The influence of micro-Ca/In alloying on the microstructural charac teristics,electrochemical behaviors and discharge properties of extruded dilute Mg-0.5Bi-0.5Sn-based(wt.%)alloys as anodes for Mg-air batteries are e...The influence of micro-Ca/In alloying on the microstructural charac teristics,electrochemical behaviors and discharge properties of extruded dilute Mg-0.5Bi-0.5Sn-based(wt.%)alloys as anodes for Mg-air batteries are evaluated.The grain size and texture intensity of the Mg-Bi-Sn-based alloys are significantly decreased after the Ca/In alloying,particularly for the In-containing alloy.Note that,in addition to nanoscale Mg_(3)Bi_(2)phase,a new microscale Mg_(2)Bi_(2)Ca phase forms in the Ca-containing alloy.The electrochemical test results demonstrate that Ca/In micro-alloying can enhance the electrochemical activity.Using In to alloy the Mg-Bi-Sn-based alloy is effective in restricting the cathodic hydrogen evolution(CHE)kinetics,leading to a low self-corrosion rate,while severe CHE occurred after Ca alloying.The micro-alloying of Ca/In to Mg-Bi-Sn-based alloy strongly deteriorates the compactness of discharge products film and mitigates the"chunk effect"(CE),hence the cell voltage,anodic efficiency as well as discharge capacity are greatly improved.The In-containing alloy exhibits outstanding discharge performance under the combined effect of the modified microstructure and discharge products,thus making it a potential anode material for primary Mg-air battery.展开更多
Objective:To describe discharge readiness and determine whether self-efficacy,social support,and the quality of discharge teaching can predict discharge readiness among patients with mild-to-moderate ischemic stroke.M...Objective:To describe discharge readiness and determine whether self-efficacy,social support,and the quality of discharge teaching can predict discharge readiness among patients with mild-to-moderate ischemic stroke.Methods:A total of 120 patients with mild-to-moderate ischemic stroke were recruited using simple random sampling.Five instruments,namely,the Demographic Data Questionnaire,the Chinese version of the Readiness for Hospital Discharge Scale(RHDS_C),the SelfEfficacy for Managing Chronic Disease 6-Item Scale(SES6),the Perceived Social Support Scale(PSSS),and the Quality of Discharge Teaching Scale(QDTS),were used for data collection.Descriptive statistics and standard multiple linear regression were used for data analysis.Results:The mean score of discharge readiness among patients with mild-to-moderate ischemic stroke was at a moderate level(M=7.6,SD=0.92),and 75.8%of the participants felt ready for discharge.Standard multiple linear regression revealed that selfefficacy(β=0.62,P<0.001)and the quality of discharge teaching(β=0.28,P<0.001)were the influencing factors.However,social support could not predict discharge readiness significantly.All the factors combined explained 64.9%of the variance in discharge readiness.Conclusions:Intervention programs aimed at improving self-efficacy and the quality of discharge teaching may be helpful in promoting discharge readiness in patients with mild-to-moderate ischemic stroke,especially in coping ability.展开更多
The creep properties, microstructural characteristics and creep mechanisms of as-cast Mg-5Bi-5Sn(BT55) alloy without and with Mn(BTM550) addition were investigated via creep at 423, 448, and 473 K as well as stresses ...The creep properties, microstructural characteristics and creep mechanisms of as-cast Mg-5Bi-5Sn(BT55) alloy without and with Mn(BTM550) addition were investigated via creep at 423, 448, and 473 K as well as stresses of 30, 50 and 75 MPa. The results indicate that adding Mn can result in the formation of primary and the dynamic precipitated α-Mn phases. In addition, the morphology of the precipitated Mg_(3)Bi_(2) phase and the orientation relationship between Mg_(2)Sn precipitates and α-Mg can be effectively modified. Tailoring the microstructural characteristics is responsible for the improved creep performance of BTM550 alloy. The dominant creep mechanisms in BT55 and BTM550 alloys are dislocation cross-slip and climb, respectively. Furthermore, twinning and pyramidal slip play an assisting part in both alloys during creep process.展开更多
BACKGROUND Tuberculous uveitis caused by tuberculosis infection factors is common,but tuberculous uveitis caused by Mycobacterium tuberculosis found in the intraocular fluid is rare.This report describes the use of in...BACKGROUND Tuberculous uveitis caused by tuberculosis infection factors is common,but tuberculous uveitis caused by Mycobacterium tuberculosis found in the intraocular fluid is rare.This report describes the use of intraocular fluid in the diagnosis of tuberculous uveitis in a patient and reviews the relevant literature.CASE SUMMARY A 24-year-old woman who was 31-wk pregnant visited Hebei Chest Hospital due to intermittent chest pain,fever,and decreased vision for 3 mo.The hydrothorax test suggested“tuberculous pleurisy”,and yellow effusion was extracted from the chest tube twice resulting in a total volume of approximately 800 mL.The patient chose to continue the pregnancy without treatment,and was hospitalized again due to high fever.Following 2 mo of anti-tuberculosis treatment,a healthy boy was delivered by cesarean section.Tuberculous uveitis was diagnosed using tuberculosis Xpert,and intraocular infection was detected by second-generation gene sequencing.Following systemic treatment,the patient gradually improved,and the corrected visual acuity of the left eye gradually increased from 0.08 to 1.0.CONCLUSION The etiology of uveitis is complex,and it is necessary to assess the patient’s general condition and apply molecular biology methods to determine the pathogenesis and guide precise treatment,to improve clinicians’awareness and standardize treatment of the disease.展开更多
AIM: To explore the effect of Obtusifolin on retinal pigment epithelial cell growth under hypoxia.METHODS: In vitro chemical hypoxia model of ARPE-19 cells was established using cobalt chloride(CoCl2). Cell viability ...AIM: To explore the effect of Obtusifolin on retinal pigment epithelial cell growth under hypoxia.METHODS: In vitro chemical hypoxia model of ARPE-19 cells was established using cobalt chloride(CoCl2). Cell viability was tested by cell counting kit-8(CCK-8) assay. Western blot and real-time quantitative polymerase chain reaction were applied to detect proteins and mRNAs respectively. Flow cytometry was used to examine the cell cycle. Secretion of vascular endothelial growth factor(VEGF) was tested by using enzyme linked immunosorbent assay(ELISA).RESULTS: Under the chemical hypoxia model established by CoCl2, hypoxia inducible factor-1α(HIF-1α) mRNA and protein levels was up-regulated. Cell viability was increased and the proportion of S phase was higher. Obtusifolin could reduce cell viability under hypoxic conditions and arrest cells in G1 phase. Obtusifolin reduced the expression of Cyclin D1 and proliferating cell nuclear antigen(PCNA) in the hypoxic environment and increased the expression of p53 and p21. The levels of VEGF, VEGFR2 and eNOS proteins and mRNA were significantly increased under hypoxia while Obtusifolin inhibited the increasing.CONCLUSION: Obtusifolin can inhibit cell growth under hypoxic conditions and down-regulate HIF-1/VEGF/eNOS secretions in ARPE-19 cells.展开更多
BACKGROUND Lipemia retinalis(LR)is a rare disease related to hypertriglyceridemia.However,the symptoms of hypertriglyceridemia are insidious and difficult to detect without blood tests.The fundus is the only site wher...BACKGROUND Lipemia retinalis(LR)is a rare disease related to hypertriglyceridemia.However,the symptoms of hypertriglyceridemia are insidious and difficult to detect without blood tests.The fundus is the only site where blood vessels can be observed directly.Understanding the specific performance of LR in multimodal imaging fundus examinations can help diagnose more patients with abnormal hyperlipidemia.CASE SUMMARY A 29-year-old woman with type 2 diabetes presented to our clinic complaining of a six-day loss of visual acuity in the left eye.The fundus color images showed typical LR:Arteries and veins were the same pink-white color.Infrared images showed hyperinfrared reflections of the arteries and veins.Optical coherence tomography(OCT)showed numerous high point-like reflections in the retinal section,corresponding to different calibers of blood vessel sections.Medium reflections were seen in the big vessels of the choroid.Fundus fluorescein angiography(FFA)and optical coherence tomography angiography(OCTA)showed no significant changes.Laboratory examination found a total cholesterol level of 13.98 mmol/L,triglyceride 20.55 mmol/L,which confirmed the diagnosis of LR.After treatment to lower blood lipids and control blood glucose,the fundus imaging showed that the blood lipids in the patient had returned to normal.CONCLUSION LR shows specific changes in fundus color photography,infrared photography,and OCT.FFA and OCTA were not sensitive to LR changes.展开更多
Mg-0.5Sn-0.5Mn-0.5Ca(wt.%) alloys with different microstructures are designed through casting and extrusion with and without homogenization treatment prior to extrusion(HPE).The influence of HPE treatment on the micro...Mg-0.5Sn-0.5Mn-0.5Ca(wt.%) alloys with different microstructures are designed through casting and extrusion with and without homogenization treatment prior to extrusion(HPE).The influence of HPE treatment on the microstructural characteristics and resultant discharge properties of Mg-Sn-Mn-Ca alloy in extruded condition as anode for Mg-air battery was investigated.HPE treatment exerts a prominent effect on the grain structure and orientation,distribution of the second phase particles as well as the dislocation density of the extruded alloy.The HPE alloy exhibits a distinctly high cell voltage together with specific energy compared with that of Non-HPE one.Intermittent discharge tests confirm that the HPE alloy possesses a more excellent discharge activity and more stable discharge process than the NonHPE one.All results demonstrate that the HPE alloy is an attractive anode material for Mg-air battery with long-term storage and under intermittent discharge.展开更多
The twinning behavior, dynamic recrystallization(DRX) mechanism and the resultant texture evolution of the extruded Mg-xBi(x=0.5 wt.%, 2.0 wt.%) alloys were systematically investigated during hot compression at the st...The twinning behavior, dynamic recrystallization(DRX) mechanism and the resultant texture evolution of the extruded Mg-xBi(x=0.5 wt.%, 2.0 wt.%) alloys were systematically investigated during hot compression at the strain rate of 10 s^(-1) and temperature of 200℃. The results indicate that the types and intensities of the texture are greatly dependent on the twining behavior and DRX mechanism. At the initial stage, the evolution of texture is mainly domination by the formation and variation of {1012} extension twins, which is benefcial to the compression direction(CD)-tilted basal texture. With an increase in the strain, the texture evolution is more greatly regulated by the DRX mechanism. Besides, the pyramidal<c + a> slip and basal slip are activated during the compression process, resulting in the Schmid factors(SF) of pyramidal slip remain at ~0.4 and the average SFs for basal slip increase from 0.2 to0.34 as the strain increase. These fndings provide a new insight into controlling the texture of wrought Mg-Bi-based alloys during hot deformation processing.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.:51901153)Shanxi Scholarship Council of China(Grant No.:2019032)+1 种基金Natural Science Foundation of Shanxi(Grant No.:202103021224049)the Science and Technology Major Project of Shanxi Province(Grant No.:20191102008,20191102007)。
文摘The influence of micro-Ca/In alloying on the microstructural charac teristics,electrochemical behaviors and discharge properties of extruded dilute Mg-0.5Bi-0.5Sn-based(wt.%)alloys as anodes for Mg-air batteries are evaluated.The grain size and texture intensity of the Mg-Bi-Sn-based alloys are significantly decreased after the Ca/In alloying,particularly for the In-containing alloy.Note that,in addition to nanoscale Mg_(3)Bi_(2)phase,a new microscale Mg_(2)Bi_(2)Ca phase forms in the Ca-containing alloy.The electrochemical test results demonstrate that Ca/In micro-alloying can enhance the electrochemical activity.Using In to alloy the Mg-Bi-Sn-based alloy is effective in restricting the cathodic hydrogen evolution(CHE)kinetics,leading to a low self-corrosion rate,while severe CHE occurred after Ca alloying.The micro-alloying of Ca/In to Mg-Bi-Sn-based alloy strongly deteriorates the compactness of discharge products film and mitigates the"chunk effect"(CE),hence the cell voltage,anodic efficiency as well as discharge capacity are greatly improved.The In-containing alloy exhibits outstanding discharge performance under the combined effect of the modified microstructure and discharge products,thus making it a potential anode material for primary Mg-air battery.
文摘Objective:To describe discharge readiness and determine whether self-efficacy,social support,and the quality of discharge teaching can predict discharge readiness among patients with mild-to-moderate ischemic stroke.Methods:A total of 120 patients with mild-to-moderate ischemic stroke were recruited using simple random sampling.Five instruments,namely,the Demographic Data Questionnaire,the Chinese version of the Readiness for Hospital Discharge Scale(RHDS_C),the SelfEfficacy for Managing Chronic Disease 6-Item Scale(SES6),the Perceived Social Support Scale(PSSS),and the Quality of Discharge Teaching Scale(QDTS),were used for data collection.Descriptive statistics and standard multiple linear regression were used for data analysis.Results:The mean score of discharge readiness among patients with mild-to-moderate ischemic stroke was at a moderate level(M=7.6,SD=0.92),and 75.8%of the participants felt ready for discharge.Standard multiple linear regression revealed that selfefficacy(β=0.62,P<0.001)and the quality of discharge teaching(β=0.28,P<0.001)were the influencing factors.However,social support could not predict discharge readiness significantly.All the factors combined explained 64.9%of the variance in discharge readiness.Conclusions:Intervention programs aimed at improving self-efficacy and the quality of discharge teaching may be helpful in promoting discharge readiness in patients with mild-to-moderate ischemic stroke,especially in coping ability.
基金the National Natural Science Foundation of China(Nos.51704209,U1810208,U1810122)the Central Government Guided Local Science and Technology Development Projects,China(No.YDZJSX2021A010)+5 种基金the Projects of International Cooperation in Shanxi Province,China(Nos.201803D421086,201903D421076)Shanxi Province Patent Promotion Implementation Fund,China(No.20200718)the Technological Innovation Programs of Higher Education Institutions in Shanxi Province,China(No.201802034)Shanxi Province Scientific Facilities and Instruments Shared Service Platform of Magnesium-based Materials Electric Impulse Aided Forming,China(No.201805D141005)Science and Technology Major Project of Shanxi Province,China(Nos.20191102008,20191102007,20181101008)Yantai High-end Talent Introduction“Double Hundred Plan”,China(2021)。
基金the financial supports from the National Natural Science Foundation of China (Nos. 51704209, 51701060, 51901153)the Natural Science Foundation of Shanxi Province, China (Nos. 201801D121088, 201901D211096)the Science and Technology Major Project of Shanxi Province, China (Nos. 20191102007, 20191102008)。
基金jointly supported by the National Natural Science Foundation of China (Grant Nos: 51704209,51701060,51901153)Natural Science Foundation of Shanxi province (Nos: 201801D121088,201901D211096)the Science and Technology Major Project of Shanxi province (Nos: 20191102007,20191102008)。
文摘The creep properties, microstructural characteristics and creep mechanisms of as-cast Mg-5Bi-5Sn(BT55) alloy without and with Mn(BTM550) addition were investigated via creep at 423, 448, and 473 K as well as stresses of 30, 50 and 75 MPa. The results indicate that adding Mn can result in the formation of primary and the dynamic precipitated α-Mn phases. In addition, the morphology of the precipitated Mg_(3)Bi_(2) phase and the orientation relationship between Mg_(2)Sn precipitates and α-Mg can be effectively modified. Tailoring the microstructural characteristics is responsible for the improved creep performance of BTM550 alloy. The dominant creep mechanisms in BT55 and BTM550 alloys are dislocation cross-slip and climb, respectively. Furthermore, twinning and pyramidal slip play an assisting part in both alloys during creep process.
基金Supported by the Medical Science Research Project of Hebei Province,No.20191029。
文摘BACKGROUND Tuberculous uveitis caused by tuberculosis infection factors is common,but tuberculous uveitis caused by Mycobacterium tuberculosis found in the intraocular fluid is rare.This report describes the use of intraocular fluid in the diagnosis of tuberculous uveitis in a patient and reviews the relevant literature.CASE SUMMARY A 24-year-old woman who was 31-wk pregnant visited Hebei Chest Hospital due to intermittent chest pain,fever,and decreased vision for 3 mo.The hydrothorax test suggested“tuberculous pleurisy”,and yellow effusion was extracted from the chest tube twice resulting in a total volume of approximately 800 mL.The patient chose to continue the pregnancy without treatment,and was hospitalized again due to high fever.Following 2 mo of anti-tuberculosis treatment,a healthy boy was delivered by cesarean section.Tuberculous uveitis was diagnosed using tuberculosis Xpert,and intraocular infection was detected by second-generation gene sequencing.Following systemic treatment,the patient gradually improved,and the corrected visual acuity of the left eye gradually increased from 0.08 to 1.0.CONCLUSION The etiology of uveitis is complex,and it is necessary to assess the patient’s general condition and apply molecular biology methods to determine the pathogenesis and guide precise treatment,to improve clinicians’awareness and standardize treatment of the disease.
基金supported by the Natural Science Foundation of Shanxi Province, China (Nos. 20210302123135, 20210302123163, 201901D211096, 201901D111272)Youth Program of National Natural Science Foundation of China (No. 51901153)+1 种基金Science and Technology Major Project of Shanxi Province, China (Nos. 20191102008, 20191102007, 20191102004)Shanxi Province Scientific Facilities and Instruments Shared Service Platform of Magnesium-based Materials Electric Impulse Aided Forming, China (No. 201805D141005)。
文摘AIM: To explore the effect of Obtusifolin on retinal pigment epithelial cell growth under hypoxia.METHODS: In vitro chemical hypoxia model of ARPE-19 cells was established using cobalt chloride(CoCl2). Cell viability was tested by cell counting kit-8(CCK-8) assay. Western blot and real-time quantitative polymerase chain reaction were applied to detect proteins and mRNAs respectively. Flow cytometry was used to examine the cell cycle. Secretion of vascular endothelial growth factor(VEGF) was tested by using enzyme linked immunosorbent assay(ELISA).RESULTS: Under the chemical hypoxia model established by CoCl2, hypoxia inducible factor-1α(HIF-1α) mRNA and protein levels was up-regulated. Cell viability was increased and the proportion of S phase was higher. Obtusifolin could reduce cell viability under hypoxic conditions and arrest cells in G1 phase. Obtusifolin reduced the expression of Cyclin D1 and proliferating cell nuclear antigen(PCNA) in the hypoxic environment and increased the expression of p53 and p21. The levels of VEGF, VEGFR2 and eNOS proteins and mRNA were significantly increased under hypoxia while Obtusifolin inhibited the increasing.CONCLUSION: Obtusifolin can inhibit cell growth under hypoxic conditions and down-regulate HIF-1/VEGF/eNOS secretions in ARPE-19 cells.
文摘BACKGROUND Lipemia retinalis(LR)is a rare disease related to hypertriglyceridemia.However,the symptoms of hypertriglyceridemia are insidious and difficult to detect without blood tests.The fundus is the only site where blood vessels can be observed directly.Understanding the specific performance of LR in multimodal imaging fundus examinations can help diagnose more patients with abnormal hyperlipidemia.CASE SUMMARY A 29-year-old woman with type 2 diabetes presented to our clinic complaining of a six-day loss of visual acuity in the left eye.The fundus color images showed typical LR:Arteries and veins were the same pink-white color.Infrared images showed hyperinfrared reflections of the arteries and veins.Optical coherence tomography(OCT)showed numerous high point-like reflections in the retinal section,corresponding to different calibers of blood vessel sections.Medium reflections were seen in the big vessels of the choroid.Fundus fluorescein angiography(FFA)and optical coherence tomography angiography(OCTA)showed no significant changes.Laboratory examination found a total cholesterol level of 13.98 mmol/L,triglyceride 20.55 mmol/L,which confirmed the diagnosis of LR.After treatment to lower blood lipids and control blood glucose,the fundus imaging showed that the blood lipids in the patient had returned to normal.CONCLUSION LR shows specific changes in fundus color photography,infrared photography,and OCT.FFA and OCTA were not sensitive to LR changes.
基金jointly supported by the National Natural Science Foundation of China(Grant Nos.:51704209,51701060)Natural Science Foundation of Shanxi Province(Grant No.:201801D121088)+2 种基金Shanxi Province Science Foundation for Youths(Grant No.:2016021063)Shanxi Scholarship Council of China(Grant No.:2019032)the Science and Technology Major Project of Shanxi Province(Grant Nos.:20191102008,20191102007)。
文摘Mg-0.5Sn-0.5Mn-0.5Ca(wt.%) alloys with different microstructures are designed through casting and extrusion with and without homogenization treatment prior to extrusion(HPE).The influence of HPE treatment on the microstructural characteristics and resultant discharge properties of Mg-Sn-Mn-Ca alloy in extruded condition as anode for Mg-air battery was investigated.HPE treatment exerts a prominent effect on the grain structure and orientation,distribution of the second phase particles as well as the dislocation density of the extruded alloy.The HPE alloy exhibits a distinctly high cell voltage together with specific energy compared with that of Non-HPE one.Intermittent discharge tests confirm that the HPE alloy possesses a more excellent discharge activity and more stable discharge process than the NonHPE one.All results demonstrate that the HPE alloy is an attractive anode material for Mg-air battery with long-term storage and under intermittent discharge.
基金supported by the National Natural Science Foundation of China(Nos.51704209,51701060 and 51901153)the Natural Science Foundation of Shanxi province(Nos.201801D121088 and 201901D211096)the Science and Technology Major Project of Shanxi Province(Nos.20191102007 and 20191102008)。
文摘The twinning behavior, dynamic recrystallization(DRX) mechanism and the resultant texture evolution of the extruded Mg-xBi(x=0.5 wt.%, 2.0 wt.%) alloys were systematically investigated during hot compression at the strain rate of 10 s^(-1) and temperature of 200℃. The results indicate that the types and intensities of the texture are greatly dependent on the twining behavior and DRX mechanism. At the initial stage, the evolution of texture is mainly domination by the formation and variation of {1012} extension twins, which is benefcial to the compression direction(CD)-tilted basal texture. With an increase in the strain, the texture evolution is more greatly regulated by the DRX mechanism. Besides, the pyramidal<c + a> slip and basal slip are activated during the compression process, resulting in the Schmid factors(SF) of pyramidal slip remain at ~0.4 and the average SFs for basal slip increase from 0.2 to0.34 as the strain increase. These fndings provide a new insight into controlling the texture of wrought Mg-Bi-based alloys during hot deformation processing.
