Background:Adopting a healthy lifestyle during childhood could improve physical and mental health outcomes in adulthood and reduce relevant disease burdens.However,the lifestyles of children with mental,behavioral,and...Background:Adopting a healthy lifestyle during childhood could improve physical and mental health outcomes in adulthood and reduce relevant disease burdens.However,the lifestyles of children with mental,behavioral,and developmental disorders(MBDDs)remains under-described within the literature of public health field.This study aimed to examine adherence to 24-hour movement guidelines among children with MBDDs compared to population norms and whether these differences are affected by demographic characteristics.Methods:Data were from the 2016-2020 National Survey of Children’s Health—A national,population-based,cross-sectional study.We used the data of 119,406 children aged 6-17 years,which included 38,571 participants with at least 1 MBDD and 80,835 without.Adherence to the 24-hour movement guidelines was measured using parent-reported physical activity,screen time,and sleep duration.Results:Among children with MBDDs,20.3%,37.0%,60.7%,and 77.3%met the physical activity,screen time,sleep,and at least 1 of the 24-hour movement guidelines.These rates were lower than those in children without MBDDs(22.8%,46.2%,66.7%,and 83.4%,respectively;all p<0.001).Children with MBDDs were less likely to meet these guidelines(odds ratio(OR)=1.21,95%confidence interval(95%CI):1.13-1.30;OR=1.37,95%CI:1.29-1.45;OR=1.29,95%CI:1.21-1.37;OR=1.45,95%CI:1.35-1.56)than children without MBDDs.Children with emotional disorders had the highest odds of not meeting these guidelines(OR=1.43,95%CI:1.29-1.57;OR=1.48,95%CI:1.37-1.60;OR=1.49,95%CI:1.39-1.61;OR=1.72,95%CI:1.57-1.88)in comparison to children with other MBDDs.Among children aged12-17 years,the difference in proportion of meeting physical activity and screen time guidelines for children with vs.children without MBDD was larger than that among children aged 6-11 years.Furthermore,the above difference of meeting physical activity guidelines in ethnic minority children was smaller than that in white children.Conclusion:Children with MBDDs were less likely to meet individual or combined 24-hour movement guidelines than children without MBDDs.In educational and clinical settings,the primary focus should be on increasing physical activity and limiting screen time in children aged 12-17 years who have MBDDs;and specifically for white children who have MBDDs,increasing physical activity may help.展开更多
目的探讨核糖核酸结合基序蛋白45(RNA-binding motif protein 45,RBM45)在肝癌中的表达及其临床应用价值。方法应用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库分析RNA结合蛋白RBM45在肝癌中的表达,并关联临床资料及病理特征...目的探讨核糖核酸结合基序蛋白45(RNA-binding motif protein 45,RBM45)在肝癌中的表达及其临床应用价值。方法应用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库分析RNA结合蛋白RBM45在肝癌中的表达,并关联临床资料及病理特征进行统计学分析。运用基因富集分析软件GSEA对肝癌组织中与RBM45相关的基因进行KEGG信号通路富集分析。结果与癌旁组织相比,肝癌组织中RBM45表达明显升高(P<0.001),且RBM45表达水平与患者临床分期、肿瘤分级及预后均显著相关(P<0.05),通过构建单变量和多变量COX风险回归模型分析RBM45表达与临床资料的相关性,结果表明RBM45可做为肝癌患者独立预后的危险因素(HR:2.75695%CI:1.785-4.255,P=4.813e-06);KEGG富集分析显示,RBM45可能与细胞周期、卵母细胞减数分裂、泛素介导的蛋白水解等信号通路密切相关。结论RBM45在肝癌组织中高表达,且其高表达的患者预后较差;RBM45表达可作为肝癌患者预后判断的独立标志物。展开更多
BACKGROUND Breast infiltrating ductal carcinoma(BIDC)represents the largest heterotypic tumor group,and an in-depth understanding of the pathogenesis of BIDC is key to improving its prognosis.AIM To analyze the expres...BACKGROUND Breast infiltrating ductal carcinoma(BIDC)represents the largest heterotypic tumor group,and an in-depth understanding of the pathogenesis of BIDC is key to improving its prognosis.AIM To analyze the expression profiles and clinical implications of forkhead box M1(FOXM1),cyclooxygenase-2(COX-2),and glucose-regulated protein 78(GRP78)in BIDC.METHODS A total of 65 BIDC patients and 70 healthy controls who presented to our hospital between August 2019 and May 2021 were selected for analysis.The peripheral blood FOXM1,COX-2,and GRP78 levels in both groups were measured and the association between their expression profiles in BIDC was examined.Additionally,we investigated the diagnostic value of FOXM1,COX-2,and GRP78 in patients with BIDC and their correlations with clinicopathological features.Furthermore,BIDC patients were followed for 1 year to identify factors influencing patient prognosis.RESULTS The levels of FOXM1,COX-2,and GRP78 were significantly higher in BIDC patients compared to healthy controls(P<0.05),and a positive correlation was observed among them(P<0.05).Receiver operating characteristic analysis demonstrated that FOXM1,COX-2,and GRP78 had excellent diagnostic value in predicting the occurrence of BIDC(P<0.05).Subsequently,we found significant differences in FOXM1,COX-2,and GRP78 levels among patients with different histological grades and metastasis statuses(with vs without)(P<0.05).Cox analysis revealed that FOXM1,COX-2,GRP78,increased histological grade,and the presence of tumor metastasis were independent risk factors for prognostic death in BIDC(P<0.001).CONCLUSION FOXM1,COX-2,and GRP78 exhibit abnormally high expression in BIDC,promoting malignant tumor development and closely correlating with prognosis.These findings hold significant research implications for the future diagnosis and treatment of BIDC.展开更多
In the context of next-generation optical access networks beyond 10 G, for high SE and flexible dynamic bandwidth allocation (DBA), the scheme of hybrid 64/16/4QAM-OFDM signal for downlink transmission and hybrid 16/8...In the context of next-generation optical access networks beyond 10 G, for high SE and flexible dynamic bandwidth allocation (DBA), the scheme of hybrid 64/16/4QAM-OFDM signal for downlink transmission and hybrid 16/8/QPSK-OFDM signal for uplink transmission is successfully proposed and experimentally presented in a full-duplex PON based on OFDM system. Here, for the uplink, in order to unit management of the optical line terminal (OLT) and reduce cost, the optical source functioned as the optical subcarrier at optical network units (ONUs) is from OLT in the central station. Moreover, there is an external cavity laser (ECL) with center frequency of 193.2 THz not only employed as optical modulated signal but also acted as LO signal. Our simulation results show that bit error ratio (BER) under hardware detection forward error correction has been successfully gained after 20 km of SSMF transmission. It is observed that the receiver sensitivity of multilevel PSK (M-PSK) is obviously larger than that of the M-QAM in this measurement scheme.展开更多
基金financial support of the Key-Area Research and Development Program of Guangdong Province(2019B030335001)the National Natural Science Foundation of China(82103794)+2 种基金Guangdong Basic and Applied Basic Research Foundation(2021A1515011757)General Administration of Sport of China and China Institute of Sport Science(19—21)Guangxi Key Research and Development Plan(GUIKEAB18050024)。
文摘Background:Adopting a healthy lifestyle during childhood could improve physical and mental health outcomes in adulthood and reduce relevant disease burdens.However,the lifestyles of children with mental,behavioral,and developmental disorders(MBDDs)remains under-described within the literature of public health field.This study aimed to examine adherence to 24-hour movement guidelines among children with MBDDs compared to population norms and whether these differences are affected by demographic characteristics.Methods:Data were from the 2016-2020 National Survey of Children’s Health—A national,population-based,cross-sectional study.We used the data of 119,406 children aged 6-17 years,which included 38,571 participants with at least 1 MBDD and 80,835 without.Adherence to the 24-hour movement guidelines was measured using parent-reported physical activity,screen time,and sleep duration.Results:Among children with MBDDs,20.3%,37.0%,60.7%,and 77.3%met the physical activity,screen time,sleep,and at least 1 of the 24-hour movement guidelines.These rates were lower than those in children without MBDDs(22.8%,46.2%,66.7%,and 83.4%,respectively;all p<0.001).Children with MBDDs were less likely to meet these guidelines(odds ratio(OR)=1.21,95%confidence interval(95%CI):1.13-1.30;OR=1.37,95%CI:1.29-1.45;OR=1.29,95%CI:1.21-1.37;OR=1.45,95%CI:1.35-1.56)than children without MBDDs.Children with emotional disorders had the highest odds of not meeting these guidelines(OR=1.43,95%CI:1.29-1.57;OR=1.48,95%CI:1.37-1.60;OR=1.49,95%CI:1.39-1.61;OR=1.72,95%CI:1.57-1.88)in comparison to children with other MBDDs.Among children aged12-17 years,the difference in proportion of meeting physical activity and screen time guidelines for children with vs.children without MBDD was larger than that among children aged 6-11 years.Furthermore,the above difference of meeting physical activity guidelines in ethnic minority children was smaller than that in white children.Conclusion:Children with MBDDs were less likely to meet individual or combined 24-hour movement guidelines than children without MBDDs.In educational and clinical settings,the primary focus should be on increasing physical activity and limiting screen time in children aged 12-17 years who have MBDDs;and specifically for white children who have MBDDs,increasing physical activity may help.
文摘目的探讨核糖核酸结合基序蛋白45(RNA-binding motif protein 45,RBM45)在肝癌中的表达及其临床应用价值。方法应用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库分析RNA结合蛋白RBM45在肝癌中的表达,并关联临床资料及病理特征进行统计学分析。运用基因富集分析软件GSEA对肝癌组织中与RBM45相关的基因进行KEGG信号通路富集分析。结果与癌旁组织相比,肝癌组织中RBM45表达明显升高(P<0.001),且RBM45表达水平与患者临床分期、肿瘤分级及预后均显著相关(P<0.05),通过构建单变量和多变量COX风险回归模型分析RBM45表达与临床资料的相关性,结果表明RBM45可做为肝癌患者独立预后的危险因素(HR:2.75695%CI:1.785-4.255,P=4.813e-06);KEGG富集分析显示,RBM45可能与细胞周期、卵母细胞减数分裂、泛素介导的蛋白水解等信号通路密切相关。结论RBM45在肝癌组织中高表达,且其高表达的患者预后较差;RBM45表达可作为肝癌患者预后判断的独立标志物。
文摘BACKGROUND Breast infiltrating ductal carcinoma(BIDC)represents the largest heterotypic tumor group,and an in-depth understanding of the pathogenesis of BIDC is key to improving its prognosis.AIM To analyze the expression profiles and clinical implications of forkhead box M1(FOXM1),cyclooxygenase-2(COX-2),and glucose-regulated protein 78(GRP78)in BIDC.METHODS A total of 65 BIDC patients and 70 healthy controls who presented to our hospital between August 2019 and May 2021 were selected for analysis.The peripheral blood FOXM1,COX-2,and GRP78 levels in both groups were measured and the association between their expression profiles in BIDC was examined.Additionally,we investigated the diagnostic value of FOXM1,COX-2,and GRP78 in patients with BIDC and their correlations with clinicopathological features.Furthermore,BIDC patients were followed for 1 year to identify factors influencing patient prognosis.RESULTS The levels of FOXM1,COX-2,and GRP78 were significantly higher in BIDC patients compared to healthy controls(P<0.05),and a positive correlation was observed among them(P<0.05).Receiver operating characteristic analysis demonstrated that FOXM1,COX-2,and GRP78 had excellent diagnostic value in predicting the occurrence of BIDC(P<0.05).Subsequently,we found significant differences in FOXM1,COX-2,and GRP78 levels among patients with different histological grades and metastasis statuses(with vs without)(P<0.05).Cox analysis revealed that FOXM1,COX-2,GRP78,increased histological grade,and the presence of tumor metastasis were independent risk factors for prognostic death in BIDC(P<0.001).CONCLUSION FOXM1,COX-2,and GRP78 exhibit abnormally high expression in BIDC,promoting malignant tumor development and closely correlating with prognosis.These findings hold significant research implications for the future diagnosis and treatment of BIDC.
文摘In the context of next-generation optical access networks beyond 10 G, for high SE and flexible dynamic bandwidth allocation (DBA), the scheme of hybrid 64/16/4QAM-OFDM signal for downlink transmission and hybrid 16/8/QPSK-OFDM signal for uplink transmission is successfully proposed and experimentally presented in a full-duplex PON based on OFDM system. Here, for the uplink, in order to unit management of the optical line terminal (OLT) and reduce cost, the optical source functioned as the optical subcarrier at optical network units (ONUs) is from OLT in the central station. Moreover, there is an external cavity laser (ECL) with center frequency of 193.2 THz not only employed as optical modulated signal but also acted as LO signal. Our simulation results show that bit error ratio (BER) under hardware detection forward error correction has been successfully gained after 20 km of SSMF transmission. It is observed that the receiver sensitivity of multilevel PSK (M-PSK) is obviously larger than that of the M-QAM in this measurement scheme.
