Parkinson disease (PD) is a neurological disorder with huge destruction to human body, which affects approximately 2% of the population aged 65 years or older. As antioxidants in the stress defence systems, glutathion...Parkinson disease (PD) is a neurological disorder with huge destruction to human body, which affects approximately 2% of the population aged 65 years or older. As antioxidants in the stress defence systems, glutathione S-transferases (GSTs) are dimeric cytosolic enzymes with an important role in the pathogenesis of PD. The aim of this study was to evaluate the association between the polymorphisms of GST genes and PD. Meta-analyses were conducted from 17 studies (38 stages) among 3419 cases and 5686 controls between four polymorphisms (GSTT1 deletion polymorphism;GSTM1 deletion polymorphism;GSTP1-104: rs1695;GSTP1-114: rs1799811) and PD. There is no significant association between the four GST gene variants and PD. A further subgroup study by ethnicity observed a risky role of GSTM1 deletion polymorphism with PD in Europeans (p = 0.013, OR = 1.126, 95% CI = 1.025-1.236), and a protective role of GSTM1 deletion polymorphism with PD in Latin Americans (p = 0.032, OR = 0.750, 95% CI = 0.577-0.975). Our meta-analysis suggested that GSTM1 deletion polymorphism increased the risk of PD in Europeans, but reduced the risk of PD in Latin Americans. Future large-scale studies might be needed to confirm the ethnic difference of GSTM1 deletion polymorphism, and to check whether there was significant association of PD for other GST genetic polymorphisms.展开更多
Rheumatoid arthritis (RA) is an immune-mediated chronic inflammatory disease that causes huge destruction to human body. IL1B encodes key mediator IL-1β protein, which plays an important role in the pathogenesis of i...Rheumatoid arthritis (RA) is an immune-mediated chronic inflammatory disease that causes huge destruction to human body. IL1B encodes key mediator IL-1β protein, which plays an important role in the pathogenesis of inflammatory syndromes. The aim of this study was to evaluate the association between IL1B polymorphisms and RA. A meta-analysis was performed on the association between three IL1B polymorphisms (IL1B-31: rs1143627;IL1B-511: rs16944;IL1B + 3954: rs1143634) and RA. A trend of significant association was observed between IL1B + 3954 and RA (p = 0.06, odd ratio (OR) = 1.19, 95% confidential interval (CI) = 1.00-1.42). A significant association was found in Europeans under the dominant model between IL1B-511T and RA (p = 0.03, OR = 0.89, 95% CI = 0.81-0.99). Our meta-analysis indicated that IL1B ? 511-T played a protective role against RA in Europeans, and that IL1B + 3954-T had the potential to increase the risk of RA. Future large-scale studies should be considered to confirm the association between IL1B polymorphisms and RA.展开更多
To the Editor:Acute concomitant esotropia(ACE)is an acquired esotropia with a sudden appearance and no pathologic changes on cerebral imaging.There are various treatments for ACE,including extraocular muscle surgery,b...To the Editor:Acute concomitant esotropia(ACE)is an acquired esotropia with a sudden appearance and no pathologic changes on cerebral imaging.There are various treatments for ACE,including extraocular muscle surgery,botulinum toxin A(BTA)injection,prisms,and divergence training.[1]BTA had been used in the treatment of ACE since it was approved by Food and Drug Administration(FDA,USA)in 1989.[2]Some researchers have confirmed that its effect is stable and has unique advantages in the treatment of ACE.展开更多
纤维状超级电容器是柔性储能器件的一个重要分支,被学术界和产业界广泛关注.如何制备高性能纤维电极及器件是目前的研究重点之一.针对这一问题,我们制备了一类具有双亲性核壳结构的碳纳米管复合纤维电极.该复合纤维电极的壳层为聚苯胺...纤维状超级电容器是柔性储能器件的一个重要分支,被学术界和产业界广泛关注.如何制备高性能纤维电极及器件是目前的研究重点之一.针对这一问题,我们制备了一类具有双亲性核壳结构的碳纳米管复合纤维电极.该复合纤维电极的壳层为聚苯胺修饰的亲水碳纳米管以实现更好的离子可接近性,从而有效提升电极的电化学性能;而核层为纳米金沉积疏水碳纳米管以实现快速电子传输,从而显著提高电极的电导率.得益于各组分之间的协同效应,在0.5 A cm^-3的电流密度下,该复合纤维电极的比容量可以达到324 F cm^-3.同时该纤维电极也展示了优异的倍率性能,在50 A cm^-3电流密度下>比容量可以保持为小电流下比容量的79%(即256 F cm^-3).由此得到的纤维状超级电容器也实现了高能量密度和高功率密度,分别可达到7.2 mW h cm^-3和10 W cm^-3.这种多层次的复合电极设计为制备其他高性能可穿戴器件提供了一种可行的方法.展开更多
General strategies leading to scale-span molecular self-assembly are of crucial importance in creating bulk supramolecular materials.Here,we report that under mechanical pressure,caking of the precipitatedmolecular se...General strategies leading to scale-span molecular self-assembly are of crucial importance in creating bulk supramolecular materials.Here,we report that under mechanical pressure,caking of the precipitatedmolecular self-assemblies led to bulk supramolecular films.Massive fabrication of supramolecular films became possible by employing a simple household noodle machine.The film could be endowed to acquire diversified functions by depositing various functional ingredients via coprecipitation.We expect that our current work opens up a new paradigm leading to large-scale functional solid molecular self-assembled materials.展开更多
文摘Parkinson disease (PD) is a neurological disorder with huge destruction to human body, which affects approximately 2% of the population aged 65 years or older. As antioxidants in the stress defence systems, glutathione S-transferases (GSTs) are dimeric cytosolic enzymes with an important role in the pathogenesis of PD. The aim of this study was to evaluate the association between the polymorphisms of GST genes and PD. Meta-analyses were conducted from 17 studies (38 stages) among 3419 cases and 5686 controls between four polymorphisms (GSTT1 deletion polymorphism;GSTM1 deletion polymorphism;GSTP1-104: rs1695;GSTP1-114: rs1799811) and PD. There is no significant association between the four GST gene variants and PD. A further subgroup study by ethnicity observed a risky role of GSTM1 deletion polymorphism with PD in Europeans (p = 0.013, OR = 1.126, 95% CI = 1.025-1.236), and a protective role of GSTM1 deletion polymorphism with PD in Latin Americans (p = 0.032, OR = 0.750, 95% CI = 0.577-0.975). Our meta-analysis suggested that GSTM1 deletion polymorphism increased the risk of PD in Europeans, but reduced the risk of PD in Latin Americans. Future large-scale studies might be needed to confirm the ethnic difference of GSTM1 deletion polymorphism, and to check whether there was significant association of PD for other GST genetic polymorphisms.
文摘Rheumatoid arthritis (RA) is an immune-mediated chronic inflammatory disease that causes huge destruction to human body. IL1B encodes key mediator IL-1β protein, which plays an important role in the pathogenesis of inflammatory syndromes. The aim of this study was to evaluate the association between IL1B polymorphisms and RA. A meta-analysis was performed on the association between three IL1B polymorphisms (IL1B-31: rs1143627;IL1B-511: rs16944;IL1B + 3954: rs1143634) and RA. A trend of significant association was observed between IL1B + 3954 and RA (p = 0.06, odd ratio (OR) = 1.19, 95% confidential interval (CI) = 1.00-1.42). A significant association was found in Europeans under the dominant model between IL1B-511T and RA (p = 0.03, OR = 0.89, 95% CI = 0.81-0.99). Our meta-analysis indicated that IL1B ? 511-T played a protective role against RA in Europeans, and that IL1B + 3954-T had the potential to increase the risk of RA. Future large-scale studies should be considered to confirm the association between IL1B polymorphisms and RA.
基金Key Program on Basic Research Project of Universities of Henan(No.22B320016)Scientific Research Fund of National Health Commission-Henan Province Medical Science and Technology Project(No.SB201901013)
文摘To the Editor:Acute concomitant esotropia(ACE)is an acquired esotropia with a sudden appearance and no pathologic changes on cerebral imaging.There are various treatments for ACE,including extraocular muscle surgery,botulinum toxin A(BTA)injection,prisms,and divergence training.[1]BTA had been used in the treatment of ACE since it was approved by Food and Drug Administration(FDA,USA)in 1989.[2]Some researchers have confirmed that its effect is stable and has unique advantages in the treatment of ACE.
基金supported by the Ministry of Science and Technology (2016YFA0203302)the National Natural Science Foundation of China (21634003, 51573027, 51673043, 21604012, 21805044 and 21875042)+1 种基金Shanghai Science and Technology Committee (16JC1400702, 17QA1400400, 18QA1400700 and 18QA1400800)SHMEC (2017-01-07-00-07-E00062)
文摘纤维状超级电容器是柔性储能器件的一个重要分支,被学术界和产业界广泛关注.如何制备高性能纤维电极及器件是目前的研究重点之一.针对这一问题,我们制备了一类具有双亲性核壳结构的碳纳米管复合纤维电极.该复合纤维电极的壳层为聚苯胺修饰的亲水碳纳米管以实现更好的离子可接近性,从而有效提升电极的电化学性能;而核层为纳米金沉积疏水碳纳米管以实现快速电子传输,从而显著提高电极的电导率.得益于各组分之间的协同效应,在0.5 A cm^-3的电流密度下,该复合纤维电极的比容量可以达到324 F cm^-3.同时该纤维电极也展示了优异的倍率性能,在50 A cm^-3电流密度下>比容量可以保持为小电流下比容量的79%(即256 F cm^-3).由此得到的纤维状超级电容器也实现了高能量密度和高功率密度,分别可达到7.2 mW h cm^-3和10 W cm^-3.这种多层次的复合电极设计为制备其他高性能可穿戴器件提供了一种可行的方法.
基金This work was supported by grants from the National Key Basic Research Program of China （2010CB529901 and 2010CB530600）, the National Natural Science Foundation of China （31100619 and 30972705）, the China Postdoctoral Science Foundation （20110490186）, the Chen-guang Plan Project of Shanghai Educational Municipal Education Commission （11CG48 and szyl0004）, the Specialized Research Fund for the Doctoral Program of Higher Education （20113107120014） and the Leading Academic Discipline Project of Shanghai Municipal Education Commission （J50301） （Yuejuan Zheng, Shanghai University of T.C.M）.
基金the National Natural Science Foundation of China(NSFC 91856120,21573011,and 21633002).
文摘General strategies leading to scale-span molecular self-assembly are of crucial importance in creating bulk supramolecular materials.Here,we report that under mechanical pressure,caking of the precipitatedmolecular self-assemblies led to bulk supramolecular films.Massive fabrication of supramolecular films became possible by employing a simple household noodle machine.The film could be endowed to acquire diversified functions by depositing various functional ingredients via coprecipitation.We expect that our current work opens up a new paradigm leading to large-scale functional solid molecular self-assembled materials.
