This present study was aimed to investigate the roles of the receptors of Thl/Th2 cytokines and chemokines in lhe pathogenesis of chronic idiopathic urticaria （CIU）. Thirty patients with CIU, 30 patients with dermog...This present study was aimed to investigate the roles of the receptors of Thl/Th2 cytokines and chemokines in lhe pathogenesis of chronic idiopathic urticaria （CIU）. Thirty patients with CIU, 30 patients with dermographism and 30 healthy controls were randomly enrolled. Reverse transcription-PCR （RT-PCR） was used to analyze the mRNA of cytokine receptors in peripheral blood mononuclear cells （PBMCs）. The mRNA levels of tumor necro- sis factor receptor （TNFR）, interferon-7 receptor （IFN-yR）, and interleukin-10 receptor （IL-IOR） were statistically increased in the CIU group （P 〈 0.05）, while IL-2R, IL-4R, IL-6R, and IL-13R showed no significant differences between the CIU and other groups. The mRNA levels of CCR3 and CCR6 were statistically increased in the CIU group （P 〈 0.05）. The toll-like receptor 2 （TLR2） mRNA level was significantly lower in the CIU group than the healthy control group （P 〈 0.05）. These findings indicate that the regulation of mRNA of TNFR, IFN-γR, IL-IOR, CCR3, CCR6 and TLR2 may be involved in the pathogenesis of CIU.展开更多
Syringocystadenoma papilliferum(SCAP)is a rare benign skin tumor that develops from the apocrine or eccrine glands.Here,we report the case of a 2-year-old girl who presented with an asymptomatic,slowly growing lesion ...Syringocystadenoma papilliferum(SCAP)is a rare benign skin tumor that develops from the apocrine or eccrine glands.Here,we report the case of a 2-year-old girl who presented with an asymptomatic,slowly growing lesion on her scalp.On physical examination,a 2 cm×1 cm red papillary plaque with a crusted surface was noted on her scalp.Histopathological examination revealed papillomatous expansion of the epidermis and cystic invaginations extending from the epidermis down to the deep dermis.The cystic structures were lined by papillae with two layers of columnar epithelium,which showed decapitation secretion.Based on the above clinicopathological findings,a diagnosis of congenital scalp SCAP was made.展开更多
Aplasia cutis congenita(ACC)is a rare disease that is characterized by complete or partial absence of skin at birth,either in a localized or widespread region.Melanocytic nevi refers to tumor-like malformations of the...Aplasia cutis congenita(ACC)is a rare disease that is characterized by complete or partial absence of skin at birth,either in a localized or widespread region.Melanocytic nevi refers to tumor-like malformations of the skin or mucous membrane caused by benign proliferation of melanocytes.It is classified as a giant congenital melanocytic nevus(GCMN)when the diameter of the largest nevus exceeds 20 cm.The co-occurrence of ACC and GCMN is extremely rare,to the best of our knowledge.We report a case of coexistence of ACC and GCMN of infancy in a 2-month-old male infant.The lesions consisted of a large hyperpigmented plaque occupying most of the trunk and pelvic region,and smaller hyperpigmented plaques on the trunk,head,and extremities.Additionally,there were large,sharply marginated,triangular,depressed atrophic plaques covered by thin,translucent,glistening epithelial membranes in the center of the GCMN on the back.The presumptive diagnosis was coexistence of GCMN and ACC.This could be a manifestation of SCALP syndrome,a rare neuro-cutaneous condition characterized by the presence of Sebaceous nevus,Central nervous system(CNS)malformations,Aplasia cutis congenita,Limbal dermoid and Pigmented(giant melanocytic)nevus.展开更多
Superficial angiomyxoma(SA)is a rare superficial benign tumor of the skin that is characterized by slow growth.It is painless,non-invasive,and prone to relapse.It commonly occurs on the head,neck,trunk,and limbs and i...Superficial angiomyxoma(SA)is a rare superficial benign tumor of the skin that is characterized by slow growth.It is painless,non-invasive,and prone to relapse.It commonly occurs on the head,neck,trunk,and limbs and in the genital region.Herein,we describe a case of a 33-year-old man who presented with a soft tender tumor measuring 1.5×2.0 cm on the lateral aspect of the left second finger.The histopathology of the tumor indicated that it was a lobulated tumor rich in myxoid stroma and parenchymal blood vessels in the dermis,with spindle-to-stellate tumor cells in higher-power view and no mitotic or atypical figures.Immunohistochemical studies revealed that the tumor cells were positive for CD34 and negative for S100.Based on these clinical and histological findings,the patient was diagnosed with SA.展开更多
文摘This present study was aimed to investigate the roles of the receptors of Thl/Th2 cytokines and chemokines in lhe pathogenesis of chronic idiopathic urticaria （CIU）. Thirty patients with CIU, 30 patients with dermographism and 30 healthy controls were randomly enrolled. Reverse transcription-PCR （RT-PCR） was used to analyze the mRNA of cytokine receptors in peripheral blood mononuclear cells （PBMCs）. The mRNA levels of tumor necro- sis factor receptor （TNFR）, interferon-7 receptor （IFN-yR）, and interleukin-10 receptor （IL-IOR） were statistically increased in the CIU group （P 〈 0.05）, while IL-2R, IL-4R, IL-6R, and IL-13R showed no significant differences between the CIU and other groups. The mRNA levels of CCR3 and CCR6 were statistically increased in the CIU group （P 〈 0.05）. The toll-like receptor 2 （TLR2） mRNA level was significantly lower in the CIU group than the healthy control group （P 〈 0.05）. These findings indicate that the regulation of mRNA of TNFR, IFN-γR, IL-IOR, CCR3, CCR6 and TLR2 may be involved in the pathogenesis of CIU.
文摘Syringocystadenoma papilliferum(SCAP)is a rare benign skin tumor that develops from the apocrine or eccrine glands.Here,we report the case of a 2-year-old girl who presented with an asymptomatic,slowly growing lesion on her scalp.On physical examination,a 2 cm×1 cm red papillary plaque with a crusted surface was noted on her scalp.Histopathological examination revealed papillomatous expansion of the epidermis and cystic invaginations extending from the epidermis down to the deep dermis.The cystic structures were lined by papillae with two layers of columnar epithelium,which showed decapitation secretion.Based on the above clinicopathological findings,a diagnosis of congenital scalp SCAP was made.
文摘Aplasia cutis congenita(ACC)is a rare disease that is characterized by complete or partial absence of skin at birth,either in a localized or widespread region.Melanocytic nevi refers to tumor-like malformations of the skin or mucous membrane caused by benign proliferation of melanocytes.It is classified as a giant congenital melanocytic nevus(GCMN)when the diameter of the largest nevus exceeds 20 cm.The co-occurrence of ACC and GCMN is extremely rare,to the best of our knowledge.We report a case of coexistence of ACC and GCMN of infancy in a 2-month-old male infant.The lesions consisted of a large hyperpigmented plaque occupying most of the trunk and pelvic region,and smaller hyperpigmented plaques on the trunk,head,and extremities.Additionally,there were large,sharply marginated,triangular,depressed atrophic plaques covered by thin,translucent,glistening epithelial membranes in the center of the GCMN on the back.The presumptive diagnosis was coexistence of GCMN and ACC.This could be a manifestation of SCALP syndrome,a rare neuro-cutaneous condition characterized by the presence of Sebaceous nevus,Central nervous system(CNS)malformations,Aplasia cutis congenita,Limbal dermoid and Pigmented(giant melanocytic)nevus.
文摘Superficial angiomyxoma(SA)is a rare superficial benign tumor of the skin that is characterized by slow growth.It is painless,non-invasive,and prone to relapse.It commonly occurs on the head,neck,trunk,and limbs and in the genital region.Herein,we describe a case of a 33-year-old man who presented with a soft tender tumor measuring 1.5×2.0 cm on the lateral aspect of the left second finger.The histopathology of the tumor indicated that it was a lobulated tumor rich in myxoid stroma and parenchymal blood vessels in the dermis,with spindle-to-stellate tumor cells in higher-power view and no mitotic or atypical figures.Immunohistochemical studies revealed that the tumor cells were positive for CD34 and negative for S100.Based on these clinical and histological findings,the patient was diagnosed with SA.
