La2Zr2O7 （LZ） is a promising thermal barrier coating material for the high temperature applications. The fracture toughness and microhardness of nanocrystalline LZ （n-LZ）, microcrystalline LZ （m-LZ） and LZ-5mol%...La2Zr2O7 （LZ） is a promising thermal barrier coating material for the high temperature applications. The fracture toughness and microhardness of nanocrystalline LZ （n-LZ）, microcrystalline LZ （m-LZ） and LZ-5mol%8YSZ （LZ-5-8YSZ） composite （8YSZ for zirconia stabilized by 8 mol% ytrria） were studied. The n-LZ had a thermal expansion coefficient of （9.6±0.4）×10 -6 K -1 （200～1000℃） and fracture toughness of （1.98±0.07） MPa·m 1/2 which are obviously higher than those of the m-LZ （ （9.1±0.4）×10 -6 K -1 and （1.40±0.23） MPa·m 1/2, respectively）, indicating that nanofication was an efficient way to increase the toughness and thermal expansion coefficient of LZ. The composite LZ-5-8YSZ had a higher fracture toughness （（1.88±0.30） MPa·m 1/2） than LZ, which was close to that of 8YSZ densified by superhigh pressure （SHP）.展开更多
INTRODUCTIONAmino acid consumption test (AACT) has a highsensitivity and specificity in evaluating exocrinepancreatic insufficiency,but its diagnostic valueto exocrine pancreatic insufficiency in Chinese hasnot been w...INTRODUCTIONAmino acid consumption test (AACT) has a highsensitivity and specificity in evaluating exocrinepancreatic insufficiency,but its diagnostic valueto exocrine pancreatic insufficiency in Chinese hasnot been well understood.In this study,the oralreagent stimulating pancreatic secretion (O-AACT)was used instead of cerulein(I-AACT) for amidoacid consumption test and the dignostic efficiency ofO-AACT was evaluated and compared with I-AACTon the exocrine pancreatic insufficiency in Chinese.展开更多
OBJECTIVE Aconitine(ACO)as the main active component in Aconitum carmichaelii debeaux(family Ranunlaceae),has highly toxicity in heart and the mechanisms are not clear yet.Paeoniflorin(PF),the main chemical ingredient...OBJECTIVE Aconitine(ACO)as the main active component in Aconitum carmichaelii debeaux(family Ranunlaceae),has highly toxicity in heart and the mechanisms are not clear yet.Paeoniflorin(PF),the main chemical ingredient in Herbaceous peony,can protect heart hurt by antioxidant,vasodilator effect and other effects.In this study,we focused on investigating the mechanism of PF reducing the cardiotoxicity of ACO.METHODS We chose H9c2 cells as experimental subject.MTT,Western blotting and real-time PCR were used to measure cell proliferation,apoptosis,ion channels and oxidative stress.RESULTS Cell proliferation in ACO+PF group was significantly increased compared with ACO group;the ratio with Bcl-2 and Bax and the level of p53 were upregulated by PF,while the level of caspase-3 was lightly reduced.The expression of SCN5A mRNA significantly was increased in ACO+PF group,while the expres⁃sion of RyR2 and Cx43 mRNA was dropped.Compared with ACO group,extracellular LDH and intracellular MDA were highly decreased,while intracellular SOD was regulated.CONCLUSION Cardiotoxicity of ACO in H9c2 cells was signifi⁃cantly decreased by PF.展开更多
Objective:To compare intraocular p ressure(IOP)values obtained by patients using the new Pr oview eye pressure monitor(Bausch &Lomb,Rochester,NY)with those measured with the Goldmann tonomete r and the TonoPen(Men...Objective:To compare intraocular p ressure(IOP)values obtained by patients using the new Pr oview eye pressure monitor(Bausch &Lomb,Rochester,NY)with those measured with the Goldmann tonomete r and the TonoPen(Mentor,Norwell,Mass).Methods:Eighty-six patients(a total of 171eyes)-with a diagnosis of glaucoma or glaucoma suspect successfully comp leted the study.The IOP was measured by 3methods in the fo llowing order:Goldmann tonometer,TonoPen,and Pr oview eye pressure monitor.The central corneal thickn ess was measured by an ultrasonic pachymeter.Separate ly for each eye,the differences in mean IOP values betwe en measurement methods were assessed with paired te sts and also in mul-tivariate models that tested the dep endence of IOP differ-ence on central corneal thickness.R esults:There was a significant difference(P<.001)in the mean IOPs measured by the 3different methods(Goldmann vs Proview,Goldmann vs TonoPen,and TonoPen vs Proview)for both eyes,and the difference was indepen-dent of the central corneal thickness.The differences be-tween IOP measured by Goldmann and Pr oview were sim-ilar in all categories of patient-re ported ease of using the Proview.Conclusions:The IOPs obta ined with the Proview eye pressure monitor are sig nificantly lower than those measured with Goldmann tonome ter and the TonoPen,and variations of the centr al corneal thickness do not contribute to the difference.Intraclass correlations of IOP values obtained with the Goldm ann and the Proview or TonoPen and Proview are not strong.On the other hand,as expected,measurements with Goldmann and TonoPen agreed fairly well.展开更多
文摘La2Zr2O7 （LZ） is a promising thermal barrier coating material for the high temperature applications. The fracture toughness and microhardness of nanocrystalline LZ （n-LZ）, microcrystalline LZ （m-LZ） and LZ-5mol%8YSZ （LZ-5-8YSZ） composite （8YSZ for zirconia stabilized by 8 mol% ytrria） were studied. The n-LZ had a thermal expansion coefficient of （9.6±0.4）×10 -6 K -1 （200～1000℃） and fracture toughness of （1.98±0.07） MPa·m 1/2 which are obviously higher than those of the m-LZ （ （9.1±0.4）×10 -6 K -1 and （1.40±0.23） MPa·m 1/2, respectively）, indicating that nanofication was an efficient way to increase the toughness and thermal expansion coefficient of LZ. The composite LZ-5-8YSZ had a higher fracture toughness （（1.88±0.30） MPa·m 1/2） than LZ, which was close to that of 8YSZ densified by superhigh pressure （SHP）.
基金the Science Fund of Department of Health,Sichuan Province,No.9241-920054
文摘INTRODUCTIONAmino acid consumption test (AACT) has a highsensitivity and specificity in evaluating exocrinepancreatic insufficiency,but its diagnostic valueto exocrine pancreatic insufficiency in Chinese hasnot been well understood.In this study,the oralreagent stimulating pancreatic secretion (O-AACT)was used instead of cerulein(I-AACT) for amidoacid consumption test and the dignostic efficiency ofO-AACT was evaluated and compared with I-AACTon the exocrine pancreatic insufficiency in Chinese.
文摘OBJECTIVE Aconitine(ACO)as the main active component in Aconitum carmichaelii debeaux(family Ranunlaceae),has highly toxicity in heart and the mechanisms are not clear yet.Paeoniflorin(PF),the main chemical ingredient in Herbaceous peony,can protect heart hurt by antioxidant,vasodilator effect and other effects.In this study,we focused on investigating the mechanism of PF reducing the cardiotoxicity of ACO.METHODS We chose H9c2 cells as experimental subject.MTT,Western blotting and real-time PCR were used to measure cell proliferation,apoptosis,ion channels and oxidative stress.RESULTS Cell proliferation in ACO+PF group was significantly increased compared with ACO group;the ratio with Bcl-2 and Bax and the level of p53 were upregulated by PF,while the level of caspase-3 was lightly reduced.The expression of SCN5A mRNA significantly was increased in ACO+PF group,while the expres⁃sion of RyR2 and Cx43 mRNA was dropped.Compared with ACO group,extracellular LDH and intracellular MDA were highly decreased,while intracellular SOD was regulated.CONCLUSION Cardiotoxicity of ACO in H9c2 cells was signifi⁃cantly decreased by PF.
文摘Objective:To compare intraocular p ressure(IOP)values obtained by patients using the new Pr oview eye pressure monitor(Bausch &Lomb,Rochester,NY)with those measured with the Goldmann tonomete r and the TonoPen(Mentor,Norwell,Mass).Methods:Eighty-six patients(a total of 171eyes)-with a diagnosis of glaucoma or glaucoma suspect successfully comp leted the study.The IOP was measured by 3methods in the fo llowing order:Goldmann tonometer,TonoPen,and Pr oview eye pressure monitor.The central corneal thickn ess was measured by an ultrasonic pachymeter.Separate ly for each eye,the differences in mean IOP values betwe en measurement methods were assessed with paired te sts and also in mul-tivariate models that tested the dep endence of IOP differ-ence on central corneal thickness.R esults:There was a significant difference(P<.001)in the mean IOPs measured by the 3different methods(Goldmann vs Proview,Goldmann vs TonoPen,and TonoPen vs Proview)for both eyes,and the difference was indepen-dent of the central corneal thickness.The differences be-tween IOP measured by Goldmann and Pr oview were sim-ilar in all categories of patient-re ported ease of using the Proview.Conclusions:The IOPs obta ined with the Proview eye pressure monitor are sig nificantly lower than those measured with Goldmann tonome ter and the TonoPen,and variations of the centr al corneal thickness do not contribute to the difference.Intraclass correlations of IOP values obtained with the Goldm ann and the Proview or TonoPen and Proview are not strong.On the other hand,as expected,measurements with Goldmann and TonoPen agreed fairly well.
