There is a bottleneck in the design of vehicle sound that the subjective perception of sound quality that combines multiple psychological factors fails to be accurately and objectively quantified.Therefore,EEG signals...There is a bottleneck in the design of vehicle sound that the subjective perception of sound quality that combines multiple psychological factors fails to be accurately and objectively quantified.Therefore,EEG signals are introduced in this paper to investigate the evaluation and design method of vehicle acceleration sound with powerful sound quality.Firstly,the experiment of EEG acquisition and subjective evaluation under the stimulation of powerful vehicle sounds is conducted,respectively,then three physiological EEG features of PSD_β,PSD_γand DE are constructed to evaluate the vehicle sounds based on the correlation analysis algorithms.Subsequently,the Adaptive Genetic Algorithm(AGA)is proposed to optimize the Elman model,where an intelligent model(AGA–Elman)is constructed to objectively predicate the perception of subjects for the vehicle sounds with powerful sound quality.The results demonstrate that the error of the constructed AGA–Elman model is only 2.88%,which outperforms than the traditional BP and Elman model;Finally,two vehicle acceleration sounds(Design1 and Design2)are designed based on the constructed AGA–Elman model from the perspective of order modulation and frequency modulation,which provide the acoustic theoretical guidance for the design of vehicle sound incorporating the EEG signals.展开更多
In the past 2 decades,endoscopic enucleation of the prostate has become a safe and effective surgical treatment for benign prostatic hyperplasia(BPH),with comparable outcomes to traditional surgeries.Transurethral vap...In the past 2 decades,endoscopic enucleation of the prostate has become a safe and effective surgical treatment for benign prostatic hyperplasia(BPH),with comparable outcomes to traditional surgeries.Transurethral vapor enucleation and resection of the prostate(TVERP),transurethral vapor enucleation of the prostate(TVEP),and ultrasound-navigated TVEP(US-TVEP)are new,innovative endoscopic enucleation procedures.These procedures are named Xie’s Prostate Enucleations(Xie’s Procedures for short).Current clinical data indicate that Xie’s Procedures are safe and effective treatment options for patients with BPH,especially for patients with larger prostates.Further prospective,randomized clinical trials compared with traditional transurethral resection of prostate(TURP)are still needed.展开更多
Compressed sensing(CS),as an efficient data transmission method,has achieved great success in the field of data transmission such as image,video and text.It can robustly recover signals from fewer Measurements,effecti...Compressed sensing(CS),as an efficient data transmission method,has achieved great success in the field of data transmission such as image,video and text.It can robustly recover signals from fewer Measurements,effectively alleviating the bandwidth pressure during data transmission.However,CS has many shortcomings in the transmission of hyperspectral image(HSI)data.This work aims to consider the application of CS in the transmission of hyperspectral image(HSI)data,and provides a feasible research scheme for CS of HSI data.HSI has rich spectral information and spatial information in bands,which can reflect the physical properties of the target.Most of the hyperspectral image compressed sensing(HSICS)algorithms cannot effectively use the inter-band information of HSI,resulting in poor reconstruction effects.In this paper,A three-stage hyperspectral image compression sensing algorithm(Three-stages HSICS)is proposed to obtain intra-band and inter-band characteristics of HSI,which can improve the reconstruction accuracy of HSI.Here,we establish a multi-objective band selection(Mop-BS)model,amulti-hypothesis prediction(MHP)model and a residual sparse(ReWSR)model for HSI,and use a staged reconstruction method to restore the compressed HSI.The simulation results show that the three-stage HSICS successfully improves the reconstruction accuracy of HSICS,and it performs best among all comparison algorithms.展开更多
Hydrogen sulfide(H_2S) is a gasotransmitter that regulates cardiovascular functions.The present study aimed to determine the protective effect of slow-releasing H_2S donor GYY4137 on myocardial ischemia and reperfusio...Hydrogen sulfide(H_2S) is a gasotransmitter that regulates cardiovascular functions.The present study aimed to determine the protective effect of slow-releasing H_2S donor GYY4137 on myocardial ischemia and reperfusion(I/R) injury and to investigate the possible signaling mechanisms involved.Male Sprague-Dawley rats were treated with GYY4137 at 12.5 mg/(kg·day),25 mg/(kg·day) or 50 mg/(kg·day) intraperitoneally for7 days.Then,rats were subjected to 30 minutes of left anterior descending coronary artery occlusion followed by reperfusion for 24 hours.We found that GYY4137 increased the cardiac ejection fraction and fractional shortening,reduced the ischemia area,alleviated histological injury and decreased plasma creatine kinase after myocardial I/R.Both H_2S concentration in plasma and cystathionine-γ-lyase(CSE) activity in the myocardium were enhanced in the GYY4137 treated groups.GYY4137 also decreased malondialdehyde and myeloperoxidase levels in serum,attenuated superoxide anion level and suppressed phosphorylation of mitogen activated protein kinases in the myocardium after I/R.Meanwhile,GYY4137 increased the expression of Bcl-2 but decreased the expression of Bax,caspase-3 activity and apoptosis in the myocardium.The data suggest that GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis.展开更多
The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapi...The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers.展开更多
Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort wit...Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years.展开更多
Objective: Potential of combined androgen blockade(CAB) has not been explored extensively in Chinese males with prostate cancer(PCa). Therefore, this study evaluated the 2-year prostate-specific antigen(PSA) recurrenc...Objective: Potential of combined androgen blockade(CAB) has not been explored extensively in Chinese males with prostate cancer(PCa). Therefore, this study evaluated the 2-year prostate-specific antigen(PSA) recurrence rate and quality of life(Qo L) in patients with high-risk localized and locally advanced PCa receiving adjuvant hormone therapy(HT) after radical prostatectomy(RP).Methods: This prospective, multicenter, observational study conducted in 18 centers across China enrolled patients with high-risk factor(preoperative PSA>20 ng/m L or Gleason score >7) or locally advanced PCa. Different adjuvant HT were administered after RP according to investigator’s decision in routine clinical practice.Relationship of baseline and postoperative characteristics was assessed with recurrence rate. PSA recurrence rate and Functional Assessment of Cancer Therapy-Prostate(FACT-P) Qo L scores were recorded at 12 months and 24 months. Kaplan-Meier analysis was used to construct the PSA recurrence rate during follow-up.Results: A total of 189 patients(mean age: 66.9±6.5 years) were recruited, among which 112(59.3%) patients showed serum PSA>20 ng/m L preoperatively. The highest postoperative pathological advancement noticed was from clinical T2(c T2) to pathological T3(p T3)(43.9%) stage. The majority of the patients(66.1%) received CAB as adjuvant HT, for a median duration of 20.0 months. The least recurrence(15.2%) was noticed in patients treated with CAB, followed by those treated with luteinizing hormone-releasing hormone agonist(LHRHa)(16.1%), and antiandrogen(19.0%), with non-significant difference noted among the groups. None of the baseline or postoperative characteristics was related with PSA recurrence in our study. The 24-month FACT-P Qo L score of119 patients treated for >12 months showed significant improvement above baseline compared with those treated for ≤12 months.Conclusions: Adjuvant CAB therapy after RP showed reduction trend in 2-year PSA recurrence rate in highrisk Chinese patients with localized and locally advanced PCa, compared with adjuvant anti-androgens(AA) or LHRHa therapy. Further long-term therapy(>12 months) significantly improved Qo L compared to short-term HT therapy, suggesting the beneficial effect of long-term CAB therapy in improving Qo L.展开更多
Objective:To establish non-inferiority of gonadotropin-releasing hormone degarelix compared with goserelin in suppressing and maintaining castrate testosterone levels from Day 28 to Day 364 in Chinese patients with pr...Objective:To establish non-inferiority of gonadotropin-releasing hormone degarelix compared with goserelin in suppressing and maintaining castrate testosterone levels from Day 28 to Day 364 in Chinese patients with prostate cancer.Methods:This is an open-label,multi-centre study in which men aged18 years were randomised in a 1:1 ratio to once-a-month subcutaneous injection of either degarelix(240/80 mg)or goserelin(3.6 mg)for 12 months.The primary endpoint was difference in 1-year cumulative probability of suppressing testosterone to ≤0.5 ng/mL.Non-inferiority was to be established if the lower 95% confidence interval(CI)limit for difference in cumulative probability between the treatment arms was greater than -10%.Secondary endpoints included cumulative probability of prostate-specific-antigen-progression-free-survival(PSA-PFS).Safety was also assessed.Results:Baseline demographics and disease characteristics were similar between degarelix(n=142)and goserelin(n=141)treatment arms.The difference in cumulative probability of maintaining castrate levels from Day 28-364 was 3.6%(95%CI:-1.5%,8.7%),demonstrating non-inferiority of degarelix.The cumulative probability of PSA-PFS at Day 364 was higher for degarelix(82.3%,95%CI:74.7%,87.7%)versus goserelin(71.7%,95%CI:63.2%,78.5%,p=0.038).Adverse events(AEs)were similar between treatment arms,except for more injection site reactions with degarelix versus goserelin.Four(2.8%)and nine(6.4%)patients discontinued due to AEs in degarelix and goserelin groups,respectively.展开更多
Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and cond...Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors.展开更多
1.Updates in prostate cancer(PCa)detections 1.1.Screening of PCa The discovery of prostate specific antigen(PSA)undoubtedly marked a new era for the efficient screening of PCa.In addition,the screening of PCa has been...1.Updates in prostate cancer(PCa)detections 1.1.Screening of PCa The discovery of prostate specific antigen(PSA)undoubtedly marked a new era for the efficient screening of PCa.In addition,the screening of PCa has been the hot area of studies all the time,and it is still the most commonly discussed topic of European Association of Urology(EAU)and American Urological Association(AUA).展开更多
[Objectives] This study was conducted to explore the differences in soil nutrient contents of cultivated land in different regions of Laos,and to provide a basis for soil nutrient management and scientific fertilizati...[Objectives] This study was conducted to explore the differences in soil nutrient contents of cultivated land in different regions of Laos,and to provide a basis for soil nutrient management and scientific fertilization in Laos. [Methods] By collecting 166 samples of the 0-20 cm cultivated soil layer from farmland in the farming areas of Luang Namtha Province in the northern part of Laos and Vientiane Province in the middle of the country,the contents of soil organic matter,total nitrogen,available phosphorus,available potassium,available calcium and available magnesium were analyzed,so as to evaluate the current status of soil nutrient fertility and explore the differences in soil nutrient contents of regional cultivated land. [Results] The soil organic matter was relatively abundant,the total nitrogen and available potassium contents were at the lower-middle level,and the available phosphorus,available calcium and available magnesium were insufficient or extremely insufficient. The soil nutrient contents of cultivated land were different in different regions. [Conclusions] It is suggested that lime or other alkaline fertilizers should be applied on the farmland with acid soil,and nitrogen,phosphorus,and potassium fertilizers should be added at the same time to improve soil nutrient fertility.展开更多
This paper reviewed the meaning of facility agriculture and the development status and trends of facility agriculture at home and abroad,analyzed the development status and existing problems of facility agriculture in...This paper reviewed the meaning of facility agriculture and the development status and trends of facility agriculture at home and abroad,analyzed the development status and existing problems of facility agriculture in Guangxi,and proposed corresponding solutions to the problems in the development of facility agriculture in Guangxi,aiming to provide reference for promoting the sustainable development of facility agriculture in Guangxi.展开更多
Since existing selection methods of surgical treatment schemes of renal cancer patients mainly depend on physicians’clinical experience and judgments,the surgical treatment options of renal cancer patients lack their...Since existing selection methods of surgical treatment schemes of renal cancer patients mainly depend on physicians’clinical experience and judgments,the surgical treatment options of renal cancer patients lack their scientifical and reasonable information expression and group decision-making model for renal cancer patients.Fuzzy multi-sets(FMSs)have a number of properties,which make them suitable for expressing the uncertain information of medical diagnoses and treatments in group decision-making(GDM)problems.To choose the most appropriate surgical treatment scheme for a patient with localized renal cell carcinoma(RCC)(T1 stage kidney tumor),this article needs to develop an effective GDM model based on the fuzzy multivalued evaluation information of the renal cancer patients.First,we propose a conversionmethod of transforming FMSs into entropy fuzzy sets(EFSs)based on the mean and Shannon entropy of a fuzzy sequence in FMS to reasonably simplify the information expression and operations of FMSs and define the score function of an entropy fuzzy element(EFE)for ranking EFEs.Second,we present the Aczel-Alsina t-norm and t-conorm operations of EFEs and the EFE Aczel-Alsina weighted arithmetic averaging(EFEAAWAA)and EFE Aczel-Alsina weighted geometric averaging(EFEAAWGA)operators.Third,we develop a multicriteria GDM model of renal cancer surgery options in the setting of FMSs.Finally,the proposed GDM model is applied to two clinical cases of renal cancer patients to choose the best surgical treatment scheme for a renal cancer patient in the setting of FMSs.The selected results of two clinical cases verify the efficiency and rationality of the proposed GDM model in the setting of FMSs.展开更多
Ignoring the influence of flow velocity and flow temperature on muffling performance,performance tests were conducted without airflow in the development phase of the muffler which accounts to the difficulty of obtaini...Ignoring the influence of flow velocity and flow temperature on muffling performance,performance tests were conducted without airflow in the development phase of the muffler which accounts to the difficulty of obtaining a perfect match between the actual noise reduction effect and the design goal.Based on the two-load test theory,a set of high-temperature and high-speed airflow simulation measurement devices for the muffler has been built.In order to avoid the impact of high-temperature and high-speed airflow on the sensor,a high temperature resistant sensor holder has been designed for the test rig.The sound pressure has been measured in the pipe by using the lead-out measurement.In addition,a variable impedance load is placed at the end of the test tube to realize the switch between two different impedance loads by the wave handle of the variable impedance load.A sound source correction method is proposed to decrease the random fluctuation of the spectral characteristics of the output noise signal,which is caused by the acoustic impedance variation at the connection between the transition pipeline and the combined sound source system.Finally,an acoustic software has been used to calculate the transmission loss of the muffler in the presence of high temperature airflow.In comparing the experimental measurements and the simulation results,the small difference shows that:the bench not only can effectively simulate high-temperature and flow velocity environment of the engine but also accurately test the transmission loss of the muffler.展开更多
Cardiac fibrosis is a common pathological change of many cardiovascular diseases. β-catenin has been shown to promote fibrosis. However, the precise role of its homolog γ-catenin in the process of fibrosis remains l...Cardiac fibrosis is a common pathological change of many cardiovascular diseases. β-catenin has been shown to promote fibrosis. However, the precise role of its homolog γ-catenin in the process of fibrosis remains largely unclear. In this study, we found that the expression of γ-catenin was significantly decreased in angiotensin Ⅱ(Ang Ⅱ)-induced cardiac fibrosis model, contrary to most reports of β-catenin. Overexpression of γ-catenin in cardiac fibroblasts(CFs) significantly inhibited the expression of α-smooth muscle actin(α-SMA), whereas knocking down the expression of γ-catenin with si RNA promoted the occurrence of cardiac fibrosis.Mechanistically, γ-catenin could bind to GSK-3β to inhibit the phosphorylation of GSK-3β, therefore preventing cardiac fibrosis. Our study shows that γ-catenin is an important protective factor in cardiac fibrosis, which provides a new potential target for the treatment of cardiac fibrosis.展开更多
[Objective] The study aims to resolve water resource problem availably. [Method] On the basis of wetland self-purification capacity, Yanshan River water was purified by Xixi Wetland,and the feasibility of using treate...[Objective] The study aims to resolve water resource problem availably. [Method] On the basis of wetland self-purification capacity, Yanshan River water was purified by Xixi Wetland,and the feasibility of using treated Yanshan River water for urban greening and watering road was analyzed. [Result]Compared with direct utilization of tap water,it is more economic to recycle Yanshan River water purified by Xixi Wetland for urban greening and watering road,with obvious economic,ecological and social benefits,so it is an effective method to address shortage of water resources and is worth spreading. [Conclusion]It is feasible to use Yanshan River water purified by Xixi Wetland for urban greening and watering road.展开更多
Objective:To summarize the experience of diagnosis and treatment outcomes for bone metastatic prostate cancer.Methods:A retrospective study with a total of 128 prostate cancer(Pca) was performed from 2000 to 2005,in o...Objective:To summarize the experience of diagnosis and treatment outcomes for bone metastatic prostate cancer.Methods:A retrospective study with a total of 128 prostate cancer(Pca) was performed from 2000 to 2005,in our institute.We analyzed the clinical features and outcomes of patients with bone metastases and the data and follow-up of 63 bone metastases was collected by one registrar.Cochran Armitage trend test was used for statistic analysis and a P-value of < 0.05 was taken as statistically significant.Results:The mean age was 73(range 55 to 87) years.The PSA level was from 0.083 ng/mL to 6462 ng/mL.Bone metastases morbidity had good relationship with PSA level.With the mean follow up of 30(range 6 to 72) months for 52/63(82.5%) patients,15(28.8%) died from Pca with a mean survival of 21 months and 1 patient with PSA less than 4 ng/mL at the time died from cerebrovascular suddenness 6 months post-treatment.Conclusion:The early effect of endocrine treatment for bone metastases is obvious,and palliative prostatectomy is satisfactory and able to improve the quality of life rapidly for patients with obstructive symptoms.展开更多
[Objectives]To evaluate the status of soil nutrient and fertility in main dry farming regions of Laos,and to explore differences in soil nutrient content between regions and crop types.[Methods]By collecting 57 soil s...[Objectives]To evaluate the status of soil nutrient and fertility in main dry farming regions of Laos,and to explore differences in soil nutrient content between regions and crop types.[Methods]By collecting 57 soil samples in the 0-20 cm layer of the main dryland in southern and northern provinces of Laos.Soil pH,organic matter,total nitrogen,available nitrogen,available phosphorus,available potassium,exchangeable calcium,exchangeable magnesium and available zinc content were analyzed.[Results]The soil in the main dry farming regions of Laos was acidic,the overall fertility level was good,and the exchangeable calcium and magnesium contents were low.There were differences in soil nutrient content in the dry farming regions of southern and northern Laos.Drylands where cassava and maize were growed had higher fertility.[Conclusions]It is suggested to apply lime or alkaline fertilizer in the dry land with acid soil to increase soil pH and increase the supply of soil calcium and magnesium.Organic fertilizer should be applied to improve soil water retention capacity,and it is necessary to pay attention to the fertilization ratio of macroelements to balance fertilization.展开更多
Bladder cancer (BC) is one of the most common malignant tumors in the urinary system.Due to the poor prognosis and high mortality rate of the disease,it is urgent to develop new drugs with high efficacy and low toxici...Bladder cancer (BC) is one of the most common malignant tumors in the urinary system.Due to the poor prognosis and high mortality rate of the disease,it is urgent to develop new drugs with high efficacy and low toxicity to treat BC.Echinatin (Ecn) is a bioactive natural flavonoid oflicorice that has attracted special attention for its promising anti-tumor potential.Herein,we explored the inhibitory effects of Echinatin on BC cells and probed the possible molecular mechanism.We found that Ecnin vitro inhibited the proliferation,migration,and invasion,arrested the cell cycle at the G2/M phase,and promoted apoptosis in BC cells.Besides,Ecn had no notable cytotoxicity towards human normal cells.We subsequently confirmed that Ecn restrained xenograft tumor growth and metastasis of BC cells in vivo .Mechanistically,Ecn activated the p38 signaling pathway but inactivated the Wnt/β-catenin signaling pathway,while over-expression of β-catenin and the p38 inhibitor both attenuated the inhibitory effects of Ecn on BC cells.Remarkably,Ecn combined with cisplatin (DDP) or gemcitabine (Gem) had synergistic inhibitory effects on BC cells.In summary,our results validate that Ecn inhibits the tumor growth of human BC cells via p38 and Wnt/β-catenin signaling pathways.More meaningfully,our results suggest a potential strategy to enhance DDP- or Gem-induced inhibitory effects on BC cells by combining with Ecn.展开更多
基金supported by the National Natural Science Foundation of China(No.52272389)the National Natural Science Foundation of China(No.52175111).
文摘There is a bottleneck in the design of vehicle sound that the subjective perception of sound quality that combines multiple psychological factors fails to be accurately and objectively quantified.Therefore,EEG signals are introduced in this paper to investigate the evaluation and design method of vehicle acceleration sound with powerful sound quality.Firstly,the experiment of EEG acquisition and subjective evaluation under the stimulation of powerful vehicle sounds is conducted,respectively,then three physiological EEG features of PSD_β,PSD_γand DE are constructed to evaluate the vehicle sounds based on the correlation analysis algorithms.Subsequently,the Adaptive Genetic Algorithm(AGA)is proposed to optimize the Elman model,where an intelligent model(AGA–Elman)is constructed to objectively predicate the perception of subjects for the vehicle sounds with powerful sound quality.The results demonstrate that the error of the constructed AGA–Elman model is only 2.88%,which outperforms than the traditional BP and Elman model;Finally,two vehicle acceleration sounds(Design1 and Design2)are designed based on the constructed AGA–Elman model from the perspective of order modulation and frequency modulation,which provide the acoustic theoretical guidance for the design of vehicle sound incorporating the EEG signals.
文摘In the past 2 decades,endoscopic enucleation of the prostate has become a safe and effective surgical treatment for benign prostatic hyperplasia(BPH),with comparable outcomes to traditional surgeries.Transurethral vapor enucleation and resection of the prostate(TVERP),transurethral vapor enucleation of the prostate(TVEP),and ultrasound-navigated TVEP(US-TVEP)are new,innovative endoscopic enucleation procedures.These procedures are named Xie’s Prostate Enucleations(Xie’s Procedures for short).Current clinical data indicate that Xie’s Procedures are safe and effective treatment options for patients with BPH,especially for patients with larger prostates.Further prospective,randomized clinical trials compared with traditional transurethral resection of prostate(TURP)are still needed.
基金supported by the National Natural Science Foundation of China under Grant No.61806138Key R&D program of Shanxi Province(High Technology)under Grant No.201903D121119Science and Technology Development Foundation of the Central Guiding Local under Grant No.YDZJSX2021A038.
文摘Compressed sensing(CS),as an efficient data transmission method,has achieved great success in the field of data transmission such as image,video and text.It can robustly recover signals from fewer Measurements,effectively alleviating the bandwidth pressure during data transmission.However,CS has many shortcomings in the transmission of hyperspectral image(HSI)data.This work aims to consider the application of CS in the transmission of hyperspectral image(HSI)data,and provides a feasible research scheme for CS of HSI data.HSI has rich spectral information and spatial information in bands,which can reflect the physical properties of the target.Most of the hyperspectral image compressed sensing(HSICS)algorithms cannot effectively use the inter-band information of HSI,resulting in poor reconstruction effects.In this paper,A three-stage hyperspectral image compression sensing algorithm(Three-stages HSICS)is proposed to obtain intra-band and inter-band characteristics of HSI,which can improve the reconstruction accuracy of HSI.Here,we establish a multi-objective band selection(Mop-BS)model,amulti-hypothesis prediction(MHP)model and a residual sparse(ReWSR)model for HSI,and use a staged reconstruction method to restore the compressed HSI.The simulation results show that the three-stage HSICS successfully improves the reconstruction accuracy of HSICS,and it performs best among all comparison algorithms.
基金supported by grants from the National Natural Science Foundation of China(Grant No.81170083,81400203)Universities Natural Science Research Project of Jiangsu Province(No.10KJA310033)+1 种基金Major Science and Technology Development Fund Project of Nanjing Medical University(2011NJMU264)the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions
文摘Hydrogen sulfide(H_2S) is a gasotransmitter that regulates cardiovascular functions.The present study aimed to determine the protective effect of slow-releasing H_2S donor GYY4137 on myocardial ischemia and reperfusion(I/R) injury and to investigate the possible signaling mechanisms involved.Male Sprague-Dawley rats were treated with GYY4137 at 12.5 mg/(kg·day),25 mg/(kg·day) or 50 mg/(kg·day) intraperitoneally for7 days.Then,rats were subjected to 30 minutes of left anterior descending coronary artery occlusion followed by reperfusion for 24 hours.We found that GYY4137 increased the cardiac ejection fraction and fractional shortening,reduced the ischemia area,alleviated histological injury and decreased plasma creatine kinase after myocardial I/R.Both H_2S concentration in plasma and cystathionine-γ-lyase(CSE) activity in the myocardium were enhanced in the GYY4137 treated groups.GYY4137 also decreased malondialdehyde and myeloperoxidase levels in serum,attenuated superoxide anion level and suppressed phosphorylation of mitogen activated protein kinases in the myocardium after I/R.Meanwhile,GYY4137 increased the expression of Bcl-2 but decreased the expression of Bax,caspase-3 activity and apoptosis in the myocardium.The data suggest that GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis.
基金supported by the Program for Changjiang Scholars and Innovative Research Team in University scheme of the Ministry of Education of China(NO.IRT1111)the National Basic Research Program of China(2012CB518300)+2 种基金the National Natural Science Foundation of China(81101946)the Shanghai Pujiang Program(12PJD008)Prostate Cancer Foundation Young Investigator Award,Shanghai Municipal Health and Family Planning Commission Outstanding Young Investigator(XYQ2013077).
文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers.
文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years.
文摘Objective: Potential of combined androgen blockade(CAB) has not been explored extensively in Chinese males with prostate cancer(PCa). Therefore, this study evaluated the 2-year prostate-specific antigen(PSA) recurrence rate and quality of life(Qo L) in patients with high-risk localized and locally advanced PCa receiving adjuvant hormone therapy(HT) after radical prostatectomy(RP).Methods: This prospective, multicenter, observational study conducted in 18 centers across China enrolled patients with high-risk factor(preoperative PSA>20 ng/m L or Gleason score >7) or locally advanced PCa. Different adjuvant HT were administered after RP according to investigator’s decision in routine clinical practice.Relationship of baseline and postoperative characteristics was assessed with recurrence rate. PSA recurrence rate and Functional Assessment of Cancer Therapy-Prostate(FACT-P) Qo L scores were recorded at 12 months and 24 months. Kaplan-Meier analysis was used to construct the PSA recurrence rate during follow-up.Results: A total of 189 patients(mean age: 66.9±6.5 years) were recruited, among which 112(59.3%) patients showed serum PSA>20 ng/m L preoperatively. The highest postoperative pathological advancement noticed was from clinical T2(c T2) to pathological T3(p T3)(43.9%) stage. The majority of the patients(66.1%) received CAB as adjuvant HT, for a median duration of 20.0 months. The least recurrence(15.2%) was noticed in patients treated with CAB, followed by those treated with luteinizing hormone-releasing hormone agonist(LHRHa)(16.1%), and antiandrogen(19.0%), with non-significant difference noted among the groups. None of the baseline or postoperative characteristics was related with PSA recurrence in our study. The 24-month FACT-P Qo L score of119 patients treated for >12 months showed significant improvement above baseline compared with those treated for ≤12 months.Conclusions: Adjuvant CAB therapy after RP showed reduction trend in 2-year PSA recurrence rate in highrisk Chinese patients with localized and locally advanced PCa, compared with adjuvant anti-androgens(AA) or LHRHa therapy. Further long-term therapy(>12 months) significantly improved Qo L compared to short-term HT therapy, suggesting the beneficial effect of long-term CAB therapy in improving Qo L.
文摘Objective:To establish non-inferiority of gonadotropin-releasing hormone degarelix compared with goserelin in suppressing and maintaining castrate testosterone levels from Day 28 to Day 364 in Chinese patients with prostate cancer.Methods:This is an open-label,multi-centre study in which men aged18 years were randomised in a 1:1 ratio to once-a-month subcutaneous injection of either degarelix(240/80 mg)or goserelin(3.6 mg)for 12 months.The primary endpoint was difference in 1-year cumulative probability of suppressing testosterone to ≤0.5 ng/mL.Non-inferiority was to be established if the lower 95% confidence interval(CI)limit for difference in cumulative probability between the treatment arms was greater than -10%.Secondary endpoints included cumulative probability of prostate-specific-antigen-progression-free-survival(PSA-PFS).Safety was also assessed.Results:Baseline demographics and disease characteristics were similar between degarelix(n=142)and goserelin(n=141)treatment arms.The difference in cumulative probability of maintaining castrate levels from Day 28-364 was 3.6%(95%CI:-1.5%,8.7%),demonstrating non-inferiority of degarelix.The cumulative probability of PSA-PFS at Day 364 was higher for degarelix(82.3%,95%CI:74.7%,87.7%)versus goserelin(71.7%,95%CI:63.2%,78.5%,p=0.038).Adverse events(AEs)were similar between treatment arms,except for more injection site reactions with degarelix versus goserelin.Four(2.8%)and nine(6.4%)patients discontinued due to AEs in degarelix and goserelin groups,respectively.
基金This clinical research was funded by the Ministry of Health People’s Republic of China(No.WKJ2007-3-001).
文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors.
文摘1.Updates in prostate cancer(PCa)detections 1.1.Screening of PCa The discovery of prostate specific antigen(PSA)undoubtedly marked a new era for the efficient screening of PCa.In addition,the screening of PCa has been the hot area of studies all the time,and it is still the most commonly discussed topic of European Association of Urology(EAU)and American Urological Association(AUA).
基金Supported by Guangxi R&D Project (Gui Ke-AD17195026)Fund of Guangxi Academy of Agricultural Sciences (2019ZX121)。
文摘[Objectives] This study was conducted to explore the differences in soil nutrient contents of cultivated land in different regions of Laos,and to provide a basis for soil nutrient management and scientific fertilization in Laos. [Methods] By collecting 166 samples of the 0-20 cm cultivated soil layer from farmland in the farming areas of Luang Namtha Province in the northern part of Laos and Vientiane Province in the middle of the country,the contents of soil organic matter,total nitrogen,available phosphorus,available potassium,available calcium and available magnesium were analyzed,so as to evaluate the current status of soil nutrient fertility and explore the differences in soil nutrient contents of regional cultivated land. [Results] The soil organic matter was relatively abundant,the total nitrogen and available potassium contents were at the lower-middle level,and the available phosphorus,available calcium and available magnesium were insufficient or extremely insufficient. The soil nutrient contents of cultivated land were different in different regions. [Conclusions] It is suggested that lime or other alkaline fertilizers should be applied on the farmland with acid soil,and nitrogen,phosphorus,and potassium fertilizers should be added at the same time to improve soil nutrient fertility.
基金Supported by Guangxi Science and Technology Planning Project(GK AB18221096)Fund of Guangxi Academy of Agricultural Sciences(CNK 2015YT322019ZX121).
文摘This paper reviewed the meaning of facility agriculture and the development status and trends of facility agriculture at home and abroad,analyzed the development status and existing problems of facility agriculture in Guangxi,and proposed corresponding solutions to the problems in the development of facility agriculture in Guangxi,aiming to provide reference for promoting the sustainable development of facility agriculture in Guangxi.
基金This study has received funding by the Science and Technology Plan Project of Keqiao District(No.2020KZ58).
文摘Since existing selection methods of surgical treatment schemes of renal cancer patients mainly depend on physicians’clinical experience and judgments,the surgical treatment options of renal cancer patients lack their scientifical and reasonable information expression and group decision-making model for renal cancer patients.Fuzzy multi-sets(FMSs)have a number of properties,which make them suitable for expressing the uncertain information of medical diagnoses and treatments in group decision-making(GDM)problems.To choose the most appropriate surgical treatment scheme for a patient with localized renal cell carcinoma(RCC)(T1 stage kidney tumor),this article needs to develop an effective GDM model based on the fuzzy multivalued evaluation information of the renal cancer patients.First,we propose a conversionmethod of transforming FMSs into entropy fuzzy sets(EFSs)based on the mean and Shannon entropy of a fuzzy sequence in FMS to reasonably simplify the information expression and operations of FMSs and define the score function of an entropy fuzzy element(EFE)for ranking EFEs.Second,we present the Aczel-Alsina t-norm and t-conorm operations of EFEs and the EFE Aczel-Alsina weighted arithmetic averaging(EFEAAWAA)and EFE Aczel-Alsina weighted geometric averaging(EFEAAWGA)operators.Third,we develop a multicriteria GDM model of renal cancer surgery options in the setting of FMSs.Finally,the proposed GDM model is applied to two clinical cases of renal cancer patients to choose the best surgical treatment scheme for a renal cancer patient in the setting of FMSs.The selected results of two clinical cases verify the efficiency and rationality of the proposed GDM model in the setting of FMSs.
基金Supported by National Key Research and Development Program(2016YFD0700704B)。
文摘Ignoring the influence of flow velocity and flow temperature on muffling performance,performance tests were conducted without airflow in the development phase of the muffler which accounts to the difficulty of obtaining a perfect match between the actual noise reduction effect and the design goal.Based on the two-load test theory,a set of high-temperature and high-speed airflow simulation measurement devices for the muffler has been built.In order to avoid the impact of high-temperature and high-speed airflow on the sensor,a high temperature resistant sensor holder has been designed for the test rig.The sound pressure has been measured in the pipe by using the lead-out measurement.In addition,a variable impedance load is placed at the end of the test tube to realize the switch between two different impedance loads by the wave handle of the variable impedance load.A sound source correction method is proposed to decrease the random fluctuation of the spectral characteristics of the output noise signal,which is caused by the acoustic impedance variation at the connection between the transition pipeline and the combined sound source system.Finally,an acoustic software has been used to calculate the transmission loss of the muffler in the presence of high temperature airflow.In comparing the experimental measurements and the simulation results,the small difference shows that:the bench not only can effectively simulate high-temperature and flow velocity environment of the engine but also accurately test the transmission loss of the muffler.
基金supported by grants from the National Natural Science Foundation of China(Grant No.81670209)。
文摘Cardiac fibrosis is a common pathological change of many cardiovascular diseases. β-catenin has been shown to promote fibrosis. However, the precise role of its homolog γ-catenin in the process of fibrosis remains largely unclear. In this study, we found that the expression of γ-catenin was significantly decreased in angiotensin Ⅱ(Ang Ⅱ)-induced cardiac fibrosis model, contrary to most reports of β-catenin. Overexpression of γ-catenin in cardiac fibroblasts(CFs) significantly inhibited the expression of α-smooth muscle actin(α-SMA), whereas knocking down the expression of γ-catenin with si RNA promoted the occurrence of cardiac fibrosis.Mechanistically, γ-catenin could bind to GSK-3β to inhibit the phosphorylation of GSK-3β, therefore preventing cardiac fibrosis. Our study shows that γ-catenin is an important protective factor in cardiac fibrosis, which provides a new potential target for the treatment of cardiac fibrosis.
基金Supported by the Project for Science and Technology Innovation Team of Zhejiang Province,China
文摘[Objective] The study aims to resolve water resource problem availably. [Method] On the basis of wetland self-purification capacity, Yanshan River water was purified by Xixi Wetland,and the feasibility of using treated Yanshan River water for urban greening and watering road was analyzed. [Result]Compared with direct utilization of tap water,it is more economic to recycle Yanshan River water purified by Xixi Wetland for urban greening and watering road,with obvious economic,ecological and social benefits,so it is an effective method to address shortage of water resources and is worth spreading. [Conclusion]It is feasible to use Yanshan River water purified by Xixi Wetland for urban greening and watering road.
文摘Objective:To summarize the experience of diagnosis and treatment outcomes for bone metastatic prostate cancer.Methods:A retrospective study with a total of 128 prostate cancer(Pca) was performed from 2000 to 2005,in our institute.We analyzed the clinical features and outcomes of patients with bone metastases and the data and follow-up of 63 bone metastases was collected by one registrar.Cochran Armitage trend test was used for statistic analysis and a P-value of < 0.05 was taken as statistically significant.Results:The mean age was 73(range 55 to 87) years.The PSA level was from 0.083 ng/mL to 6462 ng/mL.Bone metastases morbidity had good relationship with PSA level.With the mean follow up of 30(range 6 to 72) months for 52/63(82.5%) patients,15(28.8%) died from Pca with a mean survival of 21 months and 1 patient with PSA less than 4 ng/mL at the time died from cerebrovascular suddenness 6 months post-treatment.Conclusion:The early effect of endocrine treatment for bone metastases is obvious,and palliative prostatectomy is satisfactory and able to improve the quality of life rapidly for patients with obstructive symptoms.
基金Guangxi Science and Technology Plan Project(Gui Ke AD17195026&Gui Ke AD19259007)Science and Technology Development Fund Project of Guangxi Academy of Agricultural Sciences(Gui Nong Ke 2016ZX11)Fund Project of Guangxi Academy of Agricultural Sciences(2019ZX121).
文摘[Objectives]To evaluate the status of soil nutrient and fertility in main dry farming regions of Laos,and to explore differences in soil nutrient content between regions and crop types.[Methods]By collecting 57 soil samples in the 0-20 cm layer of the main dryland in southern and northern provinces of Laos.Soil pH,organic matter,total nitrogen,available nitrogen,available phosphorus,available potassium,exchangeable calcium,exchangeable magnesium and available zinc content were analyzed.[Results]The soil in the main dry farming regions of Laos was acidic,the overall fertility level was good,and the exchangeable calcium and magnesium contents were low.There were differences in soil nutrient content in the dry farming regions of southern and northern Laos.Drylands where cassava and maize were growed had higher fertility.[Conclusions]It is suggested to apply lime or alkaline fertilizer in the dry land with acid soil to increase soil pH and increase the supply of soil calcium and magnesium.Organic fertilizer should be applied to improve soil water retention capacity,and it is necessary to pay attention to the fertilization ratio of macroelements to balance fertilization.
基金supported by the National Natural Science Foundation of China(No.81874001)the Program for Youth Innovation in Future Medicine of Chongqing Medical University(China)(No.W0086).
文摘Bladder cancer (BC) is one of the most common malignant tumors in the urinary system.Due to the poor prognosis and high mortality rate of the disease,it is urgent to develop new drugs with high efficacy and low toxicity to treat BC.Echinatin (Ecn) is a bioactive natural flavonoid oflicorice that has attracted special attention for its promising anti-tumor potential.Herein,we explored the inhibitory effects of Echinatin on BC cells and probed the possible molecular mechanism.We found that Ecnin vitro inhibited the proliferation,migration,and invasion,arrested the cell cycle at the G2/M phase,and promoted apoptosis in BC cells.Besides,Ecn had no notable cytotoxicity towards human normal cells.We subsequently confirmed that Ecn restrained xenograft tumor growth and metastasis of BC cells in vivo .Mechanistically,Ecn activated the p38 signaling pathway but inactivated the Wnt/β-catenin signaling pathway,while over-expression of β-catenin and the p38 inhibitor both attenuated the inhibitory effects of Ecn on BC cells.Remarkably,Ecn combined with cisplatin (DDP) or gemcitabine (Gem) had synergistic inhibitory effects on BC cells.In summary,our results validate that Ecn inhibits the tumor growth of human BC cells via p38 and Wnt/β-catenin signaling pathways.More meaningfully,our results suggest a potential strategy to enhance DDP- or Gem-induced inhibitory effects on BC cells by combining with Ecn.
