BACKGROUND Esophageal cancer(EC)often occurs in the elderly,with approximately 33%of patients aged≥75 years at the time of diagnosis.AIM To evaluate the prognostic factors for radiotherapy(RT)in elderly patients with...BACKGROUND Esophageal cancer(EC)often occurs in the elderly,with approximately 33%of patients aged≥75 years at the time of diagnosis.AIM To evaluate the prognostic factors for radiotherapy(RT)in elderly patients with unresectable EC.METHODS We retrospectively analyzed the clinical characteristics,toxic reactions,and survival information of EC patients aged≥75 years who underwent intensity-modulated RT at Lu’an Hospital of Anhui Medical University between January 2016 and September 2023.Kaplan-Meier analysis was used to draw the overall survival(OS)curves,and Cox regression analysis was employed to evaluate the influence of various clinical factors on the prognosis.RESULTS A total of 139 patients were enrolled.The median follow-up time was 52.0 months.The median OS was 20.0 months.The 1-year,2-year,3-year,and 5-year OS rates were 69.8%,38.7%,28.2%,and 17.5%,respectively.Univariate analysis showed that age,radiation dose,and chemotherapy had no significant impact on prognosis.Multivariate analysis indicated that clinical stage[Ⅲ-Ⅳa vsⅠ-Ⅱ,hazard ratio(HR)=2.421,95%confidence interval(CI):1.242-4.718,P=0.009;IVb vsⅠ-Ⅱ,HR=4.222,95%CI:1.888-9.438,P<0.001),Charlson comorbidity index(CCI)(0 vs≥1,HR=1.539,95%CI:1.015-2.332,P=0.042),and nutritional risk screening 2002(NRS2002)(<3 vs≥3,HR=2.491,95%CI:1.601-3.875,P<0.001)were independent prognostic factors for OS.CONCLUSION Our results suggest that CCI and NRS2002 were independent prognostic factors of OS for unresectable elderly EC patients undergoing RT.For elderly patients with EC,full attention should be given to biological age-related indicators,such as comorbidities and nutrition,when formulating treatment protocols.These factors should be considered in future clinical practice.展开更多
Background:The easy accessibility,increasing usage,and low cost of internet make it a desirable way of providing health information and delivering interventions for health consumers.Studies in other countries have ver...Background:The easy accessibility,increasing usage,and low cost of internet make it a desirable way of providing health information and delivering interventions for health consumers.Studies in other countries have verified and confirmed the effectiveness of internet-based interventions among people with mental health problems.Similar programs have yet to commence in China.Purpose:This study investigated the willingness for,and attitude toward internet-based intervention in Chinese mental health service users and explored the feasibility of such an intervention.Methods:A cross-sectional survey utilizing a self-developed questionnaire was administered to 186 mental health service users in Beijing,between April and May 2011.Results:Most participants held a positive attitude toward online information and expressed interest in getting assistance from the internet.Some advice and suggestions were provided such as more ways of getting assistance,setting up more professional websites,increasing interaction,as well as having government funding and guidance.Conclusion:Internet-based programs are feasible and applicable,and worth implementing with Chinese people with mental illness.展开更多
In conventional optics, the Fabry–Pérot(FP) effect is only considered for transparent materials at a macroscopic dimension. Down to the nanometer scale, for absorptive metallic structures, the FP effect has not ...In conventional optics, the Fabry–Pérot(FP) effect is only considered for transparent materials at a macroscopic dimension. Down to the nanometer scale, for absorptive metallic structures, the FP effect has not been directly observed so far. It is unclear whether such a macroscopic effect still holds for a subwavelength metallic nanostructure. Here, we demonstrate the probing of FP interference in a series of nanometer-thick Au films with subwavelength hole arrays. The evidence from both linear and second harmonic generation signals, together with angle-resolved investigations, exhibit features of a FP effect. We also derive an absorptive FP interference equation, which well explains our experimental results. Our results for the first time experimentally confirm the long-persisting hypothesis that the FP effect holds ubiquitously in a metallic nanostructure.展开更多
Phosphors emitting visible and near-infrared persistent luminescence have been explored extensively owing to their unusual properties and commercial interest in their applications such as glow-in-the-dark paints,optic...Phosphors emitting visible and near-infrared persistent luminescence have been explored extensively owing to their unusual properties and commercial interest in their applications such as glow-in-the-dark paints,optical information storage,and in vivo bioimaging.However,no persistent phosphor that features emissions in the ultraviolet C range(200–280 nm)has been known to exist so far.Here,we demonstrate a strategy for creating a new generation of persistent phosphor that exhibits strong ultraviolet C emission with an initial power density over 10 milliwatts per square meter and an afterglow of more than 2 h.Experimental characterizations coupled with first-principles calculations have revealed that structural defects associated with oxygen introduction-induced anion vacancies in fluoride elpasolite can function as electron traps,which capture and store a large number of electrons triggered by Xray irradiation.Notably,we show that the ultraviolet C afterglow intensity of the yielded phosphor is sufficiently strong for sterilization.Our discovery of this ultraviolet C afterglow opens up new avenues for research on persistent phosphors,and it offers new perspectives on their applications in terms of sterilization,disinfection,drug release,cancer treatment,anti-counterfeiting,and beyond.展开更多
基金Supported by the Science and Technology Program of Lu’an,No.2022 Lakj042.
文摘BACKGROUND Esophageal cancer(EC)often occurs in the elderly,with approximately 33%of patients aged≥75 years at the time of diagnosis.AIM To evaluate the prognostic factors for radiotherapy(RT)in elderly patients with unresectable EC.METHODS We retrospectively analyzed the clinical characteristics,toxic reactions,and survival information of EC patients aged≥75 years who underwent intensity-modulated RT at Lu’an Hospital of Anhui Medical University between January 2016 and September 2023.Kaplan-Meier analysis was used to draw the overall survival(OS)curves,and Cox regression analysis was employed to evaluate the influence of various clinical factors on the prognosis.RESULTS A total of 139 patients were enrolled.The median follow-up time was 52.0 months.The median OS was 20.0 months.The 1-year,2-year,3-year,and 5-year OS rates were 69.8%,38.7%,28.2%,and 17.5%,respectively.Univariate analysis showed that age,radiation dose,and chemotherapy had no significant impact on prognosis.Multivariate analysis indicated that clinical stage[Ⅲ-Ⅳa vsⅠ-Ⅱ,hazard ratio(HR)=2.421,95%confidence interval(CI):1.242-4.718,P=0.009;IVb vsⅠ-Ⅱ,HR=4.222,95%CI:1.888-9.438,P<0.001),Charlson comorbidity index(CCI)(0 vs≥1,HR=1.539,95%CI:1.015-2.332,P=0.042),and nutritional risk screening 2002(NRS2002)(<3 vs≥3,HR=2.491,95%CI:1.601-3.875,P<0.001)were independent prognostic factors for OS.CONCLUSION Our results suggest that CCI and NRS2002 were independent prognostic factors of OS for unresectable elderly EC patients undergoing RT.For elderly patients with EC,full attention should be given to biological age-related indicators,such as comorbidities and nutrition,when formulating treatment protocols.These factors should be considered in future clinical practice.
文摘Background:The easy accessibility,increasing usage,and low cost of internet make it a desirable way of providing health information and delivering interventions for health consumers.Studies in other countries have verified and confirmed the effectiveness of internet-based interventions among people with mental health problems.Similar programs have yet to commence in China.Purpose:This study investigated the willingness for,and attitude toward internet-based intervention in Chinese mental health service users and explored the feasibility of such an intervention.Methods:A cross-sectional survey utilizing a self-developed questionnaire was administered to 186 mental health service users in Beijing,between April and May 2011.Results:Most participants held a positive attitude toward online information and expressed interest in getting assistance from the internet.Some advice and suggestions were provided such as more ways of getting assistance,setting up more professional websites,increasing interaction,as well as having government funding and guidance.Conclusion:Internet-based programs are feasible and applicable,and worth implementing with Chinese people with mental illness.
基金Supported by the National Key Research and Development Program of China under Grant Nos 2017YFA0303603 and 2016YFA0300303the National Natural Science Foundation of China under Grant Nos 11504062,11774408 and 11574383+2 种基金the Strategic Priority Research Program of Chinese Academy of Sciences under Grant No XDB30000000the Chinese Academy of Sciences Interdisciplinary Innovation Teamthe External Cooperation Program of Chinese Academy of Sciences under Grant No GJHZ1826
文摘In conventional optics, the Fabry–Pérot(FP) effect is only considered for transparent materials at a macroscopic dimension. Down to the nanometer scale, for absorptive metallic structures, the FP effect has not been directly observed so far. It is unclear whether such a macroscopic effect still holds for a subwavelength metallic nanostructure. Here, we demonstrate the probing of FP interference in a series of nanometer-thick Au films with subwavelength hole arrays. The evidence from both linear and second harmonic generation signals, together with angle-resolved investigations, exhibit features of a FP effect. We also derive an absorptive FP interference equation, which well explains our experimental results. Our results for the first time experimentally confirm the long-persisting hypothesis that the FP effect holds ubiquitously in a metallic nanostructure.
基金supported by the National Natural Science Foundation of China(Grant nos.11574225,11874275,51672106,and 11474083)a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘Phosphors emitting visible and near-infrared persistent luminescence have been explored extensively owing to their unusual properties and commercial interest in their applications such as glow-in-the-dark paints,optical information storage,and in vivo bioimaging.However,no persistent phosphor that features emissions in the ultraviolet C range(200–280 nm)has been known to exist so far.Here,we demonstrate a strategy for creating a new generation of persistent phosphor that exhibits strong ultraviolet C emission with an initial power density over 10 milliwatts per square meter and an afterglow of more than 2 h.Experimental characterizations coupled with first-principles calculations have revealed that structural defects associated with oxygen introduction-induced anion vacancies in fluoride elpasolite can function as electron traps,which capture and store a large number of electrons triggered by Xray irradiation.Notably,we show that the ultraviolet C afterglow intensity of the yielded phosphor is sufficiently strong for sterilization.Our discovery of this ultraviolet C afterglow opens up new avenues for research on persistent phosphors,and it offers new perspectives on their applications in terms of sterilization,disinfection,drug release,cancer treatment,anti-counterfeiting,and beyond.
