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The lymphatic drainage systems in the brain:a novel target for ischemic stroke? 被引量:4
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作者 Ying-Jie Wang Yan-Rong Sun +4 位作者 Yan-Hong Pei Hao-Wen Ma Ya-Kun Mu li-hua qin Jun-Hao Yan 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第3期485-491,共7页
Recent studies have proposed three lymphatic drainage systems in the brain,that is,the glymphatic system,the intramural periarterial drainage pathway,and meningeal lymphatic vessels,whose roles in various neurological... Recent studies have proposed three lymphatic drainage systems in the brain,that is,the glymphatic system,the intramural periarterial drainage pathway,and meningeal lymphatic vessels,whose roles in various neurological diseases have been widely explored.The glymphatic system is a fluid drainage and waste clearance pathway that utilizes perivascular space and aquaporin-4 protein located in the astrocyte endfeet to provide a space for exchange of cerebrospinal fluid and interstitial fluid.The intramural periarterial drainage pathway drives the flow of interstitial fluid through the capillary basement membrane and the arterial tunica media.Meningeal lymphatic vessels within the dura mater are involved in the removal of cerebral macromolecules and immune responses.After ischemic stroke,impairment of these systems could lead to cerebral edema,accumulation of toxic factors,and activation of neuroinflammation,while restoration of their normal functions can improve neurological outcomes.In this review,we summarize the basic concepts of these drainage systems,including drainage routes,physiological functions,regulatory mechanisms,and detection technologies.We also focus on the roles of lymphatic drainage systems in brain injury after ischemic stroke,as well as recent advances in therapeutic strategies targeting these drainage systems.These findings provide information for potential novel strategies for treatment of stroke. 展开更多
关键词 AQUAPORIN-4 BRAIN edema glymphatic system intramural periarterial drainage ischemic stroke lymphatic drainage meningeal lymphatic vessels neuroinflammation neurotoxicity
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Expression of NF-κ B and osteopontin of synovial fluid of patients with knee osteoarthritis 被引量:7
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作者 Li-Feng qin Wan-Chun Wang +7 位作者 Han Fang Xin-Zhan Mao Guo-Liang Huang You Chen Hou-De Zhou Yi Shen li-hua qin Dan Peng 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2013年第5期379-382,共4页
Objective:To explore the significance of osteopontin and nuclear factorκB(NF-κB) expression in patients with knee osteoarthritis.Methods:RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopon... Objective:To explore the significance of osteopontin and nuclear factorκB(NF-κB) expression in patients with knee osteoarthritis.Methods:RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin(OPN) and NF-κB concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures,and analyze the relationship between the expressiones of them.Results:OPN and NF-κB expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group, the result showed statistical significance(P【0.05).There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF-κB expression levels (P【0.05).Conclusions:The high expression of OPN and NF-κB are closely related to occurrence and development of knee osteoarthritis. 展开更多
关键词 OSTEOARTHRITIS OSTEOPONTIN SYNOVIAL FLUID
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Qian-Zheng-San promotes regeneration after sciatic nerve crush injury in rats 被引量:3
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作者 Zhi-Yong Wang li-hua qin +2 位作者 Wei-Guang Zhang Pei-Xun Zhang Bao-Guo Jiang 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第4期683-691,共9页
Qian-Zheng-San, a traditional Chinese prescription consisting of Typhonii Rhizoma, Bombyx Batryticatus, Scorpio, has been found to play an active therapeutic role in central nervous system diseases. However, it is unc... Qian-Zheng-San, a traditional Chinese prescription consisting of Typhonii Rhizoma, Bombyx Batryticatus, Scorpio, has been found to play an active therapeutic role in central nervous system diseases. However, it is unclear whether Qian-Zheng-San has therapeutic value for peripheral nerve injury. Therefore, we used Sprague-Dawley rats to investigate this. A sciatic nerve crush injury model was induced by clamping the right sciatic nerve. Subsequently, rats in the treatment group were administered 2 mL Qian-Zheng-San(1.75 g/mL) daily as systemic therapy for 1, 2, 4, or 8 weeks. Rats in the control group were not administered Qian-Zheng-San. Rats in sham group did not undergo surgery and systemic therapy. Footprint analysis was used to assess nerve motor function. Electrophysiological experiments were used to detect nerve conduction function. Immunofluorescence staining was used to assess axon counts and morphological analysis. Immunohistochemical staining was used to observe myelin regeneration of the sciatic nerve and the number of motoneurons in the anterior horn of the spinal cord. At 2 and 4 weeks postoperatively, the sciatic nerve function index, nerve conduction velocity, the number of distant regenerated axons and the axon diameter of the sciatic nerve increased in the Qian-Zheng-San treatment group compared with the control group. At 2 weeks postoperatively, nerve fiber diameter, myelin thickness, and the number of motor neurons in the lumbar spinal cord anterior horn increased in the Qian-Zheng-San treatment group compared with the control group. These results indicate that QianZheng-San has a positive effect on peripheral nerve regeneration. 展开更多
关键词 NERVE REGENERATION traditional Chinese medicine CRUSH INJURY peripheral NERVE REGENERATION NERVE conduction velocity SCIATIC function index NERVE INJURY NERVE repair formula SCORPION neural REGENERATION
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Differentially Gene Expression Profile Related to Inflammation in Endometrial Cells Induce by Lipopolysaccharide
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作者 li-hua qin Ruo-guang WANG +1 位作者 Sheng LI Chun-mei LI 《Journal of Reproduction and Contraception》 CAS 2009年第1期27-34,共8页
Objective To investigate differentially expressed genes related to inflammation in endometrial cells induced by Lipopolysaccharide(LPS). Methods Normal endometrium in the proliferative phase of specimen from 3 cases... Objective To investigate differentially expressed genes related to inflammation in endometrial cells induced by Lipopolysaccharide(LPS). Methods Normal endometrium in the proliferative phase of specimen from 3 cases for the experiment was collected. The LPS group were treated with 50 μg/ml LPS. Total RNA was extracted using Trizol reagent from cells. RNA quality was assessed by determining the OD260/280 ratio by agarose gel electrophoresis, the chip was scanned by laser scanner. The acquired was analyzed. Results A total of differentially expressed genes were found, these genes were relative to many aspects. Among them, the expression of genes involved in inflammation were up-regulated by LPS, such as overexpression of IL-1β, 8, etc. Conclusion The results indicates that inflammation-related genes may be one of the mechanisms of abnormal uterine bleeding by LPS-induced. 展开更多
关键词 gene expression profile lipopolysaccharide(LPS) endometrial cell INFLAMMATION
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