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Intra-articular transplantation of porcine adipose-derived stem cells for the treatment of canine osteoarthritis: A pilot study 被引量:3
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作者 Shen-Yang Tsai Yun-Ching Huang +2 位作者 Ling-Ling Chueh lih-seng yeh Ching-Shwun Lin 《World Journal of Transplantation》 2014年第3期196-205,共10页
AIM: To test whether intra-articular injection of porcine adipose-derived stem cells(ADSCs) can treat canine osteoarthritis(OA).METHODS: To enroll in this study dogs must have stifle joint OA that had lasted ≥ 3 mo a... AIM: To test whether intra-articular injection of porcine adipose-derived stem cells(ADSCs) can treat canine osteoarthritis(OA).METHODS: To enroll in this study dogs must have stifle joint OA that had lasted ≥ 3 mo and been treated with OA medication without significant improvement. Three dogs fulfilled these criteria and were thus subjects for ADSCs treatment. ADSCs were isolated from abdominal adipose tissue of a 2-mo-old female Yorkshire pig. Their stem cell marker expression was examined by immunofluorescence staining. For treatment, 5 million ADSCs were injected into the diseased joint of each dog. In the next 48 h, the patient was observed for signs of inflammatory and allergic reactions. Thepatient was then discharged to the owner and, at 2, 6, and 12 wk, followed up with orthopedic assessment, owner questionnaire, X-ray imaging, and force-plate gait analysis.RESULTS: Porcine ADSCs expressed mesenchymal stem cell markers CD90 and CD105. Injection of porcine ADSCs into canine stifle joints did not cause any inflammatory or allergic reactions. Orthopedic evaluation found improvements in two dogs, particularly at the longest time point. Owners' evaluation found increased capacity and decreased pain in all three dogs' activities such as walking and running. Radiographic evaluation did not find statistically significant differences before and after treatment. Force-plate analysis found significant improvements in all three dogs after treatment.CONCLUSION: Xenotransplantation of ADSCs for the treatment of OA is feasible. Further studies are needed to validate this novel treatment modality, which can then be implemented for the routine treatment of OA in veterinary medicine. 展开更多
关键词 CANINE OSTEOARTHRITIS Adipose-derived stem cells INTRA-ARTICULAR TRANSPLANTATION INTRA-ARTICULAR injection VETERINARY clinical study
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The Impact of different warming devices on bacteria contamination in surgical field
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作者 Ying-Ting Tsai Kuan-Sheng yeh lih-seng yeh 《畜牧与兽医》 北大核心 2012年第S2期54-55,共2页
Anesthesia may cause the development of hypothermia.By altering the physiologic mechanisms of thermoregulation,such as redistribution of blood flow,reducing metabolic rate,and vasodilatation,heat generation is decreas... Anesthesia may cause the development of hypothermia.By altering the physiologic mechanisms of thermoregulation,such as redistribution of blood flow,reducing metabolic rate,and vasodilatation,heat generation is decreased and heat loss is increased.Anesthesia related hypothermia is potentially associated with complications including coagulopathy,myocardial ischemia,surgical wound infection,etc.Demonstrated by numerous studies,convection warmers are though to be the most effective active warming device and are widely accepted in veterinary medicine for maintaining normother- 展开更多
关键词 WARMING CONTAMINATION REDISTRIBUTION NUMEROUS potentially maintaining convection POSSIBILITY WOUND excluded
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