Surface/interface engineering of a multimetallic nanostructure with diverse electrocatalytic properties for direct liquid fuel cells is desirable yet challenging.Herein,using visible light,a class of quaternary Pt_(1)...Surface/interface engineering of a multimetallic nanostructure with diverse electrocatalytic properties for direct liquid fuel cells is desirable yet challenging.Herein,using visible light,a class of quaternary Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)ultrathin nanosheets is fabricated and used as high-performance anode electrocatalysts for formic acid-/alcohol-air fuel cells.The modified electronic structure of Pt,enhanced hydroxyl adsorption,and abundant exterior defects afford Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C high intrinsic anodic electrocatalytic activity to boost the power densities of direct formic acid-/methanol-/ethanol-/ethylene glycol-/glycerol-air fuel cells,and the corresponding peak power density of Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C is respectively 129.7,142.3,105.4,124.3,and 128.0 mW cm^(-2),considerably outperforming Pt/C.Operando in situ Fourier transform infrared reflection spectroscopy reveals that formic acid oxidation on Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C occurs via a CO_(2)-free direct pathway.Density functional theory calculations show that the presence of Ag,Bi,and Te in Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)suppresses CO^(*)formation while optimizing dehydrogenation steps and synergistic effect and modified Pt effectively enhance H_(2)O dissociation to improve electrocatalytic performance.This synthesis strategy can be extended to 43 other types of ultrathin multimetallic nanosheets(from ternary to octonary nanosheets),and efficiently capture precious metals(i.e.,Pd,Pt,Rh,Ru,Au,and Ag)from different water sources.展开更多
Soil microorganisms play critical roles in ecosystem function.However,the relative impact of the potassium(K)fertilizer gradient on the microbial community in wheat-maize double-cropping systems remains unclear.In thi...Soil microorganisms play critical roles in ecosystem function.However,the relative impact of the potassium(K)fertilizer gradient on the microbial community in wheat-maize double-cropping systems remains unclear.In this long-term field experiment(2008-2019),we researched bacterial and fungal diversity,composition,and community assemblage in the soil along a K fertilizer gradient in the wheat season(K0,no K fertilizer;K1,45 kg ha^(-1) K_(2)O;K_(2),90 kg ha^(-1)K_(2)O;K3,135 kg ha^(-1)K_(2)O)and in the maize season(K0,no K fertilizer;K_(1),150 kg ha^(-1) K_(2)O;K_(2),300 kg ha^(-1)K_(2)O;K_(3),450 kg ha^(-1)K_(2)O)using bacterial 16S rRNA and fungal internally transcribed spacer(ITS)data.We observed that environmental variables,such as mean annual soil temperature(MAT)and precipitation,available K,ammonium,nitrate,and organic matter,impacted the soil bacterial and fungal communities,and their impacts varied with fertilizer treatments and crop species.Furthermore,the relative abundance of bacteria involved in soil nutrient transformation(phylum Actinobacteria and class Alphaproteobacteria)in the wheat season was significantly increased compared to the maize season,and the optimal K fertilizer dosage(K2 treatment)boosted the relative bacterial abundance of soil nutrient transformation(genus Lactobacillus)and soil denitrification(phylum Proteobacteria)bacteria in the wheat season.The abundance of the soil bacterial community promoting root growth and nutrient absorption(genus Herbaspirillum)in the maize season was improved compared to the wheat season,and the K2 treatment enhanced the bacterial abundance of soil nutrient transformation(genus MND1)and soil nitrogen cycling(genus Nitrospira)genera in the maize season.The results indicated that the bacterial and fungal communities in the double-cropping system exhibited variable sensitivities and assembly mechanisms along a K fertilizer gradient,and microhabitats explained the largest amount of the variation in crop yields,and improved wheat?maize yields by 11.2-22.6 and 9.2-23.8%with K addition,respectively.These modes are shaped contemporaneously by the different meteorological factors and soil nutrient changes in the K fertilizer gradients.展开更多
A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled ...A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled quantum teleportation network involving more users is in demand,which satisfies different combinations of users for practical requirements.Here we propose a highly versatile and controlled teleportation network that can switch among various combinations of different users.We use a single continuous-variable six-partite Greenberger-Horne-Zeilinger(GHZ)state to realize such a task by choosing the different measurement and feedback operations.The controlled teleportation network,which includes one sub-network,two sub-networks and three sub-networks,can be realized for different application of user combinations.Furthermore,the coherent feedback control(CFC)can manipulate and improve the teleportation performance.Our approach is flexible and scalable,and would provide a versatile platform for demonstrations of complex quantum communication and quantum computing protocols.展开更多
In this editorial,we comment on the article by Cao et al.Through applying isobaric tags for relative and absolute quantification technology coupled with liquid chromatography-tandem mass spectrometry,the researchers o...In this editorial,we comment on the article by Cao et al.Through applying isobaric tags for relative and absolute quantification technology coupled with liquid chromatography-tandem mass spectrometry,the researchers observed significant differential expression of 47 proteins when comparing serum samples from pregnant women with gestational diabetes mellitus(GDM)to the healthy ones.GDM symptoms may involve abnormalities in inflammatory response,complement system,coagulation cascade activation,and lipid metabolism.Retinol binding protein 4 and angiopoietin like 8 are potential early indicators of GDM.GDM stands out as one of the most prevalent metabolic complications during pregnancy and is linked to severe maternal and fetal outcomes like pre-eclampsia and stillbirth.Nevertheless,none of the biomarkers discovered so far have demonstrated effectiveness in predicting GDM.Our topic was designed to foster insights into advances in the application of proteomics for early prenatal screening of GDM.展开更多
In this letter,we discuss the topic of necessity of routine laboratory monitoring during isotretinoin treatment for acne.According to Park and colleagues,it is advisable to monitor the levels of triglycerides,alanine ...In this letter,we discuss the topic of necessity of routine laboratory monitoring during isotretinoin treatment for acne.According to Park and colleagues,it is advisable to monitor the levels of triglycerides,alanine aminotransferase,and aspartate aminotransferase every 5 to 6 months.Additionally,the levels of total cholesterol and low-density lipoprotein should be checked within the first two months of treatment.Isotretinoin is a commonly prescribed agent mainly used to treat acne.Despite its high effectiveness,it necessitates regular monitoring of laboratory parameters due to its side effect profile.Currently,there remains a lack of consensus on the appropriate frequency for monitoring these parameters during treatment with isotretinoin.This letter will provide insight into this complex and controversial topic.Based on existing literature,we concluded that the incidence of changes in lipid and liver aminotransferase levels during isotretinoin treatment for acne was low and likely clinically insignificant.For generally healthy people,we recommend testing lipid and liver profiles once at baseline and a second time at the peak dosage.However,frequent testing might still be beneficial in certain populations of patients.展开更多
Coating technologies are a commonly used way to protect metals against corrosion.However,with more and more severe service environments of materials,many protective coating systems often are not environmentally friend...Coating technologies are a commonly used way to protect metals against corrosion.However,with more and more severe service environments of materials,many protective coating systems often are not environmentally friendly or toxic as in the case of chromates.Based on the world’s abundant ideal magnesium(Mg)and its alloy,the smart self-healing anticorrosive coating can autonomously restore the damaged part of the coating according to the environmental changes,strengthen the corrosion protection ability,and prolong its service life.This paper reviews the research progress of smart self-healing coatings on Mg alloys.These coatings mostly contain suitable corrosion inhibitors encapsulated into micro/nano containers.Moreover,the different self-healing mechanisms and functionalities of micro/nano containers are discussed.The micro/nano containers range from inorganic nanocontainers such as mesoporous nanoparticles(silica(SiO_(2)),titanium dioxide(TiO_(2)),etc.),over inorganic clays(halloysite,hydrotalcite-like,zeolite),to organic nanocontainers such as polymer microcapsules,nanofibers,chitosan(CS)and cyclodextrin(CD),as well as,carbon materials such as graphene and carbon nanotubes and hybrids such as metal organic frameworks.The functioning of micro/nano containers can be divided in two principal groups:autonomous(based on defect filling and corrosion inhibition)and non-autonomous(based on dynamic bonds and shape memory polymers).Moreover,multi functionalities and composite applications of various micro/nano containers are summarized.At present,significant progress has been made in the preparation methods and technologies of micro/nano containers.Achieving long-term self-healing properties of coatings sensing of coating failure and early warning after self-healing function failure can be expected as the main development direction of self-healing corrosion protection coatings in the future.展开更多
Chronic liver injury leads to progressive liver fibrosis and ultimately cirrhosis,a major cause of morbidity and mortality worldwide.However,there are currently no effective anti-fibrotic therapies available,especiall...Chronic liver injury leads to progressive liver fibrosis and ultimately cirrhosis,a major cause of morbidity and mortality worldwide.However,there are currently no effective anti-fibrotic therapies available,especially for latestage patients,which is partly attributed to the major knowledge gap regarding liver cell heterogeneity and cellspecific responses in different fibrosis stages.To reveal the multicellular networks regulating mammalian liver fibrosis from mild to severe phenotypes,we generated a single-nucleus transcriptomic atlas encompassing 49919nuclei corresponding to all main liver cell types at different stages of murine carbon tetrachloride(CCl_(4))-induced progressive liver fibrosis.Integrative analysis distinguished the sequential responses to injury of hepatocytes,hepatic stellate cells and endothelial cells.Moreover,we reconstructed the cell-cell interactions and gene regulatory networks implicated in these processes.These integrative analyses uncovered previously overlooked aspects of hepatocyte proliferation exhaustion and disrupted pericentral metabolic functions,dysfunction for clearance by apoptosis of activated hepatic stellate cells,accumulation of pro-fibrotic signals,and the switch from an anti-angiogenic to a pro-angiogenic program during CCl_(4)-induced progressive liver fibrosis.Our dataset thus constitutes a useful resource for understanding the molecular basis of progressive liver fibrosis using a relevant animal model.展开更多
Magnesium-based energy materials, which combine promising energy-related functional properties with low cost, environmental compatibility and high availability, have been regarded as fascinating candidates for sustain...Magnesium-based energy materials, which combine promising energy-related functional properties with low cost, environmental compatibility and high availability, have been regarded as fascinating candidates for sustainable energy conversion and storage. In this review,we provide a timely summary on the recent progress in three types of important Mg-based energy materials, based on the fundamental strategies of composition and structure engineering. With regard to Mg-based materials for batteries, we systematically review and analyze different material systems, structure regulation strategies as well as the relevant performance in Mg-ion batteries(MIBs) and Mg-air batteries(MABs), covering cathodes, electrolytes, anodes for MIBs, and anodes for MABs;as to Mg-based hydrogen storage materials, we discuss how catalyst adding, composite, alloying and nanostructuring improve the kinetic and thermodynamic properties of de/hydrogenation reactions, and in particular, the impacts of composition and structure modification on hydrogen absorption/dissociation processes and free energy modification mechanism are focused;regarding Mg-based thermoelectric materials, the relations between composition/structure and electrical/thermal transport properties of Mg_(3)X_(2)(X = Sb, Bi), Mg_(2)X(X = Si, Ge, Sn) and Mg Ag Sb-based materials, together with the representative research progress of each material system, are summarized and discussed. Finally, by pointing out remaining challenges and providing possible solutions, this review aims to shed light on the directions and perspectives for practical applications of magnesium-based energy materials in the future.展开更多
Compressed sensing(CS)aims for seeking appropriate algorithms to recover a sparse vector from noisy linear observations.Currently,various Bayesian-based algorithms such as sparse Bayesian learning(SBL)and approximate ...Compressed sensing(CS)aims for seeking appropriate algorithms to recover a sparse vector from noisy linear observations.Currently,various Bayesian-based algorithms such as sparse Bayesian learning(SBL)and approximate message passing(AMP)based algorithms have been proposed.For SBL,it has accurate performance with robustness while its computational complexity is high due to matrix inversion.For AMP,its performance is guaranteed by the severe restriction of the measurement matrix,which limits its application in solving CS problem.To overcome the drawbacks of the above algorithms,in this paper,we present a low complexity algorithm for the single linear model that incorporates the vector AMP(VAMP)into the SBL structure with expectation maximization(EM).Specifically,we apply the variance auto-tuning into the VAMP to implement the E step in SBL,which decrease the iterations that require to converge compared with VAMP-EM algorithm when using a Gaussian mixture(GM)prior.Simulation results show that the proposed algorithm has better performance with high robustness under various cases of difficult measurement matrices.展开更多
In this work,plasma electrolytic oxidation(PEO)coatings were produced on magnesium alloy AZ31 in aluminate,silicate and phosphate-based electrolytes,and followed by hydrothermal treatments in order to synthesis layere...In this work,plasma electrolytic oxidation(PEO)coatings were produced on magnesium alloy AZ31 in aluminate,silicate and phosphate-based electrolytes,and followed by hydrothermal treatments in order to synthesis layered double hydroxides(LDHs)based nanocontainers.LDHs synthesis was done in three different growth solutions(deionized water,sodium nitrate and aluminum nitrate containing solution).In frame of this work it was shown,that it was difficult to form LDHs on Si-based PEO coating,due to more stable silicate phases in comparison with aluminate and phosphate phases in respective PEO coatings.The obtained hybrid LDH/PEO coatings were characterized using SEM,EDS and GDOES,and then the corrosion protection was further investigated by EIS.Based on the obtained results,it was confirmed that,the hydrothermal treatments in Al^(3+)containing solution played an important role on overall corrosion resistance for phosphate and silicate-based PEO coatings,but not for Al-based PEO coatings.展开更多
基金supported by the National Natural Science Foundation of China(21571038,22035004)the Education Department of Guizhou Province(2021312)+2 种基金the Foundation of Guizhou Province(2019-5666)the National Key R&D Program of China(2017YFA0700101)the State Key Laboratory of Physical Chemistry of Solid Surfaces(Xiamen University,202009)。
文摘Surface/interface engineering of a multimetallic nanostructure with diverse electrocatalytic properties for direct liquid fuel cells is desirable yet challenging.Herein,using visible light,a class of quaternary Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)ultrathin nanosheets is fabricated and used as high-performance anode electrocatalysts for formic acid-/alcohol-air fuel cells.The modified electronic structure of Pt,enhanced hydroxyl adsorption,and abundant exterior defects afford Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C high intrinsic anodic electrocatalytic activity to boost the power densities of direct formic acid-/methanol-/ethanol-/ethylene glycol-/glycerol-air fuel cells,and the corresponding peak power density of Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C is respectively 129.7,142.3,105.4,124.3,and 128.0 mW cm^(-2),considerably outperforming Pt/C.Operando in situ Fourier transform infrared reflection spectroscopy reveals that formic acid oxidation on Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)/C occurs via a CO_(2)-free direct pathway.Density functional theory calculations show that the presence of Ag,Bi,and Te in Pt_(1)Ag_(0.1)Bi_(0.16)Te_(0.29)suppresses CO^(*)formation while optimizing dehydrogenation steps and synergistic effect and modified Pt effectively enhance H_(2)O dissociation to improve electrocatalytic performance.This synthesis strategy can be extended to 43 other types of ultrathin multimetallic nanosheets(from ternary to octonary nanosheets),and efficiently capture precious metals(i.e.,Pd,Pt,Rh,Ru,Au,and Ag)from different water sources.
基金funded by the National Key Research and Development Program of China(2023YFD150050504)the Key Research and Development Program of Shandong Province,China(2022SFGC0301)the Strategic Priority Research Program of the Chinese Academy of Sciences-Development and Application Technology of Special Package Fertilizer for Improving Albic Soil(XDA28100203)。
文摘Soil microorganisms play critical roles in ecosystem function.However,the relative impact of the potassium(K)fertilizer gradient on the microbial community in wheat-maize double-cropping systems remains unclear.In this long-term field experiment(2008-2019),we researched bacterial and fungal diversity,composition,and community assemblage in the soil along a K fertilizer gradient in the wheat season(K0,no K fertilizer;K1,45 kg ha^(-1) K_(2)O;K_(2),90 kg ha^(-1)K_(2)O;K3,135 kg ha^(-1)K_(2)O)and in the maize season(K0,no K fertilizer;K_(1),150 kg ha^(-1) K_(2)O;K_(2),300 kg ha^(-1)K_(2)O;K_(3),450 kg ha^(-1)K_(2)O)using bacterial 16S rRNA and fungal internally transcribed spacer(ITS)data.We observed that environmental variables,such as mean annual soil temperature(MAT)and precipitation,available K,ammonium,nitrate,and organic matter,impacted the soil bacterial and fungal communities,and their impacts varied with fertilizer treatments and crop species.Furthermore,the relative abundance of bacteria involved in soil nutrient transformation(phylum Actinobacteria and class Alphaproteobacteria)in the wheat season was significantly increased compared to the maize season,and the optimal K fertilizer dosage(K2 treatment)boosted the relative bacterial abundance of soil nutrient transformation(genus Lactobacillus)and soil denitrification(phylum Proteobacteria)bacteria in the wheat season.The abundance of the soil bacterial community promoting root growth and nutrient absorption(genus Herbaspirillum)in the maize season was improved compared to the wheat season,and the K2 treatment enhanced the bacterial abundance of soil nutrient transformation(genus MND1)and soil nitrogen cycling(genus Nitrospira)genera in the maize season.The results indicated that the bacterial and fungal communities in the double-cropping system exhibited variable sensitivities and assembly mechanisms along a K fertilizer gradient,and microhabitats explained the largest amount of the variation in crop yields,and improved wheat?maize yields by 11.2-22.6 and 9.2-23.8%with K addition,respectively.These modes are shaped contemporaneously by the different meteorological factors and soil nutrient changes in the K fertilizer gradients.
基金Project supported by the Natural Science Foundation of Shanxi Province of China (Grant No. 202203021221214)the National Natural Science Foundation of China (Grant Nos. 62122044, 62135008, 61925503, 11904218, 12004276, 12147215, and 11834010)+4 种基金the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province of China (Grant Nos. 2019L0092 and 2020L0029)the Key Project of the National Key Research and Development Program of China (Grant No. 2022YFA1404500)the Program for the Innovative Talents of Higher Education Institutions of Shanxi Province of Chinathe Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxithe Fund for Shanxi “1331 Project” Key Subjects Construction
文摘A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled quantum teleportation network involving more users is in demand,which satisfies different combinations of users for practical requirements.Here we propose a highly versatile and controlled teleportation network that can switch among various combinations of different users.We use a single continuous-variable six-partite Greenberger-Horne-Zeilinger(GHZ)state to realize such a task by choosing the different measurement and feedback operations.The controlled teleportation network,which includes one sub-network,two sub-networks and three sub-networks,can be realized for different application of user combinations.Furthermore,the coherent feedback control(CFC)can manipulate and improve the teleportation performance.Our approach is flexible and scalable,and would provide a versatile platform for demonstrations of complex quantum communication and quantum computing protocols.
文摘In this editorial,we comment on the article by Cao et al.Through applying isobaric tags for relative and absolute quantification technology coupled with liquid chromatography-tandem mass spectrometry,the researchers observed significant differential expression of 47 proteins when comparing serum samples from pregnant women with gestational diabetes mellitus(GDM)to the healthy ones.GDM symptoms may involve abnormalities in inflammatory response,complement system,coagulation cascade activation,and lipid metabolism.Retinol binding protein 4 and angiopoietin like 8 are potential early indicators of GDM.GDM stands out as one of the most prevalent metabolic complications during pregnancy and is linked to severe maternal and fetal outcomes like pre-eclampsia and stillbirth.Nevertheless,none of the biomarkers discovered so far have demonstrated effectiveness in predicting GDM.Our topic was designed to foster insights into advances in the application of proteomics for early prenatal screening of GDM.
文摘In this letter,we discuss the topic of necessity of routine laboratory monitoring during isotretinoin treatment for acne.According to Park and colleagues,it is advisable to monitor the levels of triglycerides,alanine aminotransferase,and aspartate aminotransferase every 5 to 6 months.Additionally,the levels of total cholesterol and low-density lipoprotein should be checked within the first two months of treatment.Isotretinoin is a commonly prescribed agent mainly used to treat acne.Despite its high effectiveness,it necessitates regular monitoring of laboratory parameters due to its side effect profile.Currently,there remains a lack of consensus on the appropriate frequency for monitoring these parameters during treatment with isotretinoin.This letter will provide insight into this complex and controversial topic.Based on existing literature,we concluded that the incidence of changes in lipid and liver aminotransferase levels during isotretinoin treatment for acne was low and likely clinically insignificant.For generally healthy people,we recommend testing lipid and liver profiles once at baseline and a second time at the peak dosage.However,frequent testing might still be beneficial in certain populations of patients.
基金This work was supported by the National Natural Science Foundation of China(Nos.51971040,52171101,52001036,51971044)the Natural Science Foundation of Chongqing,China(No.cstc2021jcyj-msxmX0613)the Independent Research Project of State Key Laboratory of Mechanical Transmissions,China(No.SKLMT-ZZKT-2022M12).
基金supported by the Chongqing Municipal Human Resources and Social Security Bureau,China(No.cx2022098)the National Natural Science Foundation of China(No.52001036)China Postdoctoral Science Foundation(Nos.2022T150767,2021M693708).
基金supported by the National Natural Science Foundation of China(51971040,52171101)the Natural Science Foundation of Chongqing(cstc2021jcyj-msxmX0613)+1 种基金the National Natural Science Foundation of China(52001036,51971044)the Independent Research Project of State Key Laboratory of Mechanical Transmissions(SKLMT-ZZKT-2022M12).
文摘Coating technologies are a commonly used way to protect metals against corrosion.However,with more and more severe service environments of materials,many protective coating systems often are not environmentally friendly or toxic as in the case of chromates.Based on the world’s abundant ideal magnesium(Mg)and its alloy,the smart self-healing anticorrosive coating can autonomously restore the damaged part of the coating according to the environmental changes,strengthen the corrosion protection ability,and prolong its service life.This paper reviews the research progress of smart self-healing coatings on Mg alloys.These coatings mostly contain suitable corrosion inhibitors encapsulated into micro/nano containers.Moreover,the different self-healing mechanisms and functionalities of micro/nano containers are discussed.The micro/nano containers range from inorganic nanocontainers such as mesoporous nanoparticles(silica(SiO_(2)),titanium dioxide(TiO_(2)),etc.),over inorganic clays(halloysite,hydrotalcite-like,zeolite),to organic nanocontainers such as polymer microcapsules,nanofibers,chitosan(CS)and cyclodextrin(CD),as well as,carbon materials such as graphene and carbon nanotubes and hybrids such as metal organic frameworks.The functioning of micro/nano containers can be divided in two principal groups:autonomous(based on defect filling and corrosion inhibition)and non-autonomous(based on dynamic bonds and shape memory polymers).Moreover,multi functionalities and composite applications of various micro/nano containers are summarized.At present,significant progress has been made in the preparation methods and technologies of micro/nano containers.Achieving long-term self-healing properties of coatings sensing of coating failure and early warning after self-healing function failure can be expected as the main development direction of self-healing corrosion protection coatings in the future.
基金supported by the National Natural Science Foundation of China(32200688,92068106,U20A2015,32211530050)Guangdong Basic and Applied Basic Research Foundation(2021B1515120075,2021A1515110180)Science and Technology Program of Guangzhou(202201010408,202201011037)。
文摘Chronic liver injury leads to progressive liver fibrosis and ultimately cirrhosis,a major cause of morbidity and mortality worldwide.However,there are currently no effective anti-fibrotic therapies available,especially for latestage patients,which is partly attributed to the major knowledge gap regarding liver cell heterogeneity and cellspecific responses in different fibrosis stages.To reveal the multicellular networks regulating mammalian liver fibrosis from mild to severe phenotypes,we generated a single-nucleus transcriptomic atlas encompassing 49919nuclei corresponding to all main liver cell types at different stages of murine carbon tetrachloride(CCl_(4))-induced progressive liver fibrosis.Integrative analysis distinguished the sequential responses to injury of hepatocytes,hepatic stellate cells and endothelial cells.Moreover,we reconstructed the cell-cell interactions and gene regulatory networks implicated in these processes.These integrative analyses uncovered previously overlooked aspects of hepatocyte proliferation exhaustion and disrupted pericentral metabolic functions,dysfunction for clearance by apoptosis of activated hepatic stellate cells,accumulation of pro-fibrotic signals,and the switch from an anti-angiogenic to a pro-angiogenic program during CCl_(4)-induced progressive liver fibrosis.Our dataset thus constitutes a useful resource for understanding the molecular basis of progressive liver fibrosis using a relevant animal model.
基金financial support from the National Key Research and Development Program of China (No.2021YFB3502200)the National Natural Science Foundation of China (Grants Nos.52271202,51971040,52171101)+2 种基金the Shanghai Rising-Star Program (No.21QA1403200)supported by a start-up fund from Chongqing University (02110011044171)Liuchuang Program of Chongqing Municipality (cx2022038)。
文摘Magnesium-based energy materials, which combine promising energy-related functional properties with low cost, environmental compatibility and high availability, have been regarded as fascinating candidates for sustainable energy conversion and storage. In this review,we provide a timely summary on the recent progress in three types of important Mg-based energy materials, based on the fundamental strategies of composition and structure engineering. With regard to Mg-based materials for batteries, we systematically review and analyze different material systems, structure regulation strategies as well as the relevant performance in Mg-ion batteries(MIBs) and Mg-air batteries(MABs), covering cathodes, electrolytes, anodes for MIBs, and anodes for MABs;as to Mg-based hydrogen storage materials, we discuss how catalyst adding, composite, alloying and nanostructuring improve the kinetic and thermodynamic properties of de/hydrogenation reactions, and in particular, the impacts of composition and structure modification on hydrogen absorption/dissociation processes and free energy modification mechanism are focused;regarding Mg-based thermoelectric materials, the relations between composition/structure and electrical/thermal transport properties of Mg_(3)X_(2)(X = Sb, Bi), Mg_(2)X(X = Si, Ge, Sn) and Mg Ag Sb-based materials, together with the representative research progress of each material system, are summarized and discussed. Finally, by pointing out remaining challenges and providing possible solutions, this review aims to shed light on the directions and perspectives for practical applications of magnesium-based energy materials in the future.
基金supported by NSFC projects(61960206005,61803211,61871111,62101275,62171127,61971136,and 62001056)Jiangsu NSF project(BK20200820)+1 种基金Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX210106)Research Fund of National Mobile Communications Research Laboratory.
文摘Compressed sensing(CS)aims for seeking appropriate algorithms to recover a sparse vector from noisy linear observations.Currently,various Bayesian-based algorithms such as sparse Bayesian learning(SBL)and approximate message passing(AMP)based algorithms have been proposed.For SBL,it has accurate performance with robustness while its computational complexity is high due to matrix inversion.For AMP,its performance is guaranteed by the severe restriction of the measurement matrix,which limits its application in solving CS problem.To overcome the drawbacks of the above algorithms,in this paper,we present a low complexity algorithm for the single linear model that incorporates the vector AMP(VAMP)into the SBL structure with expectation maximization(EM).Specifically,we apply the variance auto-tuning into the VAMP to implement the E step in SBL,which decrease the iterations that require to converge compared with VAMP-EM algorithm when using a Gaussian mixture(GM)prior.Simulation results show that the proposed algorithm has better performance with high robustness under various cases of difficult measurement matrices.
基金supported by the International Cooperation in Science and Technology Innovation between Governments,National Key Research and Development Program of China(No.2018YFE0116200)the National Natural Science Foundation of China(51971040,51701029)+4 种基金the Fundamental Research Funds for the Central Universities(2020CDJQY-A007)China Postdoctoral Science Foundation Funded Project(2017M620410,2018T110942)the Chongqing Postdoctoral Scientific Research Foundation(Xm2017010)G.Z.thanks also China Scholarship Council for the award of fellowship and funding(No.201806050047)M.S.and C.B.additionally thank the ACTICOAT project(Era.Net RUS Plus Call 2017,Project 477)for the financial support of this work.
文摘In this work,plasma electrolytic oxidation(PEO)coatings were produced on magnesium alloy AZ31 in aluminate,silicate and phosphate-based electrolytes,and followed by hydrothermal treatments in order to synthesis layered double hydroxides(LDHs)based nanocontainers.LDHs synthesis was done in three different growth solutions(deionized water,sodium nitrate and aluminum nitrate containing solution).In frame of this work it was shown,that it was difficult to form LDHs on Si-based PEO coating,due to more stable silicate phases in comparison with aluminate and phosphate phases in respective PEO coatings.The obtained hybrid LDH/PEO coatings were characterized using SEM,EDS and GDOES,and then the corrosion protection was further investigated by EIS.Based on the obtained results,it was confirmed that,the hydrothermal treatments in Al^(3+)containing solution played an important role on overall corrosion resistance for phosphate and silicate-based PEO coatings,but not for Al-based PEO coatings.
