<strong>Objective:</strong> To detect the positive rate of MyD88 l265p mutation in DLBCL patients, and analyze the correlation between MYD88 L265p mutation and DLBCL prognosis. <strong>Methods:</s...<strong>Objective:</strong> To detect the positive rate of MyD88 l265p mutation in DLBCL patients, and analyze the correlation between MYD88 L265p mutation and DLBCL prognosis. <strong>Methods:</strong> In this study, 40 formalin fixed paraffin embedded tissue samples were collected from the pathology department of the Fourth Affiliated Hospital and the First Affiliated Hospital of Anhui Medical University from January 2017 to December 2019. The relationship between MYD88 L265p gene mutation and clinicopathological parameters of DLBCL, such as age, gender, Ann Arbor stage, site, B symptom, NCCN-IPI and IPI score, ECOG PS score, serum ferritin, <em>β</em>2-microglobulin and LDH levels were analyzed. <strong>Results:</strong> The positive rate of MYD88 L265p was 20% (8/40), 25.0% (6/24) in non GCB and 12.5% (2/16) in GCB. There were no significant differences in age, gender, location, extranodal invasion site, <em>β</em>2-microglobulin, serum ferritin and LDH between wild-type and mutant type of MYD88 gene, but had statistical significance with Han’s classification. MYD88 L265p gene mutation was associated with Ann Arbor stage, NCCN-IPI score and IPI score. <strong>Conclusion:</strong> MYD88 L265P mutation is closely related to the occurrence, development and prognosis of DLBCL. It is an adverse prognostic factor of DLBCL and may be used for the prognosis evaluation of DLBCL.展开更多
Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Intern...Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Internet addiction disorder. We found that individuals with Internet addiction disorder exhibited significantly longer P300 latencies than controls (N2: P = 0.035; P3a: P = 0.031; P3b: P = 0.043) and similar P300 amplitudes compared to control participants. After 3 months of cognitive behavioral therapy, P300 latencies decreased significantly in the P3a and P3b (P3a: P = 0.045; P3b: P = 0.062). These results suggest that deficits in cognitive function may be involved in Internet addiction disorder, and that clinical psychological treatment may be effective.展开更多
Ring-opening polymerization of trimethylene carbonate (TMC) with a rare earth calixarene compound as catalysthas been studied for the first time. The effect of TMC/Nd (molar ratio) and polymerization conditions were i...Ring-opening polymerization of trimethylene carbonate (TMC) with a rare earth calixarene compound as catalysthas been studied for the first time. The effect of TMC/Nd (molar ratio) and polymerization conditions were investigated indetail. It was found that calix[8]arene-neodymium is a highly effective catalyst for the bulk polymerization of TMC and giveshigh molecular weight (M_v = 60,000) polymer. The optimum conditions of TMC polymerization were found to be asfollows:TMC/Nd (molar ratio) = 2,000, 80℃, 16 h. The polymers were characterized by NMR, GPC and DSC. Studying themechanism by NMR showed that the polymerization of TMC catalyzed by calix[8]arene-neodymium proceeds via a cationicmechanism.展开更多
Background:Prosocial crowdfunding helps the underprivileged obtain non-profitseeking loans from multitudinous lenders.Some platforms introduce teamcompetition to motivate member participation and may thus induce team ...Background:Prosocial crowdfunding helps the underprivileged obtain non-profitseeking loans from multitudinous lenders.Some platforms introduce teamcompetition to motivate member participation and may thus induce team rivalry.Methods:We investigate how team rivalry affects lending decisions using data fromKiva.org.We argue that a rivalry relationship may engage teams to compete directlyagainst rivals by lending to the same project or prevent them from doing sobecause they intend not to cooperate.Result:We find that a team is less likely to lend to a project that has receivedfunding from its rival team,suggesting that rival teams tend to avoid cooperation.Conclusions:We discuss the implications of our findings for crowdfundingand competition-based motivation mechanisms in general.展开更多
Herein, the influence of the concentration design and comprehensive performance of the sulfate-phosphoric mixed acid system electrolyte is investigated to realize an electrolyte that maintains high energy density and ...Herein, the influence of the concentration design and comprehensive performance of the sulfate-phosphoric mixed acid system electrolyte is investigated to realize an electrolyte that maintains high energy density and stable operation at high temperatures. Static stability tests have shown that VOPO4 precipitation occurs only with vanadium(V) electrolyte. The concentration of vanadium ion of 2.0–2.2 mol·L^(–1), phosphoric acid of 0.10–0.15 mol·L^(–1), and sulfuric acid of 2.5–3.0 mol·L^(–1) are suitable for a vanadium redox flow battery in the temperature range from –20 to 50 ℃. The equations for predicting the viscosity and conductivity of electrolytes are obtained by the response surface method. The optimized electrolyte overcomes precipitation generation. It has 2.8 times higher energy density than the non-phosphate electrolyte, and a coulomb efficiency of 94.0% at 50 ℃. The sulfate-phosphoric mixed acid system electrolyte promotes the electrode reaction process, increases the current density, and reduces the resistance. This work systematically optimizes the concentrations of composition of positive and negative vanadium electrolytes with mixed sulfate-phosphoric acid. It provides a basis for the different valence states and comprehensive properties of sulfate-phosphoric mixed acid system vanadium electrolytes under extreme environments, guiding engineering applications.展开更多
The vanadium redox flow battery with a safe and capacity-controllable large-scale energy storage system offers a new method for the sustainability.In this case,acetic acid,methane sulfonic acid,sulfonic acid,amino met...The vanadium redox flow battery with a safe and capacity-controllable large-scale energy storage system offers a new method for the sustainability.In this case,acetic acid,methane sulfonic acid,sulfonic acid,amino methane sulfonic acid,and taurine are used to overcome the low electrolyte energy density and stability limitations,as well as to investigate the effects of various organic functional groups on the vanadium redox flow battery.When compared to the pristine electrolyte(0.22 Ah,5.0 Wh·L^(−1),85.0%),the results show that taurine has the advantage of maintaining vanadium ion concentrations,discharge capacity(1.43 Ah),energy density(33.9 Wh·L^(−1)),and energy efficiency(90.5%)even after several cycles.The acetic acid electrolyte is more conducive to the low-temperature stability of the V(II)electrolyte(177 h at−25℃)than pristine(82 h at−2℃).The−SO_(3)H group,specifically the coaction of the−NH_(2)and−SO_(3)H groups,improves electrolyte stability.The−NH_(2)and−COOH additive groups improved conductivity and electrochemical activity.展开更多
Dear Editor,Acute Myeloid Leukemia(AML)patients are often found ineligible for aggressive standard chemotherapy in clinic because of old age and poor conditions.Current evidences suggest that targeted combination ther...Dear Editor,Acute Myeloid Leukemia(AML)patients are often found ineligible for aggressive standard chemotherapy in clinic because of old age and poor conditions.Current evidences suggest that targeted combination therapy might help these patients achieve a higher response rate with acceptable adverse events(AEs).^(1)Venetoclax(VEN),a selective small-molecule BCL2 inhibitor,combined with hypomethylating agent(HMA),such as azacytidine(AZA).展开更多
文摘<strong>Objective:</strong> To detect the positive rate of MyD88 l265p mutation in DLBCL patients, and analyze the correlation between MYD88 L265p mutation and DLBCL prognosis. <strong>Methods:</strong> In this study, 40 formalin fixed paraffin embedded tissue samples were collected from the pathology department of the Fourth Affiliated Hospital and the First Affiliated Hospital of Anhui Medical University from January 2017 to December 2019. The relationship between MYD88 L265p gene mutation and clinicopathological parameters of DLBCL, such as age, gender, Ann Arbor stage, site, B symptom, NCCN-IPI and IPI score, ECOG PS score, serum ferritin, <em>β</em>2-microglobulin and LDH levels were analyzed. <strong>Results:</strong> The positive rate of MYD88 L265p was 20% (8/40), 25.0% (6/24) in non GCB and 12.5% (2/16) in GCB. There were no significant differences in age, gender, location, extranodal invasion site, <em>β</em>2-microglobulin, serum ferritin and LDH between wild-type and mutant type of MYD88 gene, but had statistical significance with Han’s classification. MYD88 L265p gene mutation was associated with Ann Arbor stage, NCCN-IPI score and IPI score. <strong>Conclusion:</strong> MYD88 L265P mutation is closely related to the occurrence, development and prognosis of DLBCL. It is an adverse prognostic factor of DLBCL and may be used for the prognosis evaluation of DLBCL.
基金the Shanxi Soft Science Research Program, No. 2008041061-03
文摘Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Internet addiction disorder. We found that individuals with Internet addiction disorder exhibited significantly longer P300 latencies than controls (N2: P = 0.035; P3a: P = 0.031; P3b: P = 0.043) and similar P300 amplitudes compared to control participants. After 3 months of cognitive behavioral therapy, P300 latencies decreased significantly in the P3a and P3b (P3a: P = 0.045; P3b: P = 0.062). These results suggest that deficits in cognitive function may be involved in Internet addiction disorder, and that clinical psychological treatment may be effective.
基金Acknowledgment We thank the laboratory, clinical and paramedical staff of the center of Reproductive Medicine, and the Departmerit of Forensic Medicine, Pathology for their assistance. We especially thank Dr Sheng-Bin Li for practical support. This study was supported by National Natural Science Foundation of China （No. 30471735） and Science ＆ Technique Research Intensive Project of Education Ministry of China （No.105157） and Sci-Technical Development Project of Shaanxi Province, China （2005K15-G2, 2006K15-G4）.
文摘瞄准：在 ubiquitin 特定的朊酶学习单个核苷酸多型性的发生 26 (USP26 ) 在在中国的自发的男不孕的基因和它的参与。方法：平淡的精液分析被执行。不孕因素象免疫学的那样，传染、生物化学的混乱被检验与自发的不孕选择病人。DNA 从选择病人和控制人口的外部血被孤立，它用聚合酶链反应单人赛海滨符合构造多型性分析为变化被检验。而且，核苷酸序列在一些病人和控制被定序。结果：41 个不肥沃的人， 9 (22.0% ， P = 0.01 ) 在 X 染色体上的 USP26 基因的有的变化。一个复合变化(364insACA；460G → A ) 在 8 个病人被检测(19.5% ， P = 0.01 ) 并且 1044T → A 替换在 1 个病人被发现(2.4% ， P 】
0.05 ) 。所有三个变化在编码氨基酸导致了变化。二替换预言一些变化：460G → A 把缬氨酸变成异白氨酸，并且 1044T → A 用白氨酸代替本氨基丙酸。三核苷酸 ACA 的另一插入引起 threonine 的插入。没有另外的变化在留下的病人和肥沃的控制被发现。结论：USP26 基因可能具有在男复制的重要性。在这基因的变化可能与男不孕被联系，并且可能否定地影响阴囊的功能。关于这个问题的进一步的研究在进行中。
基金This work was supported by the National Natural Science Foundation of China (No. 29674027, No. 29844002), the Ministry of National Education (G98402) and Organometallic Laboratory of Institute of Organic Chemistry of Chinese Academy of Sciences.
文摘Ring-opening polymerization of trimethylene carbonate (TMC) with a rare earth calixarene compound as catalysthas been studied for the first time. The effect of TMC/Nd (molar ratio) and polymerization conditions were investigated indetail. It was found that calix[8]arene-neodymium is a highly effective catalyst for the bulk polymerization of TMC and giveshigh molecular weight (M_v = 60,000) polymer. The optimum conditions of TMC polymerization were found to be asfollows:TMC/Nd (molar ratio) = 2,000, 80℃, 16 h. The polymers were characterized by NMR, GPC and DSC. Studying themechanism by NMR showed that the polymerization of TMC catalyzed by calix[8]arene-neodymium proceeds via a cationicmechanism.
基金the startup fund from City University of Hong Kong.
文摘Background:Prosocial crowdfunding helps the underprivileged obtain non-profitseeking loans from multitudinous lenders.Some platforms introduce teamcompetition to motivate member participation and may thus induce team rivalry.Methods:We investigate how team rivalry affects lending decisions using data fromKiva.org.We argue that a rivalry relationship may engage teams to compete directlyagainst rivals by lending to the same project or prevent them from doing sobecause they intend not to cooperate.Result:We find that a team is less likely to lend to a project that has receivedfunding from its rival team,suggesting that rival teams tend to avoid cooperation.Conclusions:We discuss the implications of our findings for crowdfundingand competition-based motivation mechanisms in general.
基金supported by the National Natural Science Foundation of China(Grant No.51774216)Hubei Technical Innovation Special Project of China(Grant No.2017ACA185)Science and technology innovation Talent program of Hubei Province(Grant No.2022EJD002).
文摘Herein, the influence of the concentration design and comprehensive performance of the sulfate-phosphoric mixed acid system electrolyte is investigated to realize an electrolyte that maintains high energy density and stable operation at high temperatures. Static stability tests have shown that VOPO4 precipitation occurs only with vanadium(V) electrolyte. The concentration of vanadium ion of 2.0–2.2 mol·L^(–1), phosphoric acid of 0.10–0.15 mol·L^(–1), and sulfuric acid of 2.5–3.0 mol·L^(–1) are suitable for a vanadium redox flow battery in the temperature range from –20 to 50 ℃. The equations for predicting the viscosity and conductivity of electrolytes are obtained by the response surface method. The optimized electrolyte overcomes precipitation generation. It has 2.8 times higher energy density than the non-phosphate electrolyte, and a coulomb efficiency of 94.0% at 50 ℃. The sulfate-phosphoric mixed acid system electrolyte promotes the electrode reaction process, increases the current density, and reduces the resistance. This work systematically optimizes the concentrations of composition of positive and negative vanadium electrolytes with mixed sulfate-phosphoric acid. It provides a basis for the different valence states and comprehensive properties of sulfate-phosphoric mixed acid system vanadium electrolytes under extreme environments, guiding engineering applications.
基金This work was supported by the National Natural Science Foundation of China(Grant No.51774216)Hubei Technical Innovation Special Project of China(Grant No.2017ACA185)Outstanding Young and Middle-aged Science and Technology Innovation Team Project of Hubei Province(Grant No.T201802).
文摘The vanadium redox flow battery with a safe and capacity-controllable large-scale energy storage system offers a new method for the sustainability.In this case,acetic acid,methane sulfonic acid,sulfonic acid,amino methane sulfonic acid,and taurine are used to overcome the low electrolyte energy density and stability limitations,as well as to investigate the effects of various organic functional groups on the vanadium redox flow battery.When compared to the pristine electrolyte(0.22 Ah,5.0 Wh·L^(−1),85.0%),the results show that taurine has the advantage of maintaining vanadium ion concentrations,discharge capacity(1.43 Ah),energy density(33.9 Wh·L^(−1)),and energy efficiency(90.5%)even after several cycles.The acetic acid electrolyte is more conducive to the low-temperature stability of the V(II)electrolyte(177 h at−25℃)than pristine(82 h at−2℃).The−SO_(3)H group,specifically the coaction of the−NH_(2)and−SO_(3)H groups,improves electrolyte stability.The−NH_(2)and−COOH additive groups improved conductivity and electrochemical activity.
文摘Dear Editor,Acute Myeloid Leukemia(AML)patients are often found ineligible for aggressive standard chemotherapy in clinic because of old age and poor conditions.Current evidences suggest that targeted combination therapy might help these patients achieve a higher response rate with acceptable adverse events(AEs).^(1)Venetoclax(VEN),a selective small-molecule BCL2 inhibitor,combined with hypomethylating agent(HMA),such as azacytidine(AZA).
