AIM: To evaluate the value of miniprobe sonography (MPS),spiral CT and MR imaging (MRI) in the tumor and regionallymph nocle staging of esophageal cancer.METHODS: Eight-six patients (56 men and 30 women; agerange of 3...AIM: To evaluate the value of miniprobe sonography (MPS),spiral CT and MR imaging (MRI) in the tumor and regionallymph nocle staging of esophageal cancer.METHODS: Eight-six patients (56 men and 30 women; agerange of 39-73 years, mean 62 years) with esophagealcarcinoma were staged .preoperatively with imagingmodalities. Of them, 81 (94 %) had squamous cell carcinoma,4(5 %) adenocarcinoma, and 1(1%) adenoacanthoma.Eleven patients (12 %) had malignancy of the upper onethird, 41 (48 %) of the mid-esophagus and 34 (40 %) ofthe distal one third. Forty-one were examined by spiral CTin whom 13 were co-examined by MPS, and forty-five byMRI in whom 18 were also co-examined by MPS. Theseimaging results were compared with the findings of thehistopathologic examination for resected specimens.RESULTS: In staging the depth of tumor growth, MPS wassignificantly more accurate (84 %) than spiral CT and MRI(68 % and 60 %, respectively, P＜0.05). The specificity andsensitivity were 82 % and 85 % for MPS; 60 % and 69 % forspiral CT; and 40 % and 63 % for MRI, respectively. In stagingregional lymph nodes, spiral CT was more accurate (78 %)than MPS and MRI (71% and 64 %, respectively), but thedifference was not statistically significant. The specificity andsensitivity were 79 % and 77 % for spiral CT; 75 % and 68 %for MPS; and 68 % and 62 % for MRI, respectively.CONCLUSION:MPS is superior to spiral CT or MRI for Tstaging, especially in early esophageal cancer. However,the three modalities have the similar accuracy in N staging.Spiral CT or MRI is helpful for the detection of far-distancemetastasis in esophageal cancer.展开更多
AIM: To determine the expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis and its clinical significance. METHODS: A cervical spondylosis model was established in rats by d...AIM: To determine the expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis and its clinical significance. METHODS: A cervical spondylosis model was established in rats by destroying the stability of cervical posterior column,and the cord segments C4-6 and gastric antrum were collected 3, 4 and 5 mo after the operation. Rats with sham operation were used as controls. c-fos neuronal counter-staining was performed with an immunohistochemistry method. Every third sections from C4-6 segments were drawn. The 10 most labeled c-fos-immunoreactive (Fos-IR) neurons were counted, and the average number was used for statistical analysis. The mean of Fos-IR neurons in myenteric plexus was calculated after counting Fos-IR neurons in 25 ganglia from each antral preparation, and expressed as a mean count per myenteric ganglion.RESULTS: There were a few c-fos-positive neurons in the cervical cord and antrum in the control group. There was an increased c-fos expression in model group 3, 4 and 5 mo after operation, whereas there was no significant increase in c-fos expression in the control group at 3, 4 and 5 mo.More importantly, there was a significant difference in c-fos expression between rats followed up for 3 mo and those for 5 mo in the model group (11.20±2.26 vs 27.68±4.36,P＜0.05, for the cervical cord; and 11.3±2.3 vs 29.3±4.6,P＜0.05, for the gastric antrum). There was no significant difference between rats followed up for 3 mo and those for 4 mo and between rats followed up for 4 mo and those for 5 mo in the model group.CONCLUSION: c-fos expression in gastric myenteric plexus was dramatically associated with that in the spinal cord in rats with cervical spondylosis, suggesting that the gastrointestinal function may be affected by cervical spondylosis. If this hypothesis is confirmed by further studies, functional gastrointestinal diseases such as functional dyspepsia and irritable bowel syndrome could be explained by neurogastroenterology.展开更多
文摘AIM: To evaluate the value of miniprobe sonography (MPS),spiral CT and MR imaging (MRI) in the tumor and regionallymph nocle staging of esophageal cancer.METHODS: Eight-six patients (56 men and 30 women; agerange of 39-73 years, mean 62 years) with esophagealcarcinoma were staged .preoperatively with imagingmodalities. Of them, 81 (94 %) had squamous cell carcinoma,4(5 %) adenocarcinoma, and 1(1%) adenoacanthoma.Eleven patients (12 %) had malignancy of the upper onethird, 41 (48 %) of the mid-esophagus and 34 (40 %) ofthe distal one third. Forty-one were examined by spiral CTin whom 13 were co-examined by MPS, and forty-five byMRI in whom 18 were also co-examined by MPS. Theseimaging results were compared with the findings of thehistopathologic examination for resected specimens.RESULTS: In staging the depth of tumor growth, MPS wassignificantly more accurate (84 %) than spiral CT and MRI(68 % and 60 %, respectively, P＜0.05). The specificity andsensitivity were 82 % and 85 % for MPS; 60 % and 69 % forspiral CT; and 40 % and 63 % for MRI, respectively. In stagingregional lymph nodes, spiral CT was more accurate (78 %)than MPS and MRI (71% and 64 %, respectively), but thedifference was not statistically significant. The specificity andsensitivity were 79 % and 77 % for spiral CT; 75 % and 68 %for MPS; and 68 % and 62 % for MRI, respectively.CONCLUSION:MPS is superior to spiral CT or MRI for Tstaging, especially in early esophageal cancer. However,the three modalities have the similar accuracy in N staging.Spiral CT or MRI is helpful for the detection of far-distancemetastasis in esophageal cancer.
基金Supported by the Medical Research Fund of Guangdong Province, No. A2004434
文摘AIM: To determine the expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis and its clinical significance. METHODS: A cervical spondylosis model was established in rats by destroying the stability of cervical posterior column,and the cord segments C4-6 and gastric antrum were collected 3, 4 and 5 mo after the operation. Rats with sham operation were used as controls. c-fos neuronal counter-staining was performed with an immunohistochemistry method. Every third sections from C4-6 segments were drawn. The 10 most labeled c-fos-immunoreactive (Fos-IR) neurons were counted, and the average number was used for statistical analysis. The mean of Fos-IR neurons in myenteric plexus was calculated after counting Fos-IR neurons in 25 ganglia from each antral preparation, and expressed as a mean count per myenteric ganglion.RESULTS: There were a few c-fos-positive neurons in the cervical cord and antrum in the control group. There was an increased c-fos expression in model group 3, 4 and 5 mo after operation, whereas there was no significant increase in c-fos expression in the control group at 3, 4 and 5 mo.More importantly, there was a significant difference in c-fos expression between rats followed up for 3 mo and those for 5 mo in the model group (11.20±2.26 vs 27.68±4.36,P＜0.05, for the cervical cord; and 11.3±2.3 vs 29.3±4.6,P＜0.05, for the gastric antrum). There was no significant difference between rats followed up for 3 mo and those for 4 mo and between rats followed up for 4 mo and those for 5 mo in the model group.CONCLUSION: c-fos expression in gastric myenteric plexus was dramatically associated with that in the spinal cord in rats with cervical spondylosis, suggesting that the gastrointestinal function may be affected by cervical spondylosis. If this hypothesis is confirmed by further studies, functional gastrointestinal diseases such as functional dyspepsia and irritable bowel syndrome could be explained by neurogastroenterology.
