Aiming at evaluating and predicting rapidly and accurately a high sensitivity receiver’s adaptability in complex electromagnetic environments,a novel testing and prediction method based on dual-channel multi-frequenc...Aiming at evaluating and predicting rapidly and accurately a high sensitivity receiver’s adaptability in complex electromagnetic environments,a novel testing and prediction method based on dual-channel multi-frequency is proposed to improve the traditional two-tone test.Firstly,two signal generators are used to generate signals at the radio frequency(RF)by frequency scanning,and then a rapid measurement at the intermediate frequency(IF)output port is carried out to obtain a huge amount of sample data for the subsequent analysis.Secondly,the IF output response data are modeled and analyzed to construct the linear and nonlinear response constraint equations in the frequency domain and prediction models in the power domain,which provide the theoretical criteria for interpreting and predicting electromagnetic susceptibility(EMS)of the receiver.An experiment performed on a radar receiver confirms the reliability of the method proposed in this paper.It shows that the interference of each harmonic frequency and each order to the receiver can be identified and predicted with the sensitivity model.Based on this,fast and comprehensive evaluation and prediction of the receiver’s EMS in complex environment can be efficiently realized.展开更多
背景:活髓切断术现作为永久保存活髓的治疗方法,术中选择合适的盖髓材料可在较大程度上增强其临床疗效并扩大其应用范围。目的:探讨云南白药、iRoot BP Plus及其联合应用对炎症状态下牙髓干细胞矿化的影响。方法:采用组织块法培养人原...背景:活髓切断术现作为永久保存活髓的治疗方法,术中选择合适的盖髓材料可在较大程度上增强其临床疗效并扩大其应用范围。目的:探讨云南白药、iRoot BP Plus及其联合应用对炎症状态下牙髓干细胞矿化的影响。方法:采用组织块法培养人原代牙髓干细胞,MTT法测定云南白药、iRoot BP Plus对牙髓干细胞增殖的影响,确定最佳干预质量浓度。将第3-6代牙髓干细胞分为5组:正常对照组、炎症对照组、云南白药组、iRoot BP Plus组、云南白药+iRoot BP Plus组,后4组使用1μg/mL脂多糖诱导2 h进行细胞造模,然后分别采用75μg/mL云南白药、100μg/mL iRoot BP Plus及两者联用进行刺激,采用碱性磷酸酶染色法、茜素红S染色法、Real time-PCR法、Western blot法检测药物对细胞矿化的影响。结果与结论:①与炎症对照组比较,云南白药、iRoot BP Plus及其联合应用处理后抑制了肿瘤坏死因子αmRNA的表达(P<0.001),云南白药+iRoot BP Plus组肿瘤坏死因子αmRNA的表达明显低于云南白药组、iRoot BP Plus组(P<0.001);②与炎症对照组比较,经云南白药、iRoot BP Plus及其联合应用处理后矿化结节数量、碱性磷酸酶活性显著增加,云南白药+iRoot BP Plus组矿化结节量、碱性磷酸酶活性高于云南白药组、iRoot BP Plus组(P<0.001);③与炎症对照组比较,经云南白药、iRoot BP Plus及其联合应用处理后DSPP、IBSP、MEPE mRNA的表达增加(P<0.001),云南白药+iRoot BP Plus组DSPP、IBSP、MEPE mRNA的表达高于云南白药组、iRoot BP Plus组(P<0.001);④与炎症对照组比较,云南白药组、云南白药+iRoot BP Plus组Akt、mTOR的磷酸化增加(P<0.001);⑤结果表明,云南白药、iRoot BP Plus均能促进牙髓干细胞矿化,两者联合应用矿化作用更显著;云南白药对牙髓干细胞的促矿化作用与Akt/mTOR通路相关。展开更多
基金supported by the National Natural Science Foundation of China(62071473).
文摘Aiming at evaluating and predicting rapidly and accurately a high sensitivity receiver’s adaptability in complex electromagnetic environments,a novel testing and prediction method based on dual-channel multi-frequency is proposed to improve the traditional two-tone test.Firstly,two signal generators are used to generate signals at the radio frequency(RF)by frequency scanning,and then a rapid measurement at the intermediate frequency(IF)output port is carried out to obtain a huge amount of sample data for the subsequent analysis.Secondly,the IF output response data are modeled and analyzed to construct the linear and nonlinear response constraint equations in the frequency domain and prediction models in the power domain,which provide the theoretical criteria for interpreting and predicting electromagnetic susceptibility(EMS)of the receiver.An experiment performed on a radar receiver confirms the reliability of the method proposed in this paper.It shows that the interference of each harmonic frequency and each order to the receiver can be identified and predicted with the sensitivity model.Based on this,fast and comprehensive evaluation and prediction of the receiver’s EMS in complex environment can be efficiently realized.
文摘背景:活髓切断术现作为永久保存活髓的治疗方法,术中选择合适的盖髓材料可在较大程度上增强其临床疗效并扩大其应用范围。目的:探讨云南白药、iRoot BP Plus及其联合应用对炎症状态下牙髓干细胞矿化的影响。方法:采用组织块法培养人原代牙髓干细胞,MTT法测定云南白药、iRoot BP Plus对牙髓干细胞增殖的影响,确定最佳干预质量浓度。将第3-6代牙髓干细胞分为5组:正常对照组、炎症对照组、云南白药组、iRoot BP Plus组、云南白药+iRoot BP Plus组,后4组使用1μg/mL脂多糖诱导2 h进行细胞造模,然后分别采用75μg/mL云南白药、100μg/mL iRoot BP Plus及两者联用进行刺激,采用碱性磷酸酶染色法、茜素红S染色法、Real time-PCR法、Western blot法检测药物对细胞矿化的影响。结果与结论:①与炎症对照组比较,云南白药、iRoot BP Plus及其联合应用处理后抑制了肿瘤坏死因子αmRNA的表达(P<0.001),云南白药+iRoot BP Plus组肿瘤坏死因子αmRNA的表达明显低于云南白药组、iRoot BP Plus组(P<0.001);②与炎症对照组比较,经云南白药、iRoot BP Plus及其联合应用处理后矿化结节数量、碱性磷酸酶活性显著增加,云南白药+iRoot BP Plus组矿化结节量、碱性磷酸酶活性高于云南白药组、iRoot BP Plus组(P<0.001);③与炎症对照组比较,经云南白药、iRoot BP Plus及其联合应用处理后DSPP、IBSP、MEPE mRNA的表达增加(P<0.001),云南白药+iRoot BP Plus组DSPP、IBSP、MEPE mRNA的表达高于云南白药组、iRoot BP Plus组(P<0.001);④与炎症对照组比较,云南白药组、云南白药+iRoot BP Plus组Akt、mTOR的磷酸化增加(P<0.001);⑤结果表明,云南白药、iRoot BP Plus均能促进牙髓干细胞矿化,两者联合应用矿化作用更显著;云南白药对牙髓干细胞的促矿化作用与Akt/mTOR通路相关。
