BACKGROUND Neuroendocrine neoplasms of the female genital tract are rare.AIM To enhance our clinical understanding of neuroendocrine carcinoma(NEC)of the ovary.METHODS A retrospective review was conducted on 12 patien...BACKGROUND Neuroendocrine neoplasms of the female genital tract are rare.AIM To enhance our clinical understanding of neuroendocrine carcinoma(NEC)of the ovary.METHODS A retrospective review was conducted on 12 patients diagnosed with NEC of the ovary,analyzing clinicopathological characteristics,treatment modalities,and survival status.RESULTS The median age at diagnosis was 34.5 years(range:20 to 62 years).Among the 12 cases,9 were small cell carcinoma of the ovary and 3 were large cell NEC.Five cases were stage I tumors,one case was stage IV,and six cases were stage III.Eleven patients underwent surgery as part of their treatment.All patients received adjuvant chemotherapy.Among the 12 patients,one patient received radiotherapy,and one patient with a BRCA2 mutation was administered PARP inhibitor maintenance after chemotherapy.The median progression-free survival was 13 months,and the median overall survival was 19.5 months.Four cases remained disease-free,while eight cases experienced tumor recurrence,including three cases that resulted in death due to disease recurrence.CONCLUSION NEC of the ovary is a rare condition that is more common in women of childbearing age and is associated with aggressive behavior and poor clinical outcomes.Surgical resection remains the mainstay of treatment,with some patients benefiting from adjuvant chemoradiation therapy.展开更多
The post-functionalization of gold nanoclusters with organic molecules into organic-inorganic hybrid functional materials is an efficient approach to develop multifunctional materials.By introducing 1-pyrenamine and 3...The post-functionalization of gold nanoclusters with organic molecules into organic-inorganic hybrid functional materials is an efficient approach to develop multifunctional materials.By introducing 1-pyrenamine and 3-aminofluoranthene into[O(AuPPh_(3))_(3)][BF_(4)]with a covalent bond,two novel organoimido functionalized trinuclear gold nanoclusters[C_(16)H_(9)N(AuPPh_(3))_(3)][BF_(4)](Au_(3)-P)and[C_(6)H_(4)-C_(10)H_(5)N(AuPPh_(3))_(3)][BF_(4)](Au_(3)-F)have been successfully obtained.Their structures have been determined by electrospray ionization mass spectroscopy(ESI-MS)and single-crystal X-ray diffraction(SC-XRD),and the photoluminescence properties have been investigated from both experimental and theoretical aspects.It is found that the lowest-energy electronic transitions in the ultraviolet-visible(UV-Vis)absorption spectra of Au_(3)-P(403 nm)and Au_(3)-F(425 nm)exhibit a slight bathochromic shift compared to the corresponding transitions in the spectra of 1-pyrenamine and 3-aminofluoranthene,respectively.In addition,the dichloromethane solutions of Au_(3)-P and Au_(3)-F complexes clearly display blue and yellowish-green fluorescence,respectively.These results will help to design and prepare organic-inorganic nanocluster hybrid luminescent materials for potential applications in(bio)sensors,bioimaging and optoelectronic devices.展开更多
文摘BACKGROUND Neuroendocrine neoplasms of the female genital tract are rare.AIM To enhance our clinical understanding of neuroendocrine carcinoma(NEC)of the ovary.METHODS A retrospective review was conducted on 12 patients diagnosed with NEC of the ovary,analyzing clinicopathological characteristics,treatment modalities,and survival status.RESULTS The median age at diagnosis was 34.5 years(range:20 to 62 years).Among the 12 cases,9 were small cell carcinoma of the ovary and 3 were large cell NEC.Five cases were stage I tumors,one case was stage IV,and six cases were stage III.Eleven patients underwent surgery as part of their treatment.All patients received adjuvant chemotherapy.Among the 12 patients,one patient received radiotherapy,and one patient with a BRCA2 mutation was administered PARP inhibitor maintenance after chemotherapy.The median progression-free survival was 13 months,and the median overall survival was 19.5 months.Four cases remained disease-free,while eight cases experienced tumor recurrence,including three cases that resulted in death due to disease recurrence.CONCLUSION NEC of the ovary is a rare condition that is more common in women of childbearing age and is associated with aggressive behavior and poor clinical outcomes.Surgical resection remains the mainstay of treatment,with some patients benefiting from adjuvant chemoradiation therapy.
基金financially supported by the foundation of Key Laboratory of Ethnomedicine(Minzu University of China),Ministry of Education(No.KLEM-ZZ201804)the Young Teachers’Scientific Research Ability Promotion Program of Minzu University of China(No.2018QNPY57)Beijing Municipal Natural Science Foundation(No.2154049)。
文摘The post-functionalization of gold nanoclusters with organic molecules into organic-inorganic hybrid functional materials is an efficient approach to develop multifunctional materials.By introducing 1-pyrenamine and 3-aminofluoranthene into[O(AuPPh_(3))_(3)][BF_(4)]with a covalent bond,two novel organoimido functionalized trinuclear gold nanoclusters[C_(16)H_(9)N(AuPPh_(3))_(3)][BF_(4)](Au_(3)-P)and[C_(6)H_(4)-C_(10)H_(5)N(AuPPh_(3))_(3)][BF_(4)](Au_(3)-F)have been successfully obtained.Their structures have been determined by electrospray ionization mass spectroscopy(ESI-MS)and single-crystal X-ray diffraction(SC-XRD),and the photoluminescence properties have been investigated from both experimental and theoretical aspects.It is found that the lowest-energy electronic transitions in the ultraviolet-visible(UV-Vis)absorption spectra of Au_(3)-P(403 nm)and Au_(3)-F(425 nm)exhibit a slight bathochromic shift compared to the corresponding transitions in the spectra of 1-pyrenamine and 3-aminofluoranthene,respectively.In addition,the dichloromethane solutions of Au_(3)-P and Au_(3)-F complexes clearly display blue and yellowish-green fluorescence,respectively.These results will help to design and prepare organic-inorganic nanocluster hybrid luminescent materials for potential applications in(bio)sensors,bioimaging and optoelectronic devices.
