Artificial intelligence can be indirectly applied to the repair of peripheral nerve injury.Specifically,it can be used to analyze and process data regarding peripheral nerve injury and repair,while study findings on p...Artificial intelligence can be indirectly applied to the repair of peripheral nerve injury.Specifically,it can be used to analyze and process data regarding peripheral nerve injury and repair,while study findings on peripheral nerve injury and repair can provide valuable data to enrich artificial intelligence algorithms.To investigate advances in the use of artificial intelligence in the diagnosis,rehabilitation,and scientific examination of peripheral nerve injury,we used CiteSpace and VOSviewer software to analyze the relevant literature included in the Web of Science from 1994–2023.We identified the following research hotspots in peripheral nerve injury and repair:(1)diagnosis,classification,and prognostic assessment of peripheral nerve injury using neuroimaging and artificial intelligence techniques,such as corneal confocal microscopy and coherent anti-Stokes Raman spectroscopy;(2)motion control and rehabilitation following peripheral nerve injury using artificial neural networks and machine learning algorithms,such as wearable devices and assisted wheelchair systems;(3)improving the accuracy and effectiveness of peripheral nerve electrical stimulation therapy using artificial intelligence techniques combined with deep learning,such as implantable peripheral nerve interfaces;(4)the application of artificial intelligence technology to brain-machine interfaces for disabled patients and those with reduced mobility,enabling them to control devices such as networked hand prostheses;(5)artificial intelligence robots that can replace doctors in certain procedures during surgery or rehabilitation,thereby reducing surgical risk and complications,and facilitating postoperative recovery.Although artificial intelligence has shown many benefits and potential applications in peripheral nerve injury and repair,there are some limitations to this technology,such as the consequences of missing or imbalanced data,low data accuracy and reproducibility,and ethical issues(e.g.,privacy,data security,research transparency).Future research should address the issue of data collection,as large-scale,high-quality clinical datasets are required to establish effective artificial intelligence models.Multimodal data processing is also necessary,along with interdisciplinary collaboration,medical-industrial integration,and multicenter,large-sample clinical studies.展开更多
MdMYB88 and MdMYB124 have been demonstrated to be responsible for lignin accumulation in apple under drought stress.In this study,using a metabolomic approach,we identified differentially accumulated phenylpropanoid a...MdMYB88 and MdMYB124 have been demonstrated to be responsible for lignin accumulation in apple under drought stress.In this study,using a metabolomic approach,we identified differentially accumulated phenylpropanoid and flavonoid metabolites in MdMYB88/124 transgenic RNAi plants under control and long-term drought stress conditions in apple roots.We confirmed the regulation of phenylalanine by MdMYB88 and MdMYB124 via UPLC-MS in apple roots under both control and drought conditions.Using Electrophoretic Mobility Shift Assay(EMSA)and ChIPquantitative PCR(qPCR)analyses,we found that MdMYB88 positively regulates the MdCM2 gene,which is responsible for phenylalanine biosynthesis,through binding to its promoter region.Under long-term drought conditions,MdMYB88/124 RNAi plants consistently accumulated increased amounts of H2O2 and MDA,while MdMYB88 and MdMYB124 overexpression plants accumulated decreased amounts of H2O2 and MDA.We also examined the accumulation of metabolites in the phenylpropanoid biosynthesis pathway in the leaves of MdMYB88 and MdMYB124 transgenic apple plants after long-term drought stress.We found that metabolites responsible for plant defense,including phenylpropanoids and flavonoids,accumulated less in the RNAi plants but more in the overexpression plants under both control and drought conditions.We further demonstrated that MdMYB88/124 RNAi plants were more sensitive to Alternaria alternata f.sp.mali and Valsa mali,two pathogens that currently severely threaten apple production.In contrast,MdMYB88 and MdMYB124 overexpression plants were more tolerant to these pathogens.The cumulative results of this study provided evidence for secondary metabolite regulation by MdMYB88 and MdMYB124,further explained the molecular roles of MdMYB88 and MdMYB124 in drought resistance,and provided information concerning molecular aspects of their roles in disease resistance.展开更多
An experimental setup has been designed and realized in order to optimize the characteristics of laser-induced breakdown spectroscopy system working in various pressure environments. An approach combined the normaliza...An experimental setup has been designed and realized in order to optimize the characteristics of laser-induced breakdown spectroscopy system working in various pressure environments. An approach combined the normalization methods with the partial least squares(PLS) method are developed for quantitative analysis of molybdenum(Mo) element in the multi-component alloy,which is the first wall material in the Experimental Advanced Superconducting Tokamak. In this study, the different spectral normalization methods(total spectral area normalization,background normalization, and reference line normalization) are investigated for reducing the uncertainty and improving the accuracy of spectral measurement. The results indicates that the approach of PLS based on inter-element interference is significantly better than the conventional PLS methods as well as the univariate linear methods in the various pressure for molybdenum element analysis.展开更多
Fuel retention measurement on plasma-facing components is an active field of study in magnetic confinement nuclear fusion devices.The laser-induced breakdown spectroscopy(LIBS)diagnostic method has been well demonstra...Fuel retention measurement on plasma-facing components is an active field of study in magnetic confinement nuclear fusion devices.The laser-induced breakdown spectroscopy(LIBS)diagnostic method has been well demonstrated to detect the elemental distribution in PFCs.In this work,an upgraded co-axis LIBS system based on a linear fiber bundle collection system has been developed to measure the hydrogen(H) retention on a tantalum(Ta) sample under a vacuum condition.The spatial resolution measurement of the different positions of the LIBS plasma can be achieved simultaneously with varying delay times.The temporal and spatial evolution results of LIBS plasma emission show that the H plasma observably expands from the delay times of 0-200 ns.The diameter of Ta plasma is about 6 mm which is much less than the size of H plasma after 200 ns.The difference in the temporal and spatial evolution behaviors between H plasma and Ta plasma is due to the great difference in the atomic mass of H and Ta.The depth profile result shows that H retention mainly exists on the surface of the sample.The temporal and spatial evolution behaviors of the electron excited temperature are consistent with that of the Ta emission.The result will further improve the understanding of the evolution of the dynamics of LIBS plasma and optimize the current collection system of in situ LIBS in fusion devices.展开更多
The complex nature of laser-material interaction causes non-stoichiometric ablation of alloy samples.This is attributed to matrix effect, which reduces analyzing capability. To address this issue, the analytical perfo...The complex nature of laser-material interaction causes non-stoichiometric ablation of alloy samples.This is attributed to matrix effect, which reduces analyzing capability. To address this issue, the analytical performance of three different normalization methods, namely normalization with background, internal normalization and three point smoothing techniques at different parameter settings is studied for quantification of Ag and Zn by Laser induced breakdown spectroscopy(LIBS).The LIBS spectra of five known concentration of silver zinc binary composites have been investigated at various laser irradiances(LIs). Calibration curves for both Ag(I) line(4d^(10)5s^2S_(1/2)→4d^(10)5p^2P_(1/2) at 338.28 nm) and Zn(I) line(4s5s^3S_1→4s4p^3P_2 at 481.053 nm) have been determined at LI of 5.86?×?10^(10)W cm^(-2). Slopes of these calibration curves provide the valuation of matrix effect in the Ag–Zn composites. With careful sample preparation and normalization after smoothing at optimum parameter setting(OPS), the minimization of sample matrix effect has been successfully achieved. A good linearity has been obtained in Ag and Zn calibration curve at OPS when normalized the whole area of spectrum after smoothing and the obtained coefficients of determination values were R^2?=?0.995 and 0.998 closer to 1. The results of matrix effect have been further verified by analysis of plasma parameters. Both plasma parameters showed no change with varying concentration at OPS. However, at high concentration of Ag, the observed significant changes in both plasma parameters at common parameter setting PS-1 and PS-2 were the gesture of matrix effect. In our case, the better analytical results were obtained at smoothing function with optimized parameter setting that indicates it is more efficient than normalization with background and internal normalization method.展开更多
Background Acute Achilles tendon rupture is a severe injury of the lower extremities;however,optimal treatment options are not yet available.This study aimed to investigate the surgical method and clinical effect of t...Background Acute Achilles tendon rupture is a severe injury of the lower extremities;however,optimal treatment options are not yet available.This study aimed to investigate the surgical method and clinical effect of the Krackow and tendon-bundle techniques for managing acute Achilles tendon rupture.Methods This retrospective case series study analyzed 17 cases of acute Achilles tendon rupture at the Beijing Jishuitan Hospital from December 2012 to January 2020.There were 16 men and one woman,aged 27–45 years,with an average of 39.6 years.Thirteen patients were injured while playing basketball or badminton,and 4 patients were injured while participating in a football match or other sports.All injuries were repaired using the Krackow and tendon-bundle techniques.Postoperative evaluation indicators included active range of motion during ankle plantar flexion and dorsiflexion,height of single foot heel lifting,Amer-Lindholm Achilles tendon function score,and American Orthopedic Foot and Ankle Society(AOFAS)score.Results The patients were followed-up for 6–45 months(average,18.9 months).There was no re-rupture of the Achilles tendon,wound infection,or sural nerve injury.At the final follow-up,the affected and contralateral sides exhibited plantar flexion of 42.1±4.4°and 43.8±2.8°,dorsiflexion of 15.8±2.9°and 16.6±2.9°,respectively,and one foot exhibited a heel lifting height of 7.2±1.0 cm and 7.5±0.9 cm,respectively.There was no significant difference between the affected and contralateral sides(P>0.05).At the final follow-up,the Amer-Lindholm Achilles tendon function score was excellent in 94.1%(16/17)of the patients and good in 5.9%(1/17)of the patients.The AOFAS scores ranged from 90 to 100,with an average of 96.4±3.7.Conclusion Krackow and tendon-bundle techniques can improve the strength of the suture used for the Achilles tendon repair and ensure good matching for broken ends,and thus it is an effective repair method for closed Achilles tendon injury.展开更多
Waterflood-assisted oil recovery with sulfate-spiked seawater would cause incompatibility scaling in carbonate reservoirs and reduce economic benefits.This research investigated the benefits of polyphosphate compounds...Waterflood-assisted oil recovery with sulfate-spiked seawater would cause incompatibility scaling in carbonate reservoirs and reduce economic benefits.This research investigated the benefits of polyphosphate compounds in reducing scaling potential as well as its effect on oil recovery when mixed in high sulfate flood water.Severity of scaling potential of sulfate-spiked water in a carbonate reservoir environment was measured,followed by systematic screening of a polyphosphate compound,which successfully inhibited the sulfate scale precipitation at concentration as low as 100 ppm.The new formulation(seawater with four times sulfate and phosphate,SW4 SP)was evaluated and compared with benchmark formulation(modified seawater with four times sulfate,SW4 S).Contact angle,ζ-potential and drainage studies show that SW4 SP changed the rock wettability from oil wet to water wet to a larger degree compared to SW4 S.Improved recovery efficiency of SW4 SP was confirmed through a set of core flooding studies in the tertiary and quaternary flood modes.Whereas SW4 S recovered 7.7%of original oil in place(OOIP),SW4 SP recovered about 8%of OOIP in the tertiary mode under approximately identical flow conditions.Flooding with SW4 SP in the quaternary mode following a tertiary flood with SW4 S on the same core resulted in 1.7%additional oil recovery,showing improved efficiency of the new flood water formulation.展开更多
ZSM-5 aggregates consisting of superfine and hierarchical nanocrystals(combined with micropores and intra-crystalline mesopores) with an average size of 30 nm were prepared through one-pot synthesis with the assistanc...ZSM-5 aggregates consisting of superfine and hierarchical nanocrystals(combined with micropores and intra-crystalline mesopores) with an average size of 30 nm were prepared through one-pot synthesis with the assistance of anionic polyacrylamide(APAM). The resultant zeolites(AHN-ZSM-5) were characterized by XRD, ICP-OES, SEM, TEM, BET, NH_3-TPD, Py-IR, and TG analyses and evaluated in the methanol to gasoline(MTG) reaction. Characterization results show that the hierarchical ZSM-5 aggregates possessed two kinds of mesopores, namely inter-and intra-crystalline mesopores. The amount of APAM considerably influenced the mesoporosity and textural properties of AHN-ZSM-5 zeolites. With the addition of APAM in the synthesis, the AHN-ZSM-5 zeolites exhibited large mesopore volume, large external surface area, and appropriate acidity. When applied in the MTG reaction, AHN-ZSM-5 demonstrated a catalytic lifetime that was 1.6 times longer than that of conventional ZSM-5 synthesized in the absence of APAM.展开更多
To attain the goal of carbon peaking and carbon neutralization,the inevitable choice is the open sharing of power data and connection to the grid of high-permeability renewable energy.However,this approach is hindered...To attain the goal of carbon peaking and carbon neutralization,the inevitable choice is the open sharing of power data and connection to the grid of high-permeability renewable energy.However,this approach is hindered by the lack of training data for predicting new grid-connected PV power stations.To overcome this problem,this work uses open and shared power data as input for a short-term PV-power-prediction model based on feature transfer learning to facilitate the generalization of the PV-power-prediction model to multiple PV-power stations.The proposed model integrates a structure model,heat-dissipation conditions,and the loss coefficients of PV modules.Clear-Sky entropy,characterizes seasonal and weather data features,describes the main meteorological characteristics at the PV power station.Taking gate recurrent unit neural networks as the framework,the open and shared PV-power data as the source-domain training label,and a small quantity of power data from a new grid-connected PV power station as the target-domain training label,the neural network hidden layer is shared between the target domain and the source domain.The fully connected layer is established in the target domain,and the regularization constraint is introduced to fine-tune and suppress the overfitting in feature transfer.The prediction of PV power is completed by using the actual power data of PV power stations.The average measures of the normalized root mean square error(NRMSE),the normalized mean absolute percentage error(NMAPE),and the normalized maximum absolute percentage error(NLAE)for the model decrease by 15%,12%,and 35%,respectively,which reflects a much greater adaptability than is possible with other methods.These results show that the proposed method is highly generalizable to different types of PV devices and operating environments that offer insufficient training data.展开更多
Dear Editor,Bacterial antimicrobial resistance(AMR)poses a serious threat to global human health(Antimicrobial Resistance Collaborators,2022).Comprehensive profiling of AMR and accurate molecular typing are important ...Dear Editor,Bacterial antimicrobial resistance(AMR)poses a serious threat to global human health(Antimicrobial Resistance Collaborators,2022).Comprehensive profiling of AMR and accurate molecular typing are important for tracking and controlling the emergence and dissemination of antibiotic-resistant bacteria(Yahara et al.,2021).We previously developed a multiplex amplicon sequencing-based method for directly sequencing AMR-related loci in N.gonorrhoeae from clinical samples(Zhang et al.,2021).展开更多
The recent outbreak of the coronavirus disease 2019(COVID-19)pandemic and the continuous evolution of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have highlighted the significance of new detection m...The recent outbreak of the coronavirus disease 2019(COVID-19)pandemic and the continuous evolution of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have highlighted the significance of new detection methods for global monitoring and prevention.Although quantitative reverse transcription PCR(RT-qPCR),the current gold standard for diagnosis,performs excellently in genetic testing,its multiplexing capability is limited because of the signal crosstalk of various fluorophores.Herein,we present a highly effi-cient platform which combines 17-plex assays with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS),enabling the targeting of 14 different mutation sites of the spike gene.Diagnosis using a set of 324 nasopharyngeal swabs or sputum clinical samples with SARS-CoV-2 MS method was identical to that with the RT-qPCR.The detection consistency of mutation sites was 97.9%(47/48)com-pared to Sanger sequencing without cross-reaction with other respiratory-related pathogens.Therefore,the MS method is highly potent to track and assess SARS-CoV-2 changes in a timely manner,thereby aiding the continuous response to viral variation and prevention of further transmission.展开更多
Viral infection commonly induces autophagy,leading to antiviral responses or conversely,promoting viral infection or replication.In this study,using the experimental plant Nicotiana benthamiana,we demonstrated that th...Viral infection commonly induces autophagy,leading to antiviral responses or conversely,promoting viral infection or replication.In this study,using the experimental plant Nicotiana benthamiana,we demonstrated that the rice stripe virus(RSV)coat protein(CP)enhanced autophagic activity through interaction with cytosolic glyceraldehyde-3-phosphate dehydrogenase 2(GAPC2),a negative regulator of plant autophagy that binds to an autophagy key factor,autophagy-related protein 3(ATG3).Competitive pull-down and co-immunoprecipitation(Co-IP)assays showed that RSV CP activated autophagy by disrupting the interaction between GAPC2 and ATG3.An RSV CP mutant that was unable to bind GAPC2 failed to disrupt the interaction between GAPC2 and ATG3 and therefore lost its ability to induce autophagy.RSV CP enhanced the autophagic degradation of a viral movement protein(MP)encoded by a heterologous virus,citrus leaf blotch virus(CLBV).However,the autophagic degradation of RSV-encoded MP and RNA-silencing suppressor(NS3)proteins was inhibited in the presence of CP,suggesting that RSV CP can protect MP and NS3 against autophagic degradation.Moreover,in the presence of MP,RSV CP could induce the autophagic degradation of a remorin protein(NbREM1),which negatively regulates RSV infection through the inhibition of viral cell-to-cell movement.Overall,our results suggest that RSV CP induces a selective autophagy to suppress the antiviral factors while protecting RSV-encoded viral proteins against autophagic degradation through an as-yet-unknown mechanism.This study showed that RSV CP plays dual roles in the autophagy-related interaction between plants and viruses.展开更多
In this study,we aimed at constructing polycaprolactone(PCL)reinforced keratin/bioactive glass composite scaffolds with a double cross-linking network structure for potential bone repair application.Thus,the PCL-kerat...In this study,we aimed at constructing polycaprolactone(PCL)reinforced keratin/bioactive glass composite scaffolds with a double cross-linking network structure for potential bone repair application.Thus,the PCL-keratin-BG composite scaffold was prepared by using keratin extracted from wool as main organic component and bioactive glass(BG)as main inorganic component,through both cross-linking systems,such as the thiol-ene click reaction between abundant sulfhydryl groups of keratin and the unsaturated double bond of 3-methacryloxy propyltrimethoxy silane(MPTS),and the amino-epoxy reaction between amino groups of keratin and the epoxy group in(3-glycidoxymethyl)methyldiethoxysilane(GPTMS)molecule,along with introduction of PCL as a reinforcing agent.The success of the thiol-ene reaction was verified by the FTIR and 1H-NMR analyses.And the structure of keratin-BG and PCL-keratin-BG composite scaffolds were studied and compared by the FTIR and XRD characterization,which indicated the successful preparation of the PCL-keratin-BG composite scaffold.In addition,the SEM observation,and contact angle and water absorption rate measurements demonstrated that the PCL-keratin-BG composite scaffold has interconnected porous structure,appropriate pore size and good hydrophilicity,which is helpful to cell adhesion,differentiation and proliferation.Importantly,compression experiments showed that,when compared with the keratin-BG composite scaffold,the PCL-keratin-BG composite scaffold increased greatly from 0.91±0.06 MPa and 7.25±1.7 MPa to 1.58±0.21 MPa and 14.14±1.95 MPa,respectively,which suggesting the strong reinforcement of polycaprolactone.In addition,the biomineralization experiment and MTT assay indicated that the PCL-keratin-BG scaffold has good mineralization ability and no-cytotoxicity,which can promote cell adhesion,proliferation and growth.Therefore,the results suggested that the PCL-keratin-BG composite scaffold has the potential as a candidate for application in bone regeneration field.展开更多
Autophagy is an intracellular degradation mechanism involved in antiviral defense,but the strategies employed by plant viruses to counteract autophagy-related defense remain unknown for the majority of the viruses.Her...Autophagy is an intracellular degradation mechanism involved in antiviral defense,but the strategies employed by plant viruses to counteract autophagy-related defense remain unknown for the majority of the viruses.Herein,we describe how the Chinese wheat mosaic virus(CWMV,genus Furovirus)interferes with autophagy and enhances its infection in Nicotiana benthamiana.Yeast two-hybrid screening and in vivo/in vitro assays revealed that the 19 k Da coat protein(CP19 K)of CWMV interacts with cytosolic glyceraldehyde-3-phosphate dehydrogenases(GAPCs),negative regulators of autophagy,which bind autophagy-related protein 3(ATG3),a key factor in autophagy.CP19 K also directly interacts with ATG3,possibly leading to the formation of a CP19 K–GAPC–ATG3 complex.CP19 K–GAPC interaction appeared to intensify CP19 K–ATG3 binding.Moreover,CP19 K expression upregulated GAPC gene transcripts and reduced autophagic activities.Accordingly,the silencing of GAPC genes in transgenic N.benthamiana reduced CWMV accumulation,whereas CP19 K overexpression enhanced it.Overall,our results suggest that CWMV CP19 K interferes with autophagy through the promotion and utilization of the GAPC role as a negative regulator of autophagy.展开更多
This research aims to improve erosion control practice in the Loess Plateau,by studying the surface erosion processes,including splash,sheet/interrill and rill erosion in four contrasting soils under high rainfall int...This research aims to improve erosion control practice in the Loess Plateau,by studying the surface erosion processes,including splash,sheet/interrill and rill erosion in four contrasting soils under high rainfall intensity(120 mm h^(−1))with three-scale indoor artificial experiments.Four contrasting soils as sandy loam,sandy clay loam,clay loam and loamy clay were collected from different parts of the Loess Plateau.The results showed that sediment load was significantly impacted by soil properties in all three sub-processes.Splash rate(4.0-21.6 g m^(−2∙)min^(−1))was highest in sandy loam from the north part of the Loess Plateau and showed a negative power relation with the mean weight diameter of aggregates after 20 min of rainfall duration.The average sediment load by sheet/interrill erosion(6.94-42.86 g m^(−2∙)min^(−1))was highest in clay loam from middle part of the Loess Plateau,and the stable sediment load after 20 min showed a positive power relation with the silt content in soil.The average sediment load increased dramatically by rill and interrill erosion(21.03-432.16 g m^(−2∙)min^(−1)),which was highest in loamy clay from south part of the Loess Plateau.The average sediment load after the occurrence of rill showed a positive power relation with clay content and a negative power relation with soil organic matter content.The impacts of slope gradient on the runoff rate and sediment load also changed with soil properties.The critical factors varied for different processes,which were the aggregate size for splash erosion,the content of silt particles and slope gradient for sheet/interrill erosion,and the content of clay particles,soil organic matter and slope gradient for rill erosion.Based on the results of the experiments,specific erosion control practices were proposed by targeting certain erosion processes in areas with different soil texture and different distribution of slope gradient.The findings from this study should support the improvement of erosion prediction and cropland management in different regions of the Loess Plateau.展开更多
Hepatocellular carcinoma(HCC)is the main cause of cancer-related deaths in adult men under the age of 60 years in China.^([1])Liver transplantation(LT)is generally recognized as one of the most effective therapeutic a...Hepatocellular carcinoma(HCC)is the main cause of cancer-related deaths in adult men under the age of 60 years in China.^([1])Liver transplantation(LT)is generally recognized as one of the most effective therapeutic approaches for end-stage liver diseases.LT guidelines for HCC were firstly launched in 2014 and were updated in 2018.Recently,further updates are required to adapt to the new situation of LT in China and to continue advancing the recommendations.(Full version in Supplementary file,http://links.lww.com/CM9/B362).展开更多
Silicic acid,commonly derived from cheap and easily available sodium silicate,has recently received great attention for application in leather industry to produce ecological leather with a cleaner approach.However,lea...Silicic acid,commonly derived from cheap and easily available sodium silicate,has recently received great attention for application in leather industry to produce ecological leather with a cleaner approach.However,leather tanned with silicic acid alone is poor in storage stability,which limits its practical application in leather production.In this work,a new environment-friendly combination tannage based on silicic acid and plant tannin was developed to address this issue along with improving the comprehensive performances of leather.The obtained leather was characterized by scanning electron microscopy,Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy and so on.The results showed that compared with leather tanned with silicic acid alone,the leather tanned with this combination method possessed improved thermal stability,enhanced mechanical properties,acceptable softness,appropriate hydrophilicity,and especially enhanced storage stability.More importantly,the combination tanned leather with 1:1 of the mass ratio of silicic acid to vegetable tannin(composed of valonea extract and mimosa extract with the same weight)had more prominent comprehensive performances.In addition,the results demonstrated that hydrogen bonding played an important role in the combination tanning process.Furthermore,the hydrogen bonds generated between phenolic hydroxyl groups of polyphenols with silicon hydroxyl groups of silicic acid molecules inhibited the excessive condensation of Si-OH groups between themselves.Subsequently,the assessment of environmental impact revealed the value of BOD 5/COD of the wastewater produced in this combination tanning process is more than 0.3,indicating the chrome-free combination tannage based on silicic acid and plant tannin was an environment-friendly tanning technology.These findings therefore indicated that a new chrome-free tanning method with silicon and biomass materials as main tanning agents has potential practical application prospect in leather production.展开更多
Partitioning of evapotranspiration(ET)into biological component transpiration(T)and non-biological component evaporation(E)is crucial in understanding the impact of environmental change on ecosystems and water resourc...Partitioning of evapotranspiration(ET)into biological component transpiration(T)and non-biological component evaporation(E)is crucial in understanding the impact of environmental change on ecosystems and water resources.However,direct measurement of transpiration is still challenging.In this paper,an optimality-based ecohydrological model named Vegetation Optimality Model(VOM)is applied for ET partitioning.The results show that VOM model can reasonably simulate ET and ET components in a semiarid shrubland.Overall,the ratio of transpiration to evapotranspiration is 49%for the whole period.Evaporation and plant transpiration mainly occur in monsoon following the precipitation events.Evaporation responds immediately to precipitation events,while transpiration shows a lagged response of several days to those events.Different years demonstrate different patterns of T/ET ratio dynamic in monsoon.Some of the years show a low T/ET ratio at the beginning of monsoon and slowly increased T/ET ratio.Other years show a high level of T/ET ratio for the whole monsoon.We find out that spring precipitation,especially the size of the precipitation,has a significant influence on the T/ET ratio in monsoon.展开更多
基金supported by the Capital’s Funds for Health Improvement and Research,No.2022-2-2072(to YG).
文摘Artificial intelligence can be indirectly applied to the repair of peripheral nerve injury.Specifically,it can be used to analyze and process data regarding peripheral nerve injury and repair,while study findings on peripheral nerve injury and repair can provide valuable data to enrich artificial intelligence algorithms.To investigate advances in the use of artificial intelligence in the diagnosis,rehabilitation,and scientific examination of peripheral nerve injury,we used CiteSpace and VOSviewer software to analyze the relevant literature included in the Web of Science from 1994–2023.We identified the following research hotspots in peripheral nerve injury and repair:(1)diagnosis,classification,and prognostic assessment of peripheral nerve injury using neuroimaging and artificial intelligence techniques,such as corneal confocal microscopy and coherent anti-Stokes Raman spectroscopy;(2)motion control and rehabilitation following peripheral nerve injury using artificial neural networks and machine learning algorithms,such as wearable devices and assisted wheelchair systems;(3)improving the accuracy and effectiveness of peripheral nerve electrical stimulation therapy using artificial intelligence techniques combined with deep learning,such as implantable peripheral nerve interfaces;(4)the application of artificial intelligence technology to brain-machine interfaces for disabled patients and those with reduced mobility,enabling them to control devices such as networked hand prostheses;(5)artificial intelligence robots that can replace doctors in certain procedures during surgery or rehabilitation,thereby reducing surgical risk and complications,and facilitating postoperative recovery.Although artificial intelligence has shown many benefits and potential applications in peripheral nerve injury and repair,there are some limitations to this technology,such as the consequences of missing or imbalanced data,low data accuracy and reproducibility,and ethical issues(e.g.,privacy,data security,research transparency).Future research should address the issue of data collection,as large-scale,high-quality clinical datasets are required to establish effective artificial intelligence models.Multimodal data processing is also necessary,along with interdisciplinary collaboration,medical-industrial integration,and multicenter,large-sample clinical studies.
基金supported by the National Key Research and Development Program of China(2018YFD1000100)the National Natural Science Foundation of China(31622049,31872080,and 31660565).
文摘MdMYB88 and MdMYB124 have been demonstrated to be responsible for lignin accumulation in apple under drought stress.In this study,using a metabolomic approach,we identified differentially accumulated phenylpropanoid and flavonoid metabolites in MdMYB88/124 transgenic RNAi plants under control and long-term drought stress conditions in apple roots.We confirmed the regulation of phenylalanine by MdMYB88 and MdMYB124 via UPLC-MS in apple roots under both control and drought conditions.Using Electrophoretic Mobility Shift Assay(EMSA)and ChIPquantitative PCR(qPCR)analyses,we found that MdMYB88 positively regulates the MdCM2 gene,which is responsible for phenylalanine biosynthesis,through binding to its promoter region.Under long-term drought conditions,MdMYB88/124 RNAi plants consistently accumulated increased amounts of H2O2 and MDA,while MdMYB88 and MdMYB124 overexpression plants accumulated decreased amounts of H2O2 and MDA.We also examined the accumulation of metabolites in the phenylpropanoid biosynthesis pathway in the leaves of MdMYB88 and MdMYB124 transgenic apple plants after long-term drought stress.We found that metabolites responsible for plant defense,including phenylpropanoids and flavonoids,accumulated less in the RNAi plants but more in the overexpression plants under both control and drought conditions.We further demonstrated that MdMYB88/124 RNAi plants were more sensitive to Alternaria alternata f.sp.mali and Valsa mali,two pathogens that currently severely threaten apple production.In contrast,MdMYB88 and MdMYB124 overexpression plants were more tolerant to these pathogens.The cumulative results of this study provided evidence for secondary metabolite regulation by MdMYB88 and MdMYB124,further explained the molecular roles of MdMYB88 and MdMYB124 in drought resistance,and provided information concerning molecular aspects of their roles in disease resistance.
基金supported by the National Magnetic Confinement Fusion Science Program of China (No. 2017YFE0301304)National Natural Science Foundation of China (Nos. 11 475 039, 11 605 023, 11 705 020)+2 种基金China Postdoctoral Science Foundation (Nos. 2016M591423, 2017T100172, 2018M630285)the Fundamental Research Funds for the Central Universities (Nos. DUT15RC(3)072, DUT17RC(4)53, DUT18LK38)Liaoning Provincial Natural Science Foundation of China (No. 20 170 540 153)
文摘An experimental setup has been designed and realized in order to optimize the characteristics of laser-induced breakdown spectroscopy system working in various pressure environments. An approach combined the normalization methods with the partial least squares(PLS) method are developed for quantitative analysis of molybdenum(Mo) element in the multi-component alloy,which is the first wall material in the Experimental Advanced Superconducting Tokamak. In this study, the different spectral normalization methods(total spectral area normalization,background normalization, and reference line normalization) are investigated for reducing the uncertainty and improving the accuracy of spectral measurement. The results indicates that the approach of PLS based on inter-element interference is significantly better than the conventional PLS methods as well as the univariate linear methods in the various pressure for molybdenum element analysis.
基金supported by National Key R&D Program of China(No.2017TFE0301300)the National Natural Science Foundation of China(Nos.11605023,11805028,11861131010)the China Postdoctoral Science Foundation(Nos.2017T100172,2016M591423)。
文摘Fuel retention measurement on plasma-facing components is an active field of study in magnetic confinement nuclear fusion devices.The laser-induced breakdown spectroscopy(LIBS)diagnostic method has been well demonstrated to detect the elemental distribution in PFCs.In this work,an upgraded co-axis LIBS system based on a linear fiber bundle collection system has been developed to measure the hydrogen(H) retention on a tantalum(Ta) sample under a vacuum condition.The spatial resolution measurement of the different positions of the LIBS plasma can be achieved simultaneously with varying delay times.The temporal and spatial evolution results of LIBS plasma emission show that the H plasma observably expands from the delay times of 0-200 ns.The diameter of Ta plasma is about 6 mm which is much less than the size of H plasma after 200 ns.The difference in the temporal and spatial evolution behaviors between H plasma and Ta plasma is due to the great difference in the atomic mass of H and Ta.The depth profile result shows that H retention mainly exists on the surface of the sample.The temporal and spatial evolution behaviors of the electron excited temperature are consistent with that of the Ta emission.The result will further improve the understanding of the evolution of the dynamics of LIBS plasma and optimize the current collection system of in situ LIBS in fusion devices.
基金supported by National Natural Science Foundation of China (Nos. 11475039, 11705020, 11605023)Liaoning Provincial Natural Science Foundation of China (No. 20170540153)
文摘The complex nature of laser-material interaction causes non-stoichiometric ablation of alloy samples.This is attributed to matrix effect, which reduces analyzing capability. To address this issue, the analytical performance of three different normalization methods, namely normalization with background, internal normalization and three point smoothing techniques at different parameter settings is studied for quantification of Ag and Zn by Laser induced breakdown spectroscopy(LIBS).The LIBS spectra of five known concentration of silver zinc binary composites have been investigated at various laser irradiances(LIs). Calibration curves for both Ag(I) line(4d^(10)5s^2S_(1/2)→4d^(10)5p^2P_(1/2) at 338.28 nm) and Zn(I) line(4s5s^3S_1→4s4p^3P_2 at 481.053 nm) have been determined at LI of 5.86?×?10^(10)W cm^(-2). Slopes of these calibration curves provide the valuation of matrix effect in the Ag–Zn composites. With careful sample preparation and normalization after smoothing at optimum parameter setting(OPS), the minimization of sample matrix effect has been successfully achieved. A good linearity has been obtained in Ag and Zn calibration curve at OPS when normalized the whole area of spectrum after smoothing and the obtained coefficients of determination values were R^2?=?0.995 and 0.998 closer to 1. The results of matrix effect have been further verified by analysis of plasma parameters. Both plasma parameters showed no change with varying concentration at OPS. However, at high concentration of Ag, the observed significant changes in both plasma parameters at common parameter setting PS-1 and PS-2 were the gesture of matrix effect. In our case, the better analytical results were obtained at smoothing function with optimized parameter setting that indicates it is more efficient than normalization with background and internal normalization method.
基金supported by the Beijing Health System High-level Health Talent Training Plan(grant no.2015-3-036).
文摘Background Acute Achilles tendon rupture is a severe injury of the lower extremities;however,optimal treatment options are not yet available.This study aimed to investigate the surgical method and clinical effect of the Krackow and tendon-bundle techniques for managing acute Achilles tendon rupture.Methods This retrospective case series study analyzed 17 cases of acute Achilles tendon rupture at the Beijing Jishuitan Hospital from December 2012 to January 2020.There were 16 men and one woman,aged 27–45 years,with an average of 39.6 years.Thirteen patients were injured while playing basketball or badminton,and 4 patients were injured while participating in a football match or other sports.All injuries were repaired using the Krackow and tendon-bundle techniques.Postoperative evaluation indicators included active range of motion during ankle plantar flexion and dorsiflexion,height of single foot heel lifting,Amer-Lindholm Achilles tendon function score,and American Orthopedic Foot and Ankle Society(AOFAS)score.Results The patients were followed-up for 6–45 months(average,18.9 months).There was no re-rupture of the Achilles tendon,wound infection,or sural nerve injury.At the final follow-up,the affected and contralateral sides exhibited plantar flexion of 42.1±4.4°and 43.8±2.8°,dorsiflexion of 15.8±2.9°and 16.6±2.9°,respectively,and one foot exhibited a heel lifting height of 7.2±1.0 cm and 7.5±0.9 cm,respectively.There was no significant difference between the affected and contralateral sides(P>0.05).At the final follow-up,the Amer-Lindholm Achilles tendon function score was excellent in 94.1%(16/17)of the patients and good in 5.9%(1/17)of the patients.The AOFAS scores ranged from 90 to 100,with an average of 96.4±3.7.Conclusion Krackow and tendon-bundle techniques can improve the strength of the suture used for the Achilles tendon repair and ensure good matching for broken ends,and thus it is an effective repair method for closed Achilles tendon injury.
文摘Waterflood-assisted oil recovery with sulfate-spiked seawater would cause incompatibility scaling in carbonate reservoirs and reduce economic benefits.This research investigated the benefits of polyphosphate compounds in reducing scaling potential as well as its effect on oil recovery when mixed in high sulfate flood water.Severity of scaling potential of sulfate-spiked water in a carbonate reservoir environment was measured,followed by systematic screening of a polyphosphate compound,which successfully inhibited the sulfate scale precipitation at concentration as low as 100 ppm.The new formulation(seawater with four times sulfate and phosphate,SW4 SP)was evaluated and compared with benchmark formulation(modified seawater with four times sulfate,SW4 S).Contact angle,ζ-potential and drainage studies show that SW4 SP changed the rock wettability from oil wet to water wet to a larger degree compared to SW4 S.Improved recovery efficiency of SW4 SP was confirmed through a set of core flooding studies in the tertiary and quaternary flood modes.Whereas SW4 S recovered 7.7%of original oil in place(OOIP),SW4 SP recovered about 8%of OOIP in the tertiary mode under approximately identical flow conditions.Flooding with SW4 SP in the quaternary mode following a tertiary flood with SW4 S on the same core resulted in 1.7%additional oil recovery,showing improved efficiency of the new flood water formulation.
基金supported by the National Natural Science Foundation of China (No. 21276183)
文摘ZSM-5 aggregates consisting of superfine and hierarchical nanocrystals(combined with micropores and intra-crystalline mesopores) with an average size of 30 nm were prepared through one-pot synthesis with the assistance of anionic polyacrylamide(APAM). The resultant zeolites(AHN-ZSM-5) were characterized by XRD, ICP-OES, SEM, TEM, BET, NH_3-TPD, Py-IR, and TG analyses and evaluated in the methanol to gasoline(MTG) reaction. Characterization results show that the hierarchical ZSM-5 aggregates possessed two kinds of mesopores, namely inter-and intra-crystalline mesopores. The amount of APAM considerably influenced the mesoporosity and textural properties of AHN-ZSM-5 zeolites. With the addition of APAM in the synthesis, the AHN-ZSM-5 zeolites exhibited large mesopore volume, large external surface area, and appropriate acidity. When applied in the MTG reaction, AHN-ZSM-5 demonstrated a catalytic lifetime that was 1.6 times longer than that of conventional ZSM-5 synthesized in the absence of APAM.
基金supported by the NationalNatural Science Foundation of China(No.6180802161)the Educational Commission of Liaoning Province of China(No.JZL201915401)We thank TopEdit(www.topeditsci.com)for its linguistic assistance during the preparation of this manuscript.
文摘To attain the goal of carbon peaking and carbon neutralization,the inevitable choice is the open sharing of power data and connection to the grid of high-permeability renewable energy.However,this approach is hindered by the lack of training data for predicting new grid-connected PV power stations.To overcome this problem,this work uses open and shared power data as input for a short-term PV-power-prediction model based on feature transfer learning to facilitate the generalization of the PV-power-prediction model to multiple PV-power stations.The proposed model integrates a structure model,heat-dissipation conditions,and the loss coefficients of PV modules.Clear-Sky entropy,characterizes seasonal and weather data features,describes the main meteorological characteristics at the PV power station.Taking gate recurrent unit neural networks as the framework,the open and shared PV-power data as the source-domain training label,and a small quantity of power data from a new grid-connected PV power station as the target-domain training label,the neural network hidden layer is shared between the target domain and the source domain.The fully connected layer is established in the target domain,and the regularization constraint is introduced to fine-tune and suppress the overfitting in feature transfer.The prediction of PV power is completed by using the actual power data of PV power stations.The average measures of the normalized root mean square error(NRMSE),the normalized mean absolute percentage error(NMAPE),and the normalized maximum absolute percentage error(NLAE)for the model decrease by 15%,12%,and 35%,respectively,which reflects a much greater adaptability than is possible with other methods.These results show that the proposed method is highly generalizable to different types of PV devices and operating environments that offer insufficient training data.
基金supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-1-037,2021-I2M-1-038)the National Natural Science Foundation of China(82002193)+2 种基金the National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2019-PT310-029,2021-PT310-004)the Fundamental Research Funds for the Central Universities(3332021092)。
文摘Dear Editor,Bacterial antimicrobial resistance(AMR)poses a serious threat to global human health(Antimicrobial Resistance Collaborators,2022).Comprehensive profiling of AMR and accurate molecular typing are important for tracking and controlling the emergence and dissemination of antibiotic-resistant bacteria(Yahara et al.,2021).We previously developed a multiplex amplicon sequencing-based method for directly sequencing AMR-related loci in N.gonorrhoeae from clinical samples(Zhang et al.,2021).
基金The research project was funded by grants from the CAMS Innovation Fund for Medical Sciences(CIFMS,2021-I2M-1-038)Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2019PT310029)the Fundamental Research Funds for the Central Universities(3332021092).We are grateful to Lili Ren for kindly providing us with clinical isolates of SARS-CoV-2.And we also would like to thank Editage(www.editage.cn)for English language editing.
文摘The recent outbreak of the coronavirus disease 2019(COVID-19)pandemic and the continuous evolution of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have highlighted the significance of new detection methods for global monitoring and prevention.Although quantitative reverse transcription PCR(RT-qPCR),the current gold standard for diagnosis,performs excellently in genetic testing,its multiplexing capability is limited because of the signal crosstalk of various fluorophores.Herein,we present a highly effi-cient platform which combines 17-plex assays with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS),enabling the targeting of 14 different mutation sites of the spike gene.Diagnosis using a set of 324 nasopharyngeal swabs or sputum clinical samples with SARS-CoV-2 MS method was identical to that with the RT-qPCR.The detection consistency of mutation sites was 97.9%(47/48)com-pared to Sanger sequencing without cross-reaction with other respiratory-related pathogens.Therefore,the MS method is highly potent to track and assess SARS-CoV-2 changes in a timely manner,thereby aiding the continuous response to viral variation and prevention of further transmission.
基金supported in part by the National Natural Science Foundation of China(32170163)to LSThe program of introducing Talents of Innovative discipline to universities(project 111)(B18042)to LSThe state key laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts(project 2021DG700024-KF202210)to HZ.
文摘Viral infection commonly induces autophagy,leading to antiviral responses or conversely,promoting viral infection or replication.In this study,using the experimental plant Nicotiana benthamiana,we demonstrated that the rice stripe virus(RSV)coat protein(CP)enhanced autophagic activity through interaction with cytosolic glyceraldehyde-3-phosphate dehydrogenase 2(GAPC2),a negative regulator of plant autophagy that binds to an autophagy key factor,autophagy-related protein 3(ATG3).Competitive pull-down and co-immunoprecipitation(Co-IP)assays showed that RSV CP activated autophagy by disrupting the interaction between GAPC2 and ATG3.An RSV CP mutant that was unable to bind GAPC2 failed to disrupt the interaction between GAPC2 and ATG3 and therefore lost its ability to induce autophagy.RSV CP enhanced the autophagic degradation of a viral movement protein(MP)encoded by a heterologous virus,citrus leaf blotch virus(CLBV).However,the autophagic degradation of RSV-encoded MP and RNA-silencing suppressor(NS3)proteins was inhibited in the presence of CP,suggesting that RSV CP can protect MP and NS3 against autophagic degradation.Moreover,in the presence of MP,RSV CP could induce the autophagic degradation of a remorin protein(NbREM1),which negatively regulates RSV infection through the inhibition of viral cell-to-cell movement.Overall,our results suggest that RSV CP induces a selective autophagy to suppress the antiviral factors while protecting RSV-encoded viral proteins against autophagic degradation through an as-yet-unknown mechanism.This study showed that RSV CP plays dual roles in the autophagy-related interaction between plants and viruses.
基金National Natural Science Foundation of China(No.21376153)Fundamental Research Funds for the Central University.
文摘In this study,we aimed at constructing polycaprolactone(PCL)reinforced keratin/bioactive glass composite scaffolds with a double cross-linking network structure for potential bone repair application.Thus,the PCL-keratin-BG composite scaffold was prepared by using keratin extracted from wool as main organic component and bioactive glass(BG)as main inorganic component,through both cross-linking systems,such as the thiol-ene click reaction between abundant sulfhydryl groups of keratin and the unsaturated double bond of 3-methacryloxy propyltrimethoxy silane(MPTS),and the amino-epoxy reaction between amino groups of keratin and the epoxy group in(3-glycidoxymethyl)methyldiethoxysilane(GPTMS)molecule,along with introduction of PCL as a reinforcing agent.The success of the thiol-ene reaction was verified by the FTIR and 1H-NMR analyses.And the structure of keratin-BG and PCL-keratin-BG composite scaffolds were studied and compared by the FTIR and XRD characterization,which indicated the successful preparation of the PCL-keratin-BG composite scaffold.In addition,the SEM observation,and contact angle and water absorption rate measurements demonstrated that the PCL-keratin-BG composite scaffold has interconnected porous structure,appropriate pore size and good hydrophilicity,which is helpful to cell adhesion,differentiation and proliferation.Importantly,compression experiments showed that,when compared with the keratin-BG composite scaffold,the PCL-keratin-BG composite scaffold increased greatly from 0.91±0.06 MPa and 7.25±1.7 MPa to 1.58±0.21 MPa and 14.14±1.95 MPa,respectively,which suggesting the strong reinforcement of polycaprolactone.In addition,the biomineralization experiment and MTT assay indicated that the PCL-keratin-BG scaffold has good mineralization ability and no-cytotoxicity,which can promote cell adhesion,proliferation and growth.Therefore,the results suggested that the PCL-keratin-BG composite scaffold has the potential as a candidate for application in bone regeneration field.
基金supported in part by the National Natural Science Foundation of China(32170163)the Basic Scientific Research Foundation,Ministry of education of China(Z109021801)to Liying SunThe program of introducing Talents of Innovative Discipline to Universities(project 111)(B18042)and(2016KW-069)to Liying Sun。
文摘Autophagy is an intracellular degradation mechanism involved in antiviral defense,but the strategies employed by plant viruses to counteract autophagy-related defense remain unknown for the majority of the viruses.Herein,we describe how the Chinese wheat mosaic virus(CWMV,genus Furovirus)interferes with autophagy and enhances its infection in Nicotiana benthamiana.Yeast two-hybrid screening and in vivo/in vitro assays revealed that the 19 k Da coat protein(CP19 K)of CWMV interacts with cytosolic glyceraldehyde-3-phosphate dehydrogenases(GAPCs),negative regulators of autophagy,which bind autophagy-related protein 3(ATG3),a key factor in autophagy.CP19 K also directly interacts with ATG3,possibly leading to the formation of a CP19 K–GAPC–ATG3 complex.CP19 K–GAPC interaction appeared to intensify CP19 K–ATG3 binding.Moreover,CP19 K expression upregulated GAPC gene transcripts and reduced autophagic activities.Accordingly,the silencing of GAPC genes in transgenic N.benthamiana reduced CWMV accumulation,whereas CP19 K overexpression enhanced it.Overall,our results suggest that CWMV CP19 K interferes with autophagy through the promotion and utilization of the GAPC role as a negative regulator of autophagy.
基金Financial support was provided by the National Natural Science Foundation of China(Grant No.41977069,41771314).
文摘This research aims to improve erosion control practice in the Loess Plateau,by studying the surface erosion processes,including splash,sheet/interrill and rill erosion in four contrasting soils under high rainfall intensity(120 mm h^(−1))with three-scale indoor artificial experiments.Four contrasting soils as sandy loam,sandy clay loam,clay loam and loamy clay were collected from different parts of the Loess Plateau.The results showed that sediment load was significantly impacted by soil properties in all three sub-processes.Splash rate(4.0-21.6 g m^(−2∙)min^(−1))was highest in sandy loam from the north part of the Loess Plateau and showed a negative power relation with the mean weight diameter of aggregates after 20 min of rainfall duration.The average sediment load by sheet/interrill erosion(6.94-42.86 g m^(−2∙)min^(−1))was highest in clay loam from middle part of the Loess Plateau,and the stable sediment load after 20 min showed a positive power relation with the silt content in soil.The average sediment load increased dramatically by rill and interrill erosion(21.03-432.16 g m^(−2∙)min^(−1)),which was highest in loamy clay from south part of the Loess Plateau.The average sediment load after the occurrence of rill showed a positive power relation with clay content and a negative power relation with soil organic matter content.The impacts of slope gradient on the runoff rate and sediment load also changed with soil properties.The critical factors varied for different processes,which were the aggregate size for splash erosion,the content of silt particles and slope gradient for sheet/interrill erosion,and the content of clay particles,soil organic matter and slope gradient for rill erosion.Based on the results of the experiments,specific erosion control practices were proposed by targeting certain erosion processes in areas with different soil texture and different distribution of slope gradient.The findings from this study should support the improvement of erosion prediction and cropland management in different regions of the Loess Plateau.
文摘Hepatocellular carcinoma(HCC)is the main cause of cancer-related deaths in adult men under the age of 60 years in China.^([1])Liver transplantation(LT)is generally recognized as one of the most effective therapeutic approaches for end-stage liver diseases.LT guidelines for HCC were firstly launched in 2014 and were updated in 2018.Recently,further updates are required to adapt to the new situation of LT in China and to continue advancing the recommendations.(Full version in Supplementary file,http://links.lww.com/CM9/B362).
基金This research was supported by the National Natural Science Foundation of China(No.21376153)the Fundamental Research Funds for the Central University of China,and Sichuan University-Zschimmer&Schwarz CmbH&Co.KG Scholarships(2020).
文摘Silicic acid,commonly derived from cheap and easily available sodium silicate,has recently received great attention for application in leather industry to produce ecological leather with a cleaner approach.However,leather tanned with silicic acid alone is poor in storage stability,which limits its practical application in leather production.In this work,a new environment-friendly combination tannage based on silicic acid and plant tannin was developed to address this issue along with improving the comprehensive performances of leather.The obtained leather was characterized by scanning electron microscopy,Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy and so on.The results showed that compared with leather tanned with silicic acid alone,the leather tanned with this combination method possessed improved thermal stability,enhanced mechanical properties,acceptable softness,appropriate hydrophilicity,and especially enhanced storage stability.More importantly,the combination tanned leather with 1:1 of the mass ratio of silicic acid to vegetable tannin(composed of valonea extract and mimosa extract with the same weight)had more prominent comprehensive performances.In addition,the results demonstrated that hydrogen bonding played an important role in the combination tanning process.Furthermore,the hydrogen bonds generated between phenolic hydroxyl groups of polyphenols with silicon hydroxyl groups of silicic acid molecules inhibited the excessive condensation of Si-OH groups between themselves.Subsequently,the assessment of environmental impact revealed the value of BOD 5/COD of the wastewater produced in this combination tanning process is more than 0.3,indicating the chrome-free combination tannage based on silicic acid and plant tannin was an environment-friendly tanning technology.These findings therefore indicated that a new chrome-free tanning method with silicon and biomass materials as main tanning agents has potential practical application prospect in leather production.
基金This work is supported by the National Key Research and Development Program of China[grant number 2017YFC050540503]National Natural Science Foundation of China[grant numbers 41301028,41571413,41701520 and 41471368]Lajiao Chen(201704910065)would like to acknowledge the fellowship from the China Scholarship Council(CSC).
文摘Partitioning of evapotranspiration(ET)into biological component transpiration(T)and non-biological component evaporation(E)is crucial in understanding the impact of environmental change on ecosystems and water resources.However,direct measurement of transpiration is still challenging.In this paper,an optimality-based ecohydrological model named Vegetation Optimality Model(VOM)is applied for ET partitioning.The results show that VOM model can reasonably simulate ET and ET components in a semiarid shrubland.Overall,the ratio of transpiration to evapotranspiration is 49%for the whole period.Evaporation and plant transpiration mainly occur in monsoon following the precipitation events.Evaporation responds immediately to precipitation events,while transpiration shows a lagged response of several days to those events.Different years demonstrate different patterns of T/ET ratio dynamic in monsoon.Some of the years show a low T/ET ratio at the beginning of monsoon and slowly increased T/ET ratio.Other years show a high level of T/ET ratio for the whole monsoon.We find out that spring precipitation,especially the size of the precipitation,has a significant influence on the T/ET ratio in monsoon.
