Objective: The aim of the study was to discuss the value of ultrasound examination in the diagnosis of fetal gastric teratoma. Methods: We retrospectively analyzed 2 cases with fetal gastric teratoma in our hospital (...Objective: The aim of the study was to discuss the value of ultrasound examination in the diagnosis of fetal gastric teratoma. Methods: We retrospectively analyzed 2 cases with fetal gastric teratoma in our hospital (Department of Gynecology and Obstetrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China). It involved clinical, ultrasonic, X-ray, CT and MRI, biochemical, pathological, karyotype and immunohistochemical data. Results: There both were hybrid echo masses in the abdominal of the fetus with the sonography and the ultrasound features which mostly like the teratomas. Two cases were dead after induced abortion. The pathological results of the mass were gastric immature teratoma in one, and stomach mature teratoma in another. Conclusion: Fetal gastric teratoma is rarely seen and easily be misdiagnosed in clinic. The diagnosis depends finally on pathological examination. Ultrasound scan as the easy and direct method is helpful to clew the diagnosis of fetal gastric teratoma.展开更多
Objective： The purpose of this study was to search the ultrasound features of small intestinal stromal tumor （SIST） in women by reviewing their clinical data. Methods： The study group consisted of 18 female patien...Objective： The purpose of this study was to search the ultrasound features of small intestinal stromal tumor （SIST） in women by reviewing their clinical data. Methods： The study group consisted of 18 female patients with pathologically proven SIST in our hospital from 2000 to 2009. Medical records were reviewed for clinical information such as manifestation, findings of ultrasonography and immunohistochemical phenotype. Results： The average age of 18 female patients with SIST was 55.2 years （ranged, 39-84 years）. Seventeen cases of them had abnormal hypogastric masses, no mass in one case. The shapes of masses were round or Iobulate beside tightly uterus or ovary. The echo of masses was low. It＇s borders were clear and sometimes irregular. The sizes of the masses varied from 6.89-193.05 cm3, the diameter ranged from 24 tom-110 ram, 85.3% of which 50 mm-110 mm. There were rare color flow signals under color Doppler velocity mode or color Doppler power mode. Exploratory laparotomy confirmed that 16 cases of the tumors originated from small intestine, and 2 cases from the ileocecat. The positive rate of the immunohistochemical phenotype of CDl17 was 88.2%, and CD34 was 76.5%. The examination of pathology confirmed that 16 cases were malignant and 2 cases borderline tumors. Eighteen cases underwent radical surgical resection. Conclusion： The characteristics of SISTs in women pelvic cavity are： age 〉 40 years, a mass （proven not from productive system by ultrasonography） in pelvic cavity, melena, positive findings in pathology and CD117/CD34, especially notice masses which diameter is more than 50 mm and possess potential malignant. Ultrasonography is a convenient and effective tool of screening SISTs.展开更多
Objective:In this study, we investigated the in vitro binding capacity of β-HCG antibody targeted SonoVue microbubbles to trophoblasts with distinct differentiation in order to explore the possibility of utility of t...Objective:In this study, we investigated the in vitro binding capacity of β-HCG antibody targeted SonoVue microbubbles to trophoblasts with distinct differentiation in order to explore the possibility of utility of targeted SonoVue microbubbles imaging for early locating diagnosis of malignant trophoblastic cell disease. Methods:Three cell groups were included in the study: (1) choriocarcinoma cells (poorly differentiated) (JAR, n=10), (2) early gestational trophoblastic cells (ETC, n=10) and (3) late placenta trophoblastic cells (LTC, n=10). The binding efficiency of the contrast agents to the targeted cells was evaluated by counting the ring formation rate before and after rinsing with PBS. Results: The binding rate was significantly higher in JAR group 84.3±5.5% than in the ETC group 67.3±3.9% and LTC group 60.4±4.6% (P<0.05). The binding rates of different targeted cells to the related targeted microbubble contrast agent (TMCA) before and after PBS rinse did not change significantly. The JARs group exhibited the highest binding rate of (84.3±5.5)% and (82.4±3.7)% before and after PBS rinse (P>0.05). The binding rates of the targeted microbubbles labeled with fluorescence by FCM to JARs, ETC or LTC were 90.1%, 81.5% and 69.2%, respectively (P<0.05). Conclusion: This in vitro study demonstrated that β-HCG an-tibody-targeted SonoVue had different binding capacities to trophoblasts with distinct degrees of differentiation. The highest binding rate occurred with the choriocarcinoma cell line JAR. There is the possibility that the β-HCG antibody-targeted strategy could improve the discriminative ability of SonoVue, in the locating malignant trophoblastic cells.展开更多
文摘Objective: The aim of the study was to discuss the value of ultrasound examination in the diagnosis of fetal gastric teratoma. Methods: We retrospectively analyzed 2 cases with fetal gastric teratoma in our hospital (Department of Gynecology and Obstetrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China). It involved clinical, ultrasonic, X-ray, CT and MRI, biochemical, pathological, karyotype and immunohistochemical data. Results: There both were hybrid echo masses in the abdominal of the fetus with the sonography and the ultrasound features which mostly like the teratomas. Two cases were dead after induced abortion. The pathological results of the mass were gastric immature teratoma in one, and stomach mature teratoma in another. Conclusion: Fetal gastric teratoma is rarely seen and easily be misdiagnosed in clinic. The diagnosis depends finally on pathological examination. Ultrasound scan as the easy and direct method is helpful to clew the diagnosis of fetal gastric teratoma.
文摘Objective： The purpose of this study was to search the ultrasound features of small intestinal stromal tumor （SIST） in women by reviewing their clinical data. Methods： The study group consisted of 18 female patients with pathologically proven SIST in our hospital from 2000 to 2009. Medical records were reviewed for clinical information such as manifestation, findings of ultrasonography and immunohistochemical phenotype. Results： The average age of 18 female patients with SIST was 55.2 years （ranged, 39-84 years）. Seventeen cases of them had abnormal hypogastric masses, no mass in one case. The shapes of masses were round or Iobulate beside tightly uterus or ovary. The echo of masses was low. It＇s borders were clear and sometimes irregular. The sizes of the masses varied from 6.89-193.05 cm3, the diameter ranged from 24 tom-110 ram, 85.3% of which 50 mm-110 mm. There were rare color flow signals under color Doppler velocity mode or color Doppler power mode. Exploratory laparotomy confirmed that 16 cases of the tumors originated from small intestine, and 2 cases from the ileocecat. The positive rate of the immunohistochemical phenotype of CDl17 was 88.2%, and CD34 was 76.5%. The examination of pathology confirmed that 16 cases were malignant and 2 cases borderline tumors. Eighteen cases underwent radical surgical resection. Conclusion： The characteristics of SISTs in women pelvic cavity are： age 〉 40 years, a mass （proven not from productive system by ultrasonography） in pelvic cavity, melena, positive findings in pathology and CD117/CD34, especially notice masses which diameter is more than 50 mm and possess potential malignant. Ultrasonography is a convenient and effective tool of screening SISTs.
基金Supported by a grant from the Science-Technology Program Foundation of Guangdong Province,China (No.2006B35901009)
文摘Objective:In this study, we investigated the in vitro binding capacity of β-HCG antibody targeted SonoVue microbubbles to trophoblasts with distinct differentiation in order to explore the possibility of utility of targeted SonoVue microbubbles imaging for early locating diagnosis of malignant trophoblastic cell disease. Methods:Three cell groups were included in the study: (1) choriocarcinoma cells (poorly differentiated) (JAR, n=10), (2) early gestational trophoblastic cells (ETC, n=10) and (3) late placenta trophoblastic cells (LTC, n=10). The binding efficiency of the contrast agents to the targeted cells was evaluated by counting the ring formation rate before and after rinsing with PBS. Results: The binding rate was significantly higher in JAR group 84.3±5.5% than in the ETC group 67.3±3.9% and LTC group 60.4±4.6% (P<0.05). The binding rates of different targeted cells to the related targeted microbubble contrast agent (TMCA) before and after PBS rinse did not change significantly. The JARs group exhibited the highest binding rate of (84.3±5.5)% and (82.4±3.7)% before and after PBS rinse (P>0.05). The binding rates of the targeted microbubbles labeled with fluorescence by FCM to JARs, ETC or LTC were 90.1%, 81.5% and 69.2%, respectively (P<0.05). Conclusion: This in vitro study demonstrated that β-HCG an-tibody-targeted SonoVue had different binding capacities to trophoblasts with distinct degrees of differentiation. The highest binding rate occurred with the choriocarcinoma cell line JAR. There is the possibility that the β-HCG antibody-targeted strategy could improve the discriminative ability of SonoVue, in the locating malignant trophoblastic cells.
