The relationship between support and surrounding rock is of great significance to the control of surrounding rock in mining process.In view of the fact that most of the existing numerical simulation methods construct ...The relationship between support and surrounding rock is of great significance to the control of surrounding rock in mining process.In view of the fact that most of the existing numerical simulation methods construct virtual elements and stress servo control to approximately replace the hydraulic support problem,this paper establishes a new numerical model of hydraulic support with the same working characteristics as the actual hydraulic support by integrating numerical simulation software Rhino,Griddle and FLAC3D,which can realize the simulation of different working conditions.Based on this model,the influence mechanism of the supporting strength of hydraulic support on surrounding rock stress regulation and coal stability in front of the top coal caving face in extra thick coal seam were researched.Firstly,under different support intensity,the abutment pressure of the bearing coal and the coal in front of it presents the “three-stage”evolution characteristics.The influence range of support intensity is 15%–30%.Secondly,1.5 MPa is the upper limit of impact that the support strength can have on the front coal failure area.Thirdly,within a displacement range of 2.76 m from the coal wall,a support strength of1.5 MPa provides optimal control of the horizontal displacement of the coal.展开更多
[Objectives] This study was conducted to optimize the extraction process of Sipunculus nudus polysaccharide. [Methods]S. nudus polysaccharide was extracted by ultrasonic water extraction,with the marine S. nudus as a ...[Objectives] This study was conducted to optimize the extraction process of Sipunculus nudus polysaccharide. [Methods]S. nudus polysaccharide was extracted by ultrasonic water extraction,with the marine S. nudus as a raw material from Sanya City,Hainan Province,by single factor variable method,to find the optimal extraction conditions including ultrasonic power,solid-liquid ratio,ultrasonic extraction temperature,ultrasonic extraction time,ultrasonic extraction times and lye concentration. The absorbance of the polysaccharide was determined by an ultraviolet spectrophotometer,and polysaccharide yield were calculated. The antioxidant activity of scavenging hydroxyl and DPPH radicals was measured at different concentrations. [Results]The optimal extraction conditions for S. nudus polysaccharide were as follows： solid-liquid ratio at 1∶11 mg/ml,extraction temperature at 60 ℃,three times of ultrasonic extraction,ultrasonic power of 960 W,extraction time of 1. 5 h,and lye concentration of 5%,under which the polysaccharide yield was 3. 21%. The scavenging rates of hydroxyl radical and DPPH radical were 12. 58% at the concentration of 0. 20 mg/ml. Moreover,the scavenging rates increased significantly with the increase of concentration. [Conclusions] This method is a new trial with satisfactory results.展开更多
In this paper,a time–frequency algorithm based on adaptive chirplet transform for parameter modeling and identification of Linear Time-Varying(LTV)systems under random excitation is presented.It is assumed that the s...In this paper,a time–frequency algorithm based on adaptive chirplet transform for parameter modeling and identification of Linear Time-Varying(LTV)systems under random excitation is presented.It is assumed that the solution of responses of LTV structures is expressed as the sum of multicomponent Linear Frequency Modulated(LFM)signals in a short-time.Then the measured acceleration response is used to perform the adaptive chirplet transform,in which an integral algorithm is employed to reconstruct the velocity and displacement responses.The vibration differential equation with time-varying coefficients is transformed into a simple linear equation.Furthermore,for systems under random excitation,the input–output relation based on correlation function is also derived to estimate the parameters including physicals parameters and instantaneous modal parameters.The full procedure of the method is presented and validated by using simulated responses.The results show that the presented method is accurate and robust for various LTV systems under random excitation.展开更多
Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcit...Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using 18F-fluorodeoxyglucose positron emission tomography(18FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy.展开更多
Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcit...Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using ^(18)F-fluorodeoxyglucose positron emission tomography(^(18)FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy.展开更多
High-entropy alloys(HEAs)are a promising solution for large-scale hydrogen storage(H-storage)and are therefore receiving increasing attention from the materials science community.In this study,we systematically invest...High-entropy alloys(HEAs)are a promising solution for large-scale hydrogen storage(H-storage)and are therefore receiving increasing attention from the materials science community.In this study,we systematically investigated the microstructures and H-storage properties of V_(35)Ti_(35)Cr_(10) Fe_(10)M_(10)(M=Mn,Co,Sc,or Ni)HEAs prepared by arcmelting.The cast HEAs were found to be nanocrystalline.The crystal lattice parameters and hydrogen absorption energies of the alloys were calculated using density functional theory(DFT)calculations.The alloys can be fully activated in just one cycle of hydrogen absorption/desorption under mild conditions,after which they reach hydrogen absorption saturation in approximately 100 s at ambient temperature.The hydrogenation kinetics of the HEAs are approximately five times higher than that of conventional solid-solution alloys with a body-centered cubic(BCC)structure.By performing in-situ hydriding differential scanning calorimetry in combination with DFT calculations,we revealed that the alloys are more susceptible to hydrogenation than traditional BCC structural alloys.The H-storage capacity of V_(35)Ti_(35)Cr_(10) Fe_(10)M_(10) alloys at ambient temperature was higher than that of HEAs reported in the literature.Quasi-in-situ X-ray diffraction characterization of the HEAs’hydrogenation revealed a phase transition process from a BCC to facecentered cubic,passing through a pseudo-BCC structure.Our work introduces a new perspective for designing alloys with ultrafast hydrogen absorption kinetics and high capacity for large-scale,room-temperature-applicable H-storage.展开更多
基金supported by Distinguished Youth Funds of National Natural Science Foundation of China (No.51925402)National Natural Science Foundation of China (Nos.51904203 and 52174125)+4 种基金the China Postdoctoral Science Foundation (No.2021M702049)the Tencent Foundation or XPLORER PRIZEShanxi Science and Technology Major Project Funds (No.20201102004)Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering (No.2021SX-TD001)Open Fund Research Project Supported by State Key Laboratory of Strata Intelligent Control and Green Mining Co-founded by Shandong Province and the Ministry of Science and Technology (No.SICGM202209)。
文摘The relationship between support and surrounding rock is of great significance to the control of surrounding rock in mining process.In view of the fact that most of the existing numerical simulation methods construct virtual elements and stress servo control to approximately replace the hydraulic support problem,this paper establishes a new numerical model of hydraulic support with the same working characteristics as the actual hydraulic support by integrating numerical simulation software Rhino,Griddle and FLAC3D,which can realize the simulation of different working conditions.Based on this model,the influence mechanism of the supporting strength of hydraulic support on surrounding rock stress regulation and coal stability in front of the top coal caving face in extra thick coal seam were researched.Firstly,under different support intensity,the abutment pressure of the bearing coal and the coal in front of it presents the “three-stage”evolution characteristics.The influence range of support intensity is 15%–30%.Secondly,1.5 MPa is the upper limit of impact that the support strength can have on the front coal failure area.Thirdly,within a displacement range of 2.76 m from the coal wall,a support strength of1.5 MPa provides optimal control of the horizontal displacement of the coal.
基金Supported by National Natural Science Foundation of Hainan Province(217157)Fund for Construction of Provincial Key Discipline(thalassochemistry)in 2017
文摘[Objectives] This study was conducted to optimize the extraction process of Sipunculus nudus polysaccharide. [Methods]S. nudus polysaccharide was extracted by ultrasonic water extraction,with the marine S. nudus as a raw material from Sanya City,Hainan Province,by single factor variable method,to find the optimal extraction conditions including ultrasonic power,solid-liquid ratio,ultrasonic extraction temperature,ultrasonic extraction time,ultrasonic extraction times and lye concentration. The absorbance of the polysaccharide was determined by an ultraviolet spectrophotometer,and polysaccharide yield were calculated. The antioxidant activity of scavenging hydroxyl and DPPH radicals was measured at different concentrations. [Results]The optimal extraction conditions for S. nudus polysaccharide were as follows： solid-liquid ratio at 1∶11 mg/ml,extraction temperature at 60 ℃,three times of ultrasonic extraction,ultrasonic power of 960 W,extraction time of 1. 5 h,and lye concentration of 5%,under which the polysaccharide yield was 3. 21%. The scavenging rates of hydroxyl radical and DPPH radical were 12. 58% at the concentration of 0. 20 mg/ml. Moreover,the scavenging rates increased significantly with the increase of concentration. [Conclusions] This method is a new trial with satisfactory results.
基金funded by the National Natural Science Foundation of China(Grant No.11172131 and 11232007)the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘In this paper,a time–frequency algorithm based on adaptive chirplet transform for parameter modeling and identification of Linear Time-Varying(LTV)systems under random excitation is presented.It is assumed that the solution of responses of LTV structures is expressed as the sum of multicomponent Linear Frequency Modulated(LFM)signals in a short-time.Then the measured acceleration response is used to perform the adaptive chirplet transform,in which an integral algorithm is employed to reconstruct the velocity and displacement responses.The vibration differential equation with time-varying coefficients is transformed into a simple linear equation.Furthermore,for systems under random excitation,the input–output relation based on correlation function is also derived to estimate the parameters including physicals parameters and instantaneous modal parameters.The full procedure of the method is presented and validated by using simulated responses.The results show that the presented method is accurate and robust for various LTV systems under random excitation.
基金supported by the National Natural Science Foundation of China(81672686)Special Support Program of Sun Yat-sen University Cancer Center(PT19020401)+1 种基金Science and Technology Planning Project of Guangzhou,China(202002030205)Clinical Oncology Foundation of Chinese Society of Clinical Oncology(Y-XD2019-124).
文摘Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using 18F-fluorodeoxyglucose positron emission tomography(18FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy.
基金This work was supported by the National Natural Science Foundation of China(81672686)Special Support Program of Sun Yat-sen University Cancer Center(PT19020401)+1 种基金Science and Technology Planning Project of Guangzhou,China(202002030205)Clinical Oncology Foundation of Chinese Society of Clinical Oncology(Y-XD2019-124).
文摘Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using ^(18)F-fluorodeoxyglucose positron emission tomography(^(18)FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy.
基金supported by the Natural Science Foundation of Inner Mongolia,China(grant nos.2022MS05011,2020LH01006,and 2022FX02)the National Natural Science Foundation of China(grant nos.52261041 and 51961032)+1 种基金the Major Science and Technology Project of Inner Mongolia(grant no.2021ZD0029)the Fundamental Research Funds for Inner Mongolia University of Science&Technology(grant no.2023QNJS119).
文摘High-entropy alloys(HEAs)are a promising solution for large-scale hydrogen storage(H-storage)and are therefore receiving increasing attention from the materials science community.In this study,we systematically investigated the microstructures and H-storage properties of V_(35)Ti_(35)Cr_(10) Fe_(10)M_(10)(M=Mn,Co,Sc,or Ni)HEAs prepared by arcmelting.The cast HEAs were found to be nanocrystalline.The crystal lattice parameters and hydrogen absorption energies of the alloys were calculated using density functional theory(DFT)calculations.The alloys can be fully activated in just one cycle of hydrogen absorption/desorption under mild conditions,after which they reach hydrogen absorption saturation in approximately 100 s at ambient temperature.The hydrogenation kinetics of the HEAs are approximately five times higher than that of conventional solid-solution alloys with a body-centered cubic(BCC)structure.By performing in-situ hydriding differential scanning calorimetry in combination with DFT calculations,we revealed that the alloys are more susceptible to hydrogenation than traditional BCC structural alloys.The H-storage capacity of V_(35)Ti_(35)Cr_(10) Fe_(10)M_(10) alloys at ambient temperature was higher than that of HEAs reported in the literature.Quasi-in-situ X-ray diffraction characterization of the HEAs’hydrogenation revealed a phase transition process from a BCC to facecentered cubic,passing through a pseudo-BCC structure.Our work introduces a new perspective for designing alloys with ultrafast hydrogen absorption kinetics and high capacity for large-scale,room-temperature-applicable H-storage.
