Objective:To explore the relationship between miR-181b rs322931 polymorphism and the risk of gastric cancer.Methods:The peripheral venous blood of 172 patients with gastric cancer and 224 healthy controls were collect...Objective:To explore the relationship between miR-181b rs322931 polymorphism and the risk of gastric cancer.Methods:The peripheral venous blood of 172 patients with gastric cancer and 224 healthy controls were collected.The miR-181b rs322931 was typed by TaqMan probe method,and correlation between miR-181b rs322931 and the risk of gastric cancer was evaluated using SPSS software.Results:The frequencies of miR-181b rs322931 CC,CT,TT genotype,C,and T allele were 61.6,33.7,4.7,78.5,and 21.5%in gastric cancer,and 74.1,23.7,2.2,85.9,and 14.1%in controls,respectively.After the%2 test and correction for age and gender,the risk of gastric cancer in carriers of CT and CT/TT genotypes increased by 1.71 and 1.79 times,respectively(CT vs.CC:95%CI,1.10-2.67,P=0.02;CT/TT compared with CC:95%CI,1.16-2.74,P=0.008).Moreover,compared with alleles,the risk of gastric cancer in T allele carriers increased by 1.69 times(95%CI,1.162.44,P=0.006).Conclusion:miR-181b rs322931 polymorphism may be one of the susceptibility genes of gastric cancer in the Chinese Han nationality.展开更多
文摘Objective:To explore the relationship between miR-181b rs322931 polymorphism and the risk of gastric cancer.Methods:The peripheral venous blood of 172 patients with gastric cancer and 224 healthy controls were collected.The miR-181b rs322931 was typed by TaqMan probe method,and correlation between miR-181b rs322931 and the risk of gastric cancer was evaluated using SPSS software.Results:The frequencies of miR-181b rs322931 CC,CT,TT genotype,C,and T allele were 61.6,33.7,4.7,78.5,and 21.5%in gastric cancer,and 74.1,23.7,2.2,85.9,and 14.1%in controls,respectively.After the%2 test and correction for age and gender,the risk of gastric cancer in carriers of CT and CT/TT genotypes increased by 1.71 and 1.79 times,respectively(CT vs.CC:95%CI,1.10-2.67,P=0.02;CT/TT compared with CC:95%CI,1.16-2.74,P=0.008).Moreover,compared with alleles,the risk of gastric cancer in T allele carriers increased by 1.69 times(95%CI,1.162.44,P=0.006).Conclusion:miR-181b rs322931 polymorphism may be one of the susceptibility genes of gastric cancer in the Chinese Han nationality.
