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Surfactant-Modified Hydrophobic Biochar Derived from Laver (Porphyra haitanensis) with Superior Removal Performance for Kitchen Oil
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作者 jiaxing Sun lili ji +6 位作者 Qianrui He Ran Li Xiaoyue Xia Yaning Wang Yi Yang Lu Cai jian Guo 《Journal of Renewable Materials》 EI 2023年第8期3227-3243,共17页
In this study,a novel absorpent(MSAR600℃)with a hydrophobic surface and hierarchical porous structure for the removal of kitchen oil was facilely fabricated from the macroalgae,laver(Porphyra haitanensis)by incorpor-... In this study,a novel absorpent(MSAR600℃)with a hydrophobic surface and hierarchical porous structure for the removal of kitchen oil was facilely fabricated from the macroalgae,laver(Porphyra haitanensis)by incorpor-ating high-temperature carbonization and alkyl polyglucosides(APG)and rhamnolipid(RL)surfactants modifi-cation.The characterization results showed MSAR600℃ possessed a louts-leaf-like papillae microstructure with high contact angle(137.5°),abundant porous structure with high specific surface area(23.4 m^(2)/g),and various oxygen-containing functional groups(-OH,C=O,C-O).Batch adsorption experiments were conducted to inves-tigate the effect of adsorption time,temperature,pH,and absorbent dose on kitchen oil adsorption performance.Then the practical application for the removal of kitchen oil using MSAR600℃ was also performed.The results showed that MSAR600℃ had a higher removal efficiency for kitchen oil(75.98%),compared with the commercial detergent(72.3%).This study demonstrates an example of fabricating a green tableware detergent for enhanced removal performance of kitchen oil. 展开更多
关键词 Laver biochar surfactant modification kitchen oil removal mechanism
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Suggestions on Curriculum Reform of Food Major in the Context of Educational Reform
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作者 jie CHENG Ruiqi CAO +3 位作者 lili ji Bo HOU Dayu LIU jiamin ZHANG 《Agricultural Biotechnology》 CAS 2023年第2期133-137,共5页
The food major is an application-oriented major that involves a wide range of professional knowledge and disciplines,and provides applied talents with food production,inspection,and sales skills to the society.With th... The food major is an application-oriented major that involves a wide range of professional knowledge and disciplines,and provides applied talents with food production,inspection,and sales skills to the society.With the rapid development of society,the demand of social employers for talents also shows a diversified trend.For the cultivation of food professionals in the new era,it is necessary to improve their innovative spirit and practical ability,in order to adapt to the diverse development needs of society.Under the background of education reform,this paper briefly analyzed the teaching strategies of food major,and put forward specific reform suggestions,hoping to promote education reform to effectively promote the sustainable development of food major,and effectively improve the quality of education. 展开更多
关键词 Education reform Food Major Teaching innovation Teaching methods
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Effects of Heat Treatment on Processing Characteristics of Pork
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作者 Ting BAI Li TANG +5 位作者 Lei WANG Ying ZHANG Bowen ZAN Wei WANG lili ji jiamin ZHANG 《Agricultural Biotechnology》 CAS 2023年第5期67-74,共8页
[Objectives]This study was conducted to explore the effects of heat treatment on processing characteristics of pork.[Methods]The effects of low-temperature long-term cooking(LTLT),high-temperature vacuum cooking,high-... [Objectives]This study was conducted to explore the effects of heat treatment on processing characteristics of pork.[Methods]The effects of low-temperature long-term cooking(LTLT),high-temperature vacuum cooking,high-temperature cooking and high-temperature steaming on some indexes of pork products were studied,and principal component analysis was carried out.[Results]LTLT had significant effects on the total sensory score,moisture content,cooking loss rate,a value,shear force,and TBARS of pork,and the corresponding optimal product indicators were 71.40 points,72.36%,14.20%,4.79,7089.87 g,and 0.05 mg/kg,respectively.The microstructure changes in the LTLT group were relatively small,as the muscle fiber structure was relatively dense and uniform,and the gaps between muscle fibers were small.A total of 30 volatile flavor compounds were detected in the four groups,mainly alcohols,alkenes,alkanes,lipids,ketones,and aldehydes,and the LTLT group had more types and high contents.PCA analysis showed that the sensory evaluation,moisture content,elasticity,a value and LTLT were positively correlated with principal component 1.[Conclusions]Various indexes comprehensively showed that the LTLT group had better meat color,flavor,texture characteristics and lower oxidation degree than traditional cooking and steaming methods,which provides a theoretical reference for its large-scale application in the processing of prepared meat products. 展开更多
关键词 Heat treatment PORK Processing characteristics Principal component analysis
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Highly Efficient Adsorption of P-Xylene from Aqueous Solutions by Hierarchical Nanoporous Biochar Derived from Crab Shell 被引量:1
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作者 Yingna Chen Hailong Zhang +5 位作者 jian Guo Lu Cai Yaning Wang Xinxin Yao Wendong Song lili ji 《Journal of Renewable Materials》 SCIE EI 2021年第10期1741-1755,共15页
The global consumption of p-xylene(PX)for the production of polymers has raised serious concerns about its impact on the environment.As various reports have shown the risks that PX could pose to human health,research ... The global consumption of p-xylene(PX)for the production of polymers has raised serious concerns about its impact on the environment.As various reports have shown the risks that PX could pose to human health,research into cost-effective remedial methods to remove PX from the environment has gained attraction.In this work,a hierarchical porous crab shell biochar(KCS)was synthesized,characterized,and evaluated for its efficiency to remove PX from aqueous solution.The characterizations of KCS,including the porous structure,surface functional group,phase structure,and surface morphology,were discussed by N_(2) adsorption-desorption,FTIR,XRD,and SEM.Batch adsorption experiments showed that the maximum adsorption capacity of PX on KCS was 393 mg/g within 5 min,larger than most biological/biomass materials,mainly due to the higher specific surface area of 2046 m^(2)/g,and abundant lipophilic functional groups.Subsequent adsorption kinetics study indicated a pseudo-second-order model which implied that the adsorption of PX was due to chemisorption.Thermodynamic parameters showed that the values ofΔH°andΔG°were both negative,indicating that the PX adsorption process on KCS was spontaneous and exothermic.The performance of KCS in delivering a cost-effective,fast,and efficient solution for the removal of PX from aqueous solution would greatly benefit current environmental remediation efforts. 展开更多
关键词 Crab shell porous biochar P-XYLENE ADSORPTION wastewater
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Facile Preparation of a Porous Biochar Derived from Waste Crab Shell with High Removal Performance for Diesel 被引量:1
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作者 Xiao Han Zhaodi Wu +5 位作者 Yi Yang jian Guo Yaning Wang Lu Cai Wendong Song lili ji 《Journal of Renewable Materials》 SCIE EI 2021年第8期1377-1391,共15页
In this study,a porous biochar material derived from waste crab shell was prepared by one-step hydrothermal carbonization and acetic acid activation method at 180°C,which was characterized by SEM,BET,XRD and FTIR... In this study,a porous biochar material derived from waste crab shell was prepared by one-step hydrothermal carbonization and acetic acid activation method at 180°C,which was characterized by SEM,BET,XRD and FTIR.The results show that the as-prepared crab shell biochar(CSB)exhibits a fluffy irregular layered structure with abundant pores and oxygen-containing functional groups,which can facilitate the adsorption of diesel using CSB.In addition,batch adsorption experiments had been performed,effects of initial diesel concentration,adsorption time,adsorbent dosage and pH on the diesel adsorption using CSB were analyzed,which could be observed that CSB has high removal efficiency for diesel,and the maximum removal rate is up to 80.1%.The adsorption isotherms and kinetic studies were also investigated to determine the adsorption mechanism of diesel using CSB,the results show that the Langmuir model and the pseudo-second-order model are more suitable for describing the adsorption of diesel using CSB,indicating that the adsorption of diesel oil by CSB is monolayer chemical adsorption.This study will provide a theoretical basis for the high-value utilization of waste crab shell,which has a great potential in the treatment of oil spill. 展开更多
关键词 Waste crab shell BIOCHAR ADSORPTION diesel wastewater
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Enhanced Production of Natural Carotenoids from Genetically Engineered Rhodobacter sphaeroides Overexpressing CrtA 被引量:1
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作者 Zhiping ZHAO jiahui DU +3 位作者 Hongfan CHEN lili ji jiamin ZHANG Wei WANG 《Agricultural Biotechnology》 CAS 2020年第2期1-4,共4页
Carotenoids act as precursors of vitamin A,antioxidants,enhancers of immunity,and are thus widely used in food and pharmaceutical industry.Microbial fermentation is one of the most important solutions for production o... Carotenoids act as precursors of vitamin A,antioxidants,enhancers of immunity,and are thus widely used in food and pharmaceutical industry.Microbial fermentation is one of the most important solutions for production of natural carotenoids.Rhodobacter sphaeroides is one of most promising bacteria employed for large scale production of carotenoids.In the present study,crtA located in the carotenoids biosynthesis pathway in R.sphaeroides was amplified by PCR.The overexpression vector pRKcrtA was constructed and subsequently transferred into R.sphaeroides,producing the genetically engineered strain R.sphaeroides 2.4.1/pRKcrtA overexpressing crtA.The carotenoid production from the genetically engineered strain was significantly increased.Fermentation procedure was optimized for further enhanced carotenoids production. 展开更多
关键词 Carotenoids CRTA RHODOBACTER sphaeroids FERMENTATION OVEREXPRESSION Optimization
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Mycotoxins in Chinese Traditional Cured Meats: A Review 被引量:1
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作者 lili ji Dan HE +5 位作者 Benting HUANG Rui WANG Ting BAI jiamin ZHANG Lin CHEN Wei WANG 《Agricultural Biotechnology》 CAS 2020年第2期105-109,113,共6页
Chinese cured meats are popular in the world,which are not only meat products but also cultures in China.Fungi can grow on the surface of the traditional cured meats easily during the processing and storage.Some fungi... Chinese cured meats are popular in the world,which are not only meat products but also cultures in China.Fungi can grow on the surface of the traditional cured meats easily during the processing and storage.Some fungi contribute to the specific flavors,color and sensory characteristics of cured meats,while others produce mycotoxins like aflatoxins,ochratoxins,and deoxynivalenol,which will lead to cancer.Although the mycotoxins limits in food have been published by national standard in China,the limits in cured meats are still in blank.Therefore,it is reasonable to identify and reduce the mycotoxins in Chinese cured meats and meat products.This review analyzed the causes of mycotoxins,identification and control methods for Chinese cured meats. 展开更多
关键词 FUNGUS MYCOTOXIN CAUSES IDENTIFICATION REDUCTION
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Magnetic Wakame-Based Biochar/Ni Composites with Enhanced Adsorption Performance for Diesel
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作者 Hua jing Shiyao Lu +6 位作者 lili ji Shijie Li Baikang Zhu jian Guo jiaxing Sun Lu Cai Yaning Wang 《Journal of Renewable Materials》 SCIE EI 2022年第12期3147-3165,共19页
In this study,the magnetic wakame biochar/Ni composites were prepared with three activating reagents of H_(3)PO_(4),ZnCl_(2) and KOH by one-step pyrolysis activation,characterized by BET,SEM,TEM,FI-IR,XRD,Raman,and el... In this study,the magnetic wakame biochar/Ni composites were prepared with three activating reagents of H_(3)PO_(4),ZnCl_(2) and KOH by one-step pyrolysis activation,characterized by BET,SEM,TEM,FI-IR,XRD,Raman,and elemental analyzer,and their adsorption performance for diesel were also analyzed.The results showed that wakame biochar/Ni composites had larger specific surface area,abundant porous structure,and various reactive groups,rendering its enhancement of adsorption efficiency.The adsorption experiments indicated that the maximum adsorption capacities for diesel using WBPA 0.5,WBHZ 0.5 and WBPH 0.5 were 4.11,8.83,and 13.47 g/g,respectively.The Langmuir model was more suitable for the adsorption isotherms process,and the Pseudo-second-order model could better describe the adsorption kinetic experimental.And the magnetic wakame biochar/Ni composites presented good stability and recyclability.This study provides a novel pattern for the high-value utilization of wakame,having huge potential in the treatment of oily wastewater. 展开更多
关键词 Wakeme magnetic biochar/Ni composites activating reagents diesel adsorption
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Preparation of Porous Materials Derived from Waste Mussel Shell with High Removal Performance for Tableware Oil
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作者 Yi Yang Zhaodi Wu +7 位作者 lili ji Shiyao Lu Hua jing jiaxing Sun jian Guo Wendong Song Yaning Wang Lu Cai 《Journal of Renewable Materials》 SCIE EI 2021年第11期1869-1881,共13页
In this work,carbonized mussel shell powder(CMSP)was modified by alkyl polyglucosides(APG)and rhamnolipid(RL)to render porous biomass a lipophilic surface,which was innovatively utilized as an environmentally friendly... In this work,carbonized mussel shell powder(CMSP)was modified by alkyl polyglucosides(APG)and rhamnolipid(RL)to render porous biomass a lipophilic surface,which was innovatively utilized as an environmentally friendly tableware cleaning material.The modified method was two-step hydrotherm-assisted synthesis.A contact angle meter was used to determine the surface hydrophobic property of modified samples(MTAR).The pore and the surface structure of CMSP and MTAR were characterized by BET,SEM,XRD,FTIR and XPS.The effect of removing oil was tested by gravimetric method.The results showed that the surface of MTAR was more porous and fluffier than CMSP,and the specific surface area is increased by 16.76 times.The results showed that when calcining CMSP at 1000℃,the oil removal rate of the synthesized MTAR is the best,and the decontamination rate can reach 87.05%.This research aims to develop a green and environmentally-friendly tableware cleaning material,solve environmental problems,and make full use of waste,which is very conducive to environmental protection. 展开更多
关键词 Calcined mussel shell modified tableware cleaning SURFACTANT
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Effect of Motor Relearning Combined with t DCS on Motor Function of Lower Extremities and Gait in Patients with Cerebral Infarction and 3D Gait Analysis
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作者 jing XU Su ZHENG +2 位作者 Yuanhong XU lili ji Chao QUAN 《Medicinal Plant》 CAS 2022年第5期74-76,82,共4页
[Objectives]To observe the effect of motor relearning combined with transcranial direct current stimulation on the motor function of lower extremities in patients with cerebral infarction,and to observe its effect on ... [Objectives]To observe the effect of motor relearning combined with transcranial direct current stimulation on the motor function of lower extremities in patients with cerebral infarction,and to observe its effect on gait by 3D gait analysis.[Methods]60 patients with cerebral infarction who met the inclusion criteria were randomly divided into 3 groups according to the order of treatment(n=20).Group A received motor relearning treatment,group B received transcranial direct current stimulation treatment,group C received motor relearning combined with transcranial direct current stimulation,and the curative effect was observed after 5 courses of treatment.[Results]Before treatment,FMA,MBI,spatio-temporal parameters for 3D gait analysis(gait frequency,gait cycle,stride length,gait speed,stride length deviation,double support)and lower limb joint motion parameters(affected side stride length,maximum hip flexion,maximum hip extension,maximum knee flexion,maximum knee extension,stance phase,swing phase)were compared among the three groups.After treatment,the FMA and MBI of the three groups increased,and the spatio-temporal parameters for 3D gait analysis(gait frequency,gait cycle,gait speed,double support)and the lower limb joint motion parameters(affected side stride length,maximum hip flexion,maximum hip extension,maximum knee flexion,swing phase)were all improved,while the spatio-temporal parameters(stride length and stride length deviation)and the lower limb joint motion parameters(maximum knee extension and stance phase)decreased.Compared with those before treatment,there were significant differences among the three groups(P<0.05).Through the comparison between groups,it was found that the FMA,MBI,spatio-temporal parameters for 3D gait analysis(gait frequency,gait cycle,gait speed,double support)and lower limb joint motion parameters(affected side stride length,maximum hip flexion,maximum hip extension,maximum knee flexion,swing phase)in group C were significantly higher than those in group A and B,while the spatio-temporal parameters(stride length and stride length deviation)and lower limb joint motion parameters(maximum knee extension and stance phase)in group C were significantly lower than those in group A and group B,and the difference was statistically significant(P<0.05).[Conclusions]Motor relearning combined with transcranial direct current stimulation could increase MBI and FMA,improve gait spatio-temporal parameters and lower limb joint motion parameters,and correct abnormal gait in patients with cerebral infarction. 展开更多
关键词 Motor relearning Transcranial direct current stimulation Cerebral infarction Lower extremities Motor function 3D gait analysis
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Effects of Different Sterilization Methods on the Product Characteristics of Sichuan Industrialized Huiguorou
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作者 lili ji Yinfeng ZHAO +3 位作者 Benting HUANG Wenguang FENG Yuhang ZHOU Wei WANG 《Agricultural Biotechnology》 CAS 2021年第5期120-124,130,共6页
Pasteurization,116 and 121℃sterilization were used in the development of Sichuan Industrial Huiguorou.The sensory,color,texture,lipid oxidation,preservation and flavor substance types and contents of the products wer... Pasteurization,116 and 121℃sterilization were used in the development of Sichuan Industrial Huiguorou.The sensory,color,texture,lipid oxidation,preservation and flavor substance types and contents of the products were determined,and the effects of different sterilization methods on product characteristics were compared.The results showed that pasteurization was the best way to maintain the edible quality of products,but the storage period of products was very short,so the products could only be quickly distributed and consumed.Sterilization at 116℃and sterilization at 121℃could ensure the shelf life of Huiguorou under non-refrigeration conditions,and effectively solve the problem of long-term storage and transportation of Sichuan meat dishes.However,higher temperature had more or less adverse effect on the flavor of the product,and the product texture was too soft.It suggested that the better way was to sterilize at 116℃,which had less adverse effect on the flavor of the product,and could greatly prolong the non-refrigerated storability of the product,and increase the content of aldehydes and esters,so as to improve the flavor. 展开更多
关键词 Sichuan cuisine INDUSTRIALIZATION Huiguorou Sterilization process Product characteristics Shelf life
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Analysis of Food Safety Supervision and Spot-Check in Sichuan Province in 2019
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作者 Pengyu CHEN Wei WANG +8 位作者 Xueli WU lili ji jiamin ZHANG Zhipin ZHAO Rui ZHANG Ting BAI Bo HOU Yixi YANG Lin CHEN 《Agricultural Biotechnology》 CAS 2022年第2期70-74,共5页
Through the analysis on 211614 batches of samples from 35 categories of food safety supervision and inspection in Sichuan Province by Administration for Market Regulation of Sichuan Province in 2019,four suggestions w... Through the analysis on 211614 batches of samples from 35 categories of food safety supervision and inspection in Sichuan Province by Administration for Market Regulation of Sichuan Province in 2019,four suggestions were finally put forward.The analysis results showed that in 2019,the overall trend of food safety in Sichuan Province was stable and improved.A total of 30 categories of unqualified samples were detected,and a total of 12135 batches of unqualified samples were detected,with an average sample unqualified rate of 5.73%.Among them,the main problems of unqualified samples were as follows:the use of food additives beyond the scope and limit,accounting for 40.17%of the total number of unqualified samples,microbial contamination in food,accounting for 23.61%of the total unqualified samples,the residue index of agricultural and veterinary drugs in food not meeting the standard,accounting for 15.61%of the total unqualified samples,the quality index in food not meeting the standard,accounting for 8.51%of the total number of unqualified samples,and heavy metals and other pollutants in food exceeding the standard,accounting for 7.10%of the total unqualified samples. 展开更多
关键词 SICHUAN Food safety Supervision and spot-check RECOMMENDATIONS
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Modern Ecological Chicken Raising and Its Research Progress
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作者 Qian HUANG Yinfeng ZHAO +4 位作者 Wenguang FENG Kaiqiang ZHAO Wenwen YU Xin HE lili ji 《Agricultural Biotechnology》 CAS 2021年第4期83-86,93,共5页
Modern ecological breeding has the characteristics of protecting the ecological environment,health,nutrition,delicious,and so on.In the ecological breeding of traditional breeding chicken,using non antibiotic breeding... Modern ecological breeding has the characteristics of protecting the ecological environment,health,nutrition,delicious,and so on.In the ecological breeding of traditional breeding chicken,using non antibiotic breeding,traditional Chinese medicine and other breeding technologies can not only obtain green,non-harmful and safe food products,but also reduce the cost of farmers and provide breeding efficiency This is a sustainable development path.This paper gave a brief overview of this field. 展开更多
关键词 Ecological breeding mode BROILERS Laying hens Research progress
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Outdoor Feeding Without Antibiotics,a Better Pattern for the Liver Health of Gushi Chicken
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作者 lili ji Wei WANG +3 位作者 Lin CHEN Bo HOU jiamin ZHANG Ting BAI 《Agricultural Biotechnology》 CAS 2020年第4期120-124,128,共6页
A 180 d feeding trial was conducted to evaluate the effect of different feeding modes on liver of Gushi chicken.The chickens from 1-day-old were fed in the warm house for 30 d,and then divided into four groups by diff... A 180 d feeding trial was conducted to evaluate the effect of different feeding modes on liver of Gushi chicken.The chickens from 1-day-old were fed in the warm house for 30 d,and then divided into four groups by different feeding modes(O-noant,outdoor without antibiotics;O-ant,outdoor with antibiotics;D-noant,indoor without antibiotics;D-ant,indoor with antibiotics),respectively,to evaluate the effect on liver.The results showed that different feeding modes significantly influenced the growth,liver weight,subcutaneous fat thickness,liver fat and liver free amino acid contents.The outdoor feeding without antibiotic reflected remarkably(P﹤0.05)low liver weight and fat content with normal morphology.While,other groups showed different levels of fat metabolism disorder in the liver.Based on chicken liver healthy,the outdoor feeding without antibiotic was the optimal feeding mode for Gushi chicken. 展开更多
关键词 Feeding mode Gushi chicken LIVER PHYSIOLOGY
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Optimization of Coenzyme Q10Production Procedure from Genetic Engineered Rhodobacter sphaeroides Overexpressing UbiG
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作者 Zhiping ZHAO Xinning XU +3 位作者 Ziyi YE lili ji jiamin ZHANG Wei WANG 《Agricultural Biotechnology》 CAS 2020年第1期6-8,共3页
In the present study, single factors including fermentation temperature, inoculate amount, fermentation duration, and ratio of fermentation medium volume to total flask volume(dissolved oxygen tension) were optimized ... In the present study, single factors including fermentation temperature, inoculate amount, fermentation duration, and ratio of fermentation medium volume to total flask volume(dissolved oxygen tension) were optimized for enhancing the production of coenzyme Q10 from genetic engineered Rhodobacter sphaeroides overexpressing UbiG. The experimental results suggested that optimal single factors were: inoculate amount 2%, fermentation temperature 30 ℃, fermentation duration 48 h, and ratio of fermentation medium volume to total flask volume 80%. The present study will promote the large scale production of CoQ10 from microorganisms. 展开更多
关键词 CoQ 10 Rhodobacter sphaeroides Genetic engineering OPTIMIZATION FERMENTATION
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Teaching Reform and Practice of Animal Products Processing under the Background of Intelligent Agriculture
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作者 Zhoulin WU Wei WANG +3 位作者 lili ji Bo HOU Ting BAI jiamin ZHANG 《Asian Agricultural Research》 2022年第11期74-76,共3页
Effective food professional personnel training strategies are explored and implemented,and interdisciplinary talents of food science and engineering in accordance with the background of intelligent agriculture are cul... Effective food professional personnel training strategies are explored and implemented,and interdisciplinary talents of food science and engineering in accordance with the background of intelligent agriculture are cultivated from the aspects of construction of teaching staff,reform of teaching content,upgrading of teaching model,construction of industry-education integration platform,which is of great significance to the modernization development of Chinese animal products processing industry. 展开更多
关键词 Animal products processing Intelligent agriculture Talent training Integration of production and education
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Preparation and Characterization of TiO<sub>2</sub>Photocatalytic Thin Film and Its Compounds by Micro-Arc Oxidation Technique
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作者 Qun Ma lili ji +5 位作者 Yinchang Li Tingting jiang Junxia Wang Fei Li Hongyun jin Yongqian Wang 《Advances in Materials Physics and Chemistry》 2013年第8期320-326,共7页
Mesoporous TiO2 ceramic films have been prepared upon the Ti alloy substrate by the micro-arc oxidation (MAO) technology. To enhance the photo-catalytic property of the films, Eu2O3 particles were added into the elect... Mesoporous TiO2 ceramic films have been prepared upon the Ti alloy substrate by the micro-arc oxidation (MAO) technology. To enhance the photo-catalytic property of the films, Eu2O3 particles were added into the electrolyte solution of Na2CO3/Na2SiO3. Scanning electron microscope (SEM), energy dispersive (EDS), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD) are employed to characterize the modified films. Diffuse reflectance spectra (DRS) test, photo-generated current test and photo decomposition test are applied to evaluate the photo-catalytic property of the modified films. The results show that Eu2O3 transformed into one-dimensional (1-D) nano-wires embedded within the composite film, and the film has high photo-catalytic property. 展开更多
关键词 TiO2 EU2O3 Compound Photo-Catalytic Property
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Numerical simulation of the dynamic migration mechanism and prediction of saturation of tight sandstone oil
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作者 Gaohui CAO Mian LIN +2 位作者 Likuan ZHANG lili ji Wenbin jiANG 《Science China Earth Sciences》 SCIE EI CAS CSCD 2024年第1期179-195,共17页
Quantitative characterization of tight sandstone oil migration and accumulation is an emerging research frontier in the field of oil and gas exploration.In this study,a conceptual model containing multiple basic geolo... Quantitative characterization of tight sandstone oil migration and accumulation is an emerging research frontier in the field of oil and gas exploration.In this study,a conceptual model containing multiple basic geological elements is developed,and a nonlinear seepage numerical model for tight sandstone oil migration and accumulation is established.The effects of the slip effect,overpressure driving force,buoyancy,and capillary force on the migration and accumulation of tight oil are examined.The results showed that(1)the differences in oil migration and accumulation between tight and conventional reservoirs are reflected in the growth mode of oil saturation,distribution characteristics of oil and water,and extent of the effect of the formation dip angle;(2)the slip effect has a significant impact when the average pore throat radius is less than 150 nm and the overpressure driving force and capillary force are the main mechanical mechanisms controlling oil migration and accumulation in tight sandstone,while the coupling effect of buoyancy,capillary force,and overpressure driving force controls the upper and lower limits of oil saturation.Finally,a dimensional and dimensionless identification chart for rapidly predicting the oil saturation of tight sandstone is proposed and verified using the measured data.This study provides a basis for analyzing the migration and accumulation mechanisms of tight sandstone oil and a new approach for predicting oil saturation.Additionally,we developed digital and visual analysis methods for the migration results,enriching the expression of the dynamics of hydrocarbon accumulation. 展开更多
关键词 Tight sandstone Migration and accumulation DYNAMICS Oil saturation Numerical simulation
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Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial—mesenchymal transition via directly targeting TGFβR1 被引量:1
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作者 jingnan Zhang Ze Zhang +9 位作者 Zhenlin Huang Manlin Li Fan Yang Zeqi Wu Qian Guo Xiyu Mei Bin Lu Changhong Wang Zhengtao Wang lili ji 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2023年第7期2990-3007,共18页
As the most aggressive breast cancer,triple-negative breast cancer(TNBC) is still incurable and very prone to metastasis.The transform growth factor β(TGF-β)-induced epithelial—mesenchymal transition(EMT) is crucia... As the most aggressive breast cancer,triple-negative breast cancer(TNBC) is still incurable and very prone to metastasis.The transform growth factor β(TGF-β)-induced epithelial—mesenchymal transition(EMT) is crucially involved in the growth and metastasis of TNBC.This study reported that a natural compound isotoosendanin(ITSN) reduced TNBC metastasis by inhibiting TGF-β-induced EMT and the formation of invadopodia.ITSN can directly interact with TGF-β receptor type-1(TGFβR1) and abrogated the kinase activity of TGFβR1,thereby blocking the TGF-β-initiated downstream signaling pathway.Moreover,the ITSN-provided inhibition on metastasis obviously disappeared in TGFβR1-overexpressed TNBC cells in vitro as well as in mice bearing TNBC cells overexpressed TGFβR1.Furthermore,Lys232 and Asp351 residues in the kinase domain of TGFβR1 were found to be crucial for the interaction of ITSN with TGFβR1.Additionally,ITSN also improved the inhibitory efficacy of programmed cell death 1 ligand 1(PD-L1) antibody for TNBC in vivo via inhibiting the TGF-β-mediated EMT in the tumor microenvironment.Our findings not only highlight the key role of TGFβR1 in TNBC metastasis,but also provide a leading compound targeting TGFβR1 for the treatment of TNBC metastasis.Moreover,this study also points out a potential strategy for TNBC treatment by using the combined application of anti-PD-L1 with a TGFβR1 inhibitor. 展开更多
关键词 TNBC Isotoosendanin METASTASIS TGFβR1 Epithelial-mesenchymal transition INVADOPODIA PD-L1 Tumor microenvironment
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MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
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作者 jingjing Cao lili ji +13 位作者 Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2023年第12期1413-1427,共15页
Primary immune thrombocytopenia(ITP)is an autoimmune hemorrhagic disorder in which macrophages play a critical role.Mammalian sterile-20-like kinase 4(MST4),a member of the germinal-center kinase STE20 family,has been... Primary immune thrombocytopenia(ITP)is an autoimmune hemorrhagic disorder in which macrophages play a critical role.Mammalian sterile-20-like kinase 4(MST4),a member of the germinal-center kinase STE20 family,has been demonstrated to be a regulator of inflammation.Whether MST4 participates in the macrophage-dependent inflammation of ITP remains elusive.The expression and function of MST4 in macrophages of ITP patients and THP-1 cells,and of a macrophage-specific Mst4−/−(Mst4ΔM/ΔM)ITP mouse model were determined.Macrophage phagocytic assays,RNA sequencing(RNA-seq)analysis,immunofluorescence analysis,coimmunoprecipitation(co-IP),mass spectrometry(MS),bioinformatics analysis,and phosphoproteomics analysis were performed to reveal the underlying mechanisms.The expression levels of the MST4 gene were elevated in the expanded M1-like macrophages of ITP patients,and this elevated expression of MST4 was restored to basal levels in patients with remission after high-dose dexamethasone treatment.The expression of the MST4 gene was significantly elevated in THP-1-derived M1 macrophages.Silencing of MST4 decreased the expression of M1 macrophage markers and cytokines,and impaired phagocytosis,which could be increased by overexpression of MST4.In a passive ITP mouse model,macrophage-specific depletion of Mst4 reduced the numbers of M1 macrophages in the spleen and peritoneal lavage fluid,attenuated the expression of M1 cytokines,and promoted the predominance of FcγRIIb in splenic macrophages,which resulted in amelioration of thrombocytopenia.Downregulation of MST4 directly inhibited STAT1 phosphorylation,which is essential for M1 polarization of macrophages.Our study elucidates a critical role for MST4 kinase in the pathology of ITP and identifies MST4 kinase as a potential therapeutic target for refractory ITP. 展开更多
关键词 Primary immune thrombocytopenia Mammalian sterile-20-like kinase 4(MST4) MACROPHAGES M1 polarization Signal transducer and activator of transcription-1(STAT1)
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