AIM: To investigate transarterial chemoembolization(TACE) with hepatic infusion of oxaliplatin and 5-fluorouracil and Lipiodol chemoembolization in large hepatocellular carcinoma(HCC).METHODS: In this retrospective st...AIM: To investigate transarterial chemoembolization(TACE) with hepatic infusion of oxaliplatin and 5-fluorouracil and Lipiodol chemoembolization in large hepatocellular carcinoma(HCC).METHODS: In this retrospective study, 132 patients with unresectable HCCs larger than 10 cm were treated with hepatic infusion of oxaliplatin and 5-fluorouracil followed by Lipiodol chemoembolization. The primary endpoint was overall survival(OS). Sixteen-week disease-control rate, time to progression(TTP), and major complications were also studied. Univariate and multivariate analyses were performed to identify prognostic factors affecting OS and TTP.RESULTS: A total of 319 procedures were performed in the 132 patients. Eleven(8.3%) patients received radical resection following TACE treatment(median time to initial TACE 4.3 ± 2.3 mo). The median OS and TTP were 10.3 and 3.0 mo respectively, with a 50.0% 16-wk disease-control rate. Major complications were encountered in 6.0%(8/132) of patients following TACE and included serious jaundice in 1.5%(2/132) patients, aleukia in 1.5%(2/132), and hepatic failure in 3.0%(4/132). One patient died within one month due to serious hepatic failure and severe sepsis after receiving the second TACE. The risk factor associated with TTP was baseline alpha-fetoprotein level, and vascular invasion was an independent factor related to OS.CONCLUSION: Hepatic infusion of oxaliplatin and 5-fluorouracil followed by lipiodolized-chemoembolization is a safe and promising treatment for patients with HCCs larger than 10 cm in diameter.展开更多
There is no effective treatment for hemiplegia after hypertensive intracerebral hemorrhage.Considering that the branches of L4 nerve roots in the lumbar plexus root control the movement of the lower extremity anterior...There is no effective treatment for hemiplegia after hypertensive intracerebral hemorrhage.Considering that the branches of L4 nerve roots in the lumbar plexus root control the movement of the lower extremity anterior and posterior muscles,we investigated a potential method of nerve repair using the L4 nerve roots.Rat models of hindlimb hemiplegia after a hypertensive intracerebral hemorrhage were established by injecting autogenous blood into the posterior limb of internal capsule.The L4 nerve root on the healthy side of model rats was transferred and then anastomosed with the L4 nerve root on the affected side to drive the extensor and flexor muscles of the hindlimbs.We investigated whether this method can restore the flexible movement of the hindlimbs of paralyzed rats after hypertensive intracerebral hemorrhage.In a beam-walking test and ladder rung walking task,model rats exhibited an initial high number of slips,but improved in accuracy on the paretic side over time.At 17 weeks after surgery,rats gained approximately 58.2%accuracy from baseline performance and performed ankle motions on the paretic side.At 9 weeks after surgery,a retrograde tracing test showed a large number of fluoro-gold-labeled motoneurons in the left anterior horn of the spinal cord that supports the L4-to-L4 nerve roots.In addition,histological and ultramicrostructural findings showed axon regeneration of motoneurons in the anterior horn of the spinal cord.Electromyography and paw print analysis showed that denervated hindlimb muscles regained reliable innervation and walking coordination improved.These findings suggest that the L4-to-L4 nerve root transfer method for the treatment of hindlimb hemiplegia after hypertensive intracerebral hemorrhage can improve the locomotion of hindlimb major joints,particularly of the distal ankle.Findings from study support that the L4-to-L4 nerve root transfer method can effectively repair the hindlimb hemiplegia after hypertensive intracerebral hemorrhage.All animal experiments were approved by the Animal Ethics Committee of the First Affiliated Hospital of Nanjing Medical University(No.IACUC-1906009)in June 2019.展开更多
Water quality index of reservoir source water were tracked during three years in a north frigid area,the effect on supplied water quality was also studied.Based on the analysis of the monitoring data during the same s...Water quality index of reservoir source water were tracked during three years in a north frigid area,the effect on supplied water quality was also studied.Based on the analysis of the monitoring data during the same season,the reservoir source water had typical and seasonal variation characteristics that was divided into four periods including the icebound period,spring period(or peach blossom period),stable period in summer and autumn and winter period.The icebound period was charactered by the typical low temperature and turbidity,pH and oxygen consumption decreased gradually showed that the gradually anaerobic trend existed in the reservoir.In May as the reservoir completely thawed,upstream water inflow and the total pollutant in the reservoir gradually increased,but the bottom of reservoir bottom was stable in the anaerobic state temporarily.The state completely disappeared,various index increased significantly in the middle of July.The water had high chroma characteristics,chroma and turbidity increased significantly in the summer and autumn(7-11months),but stability of water quality was poor because of rainfall.The reservoir gradually froze after the middle of November and the flow of water decreased.The peak of chroma appeared a month later than the water temperature.Due to the water turbidity was low,and the floc was small and light,the conventional water purification process design based on removal of turbidity achieved removal of chroma through a lot dosing of coagulant.展开更多
In practical development of unconventional reservoirs,fracture networks are a highly conductive transport media for subsurface fluid flow.Therefore,it is crucial to clearly determine the fracture properties used in pr...In practical development of unconventional reservoirs,fracture networks are a highly conductive transport media for subsurface fluid flow.Therefore,it is crucial to clearly determine the fracture properties used in production forecast.However,it is different to calibrate the properties of fracture networks because it is an inverse problem with multi-patterns and highcomplexity of fracture distribution and inherent defect of multiplicity of solution.In this paper,in order to solve the problem,the complex fracture model is divided into two sub-systems,namely"Pattern A"and"Pattern B."In addition,the generation method is grouped into two categories.Firstly,we construct each sub-system based on the probability density function of the fracture properties.Secondly,we recombine the sub-systems into an integral complex fracture system.Based on the generation mechanism,the estimation of the complex fracture from dynamic performance and observation data can be solved as an inverse problem.In this study,the Bayesian formulation is used to quantify the uncertainty of fracture properties.To minimize observation data misfit immediately as it occurs,we optimize the updated properties by a simultaneous perturbation stochastic algorithm which requires only two measurements of the loss function.In numerical experiments,we firstly visualize that small-scale fractures significantly contribute to the flow simulation.Then,we demonstrate the suitability and effectiveness of the Bayesian formulation for calibrating the complex fracture model in the following simulation.展开更多
AIM: To determine the levels of aquaporin-1(AQP-1) in the lens epithelial cells(LECs) of primary glaucoma and to clarify its correlation with lens thickness.METHODS: This study comprised 64 eyes of 64 patients with pr...AIM: To determine the levels of aquaporin-1(AQP-1) in the lens epithelial cells(LECs) of primary glaucoma and to clarify its correlation with lens thickness.METHODS: This study comprised 64 eyes of 64 patients with primary glaucoma, who were divided into 3 groups: 25 eyes of 25 patients with acute primary angle-closure glaucoma(APACG), 19 eyes of 19 patients with chronic primary angle-closure glaucoma(CPACG) and 20 eyes of 20 patients with primary open angle glaucoma(POAG). This study also included 12 eyes of 12 patients with senile cataract as controls. The levels of AQP-1 in LECs were examined by real-time quantitative polymerase chain reaction(RT-q PCR) and immunohistochemistry. The lens thickness was measured by A-scan ultrasonography. RESULTS: The AQP-1 m RNA levels of LECs were 0.84±0.27, 0.69±0.34, 0.44±0.19 and 0.51±0.21 in APACG, CPACG, POAG and senile cataract group, respectively. The levels of AQP-1m RNA were significantly higher in PACG groups compared with those in senile cataract and POAG group(all P<0.05). The immunohistochemistry showed the AQP-1 expression were strong-positive in PACG groups, but weak-positive in senile cataract and POAG group. A positive correlation was found between AQP-1 m RNA levels and the lens thickness(r=0.645, P<0.001). CONCLUSION: These findings show that the higher expression of AQP-1 in LECs may contribute to increased lens thickness, which might be associated with the occurrence and development of PACG.展开更多
BACKGROUND Dentition defect,a common clinical oral disease developed in humans,not only causes masticatory dysfunction and articulation difficulties but also affects facial appearance and increases the burden on the i...BACKGROUND Dentition defect,a common clinical oral disease developed in humans,not only causes masticatory dysfunction and articulation difficulties but also affects facial appearance and increases the burden on the intestinal tract.Restorative treatment is the primary option for this disease.However,traditional restorations have many drawbacks,such as mismatch with the body,low reliability,and incomplete occlusal function recovery.AIM to analyze the efficacy of orthodontics combined with 3D printing guide plate implant restoration in treating patients with dentition defects and its influence on masticatory and phonic functions.METHODS A prospective study was carried out in 86 patients with dentition defects who received implant prosthesis after orthodontic treatment in our hospital between January 2018 and January 2019.Those patients were divided into a control group and an intervention group with 43 patients in each group using a random number table.The control group received traditional implant restoration,whereas the intervention group received 3D printing guide plate implant restoration.Treatment outcomes,cosmetic appearance,dental function,implant deviation,and quality of life were compared between the two groups.RESULTS The overall response rate in the intervention group was significantly higher than that in the control group(95.35%vs 81.40%,χ^(2)=4.071,P=0.044).The number of cases with neatly trimmed cosmetic appearance(χ^(2)=4.497,P=0.034),complete coverage(χ^(2)=4.170,P=0.041),and normal occlusion(χ^(2)=5.512,P=0.019)in the intervention group was higher than that in the control group.After treatment,mastication,swallowing,and articulation were significantly improved in both groups.Masticatory(t=2.980,P=0.004),swallowing(t=2.199,P=0.031),and phonic functions(t=3.950,P=0.004)were better in the intervention group than those in the control group.The deviation value and the deviation angle(t=5.440,P=0.000)at the top(t=6.320,P=0.000)and middle parts of the implants(t=22.295,P=0.000)in the intervention group were lower than those in the control group after treatment.Functional limitations,psychosocial and physical pain and discomfort,and total scores decreased in both groups.The functional limitation(t=2.379,P=0.020),psychosocial(t=2.420,P=0.000),physical pain and discomfort(t=6.581,P=0.000),and total scores(t=2.140,P=0.035)were lower in the intervention group than those in the control group.CONCLUSION Orthodontic treatment combined with 3D printing guide plate implant restoration can significantly improve the masticatory and phonic functions,quality of life,and psychological health of patients with dentition defects.Therefore,it is highly recommended in clinic application.展开更多
Objective:To judge the efficacies of neural stem cell(NSC)transplantation on functional recovery following contusion spinal cord injuries(SCIs).Data sources:Studies in which NSCs were transplanted into a clinically re...Objective:To judge the efficacies of neural stem cell(NSC)transplantation on functional recovery following contusion spinal cord injuries(SCIs).Data sources:Studies in which NSCs were transplanted into a clinically relevant,standardized rat model of contusion SCI were identified by searching the PubMed,Embase and Cochrane databases,and the extracted data were analyzed by Stata 14.0.Data selection:Inclusion criteria were that NSCs were used in in vivo animal studies to treat contusion SCIs and that behavioral assessment of locomotor functional recovery was performed using the Basso,Beattie,and Bresnahan lo-comotor rating scale.Exclusion criteria included a follow-up of less than 4 weeks and the lack of control groups.Outcome measures:The restoration of motor function was assessed by the Basso,Beattie,and Bresnahan locomotor rating scale.Results:We identified 1756 non-duplicated papers by searching the aforementioned electronic databases,and 30 full-text articles met the inclusion criteria.A total of 37 studies reported in the 30 articles were included in the meta-analysis.The meta-analysis results showed that transplanted NSCs could improve the motor function recovery of rats following contusion SCIs,to a moderate extent(pooled standardized mean difference(SMD)=0.73;95%confidence interval(CI):0.47–1.00;P<0.001).NSCs obtained from different donor species(rat:SMD=0.74;95%CI:0.36–1.13;human:SMD=0.78;95%CI:0.31–1.25),at different donor ages(fetal:SMD=0.67;95%CI:0.43–0.92;adult:SMD=0.86;95%CI:0.50–1.22)and from different origins(brain-derived:SMD=0.59;95%CI:0.27–0.91;spinal cord-derived:SMD=0.51;95%CI:0.22–0.79)had similar efficacies on improved functional recovery;however,adult induced pluripotent stem cell-derived NSCs showed no significant efficacies.Furthermore,the use of higher doses of transplanted NSCs or the administration of immunosuppressive agents did not promote better locomotor function recovery(SMD=0.45;95%CI:0.21–0.70).However,shorter periods between the contusion induction and the NSC transplantation showed slightly higher efficacies(acute:SMD=1.22;95%CI:0.81–1.63;subacute:SMD=0.75;95%CI:0.42–1.09).For chronic injuries,NSC implantation did not significantly improve functional recovery(SMD=0.25;95%CI:–0.16 to 0.65).Conclusion:NSC transplantation alone appears to be a positive yet limited method for the treatment of contusion SCIs.展开更多
In this paper we present a new unified theory of electromagnetic and gravitational interactions. Byconsidering a four-dimensional spacetime as a hypersurface embedded in a five-dimensional bulk space-time, we derive t...In this paper we present a new unified theory of electromagnetic and gravitational interactions. Byconsidering a four-dimensional spacetime as a hypersurface embedded in a five-dimensional bulk space-time, we derive the complete set of field equations in the four-dimensional spacetime from the five-dimensional Einstein field equation. Besides the Einstein field equation in the four-dimensional space-time, an electromagnetic field equation is obtained： aF^ab -- ζR^b aA^a=-4 πJ^b with ζ = -2, whereFas is the antisymmetric electromagnetic field tensor defined by the potential vector A^a, Rab is theRicci curvature tensor of the hypersurface, and J^a is the electric current density vector. The elec-tromagnetic field equation differs from the Einstein-Maxwell equation by a curvature-coupled term ζRb^aA^a, whose presence addresses the problem of incompatibility of the Einstein-Maxwell equationwith a universe containing a uniformly distributed net charge, as discussed in a previous paper bythe author [L.-X. Li, Gen. Relativ. Gravit. 48, 28 （2016）]. Hence, the new unified theory is physicallydifferent from Kaluza-Klein theory and its variants in which the Einstein-Maxwell equation is derived.In the four-dimensional Einstein field equation derived in the new theory, the source term includes thestress-energy tensor of electromagnetic fields as well as the stress-energy tensor of other unidentifiedmatter. Under certain conditions the unidentified matter can be interpreted as a cosmological constantin the four-dimensional spacetime. We argue that, the electromagnetic field equation and hence theunified theory presented in this paper can be tested in an environment with a high mass density, e.g.,inside a neutron star or a white dwarf, and in the early epoch of the universe.展开更多
文摘AIM: To investigate transarterial chemoembolization(TACE) with hepatic infusion of oxaliplatin and 5-fluorouracil and Lipiodol chemoembolization in large hepatocellular carcinoma(HCC).METHODS: In this retrospective study, 132 patients with unresectable HCCs larger than 10 cm were treated with hepatic infusion of oxaliplatin and 5-fluorouracil followed by Lipiodol chemoembolization. The primary endpoint was overall survival(OS). Sixteen-week disease-control rate, time to progression(TTP), and major complications were also studied. Univariate and multivariate analyses were performed to identify prognostic factors affecting OS and TTP.RESULTS: A total of 319 procedures were performed in the 132 patients. Eleven(8.3%) patients received radical resection following TACE treatment(median time to initial TACE 4.3 ± 2.3 mo). The median OS and TTP were 10.3 and 3.0 mo respectively, with a 50.0% 16-wk disease-control rate. Major complications were encountered in 6.0%(8/132) of patients following TACE and included serious jaundice in 1.5%(2/132) patients, aleukia in 1.5%(2/132), and hepatic failure in 3.0%(4/132). One patient died within one month due to serious hepatic failure and severe sepsis after receiving the second TACE. The risk factor associated with TTP was baseline alpha-fetoprotein level, and vascular invasion was an independent factor related to OS.CONCLUSION: Hepatic infusion of oxaliplatin and 5-fluorouracil followed by lipiodolized-chemoembolization is a safe and promising treatment for patients with HCCs larger than 10 cm in diameter.
基金the National Natural Science Foundation of China,No.81171147(to LXL)“Key Medical Talents of Qiangwei Project”Research Foundation of Health Department of Jiangsu Province,No.ZDRCA2016010(to LXL)+3 种基金“Xingwei Project”Key Personal Medical Research Foundation of Health Department of Jiangsu Province,No.RC201156(to LXL)Jiangsu Province’s Key Discipline of Medicine,No.XK201117(to LXL)the Priority Academic Program Development of Jiangsu Higher Education Institutions,PAPD(to LXL)the Natural Science Foundation of Jiangsu Province,No.BK20171064(to BSH).
文摘There is no effective treatment for hemiplegia after hypertensive intracerebral hemorrhage.Considering that the branches of L4 nerve roots in the lumbar plexus root control the movement of the lower extremity anterior and posterior muscles,we investigated a potential method of nerve repair using the L4 nerve roots.Rat models of hindlimb hemiplegia after a hypertensive intracerebral hemorrhage were established by injecting autogenous blood into the posterior limb of internal capsule.The L4 nerve root on the healthy side of model rats was transferred and then anastomosed with the L4 nerve root on the affected side to drive the extensor and flexor muscles of the hindlimbs.We investigated whether this method can restore the flexible movement of the hindlimbs of paralyzed rats after hypertensive intracerebral hemorrhage.In a beam-walking test and ladder rung walking task,model rats exhibited an initial high number of slips,but improved in accuracy on the paretic side over time.At 17 weeks after surgery,rats gained approximately 58.2%accuracy from baseline performance and performed ankle motions on the paretic side.At 9 weeks after surgery,a retrograde tracing test showed a large number of fluoro-gold-labeled motoneurons in the left anterior horn of the spinal cord that supports the L4-to-L4 nerve roots.In addition,histological and ultramicrostructural findings showed axon regeneration of motoneurons in the anterior horn of the spinal cord.Electromyography and paw print analysis showed that denervated hindlimb muscles regained reliable innervation and walking coordination improved.These findings suggest that the L4-to-L4 nerve root transfer method for the treatment of hindlimb hemiplegia after hypertensive intracerebral hemorrhage can improve the locomotion of hindlimb major joints,particularly of the distal ankle.Findings from study support that the L4-to-L4 nerve root transfer method can effectively repair the hindlimb hemiplegia after hypertensive intracerebral hemorrhage.All animal experiments were approved by the Animal Ethics Committee of the First Affiliated Hospital of Nanjing Medical University(No.IACUC-1906009)in June 2019.
基金Sponsored by the Science and Technology Research Project of Heilongjiang Province Education Department(Grant No.12513088)PromisingYoungsters Training Program of Heilongjiang University of Science and Technology(Grant No.Q20120201)
文摘Water quality index of reservoir source water were tracked during three years in a north frigid area,the effect on supplied water quality was also studied.Based on the analysis of the monitoring data during the same season,the reservoir source water had typical and seasonal variation characteristics that was divided into four periods including the icebound period,spring period(or peach blossom period),stable period in summer and autumn and winter period.The icebound period was charactered by the typical low temperature and turbidity,pH and oxygen consumption decreased gradually showed that the gradually anaerobic trend existed in the reservoir.In May as the reservoir completely thawed,upstream water inflow and the total pollutant in the reservoir gradually increased,but the bottom of reservoir bottom was stable in the anaerobic state temporarily.The state completely disappeared,various index increased significantly in the middle of July.The water had high chroma characteristics,chroma and turbidity increased significantly in the summer and autumn(7-11months),but stability of water quality was poor because of rainfall.The reservoir gradually froze after the middle of November and the flow of water decreased.The peak of chroma appeared a month later than the water temperature.Due to the water turbidity was low,and the floc was small and light,the conventional water purification process design based on removal of turbidity achieved removal of chroma through a lot dosing of coagulant.
基金supported by the National Natural Science Foundation of China(Grant Nos.51722406,61573018 and 51874335)the Shandong Provincial Natural Science Foundation(Grant JQ201808)+1 种基金the Fundamental Research Funds for the Central Universities(Grant 18CX02097A)the National Science and Technology Major Project of China(Grant 2016ZX05025001-006)
文摘In practical development of unconventional reservoirs,fracture networks are a highly conductive transport media for subsurface fluid flow.Therefore,it is crucial to clearly determine the fracture properties used in production forecast.However,it is different to calibrate the properties of fracture networks because it is an inverse problem with multi-patterns and highcomplexity of fracture distribution and inherent defect of multiplicity of solution.In this paper,in order to solve the problem,the complex fracture model is divided into two sub-systems,namely"Pattern A"and"Pattern B."In addition,the generation method is grouped into two categories.Firstly,we construct each sub-system based on the probability density function of the fracture properties.Secondly,we recombine the sub-systems into an integral complex fracture system.Based on the generation mechanism,the estimation of the complex fracture from dynamic performance and observation data can be solved as an inverse problem.In this study,the Bayesian formulation is used to quantify the uncertainty of fracture properties.To minimize observation data misfit immediately as it occurs,we optimize the updated properties by a simultaneous perturbation stochastic algorithm which requires only two measurements of the loss function.In numerical experiments,we firstly visualize that small-scale fractures significantly contribute to the flow simulation.Then,we demonstrate the suitability and effectiveness of the Bayesian formulation for calibrating the complex fracture model in the following simulation.
基金Supported by the Science and Technology Planning Project of Guangdong Province(No.2012B050600032)the Science and Technology Planning Project of Guangzhou(No.1515000176)
文摘AIM: To determine the levels of aquaporin-1(AQP-1) in the lens epithelial cells(LECs) of primary glaucoma and to clarify its correlation with lens thickness.METHODS: This study comprised 64 eyes of 64 patients with primary glaucoma, who were divided into 3 groups: 25 eyes of 25 patients with acute primary angle-closure glaucoma(APACG), 19 eyes of 19 patients with chronic primary angle-closure glaucoma(CPACG) and 20 eyes of 20 patients with primary open angle glaucoma(POAG). This study also included 12 eyes of 12 patients with senile cataract as controls. The levels of AQP-1 in LECs were examined by real-time quantitative polymerase chain reaction(RT-q PCR) and immunohistochemistry. The lens thickness was measured by A-scan ultrasonography. RESULTS: The AQP-1 m RNA levels of LECs were 0.84±0.27, 0.69±0.34, 0.44±0.19 and 0.51±0.21 in APACG, CPACG, POAG and senile cataract group, respectively. The levels of AQP-1m RNA were significantly higher in PACG groups compared with those in senile cataract and POAG group(all P<0.05). The immunohistochemistry showed the AQP-1 expression were strong-positive in PACG groups, but weak-positive in senile cataract and POAG group. A positive correlation was found between AQP-1 m RNA levels and the lens thickness(r=0.645, P<0.001). CONCLUSION: These findings show that the higher expression of AQP-1 in LECs may contribute to increased lens thickness, which might be associated with the occurrence and development of PACG.
文摘BACKGROUND Dentition defect,a common clinical oral disease developed in humans,not only causes masticatory dysfunction and articulation difficulties but also affects facial appearance and increases the burden on the intestinal tract.Restorative treatment is the primary option for this disease.However,traditional restorations have many drawbacks,such as mismatch with the body,low reliability,and incomplete occlusal function recovery.AIM to analyze the efficacy of orthodontics combined with 3D printing guide plate implant restoration in treating patients with dentition defects and its influence on masticatory and phonic functions.METHODS A prospective study was carried out in 86 patients with dentition defects who received implant prosthesis after orthodontic treatment in our hospital between January 2018 and January 2019.Those patients were divided into a control group and an intervention group with 43 patients in each group using a random number table.The control group received traditional implant restoration,whereas the intervention group received 3D printing guide plate implant restoration.Treatment outcomes,cosmetic appearance,dental function,implant deviation,and quality of life were compared between the two groups.RESULTS The overall response rate in the intervention group was significantly higher than that in the control group(95.35%vs 81.40%,χ^(2)=4.071,P=0.044).The number of cases with neatly trimmed cosmetic appearance(χ^(2)=4.497,P=0.034),complete coverage(χ^(2)=4.170,P=0.041),and normal occlusion(χ^(2)=5.512,P=0.019)in the intervention group was higher than that in the control group.After treatment,mastication,swallowing,and articulation were significantly improved in both groups.Masticatory(t=2.980,P=0.004),swallowing(t=2.199,P=0.031),and phonic functions(t=3.950,P=0.004)were better in the intervention group than those in the control group.The deviation value and the deviation angle(t=5.440,P=0.000)at the top(t=6.320,P=0.000)and middle parts of the implants(t=22.295,P=0.000)in the intervention group were lower than those in the control group after treatment.Functional limitations,psychosocial and physical pain and discomfort,and total scores decreased in both groups.The functional limitation(t=2.379,P=0.020),psychosocial(t=2.420,P=0.000),physical pain and discomfort(t=6.581,P=0.000),and total scores(t=2.140,P=0.035)were lower in the intervention group than those in the control group.CONCLUSION Orthodontic treatment combined with 3D printing guide plate implant restoration can significantly improve the masticatory and phonic functions,quality of life,and psychological health of patients with dentition defects.Therefore,it is highly recommended in clinic application.
基金supported by the National Natural Science Foundation of China,No.81171147“Key Medical Talents of Qiangwei Project” Research Foundation of Health Department of Jiangsu Province of China,No.ZDRCA2016010+1 种基金“Xingwei Project” Key Personal Medical Research Foundation of Health Department of Jiangsu Province of China,No.RC201156Jiangsu Provincial Key Discipline of Medicine of China,No.XK201117(all to LXL)
文摘Objective:To judge the efficacies of neural stem cell(NSC)transplantation on functional recovery following contusion spinal cord injuries(SCIs).Data sources:Studies in which NSCs were transplanted into a clinically relevant,standardized rat model of contusion SCI were identified by searching the PubMed,Embase and Cochrane databases,and the extracted data were analyzed by Stata 14.0.Data selection:Inclusion criteria were that NSCs were used in in vivo animal studies to treat contusion SCIs and that behavioral assessment of locomotor functional recovery was performed using the Basso,Beattie,and Bresnahan lo-comotor rating scale.Exclusion criteria included a follow-up of less than 4 weeks and the lack of control groups.Outcome measures:The restoration of motor function was assessed by the Basso,Beattie,and Bresnahan locomotor rating scale.Results:We identified 1756 non-duplicated papers by searching the aforementioned electronic databases,and 30 full-text articles met the inclusion criteria.A total of 37 studies reported in the 30 articles were included in the meta-analysis.The meta-analysis results showed that transplanted NSCs could improve the motor function recovery of rats following contusion SCIs,to a moderate extent(pooled standardized mean difference(SMD)=0.73;95%confidence interval(CI):0.47–1.00;P<0.001).NSCs obtained from different donor species(rat:SMD=0.74;95%CI:0.36–1.13;human:SMD=0.78;95%CI:0.31–1.25),at different donor ages(fetal:SMD=0.67;95%CI:0.43–0.92;adult:SMD=0.86;95%CI:0.50–1.22)and from different origins(brain-derived:SMD=0.59;95%CI:0.27–0.91;spinal cord-derived:SMD=0.51;95%CI:0.22–0.79)had similar efficacies on improved functional recovery;however,adult induced pluripotent stem cell-derived NSCs showed no significant efficacies.Furthermore,the use of higher doses of transplanted NSCs or the administration of immunosuppressive agents did not promote better locomotor function recovery(SMD=0.45;95%CI:0.21–0.70).However,shorter periods between the contusion induction and the NSC transplantation showed slightly higher efficacies(acute:SMD=1.22;95%CI:0.81–1.63;subacute:SMD=0.75;95%CI:0.42–1.09).For chronic injuries,NSC implantation did not significantly improve functional recovery(SMD=0.25;95%CI:–0.16 to 0.65).Conclusion:NSC transplantation alone appears to be a positive yet limited method for the treatment of contusion SCIs.
文摘In this paper we present a new unified theory of electromagnetic and gravitational interactions. Byconsidering a four-dimensional spacetime as a hypersurface embedded in a five-dimensional bulk space-time, we derive the complete set of field equations in the four-dimensional spacetime from the five-dimensional Einstein field equation. Besides the Einstein field equation in the four-dimensional space-time, an electromagnetic field equation is obtained： aF^ab -- ζR^b aA^a=-4 πJ^b with ζ = -2, whereFas is the antisymmetric electromagnetic field tensor defined by the potential vector A^a, Rab is theRicci curvature tensor of the hypersurface, and J^a is the electric current density vector. The elec-tromagnetic field equation differs from the Einstein-Maxwell equation by a curvature-coupled term ζRb^aA^a, whose presence addresses the problem of incompatibility of the Einstein-Maxwell equationwith a universe containing a uniformly distributed net charge, as discussed in a previous paper bythe author [L.-X. Li, Gen. Relativ. Gravit. 48, 28 （2016）]. Hence, the new unified theory is physicallydifferent from Kaluza-Klein theory and its variants in which the Einstein-Maxwell equation is derived.In the four-dimensional Einstein field equation derived in the new theory, the source term includes thestress-energy tensor of electromagnetic fields as well as the stress-energy tensor of other unidentifiedmatter. Under certain conditions the unidentified matter can be interpreted as a cosmological constantin the four-dimensional spacetime. We argue that, the electromagnetic field equation and hence theunified theory presented in this paper can be tested in an environment with a high mass density, e.g.,inside a neutron star or a white dwarf, and in the early epoch of the universe.
