Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate ...Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate by acetaldehyde dehydrogenase type 2(ALDH2).ALDH2 deficiency can lead to ACE accumulation and DNA damage.展开更多
Spectral compressive imaging(SCI) is able to encode a high-dimensional hyperspectral image into a twodimensional snapshot measurement, and then use algorithms to reconstruct the spatio-spectral data-cube. At present, ...Spectral compressive imaging(SCI) is able to encode a high-dimensional hyperspectral image into a twodimensional snapshot measurement, and then use algorithms to reconstruct the spatio-spectral data-cube. At present, the main bottleneck of SCI is the reconstruction algorithm, and state-of-the-art(SOTA) reconstruction methods generally face problems of long reconstruction times and/or poor detail recovery. In this paper, we propose a hybrid network module, namely, a convolution and contextual Transformer(CCo T) block, that can simultaneously acquire the inductive bias ability of convolution and the powerful modeling ability of Transformer, which is conducive to improving the quality of reconstruction to restore fine details. We integrate the proposed CCo T block into a physics-driven deep unfolding framework based on the generalized alternating projection(GAP) algorithm, and further propose the GAP-CCo T network. Finally, we apply the GAP-CCo T algorithm to SCI reconstruction. Through experiments on a large amount of synthetic data and real data,our proposed model achieves higher reconstruction quality(>2 d B in peak signal-to-noise ratio on simulated benchmark datasets) and a shorter running time than existing SOTA algorithms by a large margin. The code and models are publicly available at https://github.com/ucaswangls/GAP-CCoT.展开更多
Affinity core-shell magnetic nanoparticles （MNPs） were prepared for identifying the target proteins of drugs in the cell lysate when used in combination with nano-high-performance liquid chromatography tandem mass s...Affinity core-shell magnetic nanoparticles （MNPs） were prepared for identifying the target proteins of drugs in the cell lysate when used in combination with nano-high-performance liquid chromatography tandem mass spectrometry （HPLC-MS/MS）-based shotgun proteomic analysis. A number of new potential targets of cyclosporine A （CsA） could be identified, owing to the high efficacy of the affinity MNPs in drug target identification. To the best of our knowledge, this is the first time to reveal such an abundant target spectrum of CsA.展开更多
基金supported by grants from the National Nature Science Foundation of China(No.82172565,81620108022,81872245,91129303,991729302,81572759,,31900441,82003069,82103571,882002941,82072570,91129733,81502702).
文摘Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate by acetaldehyde dehydrogenase type 2(ALDH2).ALDH2 deficiency can lead to ACE accumulation and DNA damage.
基金New Generation of Artificial Intelligence Integration and Application Demonstration of the Chinese Academy of Sciences(RTLZ2021009)Westlake Foundation(2021B1501-2)。
文摘Spectral compressive imaging(SCI) is able to encode a high-dimensional hyperspectral image into a twodimensional snapshot measurement, and then use algorithms to reconstruct the spatio-spectral data-cube. At present, the main bottleneck of SCI is the reconstruction algorithm, and state-of-the-art(SOTA) reconstruction methods generally face problems of long reconstruction times and/or poor detail recovery. In this paper, we propose a hybrid network module, namely, a convolution and contextual Transformer(CCo T) block, that can simultaneously acquire the inductive bias ability of convolution and the powerful modeling ability of Transformer, which is conducive to improving the quality of reconstruction to restore fine details. We integrate the proposed CCo T block into a physics-driven deep unfolding framework based on the generalized alternating projection(GAP) algorithm, and further propose the GAP-CCo T network. Finally, we apply the GAP-CCo T algorithm to SCI reconstruction. Through experiments on a large amount of synthetic data and real data,our proposed model achieves higher reconstruction quality(>2 d B in peak signal-to-noise ratio on simulated benchmark datasets) and a shorter running time than existing SOTA algorithms by a large margin. The code and models are publicly available at https://github.com/ucaswangls/GAP-CCoT.
基金the National Natural Science Foundations of China，the National Key Laboratory of Organic Biochemistry Opening Foundations
文摘Affinity core-shell magnetic nanoparticles （MNPs） were prepared for identifying the target proteins of drugs in the cell lysate when used in combination with nano-high-performance liquid chromatography tandem mass spectrometry （HPLC-MS/MS）-based shotgun proteomic analysis. A number of new potential targets of cyclosporine A （CsA） could be identified, owing to the high efficacy of the affinity MNPs in drug target identification. To the best of our knowledge, this is the first time to reveal such an abundant target spectrum of CsA.
