedation was noninferior to the classic sedatives and had lower average cost per case,indicating that it may be used as a promising sedative for high-risk patients during endoscopic procedures in the ICU setting.
基金supported by the National Natural Science Foundation of China for Innovative Research Groups (61521003)the National Natural Science Foundation of China (61872382)+1 种基金the National Key Research and Development Program of China (2017YFB0803204)the Research and Development Program in Key Areas of Guangdong Province (No.2018B010113001)
文摘Software-Defined Networking(SDN)adapts logically-centralized control by decoupling control plane from data plane and provides the efficient use of network resources.However,due to the limitation of traditional routing strategies relying on manual configuration,SDN may suffer from link congestion and inefficient bandwidth allocation among flows,which could degrade network performance significantly.In this paper,we propose EARS,an intelligence-driven experiential network architecture for automatic routing.EARS adapts deep reinforcement learning(DRL)to simulate the human methods of learning experiential knowledge,employs the closed-loop network control mechanism incorporating with network monitoring technologies to realize the interaction with network environment.The proposed EARS can learn to make better control decision from its own experience by interacting with network environment and optimize the network intelligently by adjusting services and resources offered based on network requirements and environmental conditions.Under the network architecture,we design the network utility function with throughput and delay awareness,differentiate flows based on their size characteristics,and design a DDPGbased automatic routing algorithm as DRL decision brain to find the near-optimal paths for mice and elephant flows.To validate the network architecture,we implement it on a real network environment.Extensive simulation results show that EARS significantly improve the network throughput and reduces the average packet delay in comparison with baseline schemes(e.g.OSPF,ECMP).
文摘AIM:To evaluate a novel biosensor-based microarray(BBM) assay for detecting rs12979860 and rs8099917 genotypes.METHODS:Four probes specific for rs8099917C/T or rs12979860G/T detection and three sets of quality control probes were designed,constructed and arrayed on an optical biosensor to develop a microarray assay.Two sets of primers were used in a one tube polymerase chain reaction(PCR) system to amplify two target fragments simultaneously.The biosensor microarray contained probes that had been sequenced to confirm that they included the rs8099917C/T or rs12979860G/T alleles of interest and could serve as the specific assay standards.In addition to rehybridization of four probes of known sequence,a total of 40 clinical samples collected from hepatitis C seropositive patients were also tested.The target fragments of all 40 samples were amplified in a 50 μL PCR system.Ten μL of each amplicon was tested by BBM assay,and another 40 μL was used for sequencing.The agreement of the results obtained by the two methods was tested statistically using the kappa coefficient.The sensitivity of the BBM assay was evaluated using serial dilutions of ten clinical blood samples containing 10 3-10 4 white cells/μL.RESULTS:As shown by polyacrylamide gel electrophoresis,two target segments of the interleukin 28Bassociated polymorphisms(SNPs) were successfully amplified in the one-tube PCR system.The lengths of the two amplified fragments were consistent with the known length of the target sequences,137 and 159 bps.After hybridization of the PCR amplicons with the probes located on the BBM array,the signals of each allele of both the rs8099917 SNPs and rs12979860 SNPs were observed simultaneously and were clearly visible by the unaided eye.The signals were distinct from each other,could be interpreted visually,and accurately recorded using an ordinary digital camera.To evaluate the specificity of the assay,both the plasmids and clinical samples were applied to the microarray.First,30 PCR amplicons of the various SNP alleles were hybridized on the BBM microarray.Full agreement between plasmids and the BBM assay was observed,with 30/30 correct matches(100%).The kappa value for the BBM assay with plasmids was 1.00(P < 0.05).For the 40 clinical blood samples,the BBM assay hybridization and direct sequencing results were compared for each amplicon.For patient blood samples,agreement was 28/28 for rs8099917T/T,9/11 for rs8099917T/G,1/1 for rs8099917G/G,24/24 for rs12979860C/C,11/14 for rs12979860C/T,and 2/2 for rs12979860T/T.Only five clinical samples of amplicon assay and direct sequencing results were discordant and heterozygotes:2/11 rs8099917T/G and 3/14 rs12979860C/T.The agreement of outcomes between BBM assay and direct sequencing for the detection of rs8099917 and rs12979860 was 95% and 92.5%,respectively;and the corresponding kappa values were 0.88 and 0.85(A kappa value > 0.75 was defined as substantial agreement).The BBM assay and sequencing had similar specificities for detection and identification of the two SNPs and their alleles.The sensitivity evaluation showed that the BBM assay could detect and identify SNP sequences present in blood samples containing as few as 10 2 white blood cells/μL.CONCLUSION:This biosensor microarray assay was highly specific,sensitive,rapid and easy to perform.It is compatible with clinical practice for detection of rs8099917 and rs12979860.
文摘The 3D orthogonal woven basalt fiber reinforced polyimide (PI) composites were fabricated and characterized in this study. The PI film was firstly prepared to determine PI processing parameters. Fourier transform infrared (FTIR) analysis showed that 300°C was the suitable imidization temperature. Thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC) results showed relatively good thermal properties of the PI film. In the fabrication of composites, the multi-step impregnation method was applied. The bending properties of 3 mm-thick composite showed increasing trend in all and the second-time impregnated composite had much higher value than the first-time impregnated composite. Moreover, the bending fracture mode photos showed obvious creases except for the first-time impregnated materials, which agreed well with the bending property values. The dielectric constants for the composites were complex because they had not regular value following the mixing rule of the composites, which was mainly due to the interfacial polarization and other effects in the fabrication processing.
文摘We studied relations between natural seedling reproduction and above ground environment in a longleaf pine ecosystem. Forty-eight 0.05 ha circular plots were sampled under single-tree selection, group-tree selection and control stands in three main longleaf pine areas in south Alabama, USA. We measured six above-ground environment factors, viz. canopy closure, stand density, basal area, average tree height, understory cover and PAR under canopy. We employed forward, back-ward and stepwise selection regression to produce one model. Three main variables：canopy closure, stand density and basal area, were left in the model; light, PAR and understory cover were not incorporated into the model at the 0.10 significance level. Basal area was a positive pa-rameter, while canopy closure and stand density were negative parame-ters. Canopy closure was the main parameter in the model. The model proved to be meaningful, and has potential to provide useful guidance for future work.
基金supported by the National Social Science Foundation of China(No.ID10CRK009)
文摘Reproductive health（RH） education and services of female migrants in China have become an important health issue.This research aimed to investigate the RH knowledge and utilization among married female migrants,and to explore the influencing factors from the perspectives of population and sociology.We conducted a cross-section survey in Shenzhen and Wuhan,China,using the purposive sampling method.A total of 1021 rural-to-urban married migrants were recruited,with 997 valid survey results obtained.A face-to-face structured questionnaire survey was used,with primary focus on knowledge of fertility,contraception,family planning policy and sexual transmitted diseases/acquired immunodeficiency syndrome（STD/AIDs）,and RH service utilization.The results showed that the RH service utilization（38.0%） was at a low level in married migrants and the accessibility of RH service was poor.Females who migrated to（OR=0.32） Wuhan obtained fewer RH consultations than those in Shenzhen.The workers with high school education received additional RH consultations and checkup services than those with other background education,apart from the white collar workers who received extra RH consultations and checkup services than the blue collar workers（P〈0.05）.We can draw a conclusion that the utilization of RH services in married female migrants remains at a low level in China.RH service utilization can be improved via the relevant health departments by enhancing the responsibility of maternal and health care in the community health service center.
基金Supported by Foundation for Humanities and Social Sciences Research Planning of Ministry of Education of China in 2019(19YJA630058)
文摘Firstly,the behavior of marine science and technology talents,such as scientific research,innovation,agglomeration and flow behavior,was analyzed,and then the problems in the training of marine science and technology talents were discussed.Finally,the training ways of marine science and technology talents were proposed.
