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Evaluation of the intracellular lipid-lowering effect of polyphenols extract from highland barley in HepG2 cells 被引量:1
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作者 Yijun Yao Zhifang Li +2 位作者 Bowen Qin Xingrong Ju lifeng wang 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期454-461,共8页
Active ingredients from highland barley have received considerable attention as natural products for developing treatments and dietary supplements against obesity.In practical application,the research of food combinat... Active ingredients from highland barley have received considerable attention as natural products for developing treatments and dietary supplements against obesity.In practical application,the research of food combinations is more significant than a specific food component.This study investigated the lipid-lowering effect of highland barley polyphenols via lipase assay in vitro and HepG2 cells induced by oleic acid(OA).Five indexes,triglyceride(TG),total cholesterol(T-CHO),low density lipoprotein-cholesterol(LDL-C),aspartate aminotransferase(AST),and alanine aminotransferase(ALT),were used to evaluate the lipidlowering effect of highland barley extract.We also preliminary studied the lipid-lowering mechanism by Realtime fluorescent quantitative polymerase chain reaction(q PCR).The results indicated that highland barley extract contains many components with lipid-lowering effects,such as hyperoside and scoparone.In vitro,the lipase assay showed an 18.4%lipase inhibition rate when the additive contents of highland barley extract were 100μg/m L.The intracellular lipid-lowering effect of highland barley extract was examined using 0.25 mmol/L OA-induced HepG2 cells.The results showed that intracellular TG,LDL-C,and T-CHO content decreased by 34.4%,51.2%,and 18.4%,respectively.ALT and AST decreased by 51.6%and 20.7%compared with the untreated hyperlipidemic HepG2 cells.q PCR results showed that highland barley polyphenols could up-regulation the expression of lipid metabolism-related genes such as PPARγand Fabp4. 展开更多
关键词 Highland barley Polyphenols extract Lipid-lowering effect HepG2 cells
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Dynamic characteristics of multi-span spinning beams with elastic constraints under an axial compressive force
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作者 Xiaodong GUO Zhu SU lifeng wang 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第2期295-310,共16页
A theoretical model for the multi-span spinning beams with elastic constraints under an axial compressive force is proposed.The displacement and bending angle functions are represented through an improved Fourier seri... A theoretical model for the multi-span spinning beams with elastic constraints under an axial compressive force is proposed.The displacement and bending angle functions are represented through an improved Fourier series,which ensures the continuity of the derivative at the boundary and enhances the convergence.The exact characteristic equations of the multi-span spinning beams with elastic constraints under an axial compressive force are derived by the Lagrange equation.The efficiency and accuracy of the present method are validated in comparison with the finite element method(FEM)and other methods.The effects of the boundary spring stiffness,the number of spans,the spinning velocity,and the axial compressive force on the dynamic characteristics of the multi-span spinning beams are studied.The results show that the present method can freely simulate any boundary constraints without modifying the solution process.The elastic range of linear springs is larger than that of torsion springs,and it is not affected by the number of spans.With an increase in the axial compressive force,the attenuation rate of the natural frequency of a spinning beam with a large number of spans becomes larger,while the attenuation rate with an elastic boundary is lower than that under a classic simply supported boundary. 展开更多
关键词 multi-span spinning beam elastic constraint improved Fourier series free vibration semi-analytical solution
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Flexible Load Participation in Peaking Shaving and Valley Filling Based on Dynamic Price Incentives
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作者 lifeng wang Jing Yu Wenlu Ji 《Energy Engineering》 EI 2024年第2期523-540,共18页
Considering the widening of the peak-valley difference in the power grid and the difficulty of the existing fixed time-of-use electricity price mechanism in meeting the energy demand of heterogeneous users at various ... Considering the widening of the peak-valley difference in the power grid and the difficulty of the existing fixed time-of-use electricity price mechanism in meeting the energy demand of heterogeneous users at various moments or motivating users,the design of a reasonable dynamic pricing mechanism to actively engage users in demand response becomes imperative for power grid companies.For this purpose,a power grid-flexible load bilevel model is constructed based on dynamic pricing,where the leader is the dispatching center and the lower-level flexible load acts as the follower.Initially,an upper-level day-ahead dispatching model for the power grid is established,considering the lowest power grid dispatching cost as the objective function and incorporating the power grid-side constraints.Then,the lower level comprehensively considers the load characteristics of industrial load,energy storage,and data centers,and then establishes a lower-level flexible load operation model with the lowest user power-consuming cost as the objective function.Finally,the proposed method is validated using the IEEE-118 system,and the findings indicate that the dynamic pricing mechanism for peaking shaving and valley filling can effectively guide users to respond actively,thereby reducing the peak-valley difference and decreasing users’purchasing costs. 展开更多
关键词 Demand response fixed time-of-use electricity price mechanism dynamic price incentives mechanism bi-level model flexible load
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基于^(18)F-FDG PET/CT代谢参数构建非小细胞肺癌PD-L1表达的列线图预测模型
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作者 郝罗罗 王丽锋 +2 位作者 张梦瑶 闫家明 张飞飞 《中国肺癌杂志》 CAS CSCD 北大核心 2023年第11期833-842,共10页
背景与目的近年来,程序性细胞死亡受体1 (programmed cell death,PD-1)/程序性细胞死亡配体1 (programmed cell death ligand 1,PD-L1)免疫抑制剂为代表的免疫疗法很大程度地改变了非小细胞肺癌(nonsmall cell lung cancer,NSCLC)的治... 背景与目的近年来,程序性细胞死亡受体1 (programmed cell death,PD-1)/程序性细胞死亡配体1 (programmed cell death ligand 1,PD-L1)免疫抑制剂为代表的免疫疗法很大程度地改变了非小细胞肺癌(nonsmall cell lung cancer,NSCLC)的治疗现状。目前PD-L1已经成为了筛选NSCLC免疫治疗获益人群的重要生物标志物,但是如何便捷且准确地检测NSCLC患者PD-L1是否表达是困扰临床医师的难题。本研究旨在基于^(18)F-脱氧葡萄糖(^(18)F-fluorodeoxy glucose,^(18)F-FDG)正电子发射计算机断层扫描(positron emission tomography/computed tomography,PET/CT)代谢参数构建NSCLC患者PD-L1表达的列线图预测模型并评估其预测价值。方法回顾性收集2016年9月至2021年7月内蒙古自治区人民医院收治的155例NSCLC患者的^(18)F-FDG PET/CT代谢参数、临床病理资料及PD-L1检测结果。将患者分为训练组(n=117)及内部验证组(n=38),按照同样的标准另收集本院2021年8月至2022年7月NSCLC患者51例作为外部验证组。然后均根据PD-L1检测结果分为PD-L1+组与PD-L1-组。对训练组患者的代谢参数及临床病理资料进行单因素及二元Logistic回归分析,基于筛选出的独立影响因素构建列线图预测模型。在训练组及内外部验证组中均通过受试者工作特征(receiver operating characteristic,ROC)曲线、校准曲线及临床决策曲线(decision curve analysis,DCA)来评估列线图模型效果。结果二元Logistic回归分析表明,肿瘤代谢体积(metabolic tumor volume,MTV)、性别及肿瘤直径是PD-L1表达的独立影响因素,然后基于上述独立影响因素构建列线图预测模型。模型在训练组中的ROC曲线显示,曲线下面积(area under the curve,AUC)为0.769 (95%CI:0.683-0.856),最佳截断值为0.538。内部验证组的AUC为0.775 (95%CI:0.614-0.936),外部验证组的AUC为0.752 (95%CI:0.612-0.893)。校准曲线经Hosmer-Lemeshow检验结果显示,训练组(χ^(2)=0.040,P=0.979)、内部验证组(χ^(2)=2.605,P=0.271)及外部验证组(χ^(2)=0.396,P=0.820)均具有良好的校准度。DCA曲线显示,模型在较大的阈值范围内(训练组:0.00-0.72,内部验证组:0.00-0.87,外部验证组:0.00-0.66)能使患者临床获益。结论基于^(18)F-FDGPET/CT代谢参数构建的列线图预测模型在预测NSCLC患者PD-L1表达中有较大的应用价值。 展开更多
关键词 肺肿瘤 ^(18)F-脱氧葡萄糖正电子发射计算机断层扫描 代谢参数 程序性细胞死亡配体1 列线图
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Machine learning-based stiffness optimization of digital composite metamaterials with desired positive or negative Poisson's ratio
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作者 Xihang Jiang Fan Liu lifeng wang 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2023年第6期424-431,共8页
Mechanical metamaterials such as auxetic materials have attracted great interest due to their unusual properties that are dictated by their architectures.However,these architected materials usually have low stiffness ... Mechanical metamaterials such as auxetic materials have attracted great interest due to their unusual properties that are dictated by their architectures.However,these architected materials usually have low stiffness because of the bending or rotation deformation mechanisms in the microstructures.In this work,a convolutional neural network(CNN)based self-learning multi-objective optimization is performed to design digital composite materials.The CNN models have undergone rigorous training using randomly generated two-phase digital composite materials,along with their corresponding Poisson's ratios and stiffness values.Then the CNN models are used for designing composite material structures with the minimum Poisson's ratio at a given volume fraction constraint.Furthermore,we have designed composite materials with optimized stiffness while exhibiting a desired Poisson's ratio(negative,zero,or positive).The optimized designs have been successfully and efficiently obtained,and their validity has been confirmed through finite element analysis results.This self-learning multi-objective optimization model offers a promising approach for achieving comprehensive multi-objective optimization. 展开更多
关键词 Digital composite materials METAMATERIALS Machine learning Convolutional neural network(CNN) Poisson's ratio STIFFNESS
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短期禁食对离体鼠心缺血心肌功能的影响
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作者 范书铎 lifeng wang +4 位作者 Saul Schaefer 黄增艳 赵红艳 张璠 郭志宏 《中国医科大学学报》 CAS CSCD 北大核心 1998年第4期337-339,共3页
目的:评估短期禁食是否影响缺血后离体鼠心的功能。方法:灌流进食组和禁食(24h)组离体鼠心。连续记录左心室发展压(LVDP)、舒张末期压(EDP)和心率(HR)。结果:与进食鼠相比,缺血后再灌期禁食鼠心显示EDP减低... 目的:评估短期禁食是否影响缺血后离体鼠心的功能。方法:灌流进食组和禁食(24h)组离体鼠心。连续记录左心室发展压(LVDP)、舒张末期压(EDP)和心率(HR)。结果:与进食鼠相比,缺血后再灌期禁食鼠心显示EDP减低,LVDP增高。缺血诱发的心律失常发生率减少,禁食鼠(126.2±17.46)次/h,进食鼠(226.33±18.79)次/h,n=6,P<0.005。结论:短期禁食离体鼠心肌缺血后恢复更快、更好。 展开更多
关键词 心肌缺血 心肌功能 禁食 心肌保护
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CO2 and SO2 emission characteristics of the whole process industry chain of coal processing and utilization in China 被引量:8
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作者 Tao Zhu Ruonan wang +3 位作者 Nengjing Yi Wenfeng Niu lifeng wang Zeyu Xue 《International Journal of Coal Science & Technology》 EI 2020年第1期19-25,共7页
The total coal consumption in China is on the rise.The characteristics of CO2 and SO2 emissions in the whole process of coal processing and utilization in China are worthy of study.Based on the five links of the whole... The total coal consumption in China is on the rise.The characteristics of CO2 and SO2 emissions in the whole process of coal processing and utilization in China are worthy of study.Based on the five links of the whole process of coal production and utilization,including coal production,raw coal processing,logistics and transportation,conversion and utilization and resource utilization,this paper summarized and analyzed the energy consumption and pollutant emission sources of these five links,combined with the US Environmental Protection Agency’s AP-42 method and IPCC method,to calculate total pollutant discharge and emission factors,where the emission factors were corrected by conversion efficiency.At the same time,uncertainty analysis is performed about CO2 and SO2 emissions.The results showed that CO2 emissions were 3.657 billion tons,and emission reductions were 61 million tons,and SO2 emissions were 4,844,500 tons,and emission reductions were 10.3595 million tons in 2015. 展开更多
关键词 COAL Industrial chain CO2 SO2 Emission characteristics
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FLEXURAL WAVE DISPERSION IN MULTI-WALLED CARBON NANOTUBES CONVEYING FLUIDS 被引量:3
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作者 lifeng wang Wanlin Guo Haiyan Hu 《Acta Mechanica Solida Sinica》 SCIE EI 2009年第6期623-629,共7页
Motivated by the great potential of carbon nanotubes for developing nanofluidic devices,this paper presents a nonlocal elastic,Timoshenko multi-beam model with the second order of strain gradient taken into considerat... Motivated by the great potential of carbon nanotubes for developing nanofluidic devices,this paper presents a nonlocal elastic,Timoshenko multi-beam model with the second order of strain gradient taken into consideration and derives the corresponding dispersion relation of flexural wave in multi-walled carbon nanotubes conveying fluids.The study shows that the moving flow reduces the phase velocity of flexural wave of the lowest branch in carbon nanotubes.The phase velocity of flexural wave of the lowest branch decreases with an increase of flow velocity.However,the effects of flow velocity on the other branches of the wave dispersion are not obvious.The effect of microstructure characterized by nonlocal elasticity on the dispersion of flexural wave becomes more and more remarkable with an increase in wave number. 展开更多
关键词 多壁碳纳米管 弯曲波 离散度 输送 体波 微流体装置 应变梯度 色散关系
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Acoustic characteristics of cold-seep methane bubble behavior in the water column and its potential environmental impact 被引量:2
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作者 Jiangong Wei Tingting Wu +2 位作者 Xiguang Deng Zongze Yu lifeng wang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2020年第5期133-144,共12页
The amount of methane leaked from deep sea cold seeps is enormous and potentially affects the global warming,ocean acidification and global carbon cycle.It is of great significance to study the methane bubble movement... The amount of methane leaked from deep sea cold seeps is enormous and potentially affects the global warming,ocean acidification and global carbon cycle.It is of great significance to study the methane bubble movement and dissolution process in the water column and its output to the atmosphere.Methane bubbles produce strong acoustic impedance in water bodies,and bubble strings released from deep sea cold seeps are called"gas flares"which expressed as flame-like strong backscatter in the water column.We characterized the morphology and movement of methane bubbles released into the water using multibeam water column data at two cold seeps.The result shows that methane at site I reached 920 m water depth without passing through the top of the gas hydrate stability zone(GHSZ,850 m),while methane bubbles at site II passed through the top of the GHSZ(597 m)and entered the non-GHSZ(above 550 m).By applying two methods on the multibeam data,the bubble rising velocity in the water column at sites I and II were estimated to be 9.6 cm/s and 24 cm/s,respectively.Bubble velocity is positively associated with water depth which is inferred to be resulted from decrease of bubble size during methane ascending in the water.Combined with numerical simulation,we concluded that formation of gas hydrate shells plays an important role in helping methane bubbles entering the upper water bodies,while other factors,including water depth,bubble velocity,initial kinetic energy and bubble size,also influence the bubble residence time in the water and the possibility of methane entering the atmosphere.We estimate that methane gas flux at these two sites is 0.4×10~6–87.6×10~6 mol/a which is extremely small compared to the total amount of methane in the ocean body,however,methane leakage might exert significant impact on the ocean acidification considering the widespread distributed cold seeps.In addition,although methane entering the atmosphere is not observed,further research is still needed to understand its potential impact on increasing methane concentration in the surface seawater and gas-water interface methane exchange rate,which consequently increase the greenhouse effect. 展开更多
关键词 gas bubble METHANE cold seep Nigerian Continental Margin Greenhouse effect Makran accretion wedge
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Trajectory Tracking of Quadrotor Aerial Robot Using Improved Dynamic Inversion Method 被引量:5
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作者 lifeng wang Yichong He +1 位作者 Zhixiang Zhang Congkui He 《Intelligent Control and Automation》 2013年第4期343-348,共6页
This paper presents trajectory tracking control works concerning quadrotor aerial robot with rigid cross structure. The quadrotor consists of four propellers which are two paired clockwise rotate and anticlockwise rot... This paper presents trajectory tracking control works concerning quadrotor aerial robot with rigid cross structure. The quadrotor consists of four propellers which are two paired clockwise rotate and anticlockwise rotate. A nonlinear dynamic model of the quadrotor is provided, and a controller based on the improved dynamic inverse is synthesized for the purpose of stabilization and trajectory tracking. The proposed control strategy has been tested in simulation that can balance the deviation of model inaccuracy well. 展开更多
关键词 AERIAL ROBOT QUADROTOR Nonlinear Model DYNAMIC INVERSION Robust Control
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Vibration of two-dimensional hexagonal boron nitride 被引量:1
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作者 Jianpeng Yi lifeng wang Yiqing Zhang 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2018年第6期408-414,I0005,共8页
The dynamic behavior of two-dimensional nanostructures is important to the future application of nano devices. The vibrational behaviors of single-layered hexagonal boron nitride(h-BN) are studied by molecular dynamic... The dynamic behavior of two-dimensional nanostructures is important to the future application of nano devices. The vibrational behaviors of single-layered hexagonal boron nitride(h-BN) are studied by molecular dynamics simulation and continuum plate model. The bending stiffness and Poisson's ratios of h-BN along zigzag direction and armchair direction are calculated. H-BN is softer compared with graphene. The continuum plate model can predict the vibration of h-BN with four edge-clamped boundary conditions well. The electric fields in different directions have obvious influence on the vibration of h-BN. The natural frequency of h-BN changes linearly with the electric field intensity along the polarization direction. The natural frequency of h-BN decreases with the increase of electric field intensity along both positive and negative nonpolarization direction. While the natural frequency of h-BN increases with the increase of electric field intensity along both positive and negative transverse electric field. 展开更多
关键词 HEXAGONAL BORON NITRIDE MOLECULAR dynamics NATURAL frequency Electric field
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Interface coupling effects of weakly nonlinear Rayleigh–Taylor instability with double interfaces 被引量:1
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作者 李志远 王立锋 +1 位作者 吴俊峰 叶文华 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第3期318-322,共5页
Taking the Rayleigh–Taylor instability with double interfaces as the research object,the interface coupling effects in the weakly nonlinear regime are studied numerically.The variation of Atwood numbers on the two in... Taking the Rayleigh–Taylor instability with double interfaces as the research object,the interface coupling effects in the weakly nonlinear regime are studied numerically.The variation of Atwood numbers on the two interfaces and the variation of the thickness between them are taken into consideration.It is shown that,when the Atwood number on the lower interface is small,the amplitude of perturbation growth on the lower interface is positively related with the Atwood number on the upper interface.However,it is negatively related when the Atwood number on the lower interface is large.The above phenomenon is quantitatively studied using an analytical formula and the underlying physical mechanism is presented. 展开更多
关键词 Rayleigh–Taylor INSTABILITY WEAKLY nonlinear REGIME numerical simulation
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Two-dimensional Boron Nitride for Electronics and Energy Applications 被引量:1
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作者 Jiemin wang Liangzhu Zhang +2 位作者 lifeng wang Weiwei Lei Zhong-Shuai Wu 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2022年第1期10-44,共35页
Two-dimensional(2D)boron nitride(BN),the so-called“white graphene,”has demonstrated a great potential in various fields,particularly in electronics and energy,by utilizing its wide bandgap(~5.5 eV),superior thermal ... Two-dimensional(2D)boron nitride(BN),the so-called“white graphene,”has demonstrated a great potential in various fields,particularly in electronics and energy,by utilizing its wide bandgap(~5.5 eV),superior thermal stability,high thermal conductance,chemical inertness,and outstanding dielectric properties.However,to further optimize the performances from the view of structure-property relationship,the determinative factors such as crystallite sizes,layer thickness,dispersibility,and surface functionalities should be precisely controlled and adjusted.Therefore,in this review,the synthesis and functionalization methods including“top-down”and“bottom-up”strategies,and non-covalent and covalent modifications for 2D BN are systematically classified and discussed at first,thus catering for the requirements of versatile applications.Then,the progresses of 2D BN applied in the fields of microelectronics such as fieldeffect transistors and dielectric capacitors,energy domains such as thermal energy management and conversion,and batteries and supercapacitors are summarized to highlight the importance of 2D BN.Notably,these contents not only contain the state-of-the-art 2D BN composites,but also bring the current novel design of 2D BN-based microelectronic units.Finally,the challenges and perspectives are proposed to better broaden the scope of this material.Therefore,this review will pave an all-around way for understanding,utilizing,and applying 2D BN in future electronics and energy applications. 展开更多
关键词 boron nitride ELECTRONICS ENERGY FUNCTIONALIZATION NANOSHEETS two-dimensional materials
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Manipulating selenium molecular configuration in N/O dual-doped porous carbon for high performance potassium-ion storage 被引量:1
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作者 Dongjun Li lifeng wang +7 位作者 Xiaolong Cheng Yu Yao Yu Jiang Pengcheng Shi Ying Wu Xiaojun Wu Cheng Ma Yan Yua 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第11期581-589,I0014,共10页
Potassium-selenium(K-Se)batteries have attracted more and more attention because of their high theoretical specific capacity and natural abundance of K resources.However,dissolution of polyselenides,large volume expan... Potassium-selenium(K-Se)batteries have attracted more and more attention because of their high theoretical specific capacity and natural abundance of K resources.However,dissolution of polyselenides,large volume expansion during cycling and low utilization of Se remain great challenges,leading to poor rate capability and cycle life.Herein,N/O dual-doped carbon nanofibers with interconnected micro/mesopores(MMCFs)are designed as hosts to manipulate Se molecular configuration for advanced flexible K-Se batteries.The micropores play a role in confining small Se molecule(Se_(2–3)),which could inhibit the formation of polyselenides and work as physical barrier to stabilize the cycle performance.While the mesopores can confine long-chain Se(Se_(4–7)),promising sufficient Se loading and contributing to higher discharge voltage of the whole Se@MMCFs composite.The N/O co-doping and the 3D interpenetrating nanostructure improve electrical conductivity and keep the structure integrity after cycling.The obtained Se_(2–3)/Se_(4–7)@MMCFs electrode exhibits an unprecedented cycle life(395 mA h g^(−1) at 1 A g^(−1) after 2000 cycles)and high specific energy density(400 Wh kg^(−1),nearly twice the specific energy density of the Se_(2–3)@MMCFs).This study offers a rational design for the realization of a high energy density and long cycle life chalcogen cathode for energy storage. 展开更多
关键词 Carbon nanofibers with interconnected micro/mesopores Manipulating Se molecules Heteroatom-doping Flexible K-Se batteries
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NLRP6 is correlated with the progression and therapeutic outcome of hepatocellular carcinoma and inhibits the function of CD14^+ cells 被引量:1
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作者 Ting Zhang Gang Chen +5 位作者 lifeng wang Xinrui Yang Dawei Wu Shanshan Lu Yinying Lu Zhen Zeng 《Cancer Biology & Medicine》 SCIE CAS CSCD 2018年第S01期6-6,共1页
Objective:Inflammasomes promote carcinogenesis through an extrinsic pathway and maintain the malignant cancer microenvironment through an intrinsic pathway.Moreover,inflammasomes exert anticancer effects by pyroptosis... Objective:Inflammasomes promote carcinogenesis through an extrinsic pathway and maintain the malignant cancer microenvironment through an intrinsic pathway.Moreover,inflammasomes exert anticancer effects by pyroptosis and immune regulatory functions.Until now,there have been few studies about how inflammasomes contribute to hepatocellular carcinoma(HCC)development. 展开更多
关键词 NLRP6 PROGRESSION therapeutic
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Culture of cryopreserved rat hepatocyte 被引量:1
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作者 Haitao Yin GaojunTen +2 位作者 lifeng wang Baorui Liu Xiaoping Qian 《Journal of Nanjing Medical University》 2006年第4期248-252,共5页
Objective:To study the method of cryopreserving rat hepatocytes and double collagen gel culture measurement after its cryopreservation.Methods:Rat hepatocytes,isolated by two-step perfusion with collagenase using an e... Objective:To study the method of cryopreserving rat hepatocytes and double collagen gel culture measurement after its cryopreservation.Methods:Rat hepatocytes,isolated by two-step perfusion with collagenase using an extra corporeal perfusion apparatus,were cryopreserved in double collagen gel with culture medium added by epidermal growth factor(EGF).The expression of cell function and cellular morphology were examined during culture.Results:The hepatocytes cryopreserved in double collagen gel concluding EGF showed good morphology and biological characteristics.After thawing,the MTT metabolism and protein synthesis of hepatocytes in sandwich ± EGF groups were better than those in control group.And the morphology and function of hepatocytes in sandwich group was better than that in EGF group(P < 0.05).Conclusion:Double collagen gel culture can keep hepatocyte’s activities.Thawed hepatocytes can be cultivated with collagenous matrix,which provides an environment that more closely resembles that in vivo and maintain the expression of certain liver-specific function of hepatocytes. 展开更多
关键词 肝细胞癌 治疗 病理机制 临床
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Earthquake Electromagnetic Precursor Anomalies Detected by a New Ground-based Observation Network 被引量:3
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作者 Bing HAN Guoze ZHAO +6 位作者 lifeng wang Ji TANG Yaxin BI Yan ZHAN Xiaobin CHEN Qibin XIAO Jihong ZHANG 《Journal of Geodesy and Geoinformation Science》 2021年第1期116-123,共8页
It is a debated topic if there are any observable precursor anomalies prior to the earthquake(EQ hereafter)and if the stronger EQ can be successfully predicted.During last few decades quite a lot of observable electro... It is a debated topic if there are any observable precursor anomalies prior to the earthquake(EQ hereafter)and if the stronger EQ can be successfully predicted.During last few decades quite a lot of observable electromagnetic(EM)precursors were published by using techniques equipped in either satellites or on ground-based stations.But there are only a few cases that the shortterm precursor anomalies of EM field before earthquakes were observed by using alternate EM fields on ground.This paper will present a new EM observation network built in recent years and show a new finding of EM field with the variation of a one-year cycle observed using the network.As an example,the short-term precursor anomalies of apparent resistivity before the Yangbi EQ(Ms 5.1)occurred on March 27,2017 in Yunnan Province will be studied.The observed anomalous phenomena indicate that the anomaly before the EQ can be captured only if reasonable effective methods including sophisticated analytical techniques are used,and it is believed that continuously observed data on the fixed observation network for a long time is an effective means for studying anomalies that appeared before earthquakes.This network can also play an important role in studying the EM environment from space. 展开更多
关键词 electromagnetic observation network natural EM phenomena precursor anomaly apparent resistivity space EM environment
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Acoustic Scattering Performance for Sources in Arbitrary Motion
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作者 Yunpeng Ma lifeng wang Mingxu Yi 《Computer Modeling in Engineering & Sciences》 SCIE EI 2017年第1期89-108,共20页
In this paper,an analytical time domain formulation based on Ffowcs Williams-Hawkings(FW-H)equation is derived for the prediction of the acoustic velocity field generated by moving bodies.This provides the imposition ... In this paper,an analytical time domain formulation based on Ffowcs Williams-Hawkings(FW-H)equation is derived for the prediction of the acoustic velocity field generated by moving bodies.This provides the imposition of the Neumann boundary condition on a rigid scattering surface.In order to calculate the scattering sound pressure of the duct,a thin-body boundary element method(BEM)has been proposed.The radiate sound pressure is calculated using the acoustic analogy FW-H equation.The scattering effect of the duct wall on the propagation of the sound wave is presented using the thin-body BEM.Computational results for a pulsating sphere,dipole source,and a tail rotor verify the method.The sound pressure directivity and scattering effect are shown to demonstrate the applicability and validity of the approach. 展开更多
关键词 SCATTERING PERFORMANCE Ffowcs Williams-Hawkings equation acoustic VELOCITY boundary element method
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六旋翼飞行器动态逆控制器设计
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作者 赵伦 王立峰 董晓婉 《建模与仿真》 2016年第2期16-25,共10页
本文针对“X”型布局六旋翼飞行器的姿态控制问题,创建其简化数学模型,并结合PID与动态逆控制方法设计出一个姿态控制器。为了提高系统的鲁棒性,增加一个自适应矢量以补偿逆模型误差。仿真实验表明该控制器能达到快速响应并稳定跟踪指... 本文针对“X”型布局六旋翼飞行器的姿态控制问题,创建其简化数学模型,并结合PID与动态逆控制方法设计出一个姿态控制器。为了提高系统的鲁棒性,增加一个自适应矢量以补偿逆模型误差。仿真实验表明该控制器能达到快速响应并稳定跟踪指令的目的。 展开更多
关键词 六旋翼飞行器 动态逆 PID 姿态控制
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Efficient Security Sequencing Problem over Insecure Channel Based on Homomorphic Encryption
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作者 Mingxu Yi lifeng wang Yunpeng Ma 《China Communications》 SCIE CSCD 2016年第9期195-202,共8页
In the field of sequencing of secret number,an important problem is how to establish an efficient and secure protocol for sorting the secret number.As a powerful tool in solving privacy sequencing problems,secure mult... In the field of sequencing of secret number,an important problem is how to establish an efficient and secure protocol for sorting the secret number.As a powerful tool in solving privacy sequencing problems,secure multipart computation is more and more popular in anonymous voting and online auction.In the present study,related secure computation protocol for sequencing problem is not many by far.In order to improve the efficiency and safety,we propose a security sequencing protocol based on homomorphic encryption.We also give analysis of correctness and security to highlight its feasibility. 展开更多
关键词 排序问题 高效安全 同态加密 安全信道 安全多方计算 加密协议 安全性 在线拍卖
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