Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to s...Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular functions.Cellular metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell death.Ferroptosis is a recently discovered form of iron-dependent programmed cell death.The inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor progression.However,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well understood.Here,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this process.Additionally,we provided a detailed overview of agents used to induce cancer ferroptosis.We explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell killing.The combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.展开更多
Glycosylation,a key mode of protein modification in living organisms,is critical in regulating various biological functions by influencing protein folding,transportation,and localization.Changes in glycosylation patte...Glycosylation,a key mode of protein modification in living organisms,is critical in regulating various biological functions by influencing protein folding,transportation,and localization.Changes in glycosylation patterns are a significant feature of cancer,are associated with a range of pathological activities in cancer-related processes,and serve as critical biomarkers providing new targets for cancer diagnosis and treatment.Glycoproteins like human epidermal growth factor receptor 2(HER2)for breast cancer,alpha-fetoprotein(AFP)for liver cancer,carcinoembryonic antigen(CEA)for colon cancer,and prostatespecific antigen(PSA)for prostate cancer are all tumor biomarkers approved for clinical use.Here,we introduce the diversity of glycosylation structures and newly discovered glycosylation substrate—glycosylated RNA(glycoRNA).This article focuses primarily on tumor metastasis,immune evasion,metabolic reprogramming,aberrant ferroptosis responses,and cellular senescence to illustrate the role of glycosylation in cancer.Additionally,we summarize the clinical applications of protein glycosylation in cancer diagnostics,treatment,and multidrug resistance.We envision a promising future for the clinical applications of protein glycosylation.展开更多
基金This work was sup-ported in part by grants from the following sources:the National Natural Science Foundation of China(82203233,82202966,82173142,82302987,82303534,and 81972636)the Natural Science Foundation of Hunan Province(2023JJ60469,2023JJ40413,2023JJ30372,2023JJ30375,2022JJ80078,and 2020JJ5336)+8 种基金the Research Project of Health Commission of Hunan Province(202203034978,202109031837,and 20201020)Key Research and Devel-opment Program of Hunan Province(2022SK2051)Hunan Provincial Science and Technology Department(2020TP1018)the Changsha Science and Technology Board(kh2201054)the Changsha Municipal Natural Science Foundation(kq2014209)Ascend Foundation of National Cancer Center(NCC201909B06)Hunan Cancer Hospital Climb Plan(ZX2020001-3 and YF2020002)the Science and Technology Innovation Program of Hunan Province(2023RC3199,2023SK4034 and 2023RC1073)by China Postdoctoral Science Foundation(2022TQ0104 and 2022M721118).
文摘Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular functions.Cellular metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell death.Ferroptosis is a recently discovered form of iron-dependent programmed cell death.The inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor progression.However,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well understood.Here,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this process.Additionally,we provided a detailed overview of agents used to induce cancer ferroptosis.We explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell killing.The combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.
基金supported in part by grants from the following sources:the National Natural Science Foundation of China(82472882,82302987,82303534,82203233,82202966,82173142)the Natural Science Foundation of Hunan Province(2024JJ4025,2023ZJ1122,Z2023086,2023JJ60469,2023JJ40413,2023JJ30372,2023JJ30375,2022JJ80078,2020JJ5336)+5 种基金Key Research and Development Program of Hunan Province(2022SK2051)Science and Technology Innovation Program of Hunan Province(2023RC3199,2023SK4034,2023RC1073)the Research Project of Health Commission of Hunan Province(R2023040,R2023093,202203034978,202202055318,202109031837,202109032010,20201020)the Changsha Science and Technology Board(kh2201054)Ascend Foundation of National cancer center(NCC201909B06)by Hunan Cancer Hospital Climb Plan(ZX2020001-3,YF2020002,2023NSFC-A001,2023NSFC-A002,2023NSFC-A004).
文摘Glycosylation,a key mode of protein modification in living organisms,is critical in regulating various biological functions by influencing protein folding,transportation,and localization.Changes in glycosylation patterns are a significant feature of cancer,are associated with a range of pathological activities in cancer-related processes,and serve as critical biomarkers providing new targets for cancer diagnosis and treatment.Glycoproteins like human epidermal growth factor receptor 2(HER2)for breast cancer,alpha-fetoprotein(AFP)for liver cancer,carcinoembryonic antigen(CEA)for colon cancer,and prostatespecific antigen(PSA)for prostate cancer are all tumor biomarkers approved for clinical use.Here,we introduce the diversity of glycosylation structures and newly discovered glycosylation substrate—glycosylated RNA(glycoRNA).This article focuses primarily on tumor metastasis,immune evasion,metabolic reprogramming,aberrant ferroptosis responses,and cellular senescence to illustrate the role of glycosylation in cancer.Additionally,we summarize the clinical applications of protein glycosylation in cancer diagnostics,treatment,and multidrug resistance.We envision a promising future for the clinical applications of protein glycosylation.
