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血清microRNA-21、microRNA-193a-3p表达与结直肠癌患者手术预后的关系
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作者 张丽 凌晨 沈轶骊 《中国现代医学杂志》 CAS 2024年第5期1-6,共6页
目的探究血清microRNA-21(miR-21)、microRNA-193a-3p(miR-193a-3p)水平与结直肠癌患者手术预后的关系。方法回顾性分析2020年1月—2022年1月苏州大学附属第一医院收治112例结直肠癌患者的病历资料。患者均接受结直肠癌根治术,术后随访1... 目的探究血清microRNA-21(miR-21)、microRNA-193a-3p(miR-193a-3p)水平与结直肠癌患者手术预后的关系。方法回顾性分析2020年1月—2022年1月苏州大学附属第一医院收治112例结直肠癌患者的病历资料。患者均接受结直肠癌根治术,术后随访16个月,记录患者的预后生存结局,多因素逐步Logistic回归分析结直肠癌患者手术预后的影响因素,评估血清miR-21、miR-193a-3p对结直肠癌患者预后的预测效能。结果112例结直肠癌患者死亡22例,病死率为19.64%;生存90例,生存率为80.36%。死亡组术前血清miR-21 mRNA相对表达量、临床分期Ⅲ期占比、淋巴结转移率均高于生存组(P<0.05),血清miR-193a-3p m RNA相对表达量低于生存组(P<0.05)。多因素逐步Logistic回归分析结果显示,临床分期Ⅲ期[OR=3.777(95%CI:1.399,10.194)]、淋巴结转移[OR=5.099(95%CI:1.715,15.156)]、miR-21表达升高[OR=4.889(95%CI:1.645,14.533)]、miR-193a-3p表达降低[OR=4.402(95%CI:1.481,13.084)]均是直肠癌患者预后的影响因素(P<0.05)。受试者工作特性曲线分析结果显示,血清miR-21、miR-193a-3p单一及联合预测结直肠癌预后的敏感性分别为69.04%(95%CI:0.487,0.813)、72.73%(95%CI:0.495,0.884)、86.36%(95%CI:0.640,0.964),特异性分别为62.22%(95%CI:0.513,0.720)、68.89%(95%CI:0.581,0.780)、90.00%(95%CI:0.814,0.950),曲线下面积分别为0.782、0.731和0.901。结论结直肠癌患者术前miR-21、miR-193a-3p表达与术后预后密切相关,且在结直肠癌患者的预后结局中表现出良好的预测效能。 展开更多
关键词 结直肠癌 手术 预后 MICRORNA-21 microRNA-193a-3p
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Effects of Chinese chestnut powder on starch digestion,texture properties,and staling characteristics of bread
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作者 Lei Wang Denghua Shi +2 位作者 Jie chen Huina Dong ling chen 《Grain & Oil Science and Technology》 CAS 2023年第2期82-90,共9页
Chestnut is a high nutritional value food that has been widely used as a tonic in traditional Chinese medicine.As an emerging functional food ingredient,Chinese chestnuts are rich in a range of bioactive nutrients suc... Chestnut is a high nutritional value food that has been widely used as a tonic in traditional Chinese medicine.As an emerging functional food ingredient,Chinese chestnuts are rich in a range of bioactive nutrients such as starch,dietary fiber,fat,protein,trace metal element and vitamins A,B,C,D and other nutrients.In our study,Chinese chestnut powder(CCP)were added into bread formulation at 2%-6%levels(based on flour weight)to produce fresh bread with enhanced anti-staling characteristics and starch digestion inhibitory ability.The texture properties,retrogradation enthalpy,water distribution,and estimated glycemic index(eGI)of wheat bread containing CCP as a functional additive were also investigated.The results showed that incorporation of CCP apparently affected bread texture,resulting in increased hardness,as well as decreased the specific volume of wheat bread.These influences were generally proportional to the amount of CCP used.It was found that adding too much CCP resulted in a dark red color,showing increased significantly higher total color difference(ΔE)and L values.Conversely,addition of CCP significantly reduced starch digestion rate and digestion extent in bread,and the reduction degree was positively related to the amount of CCP applied.The greatest reduction in eGI value from 79.40(control)to 75.02(6%CPP bread)was observed.Meanwhile,the content of resistant starch of 6%CPP bread was about 1.36 times higher than that of control bread.CCP also reduced crumb water loss and drove the water shift from the bound to the mobile state after stored for 7 days.The retrogradation enthalpy analyses further confirmed that CCP inhibited starch retrogradation and recrystallization.These results suggested that Chinese chestnut powder could be incorporated into fresh bread to provide health functions,such as lowering potential glycaemic response and improving anti-staling characteristics of bread. 展开更多
关键词 Chinese chestnut Bread quality Starch digestion Staling characteristics
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氧化苦参碱水凝胶通过激活角化细胞Nrf2/HO-1通路促进创面愈合
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作者 刘璐 刘淑丹 +5 位作者 刘晓丹 杨丽 凌晨 海小明 马会明 陈冬梅 《中国组织工程研究》 CAS 北大核心 2024年第29期4620-4627,共8页
背景:慢性创面炎症和氧化应激阻碍了角化细胞的再生,氧化苦参碱具有抗氧化、抗炎等多种生物活性,可能具有促进创面愈合的潜在效应。目的:探讨氧化苦参碱对创面愈合的作用,以及对H_(2)O_(2)诱导人角质形成细胞系HaCaT细胞氧化应激损伤的... 背景:慢性创面炎症和氧化应激阻碍了角化细胞的再生,氧化苦参碱具有抗氧化、抗炎等多种生物活性,可能具有促进创面愈合的潜在效应。目的:探讨氧化苦参碱对创面愈合的作用,以及对H_(2)O_(2)诱导人角质形成细胞系HaCaT细胞氧化应激损伤的保护作用。方法:①体内实验:分别制备含0,0.05,0.1,0.2 g/L氧化苦参碱的甲基丙烯酰化透明质酸(HAMA)水凝胶。在75只糖尿病小鼠背中部制作直径12 mm的全层皮肤缺损模型,随机分5组干预,每组15只:模型组创面包扎固定,单纯水凝胶组以HAMA水凝胶覆盖创面,低、中、高剂量氧化苦参碱组分别以含0.05,0.1,0.2 g/L氧化苦参碱的HAMA水凝胶覆盖创面,光固化后包扎固定,14 d内进行相关指标的检测。②体外实验:将人角质形成细胞系HaCaT分5组培养,正常组常规培养,H_(2)O_(2)组及低、中、高浓度氧化苦参碱组均加入H_(2)O_(2)干预4 h,然后分别更换为含0,0.05,0.1,0.2 g/L氧化苦参碱的培养基,培养24 h后进行相关指标的检测。结果与结论:①体内实验:与模型组比较,单纯水凝胶组小鼠创面愈合率无明显变化,低、中、高剂量氧化苦参碱组治疗后7,14 d的创面愈合率升高(P<0.05)。治疗后14 d的创面样本切片病理观察显示,与模型组相比,中、高剂量氧化苦参碱组再生表皮层厚度、显微血管数量与胶原沉积均增加(P<0.05)。术后7 d的创面样本Western blotting检测显示,与模型组相比,中、高剂量氧化苦参碱组肿瘤坏死因子α与白细胞介素6的蛋白表达降低(P<0.05)。②体外实验:CCK-8检测、EdU及Ki67染色显示,与H_(2)O_(2)组相比,中、高浓度氧化苦参碱组细胞增殖能力明显升高(P<0.05)。与H_(2)O_(2)组相比,中、高浓度氧化苦参碱组线粒体膜电位升高(P<0.05)、活性氧含量降低(P<0.05)。Western blotting检测显示,与H_(2)O_(2)组相比,高浓度氧化苦参碱组Nrf2核蛋白、Nrf2总蛋白、HO-1蛋白及超氧化物歧化酶1蛋白的表达增加(P<0.05)。③结果表明:氧化苦参碱能够通过上调Nrf2、HO-1蛋白减轻HaCat细胞的氧化应激损伤,加速创面愈合。 展开更多
关键词 氧化苦参碱 水凝胶 抗氧化 创面愈合 Nrf2/HO-1信号通路 HaCat细胞
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双边价值链关联:中国FDI和OFDI的作用差异分析
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作者 凌晨 王如雪 戴翔 《产经评论》 北大核心 2024年第1期145-160,共16页
长期以来,“引进来”是中国参与全球价值链的重要方式,而目前中国开放发展已从以往“引进来”为主转向“引进来”和“走出去”并重的新阶段。那么,从参与全球价值链角度看,二者作用究竟有何不同是理论研究中需要阐明的重要问题。在理论... 长期以来,“引进来”是中国参与全球价值链的重要方式,而目前中国开放发展已从以往“引进来”为主转向“引进来”和“走出去”并重的新阶段。那么,从参与全球价值链角度看,二者作用究竟有何不同是理论研究中需要阐明的重要问题。在理论分析基础上,测算1995—2018年中国与63个伙伴国之间的双边价值链关联程度指数,并采用双向固定效应模型进行实证分析。结果表明:(1)“引进来”和“走出去”均有助于提高价值链总体关联程度;(2)从关联方式看,“引进来”的价值链后向关联效应更加明显,“走出去”则价值链前向关联效应更明显;(3)机制分析发现,中间品贸易对形成双边价值链关联效应起到重要作用。因此,“引进来”和“走出去”并重有助于探寻形成更高水平开放新格局,更好地实现中国产业链供应链的“固链”和“强链”。 展开更多
关键词 利用外资 对外直接投资 双边价值链关联 全球价值链
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基于可解释机器学习的重症监护室脓毒症患者死亡风险预测
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作者 刘坤 凌晨 +2 位作者 史小强 周梦雨 徐乃岳 《软件工程》 2024年第3期15-20,共6页
为了有效预测重症监护室脓毒症患者的死亡风险并分析影响结局的因素,建立了脓毒症患者死亡风险预测模型,为脓毒症患者的早期预防和死亡风险控制提供科学的参考依据。本研究以重症监护医学信息市场数据库作为数据来源,从中挑选符合要求... 为了有效预测重症监护室脓毒症患者的死亡风险并分析影响结局的因素,建立了脓毒症患者死亡风险预测模型,为脓毒症患者的早期预防和死亡风险控制提供科学的参考依据。本研究以重症监护医学信息市场数据库作为数据来源,从中挑选符合要求的病患,使用贝叶斯网络模型训练相关特征预测脓毒症患者的死亡风险。纳入2 352例脓毒症患者,以患者是否死亡作为最终结局建立模型,模型的风险预测准确率为78.7%,优于逻辑回归模型(72.3%)和决策树模型(71.0%)。贝叶斯网络模型相较于其他模型具有更高的信服力,能够准确预测脓毒症患者的死亡风险,模型的可解释性能够辅助医护人员进行临床决策,同时能够更加合理、科学地分配医疗资源。 展开更多
关键词 脓毒症 贝叶斯网络 重症监护室 死亡预测
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Quantifying peripapillary vessel density and retinal nerve fibre layer in type 1 diabetic children without clinically detectable retinopathy using OCTA
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作者 ling chen Yun Feng +2 位作者 Sha-Sha Zhang Yan-Fang Liu Ping Lin 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第2期278-281,共4页
AIM:To quantify changes in radial peripapillary capillary vessel density(ppVD)and the peripapillary retinal nerve fiber layer(pRNFL)in children with type 1 diabetes without clinical diabetic retinopathy by optical coh... AIM:To quantify changes in radial peripapillary capillary vessel density(ppVD)and the peripapillary retinal nerve fiber layer(pRNFL)in children with type 1 diabetes without clinical diabetic retinopathy by optical coherence tomography angiography(OCTA),providing a basis for early retinopathy in children with type 1 diabetes.METHODS:This was a retrospective study.A total of 30 patients(3–14y)with type 1 diabetes without clinical diabetic retinopathy(NDR group)were included.A total of 30 age-matched healthy subjects were included as the normal control group(CON group).The HbA1c level in the last 3mo was measured once in the NDR group.The pRNFL thickness and ppVD were automatically measured,and the mean pRNFL and ppVD were calculated in the nasal,inferior,temporal,and superior quadrants.The changes in ppVD and pRNFL in the two groups were analyzed.RESULTS:Compared with CON group,the nasal and superior ppVDs decreased in the NDR group(all P<0.01).The thickness of the nasal pRNFL decreased significantly(P<0.01),while the inferior,temporal and superior pRNFLs slightly decreased but not significant in the NDR group(all P>0.05).Person and Spearman correlation analysis of ppVD and pRNFL thickness in each quadrant of the NDR group showed a positive correlation between nasal and superior(all P<0.01),while inferior and temporal had no significant correlation(all P>0.05).There was no significant correlation between the HbA1c level and ppVD and pRNFL in any quadrant(all P>0.05).There was no significant correlation between the course of diabetes mellitus and ppVD and pRNFL in any quadrant(all P>0.05).CONCLUSION:ppVD and pRNFL decrease in eyes of children with type 1 diabetes before clinically detectable retinopathy and OCTA is helpful for early monitoring. 展开更多
关键词 diabetic retinopathy CHILDREN peripapillary vessel density peripapillary retinal nerve fiber layer optical coherence tomography angiography
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Evaluation of the efficacy and safety of endoscopic band ligation in the treatment of bleeding from mild to moderate gastric varices type 1
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作者 Yue Deng Ya Jiang +4 位作者 Tong Jiang ling chen Hai-Jun Mou Bi-Guang Tuo Guo-Qing Shi 《World Journal of Gastroenterology》 SCIE CAS 2024年第5期440-449,共10页
BACKGROUND According to practice guidelines,endoscopic band ligation(EBL)and endoscopic tissue adhesive injection(TAI)are recommended for treating bleeding from esophagogastric varices.However,EBL and TAI are known to... BACKGROUND According to practice guidelines,endoscopic band ligation(EBL)and endoscopic tissue adhesive injection(TAI)are recommended for treating bleeding from esophagogastric varices.However,EBL and TAI are known to cause serious complications,such as hemorrhage from dislodged ligature rings caused by EBL and hemorrhage from operation-related ulcers resulting from TAI.However,the optimal therapy for mild to moderate type 1 gastric variceal hemorrhage(GOV1)has not been determined.Therefore,the aim of this study was to discover an individualized treatment for mild to moderate GOV1.AIM To compare the efficacy,safety and costs of EBL and TAI for the treatment of mild and moderate GOV1.METHODS A clinical analysis of the data retrieved from patients with mild or moderate GOV1 gastric varices who were treated under endoscopy was also conducted.Patients were allocated to an EBL group or an endoscopic TAI group.The differences in the incidence of varicose relief,operative time,operation success rate,mortality rate within 6 wk,rebleeding rate,6-wk operation-related ulcer healing rate,complication rate and average operation cost were compared between the two groups of patients.RESULTS The total effective rate of the two treatments was similar,but the efficacy of EBL(66.7%)was markedly better than that of TAI(39.2%)(P<0.05).The operation success rate in both groups was 100%,and the 6-wk mortality rate in both groups was 0%.The average operative time(26 min)in the EBL group was significantly shorter than that in the TAI group(46 min)(P<0.01).The rate of delayed postoperative rebleeding in the EBL group was significantly lower than that in the TAI group(11.8%vs 45.1%)(P<0.01).At 6 wk after the operation,the healing rate of operation-related ulcers in the EBL group was 80.4%,which was significantly greater than that in the TAI group(35.3%)(P<0.01).The incidence of postoperative complications in the two groups was similar.The average cost and other related economic factors were greater for the EBL than for the TAI(P<0.01).CONCLUSION For mild to moderate GOV1,patients with EBL had a greater one-time varix eradication rate,a greater 6-wk operation-related ulcer healing rate,a lower delayed rebleeding rate and a lower cost than patients with TAI. 展开更多
关键词 Gastric varices Type 1 gastric variceal hemorrhage Endoscopic band ligation Tissue adhesive injection
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350MW级压缩空气储能系统配气方式优化研究
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作者 凌晨 吴斌 +5 位作者 朱学成 陶刚 袁兵 李季 李睿 姜小峰 《汽轮机技术》 北大核心 2024年第1期9-12,17,共5页
建立了350MW级先进压缩空气储能系统膨胀侧核心设备的数学模型,基于EBSILON热力学仿真软件仿真计算了不同膨胀机配气方式对压缩空气储能系统热力性能的影响趋势。计算结果表明:采用“节流+补气”配气方式时,压缩空气储能系统整体运行经... 建立了350MW级先进压缩空气储能系统膨胀侧核心设备的数学模型,基于EBSILON热力学仿真软件仿真计算了不同膨胀机配气方式对压缩空气储能系统热力性能的影响趋势。计算结果表明:采用“节流+补气”配气方式时,压缩空气储能系统整体运行经济性更高,且储气库压力波动范围越大,经济性优势越明显,应对电网调峰调频指令的负荷响应能力更好。 展开更多
关键词 压缩空气储能 节流配气 补气阀 空气透平
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秦腔服饰中的视觉元素在游戏角色设计中的应用
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作者 凌晨 陈彬 《染整技术》 CAS 2024年第3期92-94,共3页
秦腔服饰丰富多彩,装饰复杂,具有深厚的文化内涵。在游戏角色设计中融入秦腔服饰中的视觉元素,可以丰富角色设计,有效传承和弘扬秦腔文化。对秦腔服饰中的视觉元素进行分析,对其在游戏角色设计中的应用进行探讨,可以为秦腔文化的继承和... 秦腔服饰丰富多彩,装饰复杂,具有深厚的文化内涵。在游戏角色设计中融入秦腔服饰中的视觉元素,可以丰富角色设计,有效传承和弘扬秦腔文化。对秦腔服饰中的视觉元素进行分析,对其在游戏角色设计中的应用进行探讨,可以为秦腔文化的继承和发展提供有益启示。 展开更多
关键词 秦腔 服饰 游戏角色
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近红外光谱技术快速检测清香型白酒大曲指标的研究
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作者 凌晨 耿超 +4 位作者 马清蓉 许迎子 李素琴 高晓娟 彭福东 《酿酒》 CAS 2024年第3期74-78,共5页
为实现清香型白酒大曲理化指标的快速检测,结合清香型白酒大曲制作工艺和相关大曲检测标准的要求,运用近红外光谱技术,建立了清香型白酒大曲水分、糖化力和液化力的快速检测模型。结果表明:通过筛选不同光谱预处理方法和波数范围,运用... 为实现清香型白酒大曲理化指标的快速检测,结合清香型白酒大曲制作工艺和相关大曲检测标准的要求,运用近红外光谱技术,建立了清香型白酒大曲水分、糖化力和液化力的快速检测模型。结果表明:通过筛选不同光谱预处理方法和波数范围,运用偏最小二乘法(PLS)建立模型,使用内部交叉验证得到最优模型,各理化指标模型的相关系数(R2)值大于0.75线性良好,交叉验证均方根(RMSECV)预测误差较小。使用盲样对大曲各指标的模型进行外部验证,水分、糖化力和液化力的相对标准偏差分别为3.61%、5.07%和5.84%,符合生产检测的需求,可运用于清香型白酒大曲的日常检测分析。 展开更多
关键词 清香型白酒大曲 近红外光谱技术 水分 糖化力 液化力 模型预测
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近红外光谱技术在清香型酒醅检测中的应用研究
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作者 凌晨 马清蓉 +5 位作者 耿超 许迎子 赵汉鹰 赵璇 李素琴 高晓娟 《酿酒》 CAS 2024年第2期100-106,共7页
为实现清香型酒醅理化指标的快速检测,结合清香型白酒酿造工艺同时运用近红外光谱技术,建立了入缸酒醅水分、淀粉和发酵酒醅水分、酸度、酒度、淀粉指标的快速检测模型。结果表明:通过使用不同光谱预处理方法和波数范围建立模型,使用内... 为实现清香型酒醅理化指标的快速检测,结合清香型白酒酿造工艺同时运用近红外光谱技术,建立了入缸酒醅水分、淀粉和发酵酒醅水分、酸度、酒度、淀粉指标的快速检测模型。结果表明:通过使用不同光谱预处理方法和波数范围建立模型,使用内部交叉验证得到最优模型,各理化指标模型的相关系数(R^(2))值大于0.7线性良好,交叉验证均方根(RMSECV)小于1.15预测误差较小。使用盲样对各指标的模型进行外部验证,结果的相对标准偏差均在10%以内,符合生产检测的需求,可运用于酒醅的日常检测分析。 展开更多
关键词 清香型酒醅 近红外光谱技术 理化指标 模型预测
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基于知识图谱的国防科技成果管理研究
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作者 凌晨 杨伟铭 李宏建 《科学与信息化》 2024年第3期74-76,共3页
随着国防科技成果可供用户利用数据的多元化、异构化、海量化,以及其跨学科、跨领域特征的日益明显,传统的检索方法已达不到用户对于国防科技成果信息获取的精准化和智能化需求。本文分析了国防科技报告的特点,阐述分步构建国防科技成... 随着国防科技成果可供用户利用数据的多元化、异构化、海量化,以及其跨学科、跨领域特征的日益明显,传统的检索方法已达不到用户对于国防科技成果信息获取的精准化和智能化需求。本文分析了国防科技报告的特点,阐述分步构建国防科技成果知识图谱及其关键技术使用,依据“本体构建七步法”理论,构建知识突破模式体系,实现国防科技成果的高效查询和检索,为用户提供更精准、快捷的科技成果管理服务。 展开更多
关键词 知识图谱 国防科研报告 成果管理 智能应用
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A Corpus-Based Comparative Multidimensional Analysis of the Two English Translations of Luoyang Jialan Ji
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作者 Qin Gu ling chen 《Open Journal of Applied Sciences》 2024年第4期1150-1163,共14页
By using the MD approach, this study aims at making a comparison between the lexical features in W. J. F. Jenner’s and Wang Yitong’s translations of Luoyang Jialan Ji (547 AD) from a multidimensional perspective. St... By using the MD approach, this study aims at making a comparison between the lexical features in W. J. F. Jenner’s and Wang Yitong’s translations of Luoyang Jialan Ji (547 AD) from a multidimensional perspective. Statistics show that both the two translations belong to the General Narrative Exposition Register. However, there are significant discrepancies between the two versions in Dimension 1 “Involved versus Informational Production”, Dimension 4 “Overt Expression of Persuasion” and Dimension 5 “Abstract versus Non-Abstract Information”. The differences in Dimension 2 “Narrative versus Non-Narrative Concerns” and Dimension 3 “Explicit versus Situation-Dependent Reference” are not that significant. It is found that in Dimension 1, the information density of Wang’s version is much higher than that of Jenner’s. In Dimension 4, Wang’s version contains more overt persuasive effort than Jenner’s. In Dimension 5, the positive and negative contrast between the two versions indicates that Wang’s version provides information in a more abstract way, whereas Jenner’s in a relatively non-abstract way. Combined with typical examples in the two translation versions, this study is hoped to help better understand the translations of Luoyang Jialan Ji and conduct future studies on the translation styles of the two translators. 展开更多
关键词 Luoyang Jialan Ji Multidimensional (MD) Approach W. J. F. Jenner Wang Yitong
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政府间规范秩序:一个扩展的政策过程理论 被引量:1
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作者 陈玲 孙晋 《公共行政评论》 北大核心 2023年第1期144-160,199,200,共19页
论文通过分析碳排放权交易计划政策过程中的国际、国内和地方政府互动,提出了政府间规范秩序(Trans-governmental Normative Orders,TNO)理论和共识治理模型。TNO理论揭示了全球治理背景下中国政策过程的新特征,即将政策目标背后的价值... 论文通过分析碳排放权交易计划政策过程中的国际、国内和地方政府互动,提出了政府间规范秩序(Trans-governmental Normative Orders,TNO)理论和共识治理模型。TNO理论揭示了全球治理背景下中国政策过程的新特征,即将政策目标背后的价值理念和规范作为共识目标,将复合治理机制作为共识机制,将多重规范性秩序作为共识体系。基于对地方和全国两级碳市场试点计划的详细考察,论文总结了共识治理模型三个层面的演进与发展:(1)共识目标从国内改革攻坚演进为统筹全球治理和本国治理秩序;(2)在共识机制层面发展出动员-赋权、试验-反馈、推广-扩散等多类型的政策创新机制;(3)在共识体系层面,以制度建设规范来兼容政策方案多样性、以国家治理规范来调适政策目标多元性、以社会治理规范来消纳政策风险不确定性,最终推动形成国际国内间、央地政府间以及政府与市场间的规范性秩序体系。 展开更多
关键词 政策过程 共识决策 中央与地方关系 政府间规范秩序
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硬膜外腔单次注射吗啡联合地佐辛静脉自控镇痛对腹腔镜结直肠癌根治术患者围手术期镇痛及免疫因子的影响
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作者 凌晨 魏君 +6 位作者 刘幸清 邱磊 胡旭东 文先杰 杜小丽 池鸿熙 梁肖霞 《中国现代医生》 2023年第16期95-98,103,共5页
目的探讨硬膜外腔单次注射吗啡联合地佐辛静脉自控镇痛对腹腔镜结直肠癌根治术患者围手术期镇痛及免疫因子白细胞介素-4(interleukin-4,IL-4)和γ干扰素(interferon-γ,IFN-γ)的影响。方法选取2021年1月至2022年3月于佛山市第二人民医... 目的探讨硬膜外腔单次注射吗啡联合地佐辛静脉自控镇痛对腹腔镜结直肠癌根治术患者围手术期镇痛及免疫因子白细胞介素-4(interleukin-4,IL-4)和γ干扰素(interferon-γ,IFN-γ)的影响。方法选取2021年1月至2022年3月于佛山市第二人民医院择期行腹腔镜结直肠癌根治术的患者60例,根据随机数字表法将患者分为吗啡组、地佐辛组和联合组,每组各20例。吗啡组患者术毕前30min硬膜外腔单次注射吗啡1.5mg,术后使用硬膜外自控镇痛(吗啡4mg+罗哌卡因300mg+生理盐水100ml);地佐辛组患者术毕前30min静脉注射地佐辛5mg,术后使用静脉自控镇痛(地佐辛0.5mg/kg+生理盐水100ml);联合组患者术毕前30min硬膜外腔单次注射吗啡1.5mg,静脉注射地佐辛5mg,术后使用静脉自控镇痛(地佐辛0.5mg/kg+生理盐水100ml)。评估三组患者术后6h、12h、24h、48h的疼痛视觉模拟评分法(visual analoguescale,VAS)评分,记录不良反应发生情况,比较麻醉前(T_(0))、术毕(T_(1))、术后1d(T_(2))、术后3d(T_(3))的血清IL-4、IFN-γ水平。结果术后6h、12h、24h,联合组和吗啡组患者的VAS评分均显著低于地佐辛组(P<0.05);三组患者的不良反应发生情况比较,差异均无统计学意义(P>0.05);随着时间的推移,三组患者的血清IL-4呈下降趋势,IFN-γ呈上升趋势。T_(2)、T_(3)时点,联合组患者的血清IL-4水平均显著低于吗啡组和地佐辛组(P<0.05);T_(2)时点,联合组患者的血清IFN-γ水平显著高于地佐辛组(P<0.05),T_(3)时点,联合组患者的血清IFN-γ水平显著高于吗啡组和地佐辛组(P<0.05)。结论硬膜外腔单次注射吗啡联合地佐辛静脉自控镇痛对腹腔镜结直肠癌根治术患者具有良好的术后镇痛效果,并可改善患者术后免疫抑制状态。 展开更多
关键词 吗啡 地佐辛 结直肠癌 镇痛 白细胞介素-4 γ干扰素
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Evaluating the impact of sampling schemes on leaf area index measurements from digital hemispherical photography in Larix principis-rupprechtii forest plots
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作者 Jie Zou Wei Hou +5 位作者 ling chen Qianfeng Wang Peihong Zhong Yong Zuo Shezhou Luo Peng Leng 《Forest Ecosystems》 SCIE CSCD 2020年第4期686-703,共18页
Background:Digital hemispherical photography(DHP)is widely used to estimate the leaf area index(LAI)of forest plots due to its advantages of high efficiency and low cost.A crucial step in the LAI estimation of forest ... Background:Digital hemispherical photography(DHP)is widely used to estimate the leaf area index(LAI)of forest plots due to its advantages of high efficiency and low cost.A crucial step in the LAI estimation of forest plots via DHP is choosing a sampling scheme.However,various sampling schemes involving DHP have been used for the LAI estimation of forest plots.To date,the impact of sampling schemes on LAI estimation from DHP has not been comprehensively investigated.Methods:In this study,13 commonly used sampling schemes which belong to five sampling types(i.e.dispersed,square,cross,transect and circle)were adopted in the LAI estimation of five Larix principis-rupprechtii plots(25m×25 m).An additional sampling scheme(with a sample size of 89)was generated on the basis of all the sample points of the 13 sampling schemes.Three typical inversion models and four canopy element clumping index(Ωe)algorithms were involved in the LAI estimation.The impacts of the sampling schemes on four variables,including gap fraction,Ωe,effective plant area index(PAIe)and LAI estimation from DHP were analysed.The LAI estimates obtained with different sampling schemes were then compared with those obtained from litter collection measurements.Results:Large differences were observed for all four variable estimates(i.e.gap fraction,Ωe,PAIe and LAI)under different sampling schemes.The differences in impact of sampling schemes on LAI estimation were not obvious for the three inversion models,if the fourΩe algorithms,except for the traditional gap-size analysis algorithm were adopted in the estimation.The accuracy of LAI estimation was not always improved with an increase in sample size.Moreover,results indicated that with the appropriate inversion model,Ωe algorithm and sampling scheme,the maximum estimation error of DHP-estimated LAI at elementary sampling unit can be less than 20%,which is required by the global climate observing system,except in forest plots with extremely large LAI values(~>6.0).However,obtaining an LAI from DHP with an estimation error lower than 5%is impossible regardless of which combination of inversion model,Ωe algorithm and sampling scheme is used.Conclusion:The LAI estimation of L.principis-rupprechtii forests from DHP was largely affected by the sampling schemes adopted in the estimation.Thus,the sampling scheme should be seriously considered in the LAI estimation.One square and two transect sampling schemes(with sample sizes ranging from 3 to 9)were recommended to be used to estimate the LAI of L.principis-rupprechtii forests with the smallest mean relative error(MRE).By contrast,three cross and one dispersed sampling schemes were identified to provide LAI estimates with relatively large MREs. 展开更多
关键词 Sampling scheme Elementary sampling unit Clumping index Leaf area index Digital hemispherical photography FOREST LARIX
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Effects of Dachengqi Decoctions Made from Different Processed Products of Rhubarb on ABP Mice
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作者 Chunli TANG Jiangcun WEI +6 位作者 Xiumei MA Guangli LU Dongmei HUANG Sen LIANG ling chen Ying YANG Bihua NONG 《Medicinal Plant》 CAS 2021年第1期83-86,共4页
[Objectives]This study aims to investigate the effects of Dachengqi decoctions made from different processed products of rhubarb on water intake,defecation amount,urination amount,urination volume,dryness of stool,men... [Objectives]This study aims to investigate the effects of Dachengqi decoctions made from different processed products of rhubarb on water intake,defecation amount,urination amount,urination volume,dryness of stool,mental state and activity of ABP mice.[Methods]Total 165 mice were randomly divided into Dachengqi decoction groups(made from different processed products of rhubarb,6 and 10 g/kg),positive control group,blank control group and model group.The administration dosage was 20 mL/kg.With the metabolic cage integral method,the effects of Dachengqi decoctions made from different processed products of rhubarb on the water intake,defecation amount,urination volume,dryness of stool,mental state and activity of ABP mice were compared.[Results]Dachengqi decoctions all could soften stool and promote rapid defecation of the mice with fecal peritonitis of excess heat stagnation type except that made from carbonized rhubarb.The water intakes of all the Dachengqi decoction groups were higher than those of the positive control group and the model group,except the carbonized rhubarb-made Dachengqi decoction groups.[Conclusions]Dachengqi decoctions all have obvious purgative effect except those made from carbonized rhubarb. 展开更多
关键词 RHUBARB Dachengqi decoction Processed product Fecal peritonitis
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腹部推拿对新生缺氧缺血性脑损伤大鼠学习记忆功能及PKA/CREB/BDNF信号通路的影响 被引量:1
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作者 王伟 艾坤 +4 位作者 易细芹 陈楚淘 凌晨 黄玉梅 王德军 《中医药学报》 CAS 2023年第1期20-24,共5页
目的:探讨腹部推拿对新生缺氧缺血模型大鼠学习记忆功能的影响及可能的分子机制。方法:将7 d龄SD新生大鼠42只随机分成空白组、模型组和腹部推拿组,排除死亡大鼠,每组12只。腹部推拿组在造模后24 h给予腹部推拿,连续干预28 d。各组大鼠... 目的:探讨腹部推拿对新生缺氧缺血模型大鼠学习记忆功能的影响及可能的分子机制。方法:将7 d龄SD新生大鼠42只随机分成空白组、模型组和腹部推拿组,排除死亡大鼠,每组12只。腹部推拿组在造模后24 h给予腹部推拿,连续干预28 d。各组大鼠于造模后第29天进行6 d水迷宫试验,干预结束后,电镜检测海马神经元结构变化情况,WB检测海马组织蛋白激酶A(PKA)、反应元件结合蛋白(CREB)、神经营养因子(BDNF)、突触蛋白1(syn1)表达量。结果:透射电镜下空白组海马神经元细胞核及线粒体结构完整,形态正常;模型组海马神经元水肿、变性,核周空泡增多;腹部推拿组神经元细胞有轻微水肿,核形态较为规整。干预结束后,与空白组相比,模型组水迷宫穿越平台次数显著减少(P<0.01);模型组海马PKA、CREB、BDNF、syn1蛋白表达显著降低(P<0.05);与模型组相比,腹部推拿组水迷宫试验穿越平台次数显著增加(P<0.01),腹部推拿组PKA、CREB、BDNF、syn1表达显著上调(P<0.05)。结论:腹部推拿对新生缺氧缺血性大鼠的学习记忆功能具有改善作用,可能是通过调节PKA/CREB/BDNF信号通路发挥神经康复作用。 展开更多
关键词 推拿 脑损伤 蛋白激酶A 脑神经营养因子
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In-situ pressure-preserved coring for deep exploration:Insight into the rotation behavior of the valve cover of a pressure controller 被引量:1
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作者 Da Guo He-Ping Xie +9 位作者 ling chen Zhong-Ya Zhou He-Ping Lu Lin Dai Ding-Ming Wang Tian-Yu Wang Ju Li Zhi-Qiang He Yun-Qi Hu Ming-Zhong Gao 《Petroleum Science》 SCIE EI CAS CSCD 2023年第4期2386-2398,共13页
In-situ pressure-preserved coring(IPP-Coring)is considered to be the most reliable and efficient method for the identification of the scale of oil and gas resources.During IPP-Coring,because the rotation behavior of t... In-situ pressure-preserved coring(IPP-Coring)is considered to be the most reliable and efficient method for the identification of the scale of oil and gas resources.During IPP-Coring,because the rotation behavior of the pressure controller valve cover in different medium environments is unclear,interference between the valve cover and inner pipe may occur and negatively affect the IPP-Coring success rate.To address this issue,we conducted a series of indoor experiments employing a high-speed camera to gain greater insights into the valve cover rotation behavior in different medium environments,e.g.,air,water,and simulated drilling fluids.The results indicated that the variation in the valve cover rotation angle in the air and fluid environments can be described by a one-phase exponential decay function with a constant time parameter and by biphasic dose response function,respectively.The rotation behavior in the fluid environments exhibited distinct elastic and gravitational acceleration zones.In the fluid environments,the density clearly impacted the valve cover closing time and rotation behavior,whereas the effect of viscosity was very slight.This can be attributed to the negligible influence of the fluid viscosity on the drag coefficient found in this study;meanwhile,the density can increase the buoyancy and the time period during which the valve cover experienced a high drag coefficient.Considering these results,control schemes for the valve cover rotation behavior during IPP-Coring were proposed for different layers and geological conditions in which the different drilling fluids should be used,e.g.,the use of a high-density valve cover in high-pore pressure layers. 展开更多
关键词 In-situ coring Pressure coring Pressure controller Rotation behavior Drilling fluid
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神经源性膀胱患者使用自我管理微信小程序体验的质性研究 被引量:1
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作者 赵春 梁素瑞 +6 位作者 王小姣 高灵红 赖钰虹 黄英 李珏 陈玲 蔡文智 《International Journal of Nursing Sciences》 CSCD 2023年第1期89-96,共8页
目的了解神经源性膀胱患者使用自我管理微信小程序的感知好处,并识别阻碍其使用的关键因素。方法采用质性研究设计,通过目的抽样选取深圳市2所三级甲等医院康复科住院并试用自我管理微信小程序2周的19例神经源性膀胱患者进行半结构化访... 目的了解神经源性膀胱患者使用自我管理微信小程序的感知好处,并识别阻碍其使用的关键因素。方法采用质性研究设计,通过目的抽样选取深圳市2所三级甲等医院康复科住院并试用自我管理微信小程序2周的19例神经源性膀胱患者进行半结构化访谈,运用内容分析法进行资料分析。结果患者认为该自我管理程序是有帮助的,同时存在使用的障碍因素。3个感知益处包括:方便、灵活、直观;促进患者自我管理;为照护者和家庭成员提供指导。阻碍患者使用该程序的障碍因素包括:患者消极的膀胱自我管理态度和患者特征;对移动医疗风险的担忧;小程序升级的必要性。结论神经源性膀胱患者使用微信小程序进行自我管理是可行的,可以满足患者在住院期间和出院后获取信息的需求。研究发现的自我管理程序使用促进和障碍因素,为医疗机构实施移动医疗干预措施促进神经源性膀胱患者的自我管理提供了有价值的信息。 展开更多
关键词 移动医疗 神经源性膀胱 质性研究 自我管理 微信小程序
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