The GATIS score,developed by Zeng et al,represents a significant advancement in predicting the prognosis of patients with rectal neuroendocrine neoplasms(RNENs).This study,which included 1408 patients from 17 major me...The GATIS score,developed by Zeng et al,represents a significant advancement in predicting the prognosis of patients with rectal neuroendocrine neoplasms(RNENs).This study,which included 1408 patients from 17 major medical centres in China over 12 years,introduces a novel prognostic model based on the tumour grade,T stage,tumour size,age,and the prognostic nutritional index.Compared with traditional methods such as the World Health Organization classification and TNM staging systems,the GATIS score has superior predictive power for overall survival and progression-free survival.With a C-index of 0.915 in the training set and 0.812 in the external validation set,the GATIS score’s robustness and reliability are evident.The study’s use of a large,multi-centre cohort and rigorous validation processes underscore its significance.The GATIS score offers clinicians a powerful tool to accurately predict patient outcomes,guide treatment decisions,and improve follow-up strategies.This development represents a crucial step forwards in the management of R-NENs,addressing the complexity and variability of these tumours and setting a new benchmark for future research and clinical practice.展开更多
目的评价心脑血管疾病患者围手术期抗栓药物治疗临床路径管理的干预效果。方法将2019年10月—2020年9月、2020年10月—2021年9月在北京朝阳医院外科治疗的心脑血管疾病住院患者分为常规治疗组和药师干预组。药师依据临床路径对患者用药...目的评价心脑血管疾病患者围手术期抗栓药物治疗临床路径管理的干预效果。方法将2019年10月—2020年9月、2020年10月—2021年9月在北京朝阳医院外科治疗的心脑血管疾病住院患者分为常规治疗组和药师干预组。药师依据临床路径对患者用药方案进行干预,并持续跟踪随访至患者出院。以围手术期抗栓药物使用适宜占比、药品不良事件发生率、住院天数、住院总费用、出院后3个月再入院发生率等为指标评价围手术期抗栓药物临床路径管理效果。结果常规治疗组121例,药师干预组202例,两组心脑血管事件(5.0%vs.5.0%)、静脉血栓栓塞症(2.5%vs.3.0%)、出血事件(3.3%vs.2.0%)的发生率差异均无统计学意义(P>0.05);药师干预组围手术期抗栓药物使用的各类适宜占比(术前抗血小板药物治疗61.9%vs.24.0%,术前抗凝药物治疗66.3%vs.39.7%,术后抗血小板药物治疗80.7%vs.10.0%,术后抗凝药物治疗89.6%vs.65.3%,P<0.001)、住院天数(13.00 d vs.10.00 d,P=0.004)、住院期西药费用(2692.97元vs.2110.76元,P=0.008)、住院期抗凝药物费用(406.20元vs.200.28元,P<0.001)均显著低于常规治疗组。结论心脑血管疾病患者围手术期抗栓药物治疗临床路径的建立及应用可能会改善心脑血管疾病患者围手术期抗栓药物使用不适宜情况,不增加药品不良事件发生率,且减轻了患者的经济负担。展开更多
BACKGROUND Primary central nervous system lymphoma(PCNSL)is a rare malignant tumor originating from the lymphatic hematopoietic system.It exhibits unique imaging manifestations due to its biological characteristics.CA...BACKGROUND Primary central nervous system lymphoma(PCNSL)is a rare malignant tumor originating from the lymphatic hematopoietic system.It exhibits unique imaging manifestations due to its biological characteristics.CASE SUMMARY Magnetic resonance imaging(MRI)with diffusion-weighted imaging(DWI),perfusion-weighted imaging(PWI),and magnetic resonance spectroscopy was performed.The imaging findings showed multiple space-occupying lesions with low signal on T1-weighted imaging,uniform high signal on T2-weighted imaging,and obvious enhancement on contrast-enhanced scans.DWI revealed diffusion restriction,PWI demonstrated hypoperfusion,and spectroscopy showed elevated choline peak and decreased N-acetylaspartic acid.The patient's condition significantly improved after hormone shock therapy.CONCLUSION This case highlights the distinctive imaging features of PCNSL and their importance in accurate diagnosis and management.展开更多
BACKGROUND Acute myocardial infarction(AMI)is a leading cause of mortality.Early reperfusion to restore blood flow is crucial to successful treatment.In the current reperfusion regimen,an increasing number of patients...BACKGROUND Acute myocardial infarction(AMI)is a leading cause of mortality.Early reperfusion to restore blood flow is crucial to successful treatment.In the current reperfusion regimen,an increasing number of patients have benefited from direct percutaneous coronary intervention(PCI).In order to understand whether there is a correlation between the components of coronary thrombosis and the absence of reflow or slow blood flow after coronary stent implantation in direct PCI,we collected data on direct PCI cases in our hospital between January 2016 and November 2018.AIM To investigate the correlation between intracoronary thrombus components and coronary blood flow after stent implantation in direct PCI in AMI.METHODS We enrolled 154 patients(85 male and 69 female,aged 36–81 years)with direct PCI who underwent thrombus catheter aspiration within<3,3–6 or 6–12 h of onset of AMI between January 2016 and November 2018.The thrombus was removed for pathological examination under a microscope.The patients of the three groups according to the onset time of AMI were further divided into those with a white or red thrombus.The thrombolysis in myocardial infarction(TIMI)blood flow after stent implantation was recorded based on digital subtraction angiography during PCI.The number of patients with no-reflow and slow blood flow in each group was counted.Statistical analysis was performed based on data such as onset time,TIMI blood flow.RESULTS There were significant differences in thrombus components between the patients with acute ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction(P<0.01).In the group with PCI<3 h after onset of AMI,there was no significant difference in the incidence of no-reflow and slow-flow between the white and red thrombus groups.In the groups with PCI 3-6 and 6-12 h after onset of AMI,there was a significant difference in the incidence of no-reflow and slow-flow between the white and red thrombus groups(P<0.01).There was a significant correlation between the onset time of AMI and the occurrences of no-reflow and slow blood flow during PCI(P<0.01).CONCLUSION In direct PCI,the onset time of AMI and color of coronary thrombus are often used to predict whether there will be no reflow or slow blood flow after stent implantation.展开更多
1.Objective Yican 1 well, drilled in Southeastern Ordos Basin by Oil & Gas Survey, China Geological Survey in 2014 produced 3.7×104 m3 natural gas daily, which is the most productive well in the area by far. ...1.Objective Yican 1 well, drilled in Southeastern Ordos Basin by Oil & Gas Survey, China Geological Survey in 2014 produced 3.7×104 m3 natural gas daily, which is the most productive well in the area by far. However, the reservoir quality is poor compared with those of Jingbian gas field in the middle of the Basin, which is mainly caused by the pores filling in karst reservoir.展开更多
A new compound, 3S-hydroxy-7 melleine was isolated from the endophytic fungus Xylariasp No.2508 from the mangrove tree on the South China Sea coast. It was the first time that this kind of compound was isolated from m...A new compound, 3S-hydroxy-7 melleine was isolated from the endophytic fungus Xylariasp No.2508 from the mangrove tree on the South China Sea coast. It was the first time that this kind of compound was isolated from marine fungus. The structure was elucidated by NMR data, infrared spectrum （IR） and mass spectrometry （MS）. In addition, its structure was determined by the single-crystal X-ray diffraction analysis. It crystallized in monoclinic, space group P21 with a=10.8884（19） A, b=7.2284（13） A, c=13.398（2） A,β=104.217（3）°, C10H10O4·H2O, Mr=212.20, V=1022.2（3） A^3, Z=4, Dc=1.379 mg/m^3, F（000）=448, μ=0.112 mm^-1, the final R=0.0498, wR=0.101 for 2407 observed reflections （I〉2σ（I））. The molecular backbone of the compound includes a benzopyran ring. By comparing with the melting point and the optical rotation of the known 3R-hydroxy-7 melleine in literature, the absolute configuration of the compound was determined as 3S. It didn＇t exhibit antibacterial activity against Gram-positive bacterium Staphylococcus aureus at 200 μg/disk in the preliminary test.展开更多
基金Guangdong Medical Science and Technology Research Fund Project,No.A2024475.
文摘The GATIS score,developed by Zeng et al,represents a significant advancement in predicting the prognosis of patients with rectal neuroendocrine neoplasms(RNENs).This study,which included 1408 patients from 17 major medical centres in China over 12 years,introduces a novel prognostic model based on the tumour grade,T stage,tumour size,age,and the prognostic nutritional index.Compared with traditional methods such as the World Health Organization classification and TNM staging systems,the GATIS score has superior predictive power for overall survival and progression-free survival.With a C-index of 0.915 in the training set and 0.812 in the external validation set,the GATIS score’s robustness and reliability are evident.The study’s use of a large,multi-centre cohort and rigorous validation processes underscore its significance.The GATIS score offers clinicians a powerful tool to accurately predict patient outcomes,guide treatment decisions,and improve follow-up strategies.This development represents a crucial step forwards in the management of R-NENs,addressing the complexity and variability of these tumours and setting a new benchmark for future research and clinical practice.
文摘目的评价心脑血管疾病患者围手术期抗栓药物治疗临床路径管理的干预效果。方法将2019年10月—2020年9月、2020年10月—2021年9月在北京朝阳医院外科治疗的心脑血管疾病住院患者分为常规治疗组和药师干预组。药师依据临床路径对患者用药方案进行干预,并持续跟踪随访至患者出院。以围手术期抗栓药物使用适宜占比、药品不良事件发生率、住院天数、住院总费用、出院后3个月再入院发生率等为指标评价围手术期抗栓药物临床路径管理效果。结果常规治疗组121例,药师干预组202例,两组心脑血管事件(5.0%vs.5.0%)、静脉血栓栓塞症(2.5%vs.3.0%)、出血事件(3.3%vs.2.0%)的发生率差异均无统计学意义(P>0.05);药师干预组围手术期抗栓药物使用的各类适宜占比(术前抗血小板药物治疗61.9%vs.24.0%,术前抗凝药物治疗66.3%vs.39.7%,术后抗血小板药物治疗80.7%vs.10.0%,术后抗凝药物治疗89.6%vs.65.3%,P<0.001)、住院天数(13.00 d vs.10.00 d,P=0.004)、住院期西药费用(2692.97元vs.2110.76元,P=0.008)、住院期抗凝药物费用(406.20元vs.200.28元,P<0.001)均显著低于常规治疗组。结论心脑血管疾病患者围手术期抗栓药物治疗临床路径的建立及应用可能会改善心脑血管疾病患者围手术期抗栓药物使用不适宜情况,不增加药品不良事件发生率,且减轻了患者的经济负担。
基金Supported by National Natural Science Foundation of China,No.82071871Guangdong Basic and Applied Basic Research Foundation,No.2021A1515220131+1 种基金Guangdong Medical Science and Technology Research Fund Project,No.2022111520491834and Clinical Research Project of Shenzhen Second People's Hospital,China,No.20223357022。
文摘BACKGROUND Primary central nervous system lymphoma(PCNSL)is a rare malignant tumor originating from the lymphatic hematopoietic system.It exhibits unique imaging manifestations due to its biological characteristics.CASE SUMMARY Magnetic resonance imaging(MRI)with diffusion-weighted imaging(DWI),perfusion-weighted imaging(PWI),and magnetic resonance spectroscopy was performed.The imaging findings showed multiple space-occupying lesions with low signal on T1-weighted imaging,uniform high signal on T2-weighted imaging,and obvious enhancement on contrast-enhanced scans.DWI revealed diffusion restriction,PWI demonstrated hypoperfusion,and spectroscopy showed elevated choline peak and decreased N-acetylaspartic acid.The patient's condition significantly improved after hormone shock therapy.CONCLUSION This case highlights the distinctive imaging features of PCNSL and their importance in accurate diagnosis and management.
文摘BACKGROUND Acute myocardial infarction(AMI)is a leading cause of mortality.Early reperfusion to restore blood flow is crucial to successful treatment.In the current reperfusion regimen,an increasing number of patients have benefited from direct percutaneous coronary intervention(PCI).In order to understand whether there is a correlation between the components of coronary thrombosis and the absence of reflow or slow blood flow after coronary stent implantation in direct PCI,we collected data on direct PCI cases in our hospital between January 2016 and November 2018.AIM To investigate the correlation between intracoronary thrombus components and coronary blood flow after stent implantation in direct PCI in AMI.METHODS We enrolled 154 patients(85 male and 69 female,aged 36–81 years)with direct PCI who underwent thrombus catheter aspiration within<3,3–6 or 6–12 h of onset of AMI between January 2016 and November 2018.The thrombus was removed for pathological examination under a microscope.The patients of the three groups according to the onset time of AMI were further divided into those with a white or red thrombus.The thrombolysis in myocardial infarction(TIMI)blood flow after stent implantation was recorded based on digital subtraction angiography during PCI.The number of patients with no-reflow and slow blood flow in each group was counted.Statistical analysis was performed based on data such as onset time,TIMI blood flow.RESULTS There were significant differences in thrombus components between the patients with acute ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction(P<0.01).In the group with PCI<3 h after onset of AMI,there was no significant difference in the incidence of no-reflow and slow-flow between the white and red thrombus groups.In the groups with PCI 3-6 and 6-12 h after onset of AMI,there was a significant difference in the incidence of no-reflow and slow-flow between the white and red thrombus groups(P<0.01).There was a significant correlation between the onset time of AMI and the occurrences of no-reflow and slow blood flow during PCI(P<0.01).CONCLUSION In direct PCI,the onset time of AMI and color of coronary thrombus are often used to predict whether there will be no reflow or slow blood flow after stent implantation.
基金supported by National Science Foundation of China (41802173).
文摘1.Objective Yican 1 well, drilled in Southeastern Ordos Basin by Oil & Gas Survey, China Geological Survey in 2014 produced 3.7×104 m3 natural gas daily, which is the most productive well in the area by far. However, the reservoir quality is poor compared with those of Jingbian gas field in the middle of the Basin, which is mainly caused by the pores filling in karst reservoir.
文摘A new compound, 3S-hydroxy-7 melleine was isolated from the endophytic fungus Xylariasp No.2508 from the mangrove tree on the South China Sea coast. It was the first time that this kind of compound was isolated from marine fungus. The structure was elucidated by NMR data, infrared spectrum （IR） and mass spectrometry （MS）. In addition, its structure was determined by the single-crystal X-ray diffraction analysis. It crystallized in monoclinic, space group P21 with a=10.8884（19） A, b=7.2284（13） A, c=13.398（2） A,β=104.217（3）°, C10H10O4·H2O, Mr=212.20, V=1022.2（3） A^3, Z=4, Dc=1.379 mg/m^3, F（000）=448, μ=0.112 mm^-1, the final R=0.0498, wR=0.101 for 2407 observed reflections （I〉2σ（I））. The molecular backbone of the compound includes a benzopyran ring. By comparing with the melting point and the optical rotation of the known 3R-hydroxy-7 melleine in literature, the absolute configuration of the compound was determined as 3S. It didn＇t exhibit antibacterial activity against Gram-positive bacterium Staphylococcus aureus at 200 μg/disk in the preliminary test.
