In this paper, by combining a stochastic optimization method with a refrigeration shaft work targeting method,an approach for the synthesis of a heat integrated complex distillation system in a low-temperature process...In this paper, by combining a stochastic optimization method with a refrigeration shaft work targeting method,an approach for the synthesis of a heat integrated complex distillation system in a low-temperature process is presented. The synthesis problem is formulated as a mixed-integer nonlinear programming(MINLP) problem,which is solved by simulated annealing algorithm under a random procedure to explore the optimal operating parameters and the distillation sequence structure. The shaft work targeting method is used to evaluate the minimum energy cost of the corresponding separation system during the optimization without any need for a detailed design for the heat exchanger network(HEN) and the refrigeration system(RS). The method presented in the paper can dramatically reduce the scale and complexity of the problem. A case study of ethylene cold-end separation is used to illustrate the application of the approach. Compared with the original industrial scheme, the result is encouraging.展开更多
There are many factors affecting the instability of the submarine hydrate-bearing slope (SHBS),and the interaction with hydrate is very complicated.In this paper,the mechanical mechanism of the static liquefaction and...There are many factors affecting the instability of the submarine hydrate-bearing slope (SHBS),and the interaction with hydrate is very complicated.In this paper,the mechanical mechanism of the static liquefaction and instability of submarine slope caused by the dissociation of natural gas hydrate (NGH) resulting in the rapid increase of pore pressure of gas hydrate-bearing sediments (GHBS) and the decrease of effective stress are analyzed based on the time series and type of SHBS.Then,taking the typical submarine slope in the northern South China Sea as an example,four important factors affecting the stability of SHBS are selected,such as the degree of hydrate dissociation,the depth of hydrate burial,the thickness of hydrate,and the depth of seawater.According to the principle of orthogonal method,25 orthogonal test schemes with 4 factors and 5 levels are designed and the safety factors of submarine slope stability of each scheme are calculated by using the strength reduction finite element method.By means of the orthogonal design range analysis and the variance analysis,sensitivity of influential factors on stability of SHBS are obtained.The results show that the degree of hydrate dissociation is the most sensitive,followed by hydrate burial depth,the thickness of hydrate and the depth of seawater.Finally,the concept of gas hydrate critical burial depth is put forward according to the influence law of gas hydrate burial depth,and the numerical simulation for specific submarine slope is carried out,which indicates the existence of critical burial depth.展开更多
In this paper, the mechanical properties of gas hydrate-bearing sediments (GHBS) were summarized and the instability mechanism of submarine hydrate-bearing slope (SHBS) was analyzed under the background of the test pr...In this paper, the mechanical properties of gas hydrate-bearing sediments (GHBS) were summarized and the instability mechanism of submarine hydrate-bearing slope (SHBS) was analyzed under the background of the test production of gas hydrate in the northern part of the South China Sea. The strength reduction finite element method (SRFEM) was introduced to the stability analysis of submarine slopes for the safety of the test production. Two schemes were designed to determine the physical and mechanical parameters of four target wells. Through the division of the hydrate dissociation region and the design of four working conditions, the range and degree of hydrate dissociation at different stages during the test production were simulated. Based on the software ABAQUS, 37 FEM models of SHBS were set up to analyze and assess the stability of the submarine slopes in the area of the test production. Necessary information such as safety factors, deformation, and displacement were obtained at different stages and under different working conditions. According to the calculation results, the submarine slope area is stable before the test production, and the safety factors almost remains the same during and after the test production. All these indicate that the test production has no obvious influence on the area of the test production and the submarine slopes in the area are stable during and after the test production.展开更多
Molecular layer deposition(MLD) for the deposition of polyimide(PI) at low temperature of 110 °C has been firstly introduced into the field of membrane separation. With the optimized MLD deposition parameters, su...Molecular layer deposition(MLD) for the deposition of polyimide(PI) at low temperature of 110 °C has been firstly introduced into the field of membrane separation. With the optimized MLD deposition parameters, such low deposition temperature has successfully expanded the application of MLD for the surface modification of polymeric materials. Globular PI particulates grow on both the free surfaces as well as the pore walls of the polypropylene(PP) membranes as isolated islands during progressive precursor exposures. The PI-deposited PP membranes exhibit synergistically improved performances in various aspects. Evidently improved surface hydrophilicity and permeation performance(30%) have been achieved via the MLD deposition of polyimide films. The overall separation efficiency maintained higher than 85% even after 250 cycles of MLD deposition. More importantly, the thermal stability has been improved and the integrity of the porous structure for PI-deposited PP membranes has been well preserved even after harsh treatment, which ensures its potential application in industries.展开更多
The present study analyzed data from 108 Cushing's disease patients,who underwent trans-sphenoidal surgery in one hospital between January 2003 and April 2010,to investigate the performance value of bilateral infe...The present study analyzed data from 108 Cushing's disease patients,who underwent trans-sphenoidal surgery in one hospital between January 2003 and April 2010,to investigate the performance value of bilateral inferior petrosal sinus sampling (BIPSS).Of the 108 patients,52 underwent BIPSS prior to surgery and 56 did not.Results showed that BIPSS accuracy for the diagnosis of Cushing's disease was 86.5% (45/52),and accuracy for adenoma lateralization during surgery was 76.9% (40/52).In addition,early remission rate was significantly greater compared to patients without BIPSS.Results demonstrated that BIPSS facilitated localization and diagnosis of Cushing's disease and helped to predict adenoma lateralization.展开更多
Background Dental implants have been widely used in the last few decades.However,patients with insufficient bone height need reconstructive surgeries before implant insertion.Distraction implant(Dl)has been invented t...Background Dental implants have been widely used in the last few decades.However,patients with insufficient bone height need reconstructive surgeries before implant insertion.Distraction implant(Dl)has been invented to simplify the treatment procedure,but the shortcomings of Dl have limited its clinical use.We introduced biodegradable polyester to a novel Dl,called biodegradable interference distraction implant(BIDI).The purpose of this study was to assess the radiological,histological,and biomechanical properties of BIDI in animal models.Methods BIDIs were manufactured and inserted into the atrophied mandibles of 6 dogs.展开更多
The resistance spot weldability of galvanized ultra-high-strength steels is not satisfed,the joints are prone to interfacial fracture and the weldable current range is narrow.To solve the problems,a novel method calle...The resistance spot weldability of galvanized ultra-high-strength steels is not satisfed,the joints are prone to interfacial fracture and the weldable current range is narrow.To solve the problems,a novel method called resistance spot welding with double-sided cover sheets was introduced to weld a galvanized Q&P980 steel with the thickness of 1.2 mm.Two thin SPCC mild steel sheets were chosen as cover sheets and were placed symmetrically at both sides between the Q&P980 steels and the electrodes,then the RSW process was carried out.Compared with the traditional RSW method,the joints obtained by using the novel method achieved larger tensile shear strength and energy absorption,which increased by 26.9%and 52.6%,respectively.With increasing the welding current,the failure mode transferred from interfacial fracture to nugget pull-out fracture or base metal tearing fracture.By contrast,the joints always showed interfacial fracture without cover sheets.The improvement of the joint performance was mainly attributed to the enlargement of the nugget.With the help of fnite element simulation,it was found that the cover sheets helped increase the contact area and reduced the current density during welding,which postponed the expulsion,and a larger area could be evenly heated.The application of the novel method can be easily extended to the resistance spot welding of other ultra-high-strength steels with various thicknesses.展开更多
Objective To conifgure an immunoabsorption column for hepatitis B virus. Methods Being activated by epichlorohydrin, the human antibody HBsAb-IgG was bound to the carrier of agarose gel. The configuration process was...Objective To conifgure an immunoabsorption column for hepatitis B virus. Methods Being activated by epichlorohydrin, the human antibody HBsAb-IgG was bound to the carrier of agarose gel. The configuration process was as follows: the synthesis of epoxide matrix, the synthesis and activation of amino matrix, the synthesis of aldehydic matrix, the synthesis of immunoabsorption matrix, the end capping and reduction of unbound aldehydic, the blocking of unbound mass and the iflling of the column. Results The bound rate of activated agarose gel and antibody HBsAb-IgG is 85.07%. By plasma adsorption experiment, it is revealed that the immunoabsorption column can absorb and eliminate 58.97%of HBsAg and 53.1%of hepatitis B virus particles in extracorporeal plasma. Conclusions The immunoabsorption column for hepatitis B virus can absorb and eliminate HBsAg and hepatitis B virus particles in extracorporeal plasma.展开更多
Objective: To investigate the effect of Dan seven soft capsule on the treatment of acute hemorrhagic cerebrovascular disease and the influence of serum inflammatory factors, coagulation function and blood rheology ind...Objective: To investigate the effect of Dan seven soft capsule on the treatment of acute hemorrhagic cerebrovascular disease and the influence of serum inflammatory factors, coagulation function and blood rheology indexes. Methods: A total of 112 cases of patients with acute hemorrhagic cerebrovascular disease, according to the random data table were divided into the control group (n=57) and observation group (n=55), the patients in the control group received routine treatment combined with edaravone, on the basis of the treatment of the control group, the observation group was treated with Dan seven soft capsule. The serum levels of inflammatory factors, coagulation function and blood rheology indexes were compared between the two groups before and after treatment. Results: Before treatment, there were no significant difference in the inflammatory factors (hs-CRP, TNF-α and IL-6), blood coagulation function (FIB, PT and APTT) and hemorheology (high cut whole blood viscosity, low cut whole blood viscosity and plasma viscosity) levels between the control group and observation group. Compared with the levels of the same group before treatment, two groups of hs-CRP, TNF-α, IL-6, FIB, high cut whole blood viscosity, low cut whole blood viscosity and plasma viscosity level after treatment were significantly decreased, and levels in the observation group were significantly lower than those in the control group;Compared with the group before treatment, the levels of PT and APTT in the two groups were significantly increased, and the observation group was significantly higher than the control group. Conclusion: Dan seven soft capsule in the treatment of acute hemorrhagic cerebrovascular disease can effectively reduce the level of serum inflammatory factors, improve coagulation function and blood rheology index, it has an important clinical value.展开更多
Natural scene recognition has important significance and value in the fields of image retrieval,autonomous navigation,human-computer interaction and industrial automation.Firstly,the natural scene image non-text conte...Natural scene recognition has important significance and value in the fields of image retrieval,autonomous navigation,human-computer interaction and industrial automation.Firstly,the natural scene image non-text content takes up relatively high proportion;secondly,the natural scene images have a cluttered background and complex lighting conditions,angle,font and color.Therefore,how to extract text extreme regions efficiently from complex and varied natural scene images plays an important role in natural scene image text recognition.In this paper,a Text extremum region Extraction algorithm based on Joint-Channels(TEJC)is proposed.On the one hand,it can solve the problem that the maximum stable extremum region(MSER)algorithm is only suitable for gray images and difficult to process color images.On the other hand,it solves the problem that the MSER algorithm has high complexity and low accuracy when extracting the most stable extreme region.In this paper,the proposed algorithm is tested and evaluated on the ICDAR data set.The experimental results show that the method has superiority.展开更多
Eleven organophosphate esters(OPEs)in the air and seawater were investigated from the northwestern Pacific Ocean to the Southern Ocean during the 2018 Chinese 34th Antarctic Scientific Expedition.The concentration of ...Eleven organophosphate esters(OPEs)in the air and seawater were investigated from the northwestern Pacific Ocean to the Southern Ocean during the 2018 Chinese 34th Antarctic Scientific Expedition.The concentration of total OPEs ranged from 164.82 to 3501.79 pg/m~3in air and from 4.54 to 70.09 ng/L in seawater.Two halogenated OPEs,tri(chloropropyl)phosphate(TCPP)and tri(2-chloroethyl)phosphate(TCEP),were generally more abundant than the non-halogenated OPEs.A levelⅢfugacity model was developed to simulate the transfer and fate of seven OPEs in the air and seawater regions of the central Ross Sea.The model results indicate that OPEs are transferred from the air to the seawater in the central Ross Sea in summer,during which the Ross Sea acts as a final OPE sink.Dry and wet deposition dominated the processes involving OPE transfer to seawater.The OPE degradation process was also found to be more pervasive in the atmosphere than in the seawater region.These findings highlights the importance of long-range transport of OPEs and their air–seawater interface behavior in the Antarctic.展开更多
Infection is a main cause of implant failure.The microenvironment cell experiencing after antimicrobial therapy of infected implants is very crucial for immunomodulation and subsequent osteointegration.Based on the su...Infection is a main cause of implant failure.The microenvironment cell experiencing after antimicrobial therapy of infected implants is very crucial for immunomodulation and subsequent osteointegration.Based on the superiority of photothermal therapy in anti-infection,a matrix of nanograined TiO_(2)with(Si/P)-dual ions and hierarchical nano/microporous topography is developed on Ti implant by micro-arc oxidation.It shows good photothermal properties due to the lattice distortion induced by ion doping and can kill bacteria with near-infrared(NIR)light irradiation efficiently.Due to the combined action of porous topography and release of Si/P ions,the TiO_(2)matrix achieves M1-to-M_(2)phenotype switch of macrophages timely at different simulating infection stage and accelerates recruitment,proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in vitro.In vivo,the TiO_(2)matrix also shows desired antibacterial performance after photothermal therapy and exhibits outstanding immunomodulatory ability and new bone formation efficiency.This study provides a promising TiO_(2)matrix applied in clinic for settling implant infection by NIR light irradiation and promoting bone regeneration through osteoimmunomodulation.展开更多
In quantum computing, the computation is achieved by linear operators in or between Hilbert spaces. In this work, we explore a new computation scheme, in which the linear operators in quantum computing are replaced by...In quantum computing, the computation is achieved by linear operators in or between Hilbert spaces. In this work, we explore a new computation scheme, in which the linear operators in quantum computing are replaced by (higher) functors between two (higher) categories. If from Turing computing to quantum computing is the first quantization of computation, then this new scheme can be viewed as the second quantization of computation. The fundamental problem in realizing this idea is how to realize a (higher) functor physically. We provide a theoretical idea of realizing (higher) functors physically based on the physics of topological orders.展开更多
In this study,a coupled axisymmetric finite element model (FEM) was built to simulate the resistance spot welding (RSW) process between ultra-high strength hotstamped (UHSS) and mild steel by SORPAS software.Via simul...In this study,a coupled axisymmetric finite element model (FEM) was built to simulate the resistance spot welding (RSW) process between ultra-high strength hotstamped (UHSS) and mild steel by SORPAS software.Via simulating this process,the temperature distribution and dynamic temperature curves of the welding area were studied,and welding spatter phenomena were predicted and validated by comparing them with experimental results.By adjusting the welding parameters in numerical simulation,appropriate welding parameters were achieved.Moreover,the mechanical properties of the welding joints under the optimized conditions were also compared with those of not optimized.The study results have already been applied in a manufacturing production.It can also provide guidance for the RSW on UHSS and mild steel.展开更多
Droplet-based microfluidics enables the generation of uniform microdroplets at picoliter or nanoliter scale with high frequency(∼kHz)under precise control.The droplets can function as bioreactors for versatile chemic...Droplet-based microfluidics enables the generation of uniform microdroplets at picoliter or nanoliter scale with high frequency(∼kHz)under precise control.The droplets can function as bioreactors for versatile chemical/biological study and analysis.Taking advantage of the discrete compartment with a confined volume,(1)isolation and manipulation of a single cell,(2)improvement of in-droplet effective concen-trations,(3)elimination of heterogeneous population effects,(4)diminution of contamination risks can be achieved,making it a powerful tool for rapid,sensitive,and high-throughput detection and analysis of bacteria,even for rare or unculturable strains in conventional methods.This mini-review will focus on the generation and manipulation of micro-droplets and bacteria detection and analysis carried out by droplet-based microfluidics.Finally,applications with high potential of droplet-based bacteria analysis are briefly introduced.Due to the advantages of rapid,sensitive,high throughput,and compatibility with rare and unculturable bacteria in conventional methods,droplet-based microfluidics has tremendous potential of providing novel solutions for biological medicine,microbiological engineering,environmental ecology,etc.展开更多
基金the National Basic Research Program of China(2010CB720500)the National Natural Science Foundation of China(21176178)
文摘In this paper, by combining a stochastic optimization method with a refrigeration shaft work targeting method,an approach for the synthesis of a heat integrated complex distillation system in a low-temperature process is presented. The synthesis problem is formulated as a mixed-integer nonlinear programming(MINLP) problem,which is solved by simulated annealing algorithm under a random procedure to explore the optimal operating parameters and the distillation sequence structure. The shaft work targeting method is used to evaluate the minimum energy cost of the corresponding separation system during the optimization without any need for a detailed design for the heat exchanger network(HEN) and the refrigeration system(RS). The method presented in the paper can dramatically reduce the scale and complexity of the problem. A case study of ethylene cold-end separation is used to illustrate the application of the approach. Compared with the original industrial scheme, the result is encouraging.
基金the National Natural Science Foundation of China (11572165)the China Geological Survey (DD20160217).
文摘There are many factors affecting the instability of the submarine hydrate-bearing slope (SHBS),and the interaction with hydrate is very complicated.In this paper,the mechanical mechanism of the static liquefaction and instability of submarine slope caused by the dissociation of natural gas hydrate (NGH) resulting in the rapid increase of pore pressure of gas hydrate-bearing sediments (GHBS) and the decrease of effective stress are analyzed based on the time series and type of SHBS.Then,taking the typical submarine slope in the northern South China Sea as an example,four important factors affecting the stability of SHBS are selected,such as the degree of hydrate dissociation,the depth of hydrate burial,the thickness of hydrate,and the depth of seawater.According to the principle of orthogonal method,25 orthogonal test schemes with 4 factors and 5 levels are designed and the safety factors of submarine slope stability of each scheme are calculated by using the strength reduction finite element method.By means of the orthogonal design range analysis and the variance analysis,sensitivity of influential factors on stability of SHBS are obtained.The results show that the degree of hydrate dissociation is the most sensitive,followed by hydrate burial depth,the thickness of hydrate and the depth of seawater.Finally,the concept of gas hydrate critical burial depth is put forward according to the influence law of gas hydrate burial depth,and the numerical simulation for specific submarine slope is carried out,which indicates the existence of critical burial depth.
基金This work is funded by National Key R&D Project (2017YFC0307605)the China Geological Survey (DD20160217,DD20190218)+1 种基金the National Natural Science Foundation of China (11572165)we would like to extend our sincere appreciation for these.
文摘In this paper, the mechanical properties of gas hydrate-bearing sediments (GHBS) were summarized and the instability mechanism of submarine hydrate-bearing slope (SHBS) was analyzed under the background of the test production of gas hydrate in the northern part of the South China Sea. The strength reduction finite element method (SRFEM) was introduced to the stability analysis of submarine slopes for the safety of the test production. Two schemes were designed to determine the physical and mechanical parameters of four target wells. Through the division of the hydrate dissociation region and the design of four working conditions, the range and degree of hydrate dissociation at different stages during the test production were simulated. Based on the software ABAQUS, 37 FEM models of SHBS were set up to analyze and assess the stability of the submarine slopes in the area of the test production. Necessary information such as safety factors, deformation, and displacement were obtained at different stages and under different working conditions. According to the calculation results, the submarine slope area is stable before the test production, and the safety factors almost remains the same during and after the test production. All these indicate that the test production has no obvious influence on the area of the test production and the submarine slopes in the area are stable during and after the test production.
基金Supported by the National Basic Research Program of China(2015CB655301)the Jiangsu Natural Science Foundation(BK20150063)+1 种基金the Natural Science Research Program of the Jiangsu Higher Education Institutions(13KJA430005)the Project of Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘Molecular layer deposition(MLD) for the deposition of polyimide(PI) at low temperature of 110 °C has been firstly introduced into the field of membrane separation. With the optimized MLD deposition parameters, such low deposition temperature has successfully expanded the application of MLD for the surface modification of polymeric materials. Globular PI particulates grow on both the free surfaces as well as the pore walls of the polypropylene(PP) membranes as isolated islands during progressive precursor exposures. The PI-deposited PP membranes exhibit synergistically improved performances in various aspects. Evidently improved surface hydrophilicity and permeation performance(30%) have been achieved via the MLD deposition of polyimide films. The overall separation efficiency maintained higher than 85% even after 250 cycles of MLD deposition. More importantly, the thermal stability has been improved and the integrity of the porous structure for PI-deposited PP membranes has been well preserved even after harsh treatment, which ensures its potential application in industries.
基金the Natural Science Foundation of Shanghai,No.08ZR1413800
文摘The present study analyzed data from 108 Cushing's disease patients,who underwent trans-sphenoidal surgery in one hospital between January 2003 and April 2010,to investigate the performance value of bilateral inferior petrosal sinus sampling (BIPSS).Of the 108 patients,52 underwent BIPSS prior to surgery and 56 did not.Results showed that BIPSS accuracy for the diagnosis of Cushing's disease was 86.5% (45/52),and accuracy for adenoma lateralization during surgery was 76.9% (40/52).In addition,early remission rate was significantly greater compared to patients without BIPSS.Results demonstrated that BIPSS facilitated localization and diagnosis of Cushing's disease and helped to predict adenoma lateralization.
基金supported by the National Natural Science Foundation of China(No. 30900284,No.31100668,and No.31070873)
文摘Background Dental implants have been widely used in the last few decades.However,patients with insufficient bone height need reconstructive surgeries before implant insertion.Distraction implant(Dl)has been invented to simplify the treatment procedure,but the shortcomings of Dl have limited its clinical use.We introduced biodegradable polyester to a novel Dl,called biodegradable interference distraction implant(BIDI).The purpose of this study was to assess the radiological,histological,and biomechanical properties of BIDI in animal models.Methods BIDIs were manufactured and inserted into the atrophied mandibles of 6 dogs.
基金Supported by National Key Research and Development Program of China(Grant No.2017YFB0304403)National Natural Science Foundation of China(Grant No.51871154).
文摘The resistance spot weldability of galvanized ultra-high-strength steels is not satisfed,the joints are prone to interfacial fracture and the weldable current range is narrow.To solve the problems,a novel method called resistance spot welding with double-sided cover sheets was introduced to weld a galvanized Q&P980 steel with the thickness of 1.2 mm.Two thin SPCC mild steel sheets were chosen as cover sheets and were placed symmetrically at both sides between the Q&P980 steels and the electrodes,then the RSW process was carried out.Compared with the traditional RSW method,the joints obtained by using the novel method achieved larger tensile shear strength and energy absorption,which increased by 26.9%and 52.6%,respectively.With increasing the welding current,the failure mode transferred from interfacial fracture to nugget pull-out fracture or base metal tearing fracture.By contrast,the joints always showed interfacial fracture without cover sheets.The improvement of the joint performance was mainly attributed to the enlargement of the nugget.With the help of fnite element simulation,it was found that the cover sheets helped increase the contact area and reduced the current density during welding,which postponed the expulsion,and a larger area could be evenly heated.The application of the novel method can be easily extended to the resistance spot welding of other ultra-high-strength steels with various thicknesses.
基金Sponsorship Project of Dalian Science and Technology Committee(2001480)
文摘Objective To conifgure an immunoabsorption column for hepatitis B virus. Methods Being activated by epichlorohydrin, the human antibody HBsAb-IgG was bound to the carrier of agarose gel. The configuration process was as follows: the synthesis of epoxide matrix, the synthesis and activation of amino matrix, the synthesis of aldehydic matrix, the synthesis of immunoabsorption matrix, the end capping and reduction of unbound aldehydic, the blocking of unbound mass and the iflling of the column. Results The bound rate of activated agarose gel and antibody HBsAb-IgG is 85.07%. By plasma adsorption experiment, it is revealed that the immunoabsorption column can absorb and eliminate 58.97%of HBsAg and 53.1%of hepatitis B virus particles in extracorporeal plasma. Conclusions The immunoabsorption column for hepatitis B virus can absorb and eliminate HBsAg and hepatitis B virus particles in extracorporeal plasma.
文摘Objective: To investigate the effect of Dan seven soft capsule on the treatment of acute hemorrhagic cerebrovascular disease and the influence of serum inflammatory factors, coagulation function and blood rheology indexes. Methods: A total of 112 cases of patients with acute hemorrhagic cerebrovascular disease, according to the random data table were divided into the control group (n=57) and observation group (n=55), the patients in the control group received routine treatment combined with edaravone, on the basis of the treatment of the control group, the observation group was treated with Dan seven soft capsule. The serum levels of inflammatory factors, coagulation function and blood rheology indexes were compared between the two groups before and after treatment. Results: Before treatment, there were no significant difference in the inflammatory factors (hs-CRP, TNF-α and IL-6), blood coagulation function (FIB, PT and APTT) and hemorheology (high cut whole blood viscosity, low cut whole blood viscosity and plasma viscosity) levels between the control group and observation group. Compared with the levels of the same group before treatment, two groups of hs-CRP, TNF-α, IL-6, FIB, high cut whole blood viscosity, low cut whole blood viscosity and plasma viscosity level after treatment were significantly decreased, and levels in the observation group were significantly lower than those in the control group;Compared with the group before treatment, the levels of PT and APTT in the two groups were significantly increased, and the observation group was significantly higher than the control group. Conclusion: Dan seven soft capsule in the treatment of acute hemorrhagic cerebrovascular disease can effectively reduce the level of serum inflammatory factors, improve coagulation function and blood rheology index, it has an important clinical value.
基金This work is supported by State Grid Shandong Electric Power Company Science and Technology Project Funding under Grant Nos.520613180002,62061318C002the Fundamental Research Funds for the Central Universities(Grant No.HIT.NSRIF.201714)+1 种基金Weihai Science and Technology Development Program(2016DX GJMS15)Key Research and Development Program in Shandong Provincial(2017GGX90103).
文摘Natural scene recognition has important significance and value in the fields of image retrieval,autonomous navigation,human-computer interaction and industrial automation.Firstly,the natural scene image non-text content takes up relatively high proportion;secondly,the natural scene images have a cluttered background and complex lighting conditions,angle,font and color.Therefore,how to extract text extreme regions efficiently from complex and varied natural scene images plays an important role in natural scene image text recognition.In this paper,a Text extremum region Extraction algorithm based on Joint-Channels(TEJC)is proposed.On the one hand,it can solve the problem that the maximum stable extremum region(MSER)algorithm is only suitable for gray images and difficult to process color images.On the other hand,it solves the problem that the MSER algorithm has high complexity and low accuracy when extracting the most stable extreme region.In this paper,the proposed algorithm is tested and evaluated on the ICDAR data set.The experimental results show that the method has superiority.
基金supported by the Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City (No.2021CXLH0009)the National Natural Science Foundation of China (Nos.42006195 and 41976222)+1 种基金the Scientific Research Foundation of Hainan Tropical Ocean University (No.RHDRC202201)the Science and Technology Project of Yazhou Bay Innovation Institute of Hainan Tropical Ocean University (No.2022CXYZD002)。
文摘Eleven organophosphate esters(OPEs)in the air and seawater were investigated from the northwestern Pacific Ocean to the Southern Ocean during the 2018 Chinese 34th Antarctic Scientific Expedition.The concentration of total OPEs ranged from 164.82 to 3501.79 pg/m~3in air and from 4.54 to 70.09 ng/L in seawater.Two halogenated OPEs,tri(chloropropyl)phosphate(TCPP)and tri(2-chloroethyl)phosphate(TCEP),were generally more abundant than the non-halogenated OPEs.A levelⅢfugacity model was developed to simulate the transfer and fate of seven OPEs in the air and seawater regions of the central Ross Sea.The model results indicate that OPEs are transferred from the air to the seawater in the central Ross Sea in summer,during which the Ross Sea acts as a final OPE sink.Dry and wet deposition dominated the processes involving OPE transfer to seawater.The OPE degradation process was also found to be more pervasive in the atmosphere than in the seawater region.These findings highlights the importance of long-range transport of OPEs and their air–seawater interface behavior in the Antarctic.
基金supported by the National Natural Science Foundation of China(Nos.51771142 and 51971171)Natural Science Foundation of Shaanxi Province(No.2021JC-07).
文摘Infection is a main cause of implant failure.The microenvironment cell experiencing after antimicrobial therapy of infected implants is very crucial for immunomodulation and subsequent osteointegration.Based on the superiority of photothermal therapy in anti-infection,a matrix of nanograined TiO_(2)with(Si/P)-dual ions and hierarchical nano/microporous topography is developed on Ti implant by micro-arc oxidation.It shows good photothermal properties due to the lattice distortion induced by ion doping and can kill bacteria with near-infrared(NIR)light irradiation efficiently.Due to the combined action of porous topography and release of Si/P ions,the TiO_(2)matrix achieves M1-to-M_(2)phenotype switch of macrophages timely at different simulating infection stage and accelerates recruitment,proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in vitro.In vivo,the TiO_(2)matrix also shows desired antibacterial performance after photothermal therapy and exhibits outstanding immunomodulatory ability and new bone formation efficiency.This study provides a promising TiO_(2)matrix applied in clinic for settling implant infection by NIR light irradiation and promoting bone regeneration through osteoimmunomodulation.
基金We are supported by Guangdong Provincial Key Laboratory(Grant No.2019B121203002)L.K.is also supported by the National Natural Science Foundation of China under Grant No.11971219+1 种基金Guangdong Basic and Applied Basic Research Foundation under Grant No.2020B1515120100H.Z.is also supported by the National Natural Science Foundation of China under Grant No.11871078.
文摘In quantum computing, the computation is achieved by linear operators in or between Hilbert spaces. In this work, we explore a new computation scheme, in which the linear operators in quantum computing are replaced by (higher) functors between two (higher) categories. If from Turing computing to quantum computing is the first quantization of computation, then this new scheme can be viewed as the second quantization of computation. The fundamental problem in realizing this idea is how to realize a (higher) functor physically. We provide a theoretical idea of realizing (higher) functors physically based on the physics of topological orders.
基金supported by Shanghai Automotive Industry Technology Development Foundation,China(No.1102)
文摘In this study,a coupled axisymmetric finite element model (FEM) was built to simulate the resistance spot welding (RSW) process between ultra-high strength hotstamped (UHSS) and mild steel by SORPAS software.Via simulating this process,the temperature distribution and dynamic temperature curves of the welding area were studied,and welding spatter phenomena were predicted and validated by comparing them with experimental results.By adjusting the welding parameters in numerical simulation,appropriate welding parameters were achieved.Moreover,the mechanical properties of the welding joints under the optimized conditions were also compared with those of not optimized.The study results have already been applied in a manufacturing production.It can also provide guidance for the RSW on UHSS and mild steel.
基金supported by National Natural Science Foundation of China (No. 22104117)“the Fundamental Research Funds for the Central Universities” (No. JC2110)+1 种基金Wuhu and Xidian University special fund for industry-university-research cooperation (No. XWYCXY-012020012)Open Fund of Zhijiang Lab (No. 2021MC0AB02)
文摘Droplet-based microfluidics enables the generation of uniform microdroplets at picoliter or nanoliter scale with high frequency(∼kHz)under precise control.The droplets can function as bioreactors for versatile chemical/biological study and analysis.Taking advantage of the discrete compartment with a confined volume,(1)isolation and manipulation of a single cell,(2)improvement of in-droplet effective concen-trations,(3)elimination of heterogeneous population effects,(4)diminution of contamination risks can be achieved,making it a powerful tool for rapid,sensitive,and high-throughput detection and analysis of bacteria,even for rare or unculturable strains in conventional methods.This mini-review will focus on the generation and manipulation of micro-droplets and bacteria detection and analysis carried out by droplet-based microfluidics.Finally,applications with high potential of droplet-based bacteria analysis are briefly introduced.Due to the advantages of rapid,sensitive,high throughput,and compatibility with rare and unculturable bacteria in conventional methods,droplet-based microfluidics has tremendous potential of providing novel solutions for biological medicine,microbiological engineering,environmental ecology,etc.
