Owing to the bipartite nature of honeycomb lattice,the electrons in graphene host valley degree of freedom,which gives rise to a rich set of unique physical phenomena including chiral tunneling,Klein paradox,and quant...Owing to the bipartite nature of honeycomb lattice,the electrons in graphene host valley degree of freedom,which gives rise to a rich set of unique physical phenomena including chiral tunneling,Klein paradox,and quantum Hall ferromagnetism.Atomic defects in graphene can efficiently break the local sublattice symmetry,and hence,have significant effects on the valley-based electronic behaviors.Here we demonstrate that an individual flower defect in graphene has the ability of valley filter at the atomic scale.With the combination of scanning tunneling microscopy and Landau level measurements,we observe two valley-polarized density-of-states peaks near the outside of the flower defects,implying the symmetry breaking of the K and K′valleys in graphene.Moreover,the electrons in the K valley can highly penetrate inside the flower defects.In contrast,the electrons in the K′valley cannot directly penetrate,instead,they should be assisted by the valley switch from the K′to K.Our results demonstrate that an individual flower defect in graphene can be regarded as a nanoscale valley filter,providing insight into the practical valleytronics.展开更多
The amounts of litter produced and nutrients returned play a fundamental role in the productivity and biogeochemical and nutrient cycling of forest ecosystems.We monitored annual litterfall production, nutrient return...The amounts of litter produced and nutrients returned play a fundamental role in the productivity and biogeochemical and nutrient cycling of forest ecosystems.We monitored annual litterfall production, nutrient return,and monthly dynamics over a one-year period in Chinese fir plantations aged 10, 22, and 34 years. Our objective was to quantify litterfall and nutrient return over a complete harvest rotation of Chinese fir. Annual litterfall production increased with stand age and was recorded as(3,294.6 ± 360.4),(3,733.9 ± 211.2), and(4,876.1 ± 212.8) kg ha-1a-1in stands aged 10, 22 and 34 years, respectively. Total litter production was significantly greater in the stand aged34 years than in the stand aged 10 years(p \ 0.05). With the exception of miscellaneous components, needle litterfall constituted the highest proportion(27.5–43.6 %), followed by branches/twigs(9.5–16.6 %). In all three plantations,annual total nutrient return to soil was in the order of C(1,119.95–2,709.05 kg ha-1a-1) [ N(39.32–62.04 kg ha-1a-1) [ K(15.95–22.44 kg ha-1a-1) [ P(1.30–1.63 kg ha-1a-1). C, N, K and P input to soil was significantly lower in the 10-year-old stand in comparison to the 22- and34-year-old stands(p \ 0.05). Litterfall production and nutrient return(C, N and K) followed similar patterns, and C and N input to soil was significantly related to litterfall production(needle, branch and total litterfall). C, N, P and K input to soil and total litterfall production were mainly driven by needle litterfall.展开更多
Biomass production and nutrient(N, P, K, Ca and Mg) accumulation, distribution and cycling were quantified in young, mature and over-mature(10-, 22-, and34-year old) Chinese fir [Cunninghamia lanceolate(Lamb.) Hook] p...Biomass production and nutrient(N, P, K, Ca and Mg) accumulation, distribution and cycling were quantified in young, mature and over-mature(10-, 22-, and34-year old) Chinese fir [Cunninghamia lanceolate(Lamb.) Hook] plantations in southern China. Total stand biomass of young, mature and over-mature stands was 38,104 and 138 t ha-1respectively. Biomass production increased significantly with age. Stem wood represented the highest percentage of stand biomass, accounting for 41,55 and 63 % in the young, mature and over-mature plantations respectively. Nutrients concentration was highest in live needles and branches, and lowest in stem wood. The plantations accumulated more N, followed by K, Ca, Mg,and P. Nutrient return amount, nutrient utilization efficiency, nutrient turnover time, the ratio of nutrient returnand uptake increased with stand age, which implies that young Chinese fir deplete soil nutrients to maintain growth,and efficiently utilize nutrients to decrease dependence on soil nutrients as they age. Harvesting young Chinese fir plantations would therefore lead to high nutrient loss, but prolonging the rotation length could improve soil recovery,and help sustain productivity in the long-term. Improved nutrient return through litterfall as stands get older may also be beneficial to nutrient pool recovery.展开更多
In order to realize ultralow surface reflectance and broadband antireflection effects which common pyramidal textures and antireflection coatings can't achieve in photovoltaic industry,we used low-cost and easy-ma...In order to realize ultralow surface reflectance and broadband antireflection effects which common pyramidal textures and antireflection coatings can't achieve in photovoltaic industry,we used low-cost and easy-made Ag-catalyzed etching techniques to synthesize silicon nanowires(Si NWs) arrays on the substrate of single-crystalline silicon.The dense vertically-aligned Si NWs arrays are fabricated by local oxidation and selective dissolution of Si in etching solution containing Ag catalyst.The Si NWs arrays with 3 μm in depth make reflectance reduce to less than 3% in the range of 400 to 1000 nm while reflectance gradually reached the optimum value with the increasing of etching time.The antireflection of Si NWs arrays are based on indexgraded mechanism:Si NWs arrays on a subwavelength scale strongly scatter incident light and have graded refractive index that enhance the incidence of light in usable wavelength range.However,surface recombination of Si NWs arrays are deteriorated due to numerous dangling bonds and residual Ag particles.展开更多
[Objectives]This study was conducted to explore the most suitable irrigation integration mode for"Tinglin snow melon"in Jinshan District,Shanghai City.[Methods]With the field water holding capacity as the st...[Objectives]This study was conducted to explore the most suitable irrigation integration mode for"Tinglin snow melon"in Jinshan District,Shanghai City.[Methods]With the field water holding capacity as the standard,different upper limits of irrigation were set in the four growth stage of snow melon to investigate the effects of such three water-saving irrigation modes as single-row drip irrigation pipes,double-row drip irrigation pipes and drip arrows on the traits and yield of melon plants under the same growth conditions.[Results]The results showed that different irrigation modes had certain effects on the growth,comprehensive quality and yield of snow melon,and the drop arrow mode was better than other two modes.Under the drop arrow mode,the number of snow melons was the highest,7.34 per plant,and the yield was the highest,reaching 15463.35 kg/hm^(2),showing the best yield increasing effect.In addition,the contents of soluble solids and vitamin C in the drop arrow mode were higher than those in the drip irrigation pipe mode.[Conclusions]Compared with other irrigation methods,the drop arrow mode was more suitable for the production of snow melon.展开更多
In the era of rapid development of information technology,an increasing number of educators involve blog sites in their language teaching process.Although blogs are incredibly effective in language teaching and learni...In the era of rapid development of information technology,an increasing number of educators involve blog sites in their language teaching process.Although blogs are incredibly effective in language teaching and learning,there is still space for growth.Students may be able to choose helpful learning content and share their thoughts with teachers and other language learners.Furthermore,as compared to traditional educational methods,blogs encourage students to communicate with their professors or other students in written form more frequently.As a result,it may help pupils enhance their reading and writing skills,as well as their learning initiative and vocabulary.Finally,it may allow students to track their learning progress,which may be beneficial in developing students’self-assessment,self-management,and self-education skills.展开更多
As a primary sediment source,gully erosion leads to severe land degradation and poses a threat to food and ecological security.Therefore,identification of susceptible areas is critical to the prevention and control of...As a primary sediment source,gully erosion leads to severe land degradation and poses a threat to food and ecological security.Therefore,identification of susceptible areas is critical to the prevention and control of gully erosion.This study aimed to identify areas prone to gully erosion using four machine learning methods with derived topographic attributes.Eight topographic attributes(elevation,slope aspect,slope degree,catchment area,plan curvature,profile curvature,stream power index,and topo-graphic wetness index)were derived as feature variables controlling gully occurrence from digital elevation models with four different pixel sizes(5.0 m,12.5 m,20.0 m,and 30.0 m).A gully inventory map of a small agricultural catchment in Heilongjiang,China,was prepared through a combination of field surveys and satellite imagery.Each topographic attribute dataset was randomly divided into two portions of 70%and 30%for calibrating and validating four machine learning methods,namely random forest(RF),support vector machines(SVM),artificial neural network(ANN),and generalized linear models(GLM).Accuracy(ACC),area under the receiver operating characteristic curve(AUC),root mean square error(RMSE),and mean absolute error(MAE)were calculated to assess the performance of the four machine learning methods in predicting spatial distribution of gully erosion susceptibility(GES).The results suggested that the selected topographic attributes were capable of predicting GES in the study catchment area.A pixel size of 20.0 m was optimal for all four machine learning methods.The RF method described the spatial relationship between the feature variables and gully occurrence with the greatest accuracy,as it returned the highest values of ACC(0.917)and AUC(0.905)at a 20.0 m resolution.The RF was also the least sensitive to resolutions,followed by SVM(ACC=0.781-0.891,AUC=0.724-0.861)and ANN(ACC=0.744-0.808,AUC=0.649-0.847).GLM performed poorly in this study(ACC=0.693-0.757,AUC=0.608-0.703).Based on the spatial distribution of GES determined using the optimal method(RF+pixel size of 20.0 m),16%of the study area has very high level susceptibility classes,whereas areas with high,moderate,and low levels of susceptibility make up approximately 24%,30%,and 31%of the study area,respectively.Our results demonstrate that GES assessment with machine learning methods can successfuly identify areas prone to gully erosion,providing reference information for future soil conservation plans and land management.In addition,pixel size(resolution)is the key consideration when preparing suitable datasets of feature variables for GES assessment.展开更多
Factors associated with complete and durable remissions after anti-CD19 chimeric antigen receptor T(CAR-T)cell immunotherapy for relapsed or refractory non-Hodgkin lymphoma(r/r NHL)have not been well characterized.In ...Factors associated with complete and durable remissions after anti-CD19 chimeric antigen receptor T(CAR-T)cell immunotherapy for relapsed or refractory non-Hodgkin lymphoma(r/r NHL)have not been well characterized.In this study,we found that the different sites of extranodal involvement may affect response,overall survival(OS),and progression-free survival(PFS)in patients with r/r NHL treated with anti-CD19 CAR-T cells.In a cohort of 32 treated patients,12(37.5%)and 8(25%)patients exhibited soft tissue lymphoma and bone marrow(BM)infiltrations,respectively,and 13(41%)patients exhibited infiltration at other sites.The factors that may affect prognosis were identified through multivariable analysis.As an independent risk factor,soft tissue infiltration was the only factor significantly correlated with adverse prognosis(P<0.05),whereas other factors did not reach statistical significance.Furthermore,the site of extranodal tumor infiltration significantly and negatively affected OS and PFS in patients with r/r NHL treated with anti-CD19 CAR-T cell therapy.PFS and OS in patients with BM involvement were not significantly different from those of patients with lymph node involvement alone.Thus,anti-CD19 CAR-T cell therapy may improve the prognosis of patients with BM infiltration.展开更多
Mantle cell lymphoma(MCL)is a distinct histological type of B-cell lymphoma with a poor prognosis.Several agents,such as proteasome inhibitors,immunomodulatory drugs,and inhibitors of B cell lymphoma-2 and Bruton’s t...Mantle cell lymphoma(MCL)is a distinct histological type of B-cell lymphoma with a poor prognosis.Several agents,such as proteasome inhibitors,immunomodulatory drugs,and inhibitors of B cell lymphoma-2 and Bruton’s tyrosine kinase have shown efficacy for relapsed or refractory(r/r)MCL but often have short-term responses.Chimeric antigen receptor(CAR)T-cell therapy has emerged as a novel treatment modality for r/r non-Hodgkin’s lymphoma.However,long-term safety and tolerability associated with CAR T-cell therapy are not defined well,especially in MCL.In this report,we described a 70-year-old patient with r/r MCL with 48-month duration of follow-up who achieved long-term remission after CAR T-cell therapy.CAR T-cell-related toxicities were also mild and tolerated well even in this elderly patient.This report suggested that CAR T-cell therapy is a promising treatment modality for patients with MCL,who are generally elderly and have comorbid conditions.展开更多
Low-molecular weight surfactants have significant potential as building blocks for prebiotic organization.However,reports about surfactant-based coacervates as protocell models capable of reversible transformation are...Low-molecular weight surfactants have significant potential as building blocks for prebiotic organization.However,reports about surfactant-based coacervates as protocell models capable of reversible transformation are scarce.Herein,we develop a simple system made of a surfactant(-)-N-dodecylN-methylephedrinium bromide(DMEB)and inorganic salts that is capable of spontaneous formation of vesicles,coacervates,and the reversible transformation between the two states.展开更多
基金supported by the National Key R&D Program of China(Grant Nos.2022YFA1402502,2022YFA1402602,2021YFA1400103,and 2020YFA0308800)the National Natural Science Foundation of China(Grant Nos.92163206 and 12274026)China Postdoctoral Science Foundation(Grant No.2021M700407)。
文摘Owing to the bipartite nature of honeycomb lattice,the electrons in graphene host valley degree of freedom,which gives rise to a rich set of unique physical phenomena including chiral tunneling,Klein paradox,and quantum Hall ferromagnetism.Atomic defects in graphene can efficiently break the local sublattice symmetry,and hence,have significant effects on the valley-based electronic behaviors.Here we demonstrate that an individual flower defect in graphene has the ability of valley filter at the atomic scale.With the combination of scanning tunneling microscopy and Landau level measurements,we observe two valley-polarized density-of-states peaks near the outside of the flower defects,implying the symmetry breaking of the K and K′valleys in graphene.Moreover,the electrons in the K valley can highly penetrate inside the flower defects.In contrast,the electrons in the K′valley cannot directly penetrate,instead,they should be assisted by the valley switch from the K′to K.Our results demonstrate that an individual flower defect in graphene can be regarded as a nanoscale valley filter,providing insight into the practical valleytronics.
基金supported by National Natural Science Foundation of China(Grant Nos.31370619 and 31100472)Doctoral Program of Higher Education of Ministry of Education of China(Grant No.20113515110009)+2 种基金Forestry Public Benefit Research Projects of National Forestry Administration(Grant No.201304303)Science and Technology Major Project of the Fujian Province(Grant No.2012NZ0001–1)Training Program Foundation for University Distinguished Young Talents of Fujian Province,P.R.China(Grant No.JA 12091)
文摘The amounts of litter produced and nutrients returned play a fundamental role in the productivity and biogeochemical and nutrient cycling of forest ecosystems.We monitored annual litterfall production, nutrient return,and monthly dynamics over a one-year period in Chinese fir plantations aged 10, 22, and 34 years. Our objective was to quantify litterfall and nutrient return over a complete harvest rotation of Chinese fir. Annual litterfall production increased with stand age and was recorded as(3,294.6 ± 360.4),(3,733.9 ± 211.2), and(4,876.1 ± 212.8) kg ha-1a-1in stands aged 10, 22 and 34 years, respectively. Total litter production was significantly greater in the stand aged34 years than in the stand aged 10 years(p \ 0.05). With the exception of miscellaneous components, needle litterfall constituted the highest proportion(27.5–43.6 %), followed by branches/twigs(9.5–16.6 %). In all three plantations,annual total nutrient return to soil was in the order of C(1,119.95–2,709.05 kg ha-1a-1) [ N(39.32–62.04 kg ha-1a-1) [ K(15.95–22.44 kg ha-1a-1) [ P(1.30–1.63 kg ha-1a-1). C, N, K and P input to soil was significantly lower in the 10-year-old stand in comparison to the 22- and34-year-old stands(p \ 0.05). Litterfall production and nutrient return(C, N and K) followed similar patterns, and C and N input to soil was significantly related to litterfall production(needle, branch and total litterfall). C, N, P and K input to soil and total litterfall production were mainly driven by needle litterfall.
基金supported by the Forestry Public Benefit Research Projects of National Forestry Administration under Grant No.201304303National Natural Science Foundation of China under Grant No.31370619+1 种基金Science and Technology Project of the Fujian Province under Grant No.2014N0002China Postdoctoral Science Foundation under Grant No.132300148
文摘Biomass production and nutrient(N, P, K, Ca and Mg) accumulation, distribution and cycling were quantified in young, mature and over-mature(10-, 22-, and34-year old) Chinese fir [Cunninghamia lanceolate(Lamb.) Hook] plantations in southern China. Total stand biomass of young, mature and over-mature stands was 38,104 and 138 t ha-1respectively. Biomass production increased significantly with age. Stem wood represented the highest percentage of stand biomass, accounting for 41,55 and 63 % in the young, mature and over-mature plantations respectively. Nutrients concentration was highest in live needles and branches, and lowest in stem wood. The plantations accumulated more N, followed by K, Ca, Mg,and P. Nutrient return amount, nutrient utilization efficiency, nutrient turnover time, the ratio of nutrient returnand uptake increased with stand age, which implies that young Chinese fir deplete soil nutrients to maintain growth,and efficiently utilize nutrients to decrease dependence on soil nutrients as they age. Harvesting young Chinese fir plantations would therefore lead to high nutrient loss, but prolonging the rotation length could improve soil recovery,and help sustain productivity in the long-term. Improved nutrient return through litterfall as stands get older may also be beneficial to nutrient pool recovery.
基金partly supported by Natural Science Foundation of China (No.60876045)Shanghai Leading Basic Research Pro ject (No.09JC1405900)+2 种基金Shanghai Leading Academic Discipline Pro ject (No.S30105)R&D Foundation of SHU-SOENs PV Joint Lab (No.SS-E0700601)supported by Analysis and Testing Center of Shanghai University
文摘In order to realize ultralow surface reflectance and broadband antireflection effects which common pyramidal textures and antireflection coatings can't achieve in photovoltaic industry,we used low-cost and easy-made Ag-catalyzed etching techniques to synthesize silicon nanowires(Si NWs) arrays on the substrate of single-crystalline silicon.The dense vertically-aligned Si NWs arrays are fabricated by local oxidation and selective dissolution of Si in etching solution containing Ag catalyst.The Si NWs arrays with 3 μm in depth make reflectance reduce to less than 3% in the range of 400 to 1000 nm while reflectance gradually reached the optimum value with the increasing of etching time.The antireflection of Si NWs arrays are based on indexgraded mechanism:Si NWs arrays on a subwavelength scale strongly scatter incident light and have graded refractive index that enhance the incidence of light in usable wavelength range.However,surface recombination of Si NWs arrays are deteriorated due to numerous dangling bonds and residual Ag particles.
基金Shanghai Agriculture Applied Technology Development Program,China(Grant No.T20180304)Jinshan District Science and Technology Innovation Fund Project(Grant No.T20200115).
文摘[Objectives]This study was conducted to explore the most suitable irrigation integration mode for"Tinglin snow melon"in Jinshan District,Shanghai City.[Methods]With the field water holding capacity as the standard,different upper limits of irrigation were set in the four growth stage of snow melon to investigate the effects of such three water-saving irrigation modes as single-row drip irrigation pipes,double-row drip irrigation pipes and drip arrows on the traits and yield of melon plants under the same growth conditions.[Results]The results showed that different irrigation modes had certain effects on the growth,comprehensive quality and yield of snow melon,and the drop arrow mode was better than other two modes.Under the drop arrow mode,the number of snow melons was the highest,7.34 per plant,and the yield was the highest,reaching 15463.35 kg/hm^(2),showing the best yield increasing effect.In addition,the contents of soluble solids and vitamin C in the drop arrow mode were higher than those in the drip irrigation pipe mode.[Conclusions]Compared with other irrigation methods,the drop arrow mode was more suitable for the production of snow melon.
基金The Quality Project of West Anhui Health Vocational College in 2018,“Research on the Design and Application of Project-Based Blended Teaching of Nursing English in Vocational Colleges”(Number:YJZLGC201809,Project Director:Xin Li)The Provincial Quality Teaching and Research Project of Higher Education of Anhui Province in 2019,“Application and Research of Project-Based Teaching Method in Nursing English Courses in Medical Vocational Colleges”(Number:2019jyxm0615,Project Director:Lili Zhou)The Key Project of Humanities and Social Science Research of Higher Education of Anhui Province in 2020,“Research on Employment-Oriented PBL System for Medical Students”(Number:SK2020A0721,Project Director:Lili Zhou).
文摘In the era of rapid development of information technology,an increasing number of educators involve blog sites in their language teaching process.Although blogs are incredibly effective in language teaching and learning,there is still space for growth.Students may be able to choose helpful learning content and share their thoughts with teachers and other language learners.Furthermore,as compared to traditional educational methods,blogs encourage students to communicate with their professors or other students in written form more frequently.As a result,it may help pupils enhance their reading and writing skills,as well as their learning initiative and vocabulary.Finally,it may allow students to track their learning progress,which may be beneficial in developing students’self-assessment,self-management,and self-education skills.
基金supported by the National Key R&D Program of China[Grant number 2021YFD1500700]the National Natural Science Foundation of China[Grant number 42007050]Scientific Research Foundation of Liaoning Province[Grant number LSNPT202002].
文摘As a primary sediment source,gully erosion leads to severe land degradation and poses a threat to food and ecological security.Therefore,identification of susceptible areas is critical to the prevention and control of gully erosion.This study aimed to identify areas prone to gully erosion using four machine learning methods with derived topographic attributes.Eight topographic attributes(elevation,slope aspect,slope degree,catchment area,plan curvature,profile curvature,stream power index,and topo-graphic wetness index)were derived as feature variables controlling gully occurrence from digital elevation models with four different pixel sizes(5.0 m,12.5 m,20.0 m,and 30.0 m).A gully inventory map of a small agricultural catchment in Heilongjiang,China,was prepared through a combination of field surveys and satellite imagery.Each topographic attribute dataset was randomly divided into two portions of 70%and 30%for calibrating and validating four machine learning methods,namely random forest(RF),support vector machines(SVM),artificial neural network(ANN),and generalized linear models(GLM).Accuracy(ACC),area under the receiver operating characteristic curve(AUC),root mean square error(RMSE),and mean absolute error(MAE)were calculated to assess the performance of the four machine learning methods in predicting spatial distribution of gully erosion susceptibility(GES).The results suggested that the selected topographic attributes were capable of predicting GES in the study catchment area.A pixel size of 20.0 m was optimal for all four machine learning methods.The RF method described the spatial relationship between the feature variables and gully occurrence with the greatest accuracy,as it returned the highest values of ACC(0.917)and AUC(0.905)at a 20.0 m resolution.The RF was also the least sensitive to resolutions,followed by SVM(ACC=0.781-0.891,AUC=0.724-0.861)and ANN(ACC=0.744-0.808,AUC=0.649-0.847).GLM performed poorly in this study(ACC=0.693-0.757,AUC=0.608-0.703).Based on the spatial distribution of GES determined using the optimal method(RF+pixel size of 20.0 m),16%of the study area has very high level susceptibility classes,whereas areas with high,moderate,and low levels of susceptibility make up approximately 24%,30%,and 31%of the study area,respectively.Our results demonstrate that GES assessment with machine learning methods can successfuly identify areas prone to gully erosion,providing reference information for future soil conservation plans and land management.In addition,pixel size(resolution)is the key consideration when preparing suitable datasets of feature variables for GES assessment.
基金This work was funded and supported by the National Natural Science Foundation of China （Grant No. 71073055） and the Science and Technology Commission of Shanghai Municipality （09DZ120010A）. Lin Ma and Xiaoyu Zheng are acknowledged for their help with monitoring samples, and Haiying Zhang, Meng Wu, Sheng Xie, and Yan Jin are acknowledged for their help with the sampling. We are indebted to Xin Tong for guidance regarding R software. We are also grateful to Professor Yongjie Gu for her work in the field survey and her support in the identification of the phytoplankton.
基金This study was supported by grants from the Municipal Hospital Frontier Technology Joint Project of Shanghai City(No.SHDC12015108)the National Natural Science Foundation of China(Nos.81830004 and 31301118).
文摘Factors associated with complete and durable remissions after anti-CD19 chimeric antigen receptor T(CAR-T)cell immunotherapy for relapsed or refractory non-Hodgkin lymphoma(r/r NHL)have not been well characterized.In this study,we found that the different sites of extranodal involvement may affect response,overall survival(OS),and progression-free survival(PFS)in patients with r/r NHL treated with anti-CD19 CAR-T cells.In a cohort of 32 treated patients,12(37.5%)and 8(25%)patients exhibited soft tissue lymphoma and bone marrow(BM)infiltrations,respectively,and 13(41%)patients exhibited infiltration at other sites.The factors that may affect prognosis were identified through multivariable analysis.As an independent risk factor,soft tissue infiltration was the only factor significantly correlated with adverse prognosis(P<0.05),whereas other factors did not reach statistical significance.Furthermore,the site of extranodal tumor infiltration significantly and negatively affected OS and PFS in patients with r/r NHL treated with anti-CD19 CAR-T cell therapy.PFS and OS in patients with BM involvement were not significantly different from those of patients with lymph node involvement alone.Thus,anti-CD19 CAR-T cell therapy may improve the prognosis of patients with BM infiltration.
基金This study was supported by grants from the Shanghai Municipal Hospital New Frontier Technology Joint Research Project(No.SHDC12015108)the National Natural Science Foundation of China(Nos.81830004,31301118,and 81272325)the Fundamental Research Funds for the Central Universities(No.22120170004).
文摘Mantle cell lymphoma(MCL)is a distinct histological type of B-cell lymphoma with a poor prognosis.Several agents,such as proteasome inhibitors,immunomodulatory drugs,and inhibitors of B cell lymphoma-2 and Bruton’s tyrosine kinase have shown efficacy for relapsed or refractory(r/r)MCL but often have short-term responses.Chimeric antigen receptor(CAR)T-cell therapy has emerged as a novel treatment modality for r/r non-Hodgkin’s lymphoma.However,long-term safety and tolerability associated with CAR T-cell therapy are not defined well,especially in MCL.In this report,we described a 70-year-old patient with r/r MCL with 48-month duration of follow-up who achieved long-term remission after CAR T-cell therapy.CAR T-cell-related toxicities were also mild and tolerated well even in this elderly patient.This report suggested that CAR T-cell therapy is a promising treatment modality for patients with MCL,who are generally elderly and have comorbid conditions.
基金supported by National Natural Science Foundation of China(grant nos.21972149,21988102,21811530002,21633002,and 21761142007).
文摘Low-molecular weight surfactants have significant potential as building blocks for prebiotic organization.However,reports about surfactant-based coacervates as protocell models capable of reversible transformation are scarce.Herein,we develop a simple system made of a surfactant(-)-N-dodecylN-methylephedrinium bromide(DMEB)and inorganic salts that is capable of spontaneous formation of vesicles,coacervates,and the reversible transformation between the two states.
