Biochar is a carbon-rich(】60%)organic material derived from incomplete combustion of fossil fuels and biomass.It consists of a continuum ranging from slightly charred material through char and charcoal to soot,and is...Biochar is a carbon-rich(】60%)organic material derived from incomplete combustion of fossil fuels and biomass.It consists of a continuum ranging from slightly charred material through char and charcoal to soot,and is ubiquitous in the atmosphere,marine sediment,soil and water.Moreover,】80%of biochar produced ends up in soils,where it resides for hundreds to thousands of years.Because of its resistance to biological and chemical breakdown, biochar can serve as a pool of C with long residence time in the soil.As a result,there has been increasing attention given to the potential of biochar to sequestrate carbon and counteract展开更多
Alcohol consumption alters gut microflora and damages intestinal tight junction barriers,which may affect arsenic(As)oral bioavailability.In this study,mice were exposed to arsenate in the diet(6μg/g)over a 3-week pe...Alcohol consumption alters gut microflora and damages intestinal tight junction barriers,which may affect arsenic(As)oral bioavailability.In this study,mice were exposed to arsenate in the diet(6μg/g)over a 3-week period and gavaged daily with Chinese liquor(0.05 or 0.10 mL per mouse per day).Following ingestion,78.0%and 72.9%of the total As intake was absorbed and excreted via urine when co-exposed with liquor at daily doses of 0.05 or 0.10 mL,significantly greater than when As was supplied alone(44.7%).Alcohol co-exposure significantly altered gut microbiota but did not significantly alter As biotransformation in the intestinal tract or tissue.Significantly lower relative mRNA expression was observed for genes encoding for tight junctions in the ileum of liquor co-exposed mice,contributing to greater As bioavailability attributable to enhanced As absorption via the intestinal paracellular pathway.However,As concentration in the liver,kidney,and intestinal tissue of liquortreated mice was decreased by 24.4%-42.6%,27.5%-38.1%,and 28.1%-48.9%compared to control mice.This was likely due to greater renal glomerular filtration rate induced by alcohol,as suggested by significantly lower expression of genes encoding for renal tight junctions.In addition,in mice gavaged daily with 0.05 mL liquor,the serum antidiuretic hormone level was significantly lower than control mice(2.83±0.59 vs.5.40±1.10 pg/mL),suggesting the diuretic function of alcohol consumption,which may facilitate As elimination via urine.These results highlight that alcohol consumption has a significant impact on the bioavailability and accumulation of As.展开更多
文摘Biochar is a carbon-rich(】60%)organic material derived from incomplete combustion of fossil fuels and biomass.It consists of a continuum ranging from slightly charred material through char and charcoal to soot,and is ubiquitous in the atmosphere,marine sediment,soil and water.Moreover,】80%of biochar produced ends up in soils,where it resides for hundreds to thousands of years.Because of its resistance to biological and chemical breakdown, biochar can serve as a pool of C with long residence time in the soil.As a result,there has been increasing attention given to the potential of biochar to sequestrate carbon and counteract
基金supported by the National Natural Science Foundation of China(42022058,and 41877356)Jiangsu Agricultural Independent Innovation Program[CX(21)3095].
文摘Alcohol consumption alters gut microflora and damages intestinal tight junction barriers,which may affect arsenic(As)oral bioavailability.In this study,mice were exposed to arsenate in the diet(6μg/g)over a 3-week period and gavaged daily with Chinese liquor(0.05 or 0.10 mL per mouse per day).Following ingestion,78.0%and 72.9%of the total As intake was absorbed and excreted via urine when co-exposed with liquor at daily doses of 0.05 or 0.10 mL,significantly greater than when As was supplied alone(44.7%).Alcohol co-exposure significantly altered gut microbiota but did not significantly alter As biotransformation in the intestinal tract or tissue.Significantly lower relative mRNA expression was observed for genes encoding for tight junctions in the ileum of liquor co-exposed mice,contributing to greater As bioavailability attributable to enhanced As absorption via the intestinal paracellular pathway.However,As concentration in the liver,kidney,and intestinal tissue of liquortreated mice was decreased by 24.4%-42.6%,27.5%-38.1%,and 28.1%-48.9%compared to control mice.This was likely due to greater renal glomerular filtration rate induced by alcohol,as suggested by significantly lower expression of genes encoding for renal tight junctions.In addition,in mice gavaged daily with 0.05 mL liquor,the serum antidiuretic hormone level was significantly lower than control mice(2.83±0.59 vs.5.40±1.10 pg/mL),suggesting the diuretic function of alcohol consumption,which may facilitate As elimination via urine.These results highlight that alcohol consumption has a significant impact on the bioavailability and accumulation of As.
