Wound repair is a complex challenge for both clinical practitioners and researchers.Conventional approaches for wound repair have several limitations.Stem cell-based therapy has emerged as a novel strategy to address ...Wound repair is a complex challenge for both clinical practitioners and researchers.Conventional approaches for wound repair have several limitations.Stem cell-based therapy has emerged as a novel strategy to address this issue,exhibiting significant potential for enhancing wound healing rates,improving wound quality,and promoting skin regeneration.However,the use of stem cells in skin regeneration presents several challenges.Recently,stem cells and biomaterials have been identified as crucial components of the wound-healing process.Combination therapy involving the development of biocompatible scaffolds,accompanying cells,multiple biological factors,and structures resembling the natural extracellular matrix(ECM)has gained considerable attention.Biological scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells,providing them with an environment conducive to growth,similar to that of the ECM.These scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound healing.This article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing,emphasizing their capacity to facilitate stem cell adhesion,proliferation,differentiation,and paracrine functions.Additionally,we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.展开更多
Diabetic foot ulcers(DFUs)pose a critical medical challenge,significantly impairing the quality of life of patients.Adipose-derived stem cells(ADSCs)have been identified as a promising therapeutic approach for improvi...Diabetic foot ulcers(DFUs)pose a critical medical challenge,significantly impairing the quality of life of patients.Adipose-derived stem cells(ADSCs)have been identified as a promising therapeutic approach for improving wound healing in DFUs.Despite extensive exploration of the mechanical aspects of ADSC therapy against DFU,its clinical applications remain elusive.In this review,we aimed to bridge this gap by evaluating the use and advancements of ADSCs in the clinical management of DFUs.The review begins with a discussion of the classification and clinical management of diabetic foot conditions.It then discusses the current landscape of clinical trials,focusing on their geographic distribution,reported efficacy,safety profiles,treatment timing,administration techniques,and dosing considerations.Finally,the review discusses the preclinical strategies to enhance ADSC efficacy.This review shows that many trials exhibit biases in study design,unclear inclusion criteria,and intervention protocols.In conclusion,this review underscores the potential of ADSCs in DFU treatment and emphasizes the critical need for further research and refinement of therapeutic approaches,with a focus on improving the quality of future clinical trials to enhance treatment outcomes and advance the field of diabetic wound care.展开更多
目的探讨急诊重症监护室(emergency intensive care unit,EICU)血流感染患者临床结局的风险因子,为临床决策提供依据。方法回顾性收集2019年1月至2023年4月我院就诊的141例EICU血流感染患者的病历资料及血培养记录,采用Logistic回归分...目的探讨急诊重症监护室(emergency intensive care unit,EICU)血流感染患者临床结局的风险因子,为临床决策提供依据。方法回顾性收集2019年1月至2023年4月我院就诊的141例EICU血流感染患者的病历资料及血培养记录,采用Logistic回归分析患者死亡的危险因素,运用Cox回归分析上述因素与患者生存时间和临床结局的关系。结果在141例EICU血流感染患者中,两种及以上细菌混合血流感染[比值比(OR)=5.68,95%置信区间(CI):1.20~26.98,P<0.05]及多重耐药菌血流感染(OR=6.39,95%CI:2.78~14.67,P<0.01)与患者死亡具有显著相关性;是否根据药敏结果及时调整用药[风险比(HR)=0.47,95%CI:0.30~0.74]和多重耐药菌血流感染(HR=2.02,95%CI:1.28~3.20)是EICU血流感染患者死亡的风险因子(P<0.01)。结论尽早采集血培养,明确感染病原菌,精准用药控制感染,可以有效降低患者的死亡率。展开更多
目的探讨Wilson病(Wilson disease,WD)患者冲动性对数字成瘾倾向的影响及其相关因素。方法纳入66例WD患者为研究对象,根据临床表现分为脑型组42例、肝型组24例。采用网络成瘾量表(internet addiction test,IAT)评估患者网络成瘾倾向,总...目的探讨Wilson病(Wilson disease,WD)患者冲动性对数字成瘾倾向的影响及其相关因素。方法纳入66例WD患者为研究对象,根据临床表现分为脑型组42例、肝型组24例。采用网络成瘾量表(internet addiction test,IAT)评估患者网络成瘾倾向,总分>50分界定为具有网络成瘾倾向;使用Barratt冲动量表中文版(the Chinese version of the Barratt impulsiveness scale,11version,BIS-11-C)评估患者冲动性;手机依赖量表(mobile phone addiction index,MPAI)评估对手机使用的依赖程度;通过颅脑MRI检查患者病变脑区的部位和累计频次。结果66例WD患者中有数字成瘾倾向者45例(68.2%),其中脑型组中35例(53.0%)、肝型组中10例(15.2%),两组成瘾倾向者比例差异有统计学意义(P=0.001)。脑型组患者在BIS-11-C、MPAI量表多项因子分上高于肝型组(P<0.05)。所有患者MPAI量表中失控性因子分与BIS-11-C量表中的注意力冲动性因子分(r=0.499,P=0.001)、运动冲动性因子分(r=0.553,P=0.001)、无计划冲动性因子分(r=0.535,P=0.001)、冲动控制总分(r=0.653,P=0.001)正相关。线性回归分析显示注意力冲动性因子分与额叶病变(B=-1.634,P=0.018)相关联,失控性因子分与额叶病变(B=-3.609,P=0.023)相关联,戒断性因子分与丘脑病变(B=-5.047,P=0.007)、额叶病变(B=-2.204,P=0.024)相关联,逃避性因子分与顶叶病变(B=-1.867,P=0.032)相关联,低效性因子分与壳核病变(B=-1.789,P=0.016)、额叶病变(B=-1.592,P=0.044)相关联。结论脑型WD患者较肝型有更高的数字成瘾倾向,数字成瘾倾向与冲动性相关。WD患者的数字成瘾倾向可能与壳核、丘脑、额叶等多个脑区病变引起的冲动控制障碍有关。展开更多
Superconducting microwave resonators play a pivotal role in superconducting quantum circuits.The ability to finetune their resonant frequencies provides enhanced control and flexibility.Here,we introduce a frequency-t...Superconducting microwave resonators play a pivotal role in superconducting quantum circuits.The ability to finetune their resonant frequencies provides enhanced control and flexibility.Here,we introduce a frequency-tunable superconducting coplanar waveguide resonator.By applying electrical currents through specifically designed ground wires,we achieve the generation and control of a localized magnetic field on the central line of the resonator,enabling continuous tuning of its resonant frequency.We demonstrate a frequency tuning range of 54.85 MHz in a 6.21-GHz resonator.This integrated and tunable resonator holds great potential as a dynamically tunable filter and as a key component of communication buses and memory elements in superconducting quantum computing.展开更多
Controlling the size and distribution of potential barriers within a medium of interacting particles can unveil unique collective behaviors and innovative functionalities.We introduce a unique superconducting hybrid d...Controlling the size and distribution of potential barriers within a medium of interacting particles can unveil unique collective behaviors and innovative functionalities.We introduce a unique superconducting hybrid device using a novel artificial spin ice structure composed of asymmetric nanomagnets.This structure forms a distinctive superconducting pinning potential that steers unconventional motion of superconducting vortices,thereby inducing a magnetic nonreciprocal effect,in contrast to the electric nonreciprocal effect commonly observed in superconducting diodes.Furthermore,the polarity of the magnetic nonreciprocity is in situ reversible through the tunable magnetic patterns of artificial spin ice.Our findings demonstrate that artificial spin ice not only precisely modulates superconducting characteristics but also opens the door to novel functionalities,offering a groundbreaking paradigm for superconducting electronics.展开更多
基金Supported by CAMS Innovation Fund for Medical Sciences,No.2020-I2M-C&T-A-004National High Level Hospital Clinical Research Funding,No.2022-PUMCH-A-210,No.2022-PUMCH-B-041,and No.2022-PUMCH-C-025and National Key R&D Program of China,No.2020YFE0201600.
文摘Wound repair is a complex challenge for both clinical practitioners and researchers.Conventional approaches for wound repair have several limitations.Stem cell-based therapy has emerged as a novel strategy to address this issue,exhibiting significant potential for enhancing wound healing rates,improving wound quality,and promoting skin regeneration.However,the use of stem cells in skin regeneration presents several challenges.Recently,stem cells and biomaterials have been identified as crucial components of the wound-healing process.Combination therapy involving the development of biocompatible scaffolds,accompanying cells,multiple biological factors,and structures resembling the natural extracellular matrix(ECM)has gained considerable attention.Biological scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells,providing them with an environment conducive to growth,similar to that of the ECM.These scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound healing.This article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing,emphasizing their capacity to facilitate stem cell adhesion,proliferation,differentiation,and paracrine functions.Additionally,we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.
基金Supported by National Key R&D Program of China,No.2020YFE0201600CAMS Innovation Fund for Medical Sciences,No.2020-I2MC&T-A-004National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-041,No.2022-PUMCH-A-210 and No.2022-PUMCH-C-025.
文摘Diabetic foot ulcers(DFUs)pose a critical medical challenge,significantly impairing the quality of life of patients.Adipose-derived stem cells(ADSCs)have been identified as a promising therapeutic approach for improving wound healing in DFUs.Despite extensive exploration of the mechanical aspects of ADSC therapy against DFU,its clinical applications remain elusive.In this review,we aimed to bridge this gap by evaluating the use and advancements of ADSCs in the clinical management of DFUs.The review begins with a discussion of the classification and clinical management of diabetic foot conditions.It then discusses the current landscape of clinical trials,focusing on their geographic distribution,reported efficacy,safety profiles,treatment timing,administration techniques,and dosing considerations.Finally,the review discusses the preclinical strategies to enhance ADSC efficacy.This review shows that many trials exhibit biases in study design,unclear inclusion criteria,and intervention protocols.In conclusion,this review underscores the potential of ADSCs in DFU treatment and emphasizes the critical need for further research and refinement of therapeutic approaches,with a focus on improving the quality of future clinical trials to enhance treatment outcomes and advance the field of diabetic wound care.
文摘目的探讨急诊重症监护室(emergency intensive care unit,EICU)血流感染患者临床结局的风险因子,为临床决策提供依据。方法回顾性收集2019年1月至2023年4月我院就诊的141例EICU血流感染患者的病历资料及血培养记录,采用Logistic回归分析患者死亡的危险因素,运用Cox回归分析上述因素与患者生存时间和临床结局的关系。结果在141例EICU血流感染患者中,两种及以上细菌混合血流感染[比值比(OR)=5.68,95%置信区间(CI):1.20~26.98,P<0.05]及多重耐药菌血流感染(OR=6.39,95%CI:2.78~14.67,P<0.01)与患者死亡具有显著相关性;是否根据药敏结果及时调整用药[风险比(HR)=0.47,95%CI:0.30~0.74]和多重耐药菌血流感染(HR=2.02,95%CI:1.28~3.20)是EICU血流感染患者死亡的风险因子(P<0.01)。结论尽早采集血培养,明确感染病原菌,精准用药控制感染,可以有效降低患者的死亡率。
文摘目的探讨Wilson病(Wilson disease,WD)患者冲动性对数字成瘾倾向的影响及其相关因素。方法纳入66例WD患者为研究对象,根据临床表现分为脑型组42例、肝型组24例。采用网络成瘾量表(internet addiction test,IAT)评估患者网络成瘾倾向,总分>50分界定为具有网络成瘾倾向;使用Barratt冲动量表中文版(the Chinese version of the Barratt impulsiveness scale,11version,BIS-11-C)评估患者冲动性;手机依赖量表(mobile phone addiction index,MPAI)评估对手机使用的依赖程度;通过颅脑MRI检查患者病变脑区的部位和累计频次。结果66例WD患者中有数字成瘾倾向者45例(68.2%),其中脑型组中35例(53.0%)、肝型组中10例(15.2%),两组成瘾倾向者比例差异有统计学意义(P=0.001)。脑型组患者在BIS-11-C、MPAI量表多项因子分上高于肝型组(P<0.05)。所有患者MPAI量表中失控性因子分与BIS-11-C量表中的注意力冲动性因子分(r=0.499,P=0.001)、运动冲动性因子分(r=0.553,P=0.001)、无计划冲动性因子分(r=0.535,P=0.001)、冲动控制总分(r=0.653,P=0.001)正相关。线性回归分析显示注意力冲动性因子分与额叶病变(B=-1.634,P=0.018)相关联,失控性因子分与额叶病变(B=-3.609,P=0.023)相关联,戒断性因子分与丘脑病变(B=-5.047,P=0.007)、额叶病变(B=-2.204,P=0.024)相关联,逃避性因子分与顶叶病变(B=-1.867,P=0.032)相关联,低效性因子分与壳核病变(B=-1.789,P=0.016)、额叶病变(B=-1.592,P=0.044)相关联。结论脑型WD患者较肝型有更高的数字成瘾倾向,数字成瘾倾向与冲动性相关。WD患者的数字成瘾倾向可能与壳核、丘脑、额叶等多个脑区病变引起的冲动控制障碍有关。
基金Project supported by the National Key Research and Development Program of China(Grant Nos.2021YFA0718802 and 2018YFA0209002)the National Natural Science Foundation of China(Grant Nos.62274086,62288101,61971464,62101243,and 11961141002)+3 种基金the Excellent Young Scholar Program of Jiangsu Province,China(Grant Nos.BK20200008 and BK20200060)the Outstanding Postdoctoral Program of Jiangsu Province,Chinathe Fundamental Research Funds for the Central Universitiesthe Fund from Jiangsu Key Laboratory of Advanced Techniques for Manipulating Electromagnetic Waves。
文摘Superconducting microwave resonators play a pivotal role in superconducting quantum circuits.The ability to finetune their resonant frequencies provides enhanced control and flexibility.Here,we introduce a frequency-tunable superconducting coplanar waveguide resonator.By applying electrical currents through specifically designed ground wires,we achieve the generation and control of a localized magnetic field on the central line of the resonator,enabling continuous tuning of its resonant frequency.We demonstrate a frequency tuning range of 54.85 MHz in a 6.21-GHz resonator.This integrated and tunable resonator holds great potential as a dynamically tunable filter and as a key component of communication buses and memory elements in superconducting quantum computing.
基金supported by the National Natural Science Foundation of China(Grant Nos.62288101 and 62274086)the National Key R&D Program of China(Grant No.2021YFA0718802)the Jiangsu Outstanding Postdoctoral Program。
文摘Controlling the size and distribution of potential barriers within a medium of interacting particles can unveil unique collective behaviors and innovative functionalities.We introduce a unique superconducting hybrid device using a novel artificial spin ice structure composed of asymmetric nanomagnets.This structure forms a distinctive superconducting pinning potential that steers unconventional motion of superconducting vortices,thereby inducing a magnetic nonreciprocal effect,in contrast to the electric nonreciprocal effect commonly observed in superconducting diodes.Furthermore,the polarity of the magnetic nonreciprocity is in situ reversible through the tunable magnetic patterns of artificial spin ice.Our findings demonstrate that artificial spin ice not only precisely modulates superconducting characteristics but also opens the door to novel functionalities,offering a groundbreaking paradigm for superconducting electronics.
