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In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds:An Update 被引量:1
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作者 Ursula Catalan laura Barrubes +2 位作者 Rosa Maria Vails Rosa Soila laura rubio 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2017年第4期236-245,共10页
Dietary phenolic compounds (PCs) have been receiving intercst lor their presumcd roles ill disease prevention. However, there is a lack of studies on the underlying molecular mechanisnls. In this regard, in vitro me... Dietary phenolic compounds (PCs) have been receiving intercst lor their presumcd roles ill disease prevention. However, there is a lack of studies on the underlying molecular mechanisnls. In this regard, in vitro metabolomic approaches are suitable for the investigation o1 the molecular changes in response to PC exposure. Up to date, the biological effects of PCs have only been cxalnined for PCs from rosemary (Rosmarinus officinalis), olive oil, and reSVCl-atrol using cell-based mctabolomic approach, although transcriptomic and/or proteomic studies have also been conducted in the same in vi[ro cell experiment in some cases. Our integral analysis of the reviewed studies suggest that PCs may be involved not only in basic cellular processes or macro-and micro-nutrient meta- bolism, but also in specific metabolic pathways that have been thoroughly investigated. These modulated pathways could have a clinical impact on neurodegenerativc diseases, type 2 diabetes, cancer, and cardiovascular diseases. In conclusion, the in vitro metabolomic approaches provide additional information of the molecular mechanisms involved in disease risk reduction of dietary PCs. In order to elucidate the mechanisms of action of PCs, more metabolomic cell-based studies are nccdcd and testing the physiological conjugated forms of PCs in these cell systems could be of special interest. 展开更多
关键词 Cell-based Metabolomics Phenolic compounds Mechanism of action Disease prevention
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