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Traditional Chinese Medicine for Bladder Cancer:a Systematic Review and Meta-Analysis 被引量:2
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作者 li-hui zhang Yao Yang +1 位作者 Ying Chen Guo-Wei zhang 《Medical Data Mining》 2018年第2期68-82,共15页
Objective:To evaluate the efficacy and safety of traditional Chinese medicine in the treatment of bladder cancer.Methods:The databases of CNKI(1989-2018.10),Wan fang Data(1989-2018.10),VIP(1989-2018.10),PubMed(1966-20... Objective:To evaluate the efficacy and safety of traditional Chinese medicine in the treatment of bladder cancer.Methods:The databases of CNKI(1989-2018.10),Wan fang Data(1989-2018.10),VIP(1989-2018.10),PubMed(1966-2018.10),EMbase(1986-2018.10)and Cochrane Library(3rd issue,2018)were searched..Evidence quality and rating recommendations were scored using the GRADE system.Results:Thirty-six eligible studies were included with 3,109 patients.The meta-analysis showed that the total effective rate OR combination=2.85[OR=2.85,95%CI(1.98,4.09),P<0.00001].Recurrence OR merge=0.33[OR=0.33,95%CI(0.26,0.42),P<0.00001];Adverse reaction rate OR combination=0.37[OR=0.37,95%CI(0.32,0.43),P<0.00001];Incidence of adverse reactions OR combination=0.41[OR=0.41,95%CI(0.30,0.55),P<0.00001];Survival rate OR combination=1.78[OR=1.78,95%CI(0.55,5.77),P=0.34];Quality of life improvement rate OR consolidation=12.42[OR=12.42 95%CI(3.21,48.11),P=0.0003].The GRADE system evaluation results show that the evidence level is B and the recommendation level is weak.The traditional Chinese medicine group was superior to the control group in the efficiency rate,postoperative recurrence rate,incidence rate of adverse reactions,survival rate,quality of life improvement rate and incidence rate of toxic and side effects in the treatment of bladder cancer.Conclusion:Traditional Chinese Medicine has a good effect on treating bladder cancer and controlling recurrence of bladder cancer.Due to the impact of the original study on the results of meta-analysis,larger sample and high-quality clinical trials are still needed to verify. 展开更多
关键词 TRADITIONAL Chinese MEDICINE BLADDER cancer Systematic review META-ANALYSIS
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Analysis of pharmacological action and clinical application of DaXueTeng based on its anti-inflammatory action 被引量:2
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作者 li-hui zhang Miao-miao Lin +4 位作者 Ying Chen Xue-song Wu Li-jing Cai Mei-shan Li Guo-wei zhang 《TMR Modern Herbal Medicine》 2018年第4期233-240,共8页
As one of the representative drugs for clearing heat-toxicity, Chinese medicine DaXueTeng (Caulis Sargentodoxae) contains various chemical substances such as tannins, glycosides, cyclic polyphenols, triterpenoid... As one of the representative drugs for clearing heat-toxicity, Chinese medicine DaXueTeng (Caulis Sargentodoxae) contains various chemical substances such as tannins, glycosides, cyclic polyphenols, triterpenoids, lignins, flavonoids, terpenoids and organic acids. It has a wide range of pharmacological effects. Meanwhile, it is valued by the doctor. Modern research suggests that DaXueTeng has antibacterial, antiviral, anti-inflammatory, anti-tumor, and immunosuppressive effects. It has been experimentally and clinically proven that the active constituents of DaXueTeng have a good therapeutic effect on inflammatory diseases. It is widely used in the treatment of pelvic inflammatory disease, annexitis, prostatitis, appendicitis, periappendiceal abscess, inflammatory intestinal obstruction, UC, endometriosis, inflammatory secondary infertility, gouty arthritis, pharyngitis, and stomatitis. Here we review the anti-inflammatory pharmacological effects and clinical applications of. 展开更多
关键词 DaXueTeng Anti-inflammatory effect REVIEW
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Involvement of cysteinyl leukotriene signaling in microglial morphological changes and CASP1 expression in vitro
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作者 Yu-xi WANG Si-ran zhang +5 位作者 Xue XU Cheng-tan LI Wei ZHENG Jian-bo ZHAO Yan-fang WANG li-hui zhang 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2017年第10期1028-1029,共2页
OBJECTIVE We have recently reported that cysteinyl leukotriene(Cys LT) signaling plays an important role in microglial interleukin(IL)-1β secretion and subsequent neurotoxicity.The present study aimed to examine micr... OBJECTIVE We have recently reported that cysteinyl leukotriene(Cys LT) signaling plays an important role in microglial interleukin(IL)-1β secretion and subsequent neurotoxicity.The present study aimed to examine microglial morphological changes and the upstream molecular underlying IL^(-1)β production in Cys LT receptor agonist leukotriene D4(LTD4)-treated BV2 microglia in vitro.METHODS Twenty-four hours after murine microglial BV2 cells were stimulated with LTD4(1-100 nmol·L^(-1)),the cell proliferation and morphology were observed.The expression level of cysteinyl aspartate-specific protease 1(CASP1) protein was measured by Western blotin BV2 cells.In addition,BV2 cells were pretreated with or without CysLT1 receptor antagonist montelukast for 1 h and the effects of monte-lukaston LTD4-stimulated microglial activation and CASP1 expression were evaluated.RESULTS The number of BV2 cells had an increasing tendency after 24 h treatment with LTD4,but no significant differences were observed between the control and LTD4-treated cells(P>0.05).Under basal and resting conditions,BV2 microglial cells displayed a ramified morphology.However,LTD4 at 100 nmool·L^(-1) drove microglial morphological changes from a ramified towards an amoeboid shape.The expression of CASP1 protein was significantly upregulated in 100 nmool·L^(-1) LTD4-treated BV2 microglia(P<0.01).Furthermore,pretreatment with CysLT1 receptor antagonist montelukast prevented cell morphological changes and suppressed the increased CASP1 expression in LTD4-treated BV2 cells(P<0.05).CONCLUSION Cys LT receptor agonist LTD4 induces morphological changes and CASP1 expressionin BV2 microglia,which can be inhibited by CysLT1 antagonist.These results suggest the involvement of Cys LT signaling in microglial morphological changes and CASP1 expression. 展开更多
关键词 cysteinyl leukotriene RECEPTOR MICROGLIA INFLAMMATION
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Double-hit lymphoma (rearrangements of MYC, BCL-2) during pregnancy: A case report
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作者 Fan Xie li-hui zhang +2 位作者 Ya-Qing Yue Lu-Lu Gu Fei Wu 《World Journal of Clinical Cases》 SCIE 2021年第2期482-488,共7页
BACKGROUND Double-hit lymphoma is a highly aggressive B-cell lymphoma that is genetically characterized by rearrangements of MYC and BCL2 and/or BCL6.Lymphoma is often accompanied by atypical systemic symptoms similar... BACKGROUND Double-hit lymphoma is a highly aggressive B-cell lymphoma that is genetically characterized by rearrangements of MYC and BCL2 and/or BCL6.Lymphoma is often accompanied by atypical systemic symptoms similar to physiological changes during pregnancy and is often ignored.Herein,we describe a gravid patient with high-grade B-cell lymphoma with a MYC and BCL-2 gene rearrangement involving multiple parts of the body.CASE SUMMARY A 32-year-old female,gestational age 22+5 wk,complained of abdominal distension,chest tightness and limb weakness lasting approximately 4 wk,and ovarian tumors were found 14 d ago.Auxiliary examinations and a trimanual gynecologic examination suggested malignant ovarian tumor and frozen pelvis.Coupled with rapid progression,severe compression symptoms of hydrothorax,ascites and moderate anemia,labor was induced.Next,biopsy and imaging examinations showed high-grade B-cell lymphoma with a MYC and BCL-2 gene rearrangement involving multiple parts of the body.She was referred to the Department of Oncology and Hematology for chemotherapy.Because of multiple recurrences after complete remission,chemotherapy plans were continuously adjusted.At present,the patient remains in treatment and follow-up.CONCLUSION The early detection and accurate diagnosis of lymphoma during pregnancy can help expedite proper multidisciplinary treatment to delay disease progression and decrease the mortality rate. 展开更多
关键词 Ovarian neoplasms Double-hit lymphoma Lymphoma non-Hodgkin PREGNANCY Case report Multidisciplinary treatment
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Analysis of herbs use law and mechanism of traditional Chinese medicine in preventing and treating postoperative complications of breast cancer
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作者 Yao Yang li-hui zhang +2 位作者 Mei-Ting Liu Miao-Miao Lin Guo-Wei zhang 《Drug Combination Therapy》 2019年第2期40-55,共16页
Objective:Excavate the compatibility rules of traditional Chinese medicine for preventing and treating postoperative complications of breast cancer,study the potential mechanism of prevention and treatment with tradit... Objective:Excavate the compatibility rules of traditional Chinese medicine for preventing and treating postoperative complications of breast cancer,study the potential mechanism of prevention and treatment with traditional Chinese medicine.Methods:Collate and analyze the relevant prescriptions collected from CNKI and the core drug combination and the new formula are obtained by adopting the traditional Chinese medicine inheritance auxiliary system(TCMISSV2.5).Use BATMAN-TCM online analysis tool to analyze KEGG pathways of high frequency drugs and predict the potential signal pathways.Results:Data mining has selected 10 pairs of core herb combinations and 5 new recipes of 133 prescriptions.In the network pharmacology analysis of bai zhu,huang qi,fu ling,the potential signaling pathways of its action are the neuroactive ligand-receptor interaction pathway and calcium signaling pathway.Conclusion:Herbs for invigorating spleen and qi and herbs for nourishing blood and activating blood are commonly used to prevent and treat postoperative complications of breast cancer.Core herbs may play their role by interfering with the neuroactive ligand-receptor interaction pathway and calcium signaling pathway. 展开更多
关键词 POSTOPERATIVE breast cancer Complications Data mining Path ANALYSIS MEDICATION LAW MECHANISM of action
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Efficacy of blood-letting puncture and cupping in the treatment of periarthritis of shoulder:a systematic review
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作者 li-hui zhang Li-Xin Wang +1 位作者 Qian Cui Guo-Wei zhang 《TMR Integrative Medicine》 2018年第4期175-191,共17页
Objective:To systematically evaluate the clinical efficacy and safety of blood-letting puncture and cupping in the treatment of periarthritis of shoulder.Methods:We electronically searched databases including CNKI,VIP... Objective:To systematically evaluate the clinical efficacy and safety of blood-letting puncture and cupping in the treatment of periarthritis of shoulder.Methods:We electronically searched databases including CNKI,VIP,PubMed,WanFang Data,EMbase Cochrane Library and to collect randomized controlled trials(RCTs)and quasi-randomized controlled trials about blood-letting puncture and cupping for periarthritis of shoulder and evaluated the quality of the documents collected by the Cochrane collaboration,provided by Review Manager 5 software for statistical analysis.Then the quality of the included trials was assessed using the Jadad scale and GRADE system was used to score the quality and grade recommendation.Results:Thirty RCTs involving 2556 patients were included.The results of meta-analysis showed that:Total effective rate OR=6.21[OR=6.21,95%CI(4.69,8.21),P<0.001].The results of GRADE system evaluation showed that the level of evidence was B,and the recommendation level was weak recommendation.Conclusion:Blood-letting puncture and cupping shows better effects than other treatments and preferably security in the treatment of periarthritis of shoulder.We do not find any serious adverse reaction reports.Due to limited quality of the included studies,more high quality studies are needed to verify the above conclusion. 展开更多
关键词 Traditional Chinese Medicine Blood-letting Puncture and Cupping Periarthritis of shoulder META-ANALYSIS Systematic review GRADE system
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Analysis of compatibility rules and mechanisms of traditional Chinese medicine for preventing and treating postoperative recurrence of bladder cancer
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作者 Xin-Zhe Zhao Yoo Yang +2 位作者 Ying Chen li-hui zhang Guo-Wei zhang 《Drug Combination Therapy》 2020年第1期16-24,共9页
Backgroud:Summarize the formula rule of traditional Chinese medicine fOr preventing and treating bladder cancer recurrence after operation and explore the molecular mechanism of core medicines.Methods:Literatures coll... Backgroud:Summarize the formula rule of traditional Chinese medicine fOr preventing and treating bladder cancer recurrence after operation and explore the molecular mechanism of core medicines.Methods:Literatures collected from CNKI,Wanfang Med Online,CMJD,PUBMED and Elsiver databases were as prescription sources,and association rules and complex system entropy clustering analysis were carried out using the Traditional Chinese Medicine Inheritance Support System(TCMISSV2.5).BATMAN-TCM online analysis tool was used to construct target-pathway-disease correlation map to reveal the potential mechanism of action.Results:A total of 122 prescriptions were eligible for data analysis.The high-frequency traditional Chinese medicines are Poria,Radix et Rhizoma Rhei,Radix Astragali,Herba Hedyotidis Diffusae and Rhizoma Atractylodis Macrocephalae.The high-frequency drug pairs are Rhizoma Atractylodis MacrocephalaeIPoria,Poria/Rhizoma Alismatis,Radix Astragali/Rhizoma Atractylodis Macrocephalaeand and Herba Hedyotidis Diffusae/Herba Scutellariae Darbatae..There are 5 groups of drug pairs with high correlation strength.Cluster analysis shows 6 core drug combinations and 3 new prescriptions.In clinical practice,the core compatibility of traditional Chinese medicines for preventing postoperative recurrence of bladder cancer is Poria,Radix Astragali and Herba Hedyotidis Diffusae.The possible signaling pathways are the neuroactive ligand receptor interaction signaling pathway and calcium signaling pathway.Conclusion:Prevention and treatment of postoperative recurrence of bladder cancer mainly use medicines with effects of eliminating dampness and diuresis for removing edema,heat-clearing and detoxifying,and qi-invigorating.The potential mechanism of the compatibility of core drugs may be realized by interfering with the signal pathway of neuroactive ligand receptor interaction and calcium signal pathway. 展开更多
关键词 Postoperative recurrence of bladder cancer Compatibility rules Mechanism of action Data mining Network pharmacology
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Systematic evaluation and Meta-analysis of acupuncture and collaterals cupping therapy for Knee Osteoarthritis
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作者 li-hui zhang Yong-Chen Zhao 《TMR Modern Herbal Medicine》 2019年第1期36-47,共12页
Objective:In order to obtain the best treatment program for Knee Osteoarthritis(KOA),to alleviate the pain of patients with KOA,and to systematically evaluate the efficacy of acupuncture cupping therapy for KOA.Method... Objective:In order to obtain the best treatment program for Knee Osteoarthritis(KOA),to alleviate the pain of patients with KOA,and to systematically evaluate the efficacy of acupuncture cupping therapy for KOA.Methods:we used computer to search the databases of CNKI(1989-2018.10),Wanfang(1989-2018.10),VIP(1989-2018.10),PubMed(1966-2018.10),EMbase(1986-2018.10)and Cochrane Library(the 3rd issue of 2018).And the literature quality was evaluated by Jadad scale.Results:A total of 19 eligible RCT studies were included,and a total of 2,088 patients participated in the eligible clinical study.Meta-analysis results showed that the total effective rate OR combination=2.85[OR=3.98,95%CI(2.98,5.32),P<0.00001].The results showed that the curative effect of acupuncture and collaterals cupping in the treatment of KOA was superior to other therapies.Conclusion:Acupuncture and cupping therapy of traditional Chinese medicine is effective and safe in treating KOA.Due to the impact of the original study on Meta-analysis results,more large samples and high-quality clinical trials are still needed to verify. 展开更多
关键词 acupuncture and collaterals cupping therapy Traditional Chinese Medicine Knee Osteoarthritis META-ANALYSIS Systematic evaluation
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Immunoregulation and anti-tumor effects of Polyporusus Bellatus: a review of recent research
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作者 Miao-Miao Lin Mei-Yu Cui +4 位作者 Hai-Yan Cao Xue-Song Wu Li-Jing Cai li-hui zhang Guo-Wei zhang 《TMR Modern Herbal Medicine》 2018年第3期181-188,共8页
Background: We summarized the Polyporusus Bellatus (PPS) efficacy of immunomodulation, liver protection and anti-tumor, then provide scientific basis for further research and clinical application. This diss... Background: We summarized the Polyporusus Bellatus (PPS) efficacy of immunomodulation, liver protection and anti-tumor, then provide scientific basis for further research and clinical application. This dissertation first overview relevant literatures of PPS recent years and describe comprehensively the research progress of the immunoregulation, liver protection and anti-tumor effects and mechanism of PPS. The review shows that the PPS play anti-tumor effects through antioxidation, scavenging free radicals, inhibiting tumor cell proliferation, inducing apoptosis, affecting tumor gene expressions and enhancing immune functions. PPS can exert immunoregulatory, hepatoprotective and anti-tumor effects through multiple pathways and multiple targets, which provides a good application prospect in clinic. 展开更多
关键词 Polyporusus Bellatus IMMUNOREGULATION ANTI-TUMOR REVIEW
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Oxygen-Glucose Deprivation Activates 5-Lipoxygenase Mediated by Oxidant Stress through p38 MAPK Pathway in PC12 cells
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作者 Cheng-Tan Li Wei-Ping zhang +8 位作者 Yun-Bi Lu San-Hua Fang Yu-Mei Yuan Ling-Ling Qi li-hui zhang Xiao-Jia Huang Lei zhang Zhong Chen Er-Qing Wei 《中国药理通讯》 2008年第3期30-31,共2页
关键词 葡萄糖 PC12细胞 氧化剂
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Optical and electrical anisotropy regulation engineering of low-dimensional materials toward polarized detection and imaging applications
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作者 Jian-Bin zhang Nan Zhou +7 位作者 li-hui zhang Cong-Hui Shang Jia-Xuan Li Yi Zhao Guo-Hui Jia Ru-Sen Yang Hua Xu Xiao-Bo Li 《Rare Metals》 SCIE EI CAS CSCD 2024年第7期2968-2993,共26页
Polarized-sensitive image sensors are a kind of photodetector with great development potential due to their enhanced ability to detect and identify the target objects from the aspect of spatial,spectral and polarized ... Polarized-sensitive image sensors are a kind of photodetector with great development potential due to their enhanced ability to detect and identify the target objects from the aspect of spatial,spectral and polarized information.Recently,low-dimensional anisotropic materials with inherent anisotropic properties,ultrathin thickness,tunable bandgap and feasible integration with complementary metal oxide semiconductor(CMOS)fabrication processes have attracted great interest for their facilitation of polarized photodetector devices miniaturization.Maximizing the polarized detection performance of low-dimensional materials to satisfy realistic needs stimulates the exploration of modulation of anisotropic properties.In this review,we comprehensively introduce the latest research progress in modulating the optical and optoelectronic anisotropy characteristics of low-dimensional materials.The strategy of anisotropy regulation through crystal structure engineering and coupling system is discussed emphatically.Then,the latest progress in image recognition applications using anisotropic low-dimensional materials is reviewed in detail.Finally,we summarize the challenge and propose future opportunities in the practical application of polarized-sensitive imaging photodetectors based on low-dimensional anisotropic materials. 展开更多
关键词 ANISOTROPY Polarized detection Image recognition Low-dimensional materials
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Autophagy in synaptic development,function,and pathology 被引量:8
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作者 Dan-Na Shen li-hui zhang +1 位作者 Er-Qing Wei Yi Yang 《Neuroscience Bulletin》 SCIE CAS CSCD 2015年第4期416-426,共11页
In the nervous system, neurons contact each other to form neuronal circuits and drive behavior, relying heavily on synaptic connections. The proper development and growth of synapses allows functional transmission of ... In the nervous system, neurons contact each other to form neuronal circuits and drive behavior, relying heavily on synaptic connections. The proper development and growth of synapses allows functional transmission of electrical information between neurons or between neurons and muscle fibers. Defects in synapse-formation or development lead to many diseases. Autophagy, a major determinant of protein turnover, is an essential process that takes place in developing synapses. During the induction of autophagy, proteins and cytoplasmic components are encapsulated in autophagosomes, which fuse with lysosomes to form autolysosomes. The cargoes are subsequently degraded and recycled. However, aberrant autophagic activity may lead to synaptic dysfunction, which is a common pathological characteristic in several disorders. Here, we review the current understanding of autophagy in regulating synaptic development and function. In addition, autophagy-related synaptic dysfunction in human diseases is also summarized. 展开更多
关键词 AUTOPHAGY SYNAPTOGENESIS synaptic elimination synaptic function synaptic pathology
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Aggravated inflammation and increased expression of cysteinyl leuko-triene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice 被引量:5
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作者 Wen-Zhen Shi Chun-Zhen Zhao +7 位作者 Bing Zhao Qiao-Juan Shi li-hui zhang Yan-Fang Wang San-Hua Fang Yun-Bi Lu Wei-Ping zhang Er-Qing Wei 《Neuroscience Bulletin》 SCIE CAS CSCD 2012年第6期680-692,共13页
Objective Aquaporin-4 (AQP4), the main water channel protein in the brain, plays a critical role in water homeostasis and brain edema. Here, we investigated its role in the inflammatory responses after focal cerebra... Objective Aquaporin-4 (AQP4), the main water channel protein in the brain, plays a critical role in water homeostasis and brain edema. Here, we investigated its role in the inflammatory responses after focal cerebral ischemia. Methods In AQP4-knockout (KO) and wild-type mice, focal cerebral ischemia was induced by 30 rain of middle cerebral arterial occlusion (MCAO). Ischemic neuronal injury and cellular inflammatory responses, as well as the expression and localization of cysteinyl leukotriene CysLT2 and CysLT~ receptors, were determined at 24 and 72 h after MCAO. Results AQP4-KO mice showed more neuronal loss, more severe microglial activation and neutrophil infiltration, but less astrocyte proliferation in the brain after MCAO than wild-type mice. In addition, the protein levels of both CysLT1 and CysLT2 receptors were up-regulated in the ischemic brain, and the up-regulation was more pronounced in AQP4-KO mice. The CysLT1 and CysLT2 receptors were primarily localized in neurons, microglia and neutrophils; those localized in microglia and neutrophils were enhanced in AQP4-KO mice. Conclusion AQP4 may play an inhibitory role in postischemic inflammation. 展开更多
关键词 aquaporin 4 gene deficiency INFLAMMATION cysteinyl leukotriene receptor MICROGLIA ASTROCYTE focal cerebral ischemia
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Peripheral Pulmonary Emboli Detected by Radial Probe Endobronchial Ultrasound 被引量:2
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作者 Xi-Qian Xing Jiao Yang +6 位作者 Zhi-Dong Li Yan-Hong Liu Yi Xiao Yan-Li Li Li-Qiong Liu li-hui zhang Xu-Wei Wu 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第22期3116-3117,共2页
To the Editor: Endobronchial ultrasound (EBUS) has been utilized as a useful noninvasive diagnostic tool for mediastinal lymph nodes or masses. Recently, convex probe EBUS (CP-EBUS) has recently come to be used t... To the Editor: Endobronchial ultrasound (EBUS) has been utilized as a useful noninvasive diagnostic tool for mediastinal lymph nodes or masses. Recently, convex probe EBUS (CP-EBUS) has recently come to be used to diagnose central pulmonary embolism.I However, CP-EBUS cannot detect peripheral pulnaonary embolism. It is here believed that the potential use of EBUS is still underestimated. 展开更多
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