期刊文献+
共找到52篇文章
< 1 2 3 >
每页显示 20 50 100
Global,regional and national burdens of bipolar disorders in adolescents and young adults:a trend analysis from 1990 to 2019 被引量:2
1
作者 Yunxi Zhong Yifan Chen +4 位作者 Xiaoying Su Meiqi Wang Qixiu Li Ziming Shao long sun 《General Psychiatry》 CSCD 2024年第1期122-132,共11页
Background Bipolar disorder is identified as a cause of severe damage to the physical,psychological and social functioning of adolescents and young adults.Aims The aim of this study is to ascertain the trends in the b... Background Bipolar disorder is identified as a cause of severe damage to the physical,psychological and social functioning of adolescents and young adults.Aims The aim of this study is to ascertain the trends in the burden of bipolar disorder among individuals aged 10-24 years at global,regional and national levels from 1990 to 2019.Methods The data analysed in this study were from the Global Burden of Diseases 2019.The numbers,rates per 100000 population,average annual percentage changes(AAPCs)of incidence,prevalence and years lived with disability(YLDs)of bipolar disorder are reported at the global,regional and national levels among individuals aged 10-24 years.Global trends by age,sex and Social Development Index(SDI)were further analysed.Results Globally,the incidence of bipolar disorder among adolescents and young adults increased from 79.21 per 100000 population(95%uncertainty interval(Ul):58.13 to 105.15)in 1990 to 84.97 per 100000 population(95%Ul:61.73 to 113.46)in 2019,AAPC 0.24(95%confidence interval(Cl):0.22 to 0.26).In the past three decades,there has been an increase in incidence,prevalence and YLDs in both males and females.The largest increase in incidence between 1990 and 2019 was observed in those aged 20-24 years old from 51.76 per 100000 population(95%Ul:26.81 to 87.20)in 1990 to 58.37 per 100000 population(95%UI:30.39 to 98.55)in 2019;AAPC 0.42(95%Cl:0.38 to 0.47).By the SDI quintile,the largest increase in incidence was observed in the middle SDl;however,the high SDI countries had the highest incidence.Regionally,the largest increase in incidence was observed in southern Latin America.At the national level,the most pronounced increase in the incidence was in Greenland.Conclusions The global increase in incidence among adolescents and young adults between 1990 and 2019 indicates that strategies to improve their mental health still need to be emphasised. 展开更多
关键词 ADOLESCENT BIPOLAR YOUNG
下载PDF
In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug 被引量:1
2
作者 Jiawei Kang Yaping Li +7 位作者 Yating Qin Zhongming Huang Yifan Wu long sun Cong Wang Wei Wang Gang Feng Yiying Qi 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第1期341-359,共19页
The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,sp... The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense significance.Herein,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their ligands.This hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural bone.The resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and miR-26a.In vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,respectively.In vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral bone.This biomaterial delivery approach represents a significant toward improved osteochondral repair. 展开更多
关键词 Osteochondral regeneration Oriented hydrogel Kartogenin miRNA-26a
下载PDF
Paleosalinity reconstruction in offshore lacustrine basins based on elemental geochemistry:a case study of Middle Upper Eocene Shahejie Formation,Zhanhua Sag,Bohai Bay Basin
3
作者 long sun Shenghe WU +1 位作者 Dali YUE Wenfu CUI 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第4期1087-1105,共19页
Salinity is a crucial property of water body and is essential for the restoration of paleoecology and paleoenvironment.However,the theoretical method of application of elemental geochemical proxies to paleosalinity re... Salinity is a crucial property of water body and is essential for the restoration of paleoecology and paleoenvironment.However,the theoretical method of application of elemental geochemical proxies to paleosalinity reconstruction is still underdeveloped.Moreover,accurate determination and reconstruction of paleosalinity and its variation in an offshore lacustrine basin have been extremely challenging thus far.This study presents detailed elemental geochemical investigations from the Zhanhua Sag in the southern Bohai Bay Basin to reconstruct the salinity variation in the Paleogene Eocene Shahejie Formation(50.8-33.9 Ma).Based on the variation of strontium barium ratio(Sr/Ba)and boron gallium ratio(B/Ga),we determined three typical salinity types of water body:salty water(Sr/Ba>0.5,B/Ga>6),brackish water(0.2<Sr/Ba<0.5,3<B/Ga<6),and fresh water(Sr/Ba<0.2,B/Ga<3),after eliminating carbonate-sourced strontium(Sr).The salinity values following Couch’s paleosalinometer r anged from 3.1 to 11.9,reflecting the overall characteristics of oligohaline(0.5<salinity value<5)to mesohaline(5<salinity value<18)brackish water.All proxies yielded similar trends in paleosalinity variation,demonstrating a clear trend of rising and then declining from 50.8 Ma to 33.9 Ma.We considered that the B/Ga ratio had the highest reliability and resolution in determining the salinity types of water body in the study area.The environmental factors causing paleosalinity variation were also thoroughly analysed based on the temporal relationship among the salinity types of watermasses,paleoclimate characteristics from pollen records,and marine transgression events from marine fossils.Our research established a model of paleoclimatic and eustatic mechanisms to explain paleosalinity variation,providing reasonable and integral driving forces for the salinity variation of all offshore lacustrine basins. 展开更多
关键词 PALEOSALINITY PALEOCLIMATE Zhanhua Sag Middle-Upper Eocene Shahejie Formation
下载PDF
Biomimetic 3D printing of composite structures with decreased cracking
4
作者 Fan Du Kai Li +7 位作者 Mingzhen Li Junyang Fang long sun Chao Wang Yexin Wang Maiqi Liu Jinbang Li Xiaoying Wang 《Nanotechnology and Precision Engineering》 EI CAS CSCD 2024年第3期24-34,共11页
The development of tissue engineering and regeneration research has created new platforms for bone transplantation.However,the preparation of scaffolds with good fiber integrity is challenging,because scaffolds prepar... The development of tissue engineering and regeneration research has created new platforms for bone transplantation.However,the preparation of scaffolds with good fiber integrity is challenging,because scaffolds prepared by traditional printing methods are prone to fiber cracking during solvent evaporation.Human skin has an excellent natural heat-management system,which helps to maintain a constant body temperature through perspiration or blood-vessel constriction.In this work,an electrohydrodynamic-jet 3D-printing method inspired by the thermal-management system of skin was developed.In this system,the evaporation of solvent in the printed fibers can be adjusted using the temperature-change rate of the substrate to prepare 3D structures with good structural integrity.To investigate the solvent evaporation and the interlayer bonding of the fibers,finite-element analysis simulations of a three-layer microscale structure were carried out.The results show that the solvent-evaporation path is from bottom to top,and the strain in the printed structure becomes smaller with a smaller temperaturechange rate.Experimental results verified the accuracy of these simulation results,and a variety of complex 3D structures with high aspect ratios were printed.Microscale cracks were reduced to the nanoscale by adjusting the temperature-change rate from 2.5 to 0.5℃s-1.Optimized process parameters were selected to prepare a tissue engineering scaffold with high integrity.It was confirmed that this printed scaffold had good biocompatibility and could be used for bone-tissue regeneration.This simple and flexible 3D-printing method can also help with the preparation of a wide range of micro-and nanostructured sensors and actuators. 展开更多
关键词 3D printing Electrohydrodynamic jet BIOMIMETIC Structural integrity Composite scaffold
下载PDF
Eff ect of prescribed burning on the small-scale spatial heterogeneity of soil microbial biomass in Pinus koraiensis and Quercus mongolica forests of China
5
作者 Xu Dou Hongzhou Yu +4 位作者 Jianyu Wang Fei Li Qi Liu long sun Tongxin Hu 《Journal of Forestry Research》 SCIE CAS CSCD 2023年第3期609-622,共14页
Prescribed burning can alter soil microbial activity and spatially redistribute soil nutrient elements.However,no systematic,in-depth studies have investigated the impact of prescribed burning on the spatial patterns ... Prescribed burning can alter soil microbial activity and spatially redistribute soil nutrient elements.However,no systematic,in-depth studies have investigated the impact of prescribed burning on the spatial patterns of soil microbial biomass in temperate forest ecosystems in Northeast China.The present study investigated the impacts of prescribed burning on the small-scale spatial heterogeneity of microbial biomass carbon(MBC)and microbial biomass nitrogen(MBN)in the upper(0–10 cm)and lower(10–20 cm)soil layers in Pinus koraiensis and Quercus mongolica forests and explored the factors that infl uence spatial variations of these variables after prescribed burning.Our results showed that,MBC declined by approximately 30%in the 10–20 cm soil layer in the Q.mongolica forest,where there were no signifi cant eff ects on the soil MBC and MBN contents of the P.koraiensis forest(p>0.05)after prescribed burning.Compared to the MBC of the Q.mongolica forest before the prescribed burn,MBC spatial dependence in the upper and lower soil layers was approximately 7%and 2%higher,respectively.After the prescribed burn,MBN spatial dependence in the upper and lower soil layers in the P.koraiensis forest was approximately 1%and 13%lower,respectively,than that before the burn,and the MBC spatial variability in the 0–10 cm soil layer in the two forest types was explained by the soil moisture content(SMC),whereas the MBN spatial variability in the 0–10 cm soil layer in the two forests was explained by the soil pH and nitrate nitrogen(NO_(3)^(–)-N),respectively.In the lower soil layer(10–20 cm)of the Q.mongolica forest,elevation and ammonium nitrogen(NH 4+-N)were the main factors aff ecting the spatial variability of MBC and MBN,respectively.In the 10–20 cm soil layer of the P.koraiensis forest,NO_(3)^(–)-N and slope were the main factors aff ecting the spatial variability of MBC and MBN,respectively,after the burn.The spatial distributions of MBC and MBN in the two forests were largely structured with higher spatial autocorrelation(relative structural variance C/[C 0+C]>0.75).However,the factors infl uencing the spatial variability of MBC and MBN in the two forest types were not consistent between the upper and lower soil layers with prescribed burning.These fi ndings have important implications for developing sustainable management and conservation policies for forest ecosystems. 展开更多
关键词 Prescribed burn Soil microbial biomass Spatial heterogeneity Temperate forest
下载PDF
蛋白质和磷脂对天然胶乳成膜性能的影响 被引量:3
6
作者 马明月 张冰冰 +2 位作者 郑兴邦 孙龙 廖双泉 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2019年第5期99-103,109,共6页
成膜性是天然胶乳的重要工艺性能,直接影响制品的质量。天然胶乳中蛋白质和磷脂的含量对其成膜性能有重要影响。文中采用高速冷冻离心、碱性蛋白酶及脂肪酶处理浓缩天然胶乳(CNRL)制备脱蛋白胶乳(DPNR)、脱脂肪胶乳(PNR)、脱蛋白脱脂肪... 成膜性是天然胶乳的重要工艺性能,直接影响制品的质量。天然胶乳中蛋白质和磷脂的含量对其成膜性能有重要影响。文中采用高速冷冻离心、碱性蛋白酶及脂肪酶处理浓缩天然胶乳(CNRL)制备脱蛋白胶乳(DPNR)、脱脂肪胶乳(PNR)、脱蛋白脱脂肪胶乳(P-DPNR),研究蛋白质和磷脂对天然胶乳粒径、相对分子质量、干燥性能及胶膜表面形貌的影响,并分析其成膜机理。结果表明,经过离心及酶处理后,蛋白质、磷脂含量降低,平均粒径变大;DPNR和PNR的重均相对分子质量分别降低1.33×10^5、1.34×10^5,相对分子质量分布变宽;胶膜干燥速率提高;胶膜表面形貌趋于平坦,粗糙度R_a值降低。分析蛋白质和磷脂对胶乳成膜过程的影响,提出成膜过程机制图,成膜过程可分为水分蒸发、颗粒变形、聚集、相互扩散4个阶段。 展开更多
关键词 天然胶乳 蛋白质 磷脂 成膜性
下载PDF
Epidermal growth factor receptor antibody plus recombinant human endostatin in treatment of hepatic metastases after remnant gastric cancer resection 被引量:16
7
作者 long sun Huang-Yang Ye +2 位作者 Ying-Hong Zhang Yong-Song Guan Hua Wu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第45期6115-6118,共4页
We report a 55-year-old male who developed advanced hepatic metastasis and peritoneal carcinomatosis after resection of remnant gastric cancer resection 3 mo ago. The patient only received epidermal growth factor (EGF... We report a 55-year-old male who developed advanced hepatic metastasis and peritoneal carcinomatosis after resection of remnant gastric cancer resection 3 mo ago. The patient only received epidermal growth factor (EGF) receptor antibody (Cetuximab) plus recombinant human endostatin (Endostar). Anti-tumor activity was assessed by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computer tomography (PET/CT) at baseline and then every 4 wk. The case illustrates that 18FDG-PET/CT could make an early prediction of the response to Cetuximab plus Endostar in such clinical situations. 18FDG-PET/CT is a useful molecular imaging modality to evaluate the biological response advanced hepatic metastasis and peritoneal carcinomatosis to Cetuximab plus Endostar in patients after remnant gastric cancer resection. 展开更多
关键词 Hepatic metastasis Remnant gastriccancer CETUXIMAB Recombinant human endostatin ^18F-fluorodeoxyglucose Positron emission tomography/computer tomography
下载PDF
Colonography by CT,MRI and PET/CT combined with conventional colonoscopy in colorectal cancer screening and staging 被引量:13
8
作者 long sun Hua Wu Yong-Song Guan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第6期853-863,共11页
Colorectal cancer (CRC) remains a leading cancer killer worldwide. But the disease is both curable and preventable at an early stage. Regular CRC cancer screening has been shown to reduce the risk of dying from CRC. H... Colorectal cancer (CRC) remains a leading cancer killer worldwide. But the disease is both curable and preventable at an early stage. Regular CRC cancer screening has been shown to reduce the risk of dying from CRC. However, the importance of large-scale screening is only now starting to be appreciated. This article reviews a variety of imaging procedures available for detecting ulcerative colitis (UC) and Crohn's disease (CD), polyps and CRC in their early stage and also presents details on various screening options. Detecting, staging and re-staging of patients with CRC also require multimodality, multistep imaging approaches. Staging and re-staging with conventional colonoscopy (CC), computer tomography colonography (CTC), magnetic resonance colonography (MRC) and positron emission tomography/computer tomography colonography (PET/CTC) are of paramount importance in determining the most appropriate therapeutic method and in predicting the risk of tumor recurrence and overall prognosis. The advantages and limitations of these modalities are also discussed. 展开更多
关键词 Colon polyps Colorectal cancer Conventional Colonoscopy Virtual colonoscopy Computer tomography colonography Magnetic resonance colonography Positron emission tomography/computer tomography coionography
下载PDF
Multiple primary malignant tumors of upper gastrointestinal tract:A novel role of ^(18)F-FDG PET/CT 被引量:14
9
作者 long sun Yong-Hong sun +4 位作者 long Zhao Zuo-Ming Luo Hua Wu Ying Wan Qin Lin 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第31期3964-3969,共6页
AIM: To evaluate the capacity of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for detecting multiple primary cancer of upper gastrointestinal (UGI) tract. METHODS: Fifteen p... AIM: To evaluate the capacity of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for detecting multiple primary cancer of upper gastrointestinal (UGI) tract. METHODS: Fifteen patients (12 without cancer histories and 3 with histories of upper GI tract cancer) were investigated due to the suspicion of primary cancer of UGI tract on X-ray barium meal and CT scan. Subsequent whole body 18F-FDG PET/CT scan was carried out for initial staging or restaging. All the patients were fi nally confi rmed by endoscopic biopsy or surgery. The detection rate of multiple primary malignant cancers was calculated based on 18F-FDG PET/CT and endoscopic examinations.RESULTS: 18F-FDG PET/CT scan was positive in 32 suspicious lesions, 30/32 were true positive primary lesions, and 2/32 were false positive. In 15 suspicious lesions with negative 18F-FDG PET/CT scan, 12/15 were true negative and 3/15 were false negative. Among the 15 patients, 12 patients had 29 primary synchronous tumors confirmed by pathology, including 8 cases of esophageal cancers accompanied with gastric cancer and 4 of hypopharynx cancers with esophageal cancer. The other 3 patients had 4 new primary metachronous tumors, which were multiple primary esophageal cancers. PET/CT imaging detected local lymph node metastases in 11 patients. Both local lymph node metastases and distant metastases were detected in 4 patients. On a per-primary lesion basis, the sensitivity, specificity, accuracy, negative predictive value and positive predictive value of 18F-FDG PET/CT for detecting multiple primary cancer of UGI tract were 90.9%, 85.7%, 89.4%, 80% and 93.7%, respectively. CONCLUSION: The whole body 18F-FDG PET/CT may play an important role in evaluating the multiple primary malignant tumors of UGI tract cancer. 展开更多
关键词 Upper gastrointestinal tract cancer Esophageal cancer Gastric cancer Positron emission tomography/computed tomography 18F-FLUORODEOXYGLUCOSE
下载PDF
Clinical role of (18)~F-fluorodeoxyglucose positron emission tomography/computed tomography in post-operative follow up of gastric cancer: Initial results 被引量:14
10
作者 long sun Xin-Hui Su +4 位作者 Yong-Song Guan Wei-Ming Pan Zuo-Ming Luo Ji-Hong Wei Hua Wu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第29期4627-4632,共6页
AIM: To evaluate the clinical role of 18F-fluorodeo-xyglucose positron emission and computed tomography (18F-FDG PET/CT) in detection of gastric cancer recurrence after initial surgical resection. METHODS: In the peri... AIM: To evaluate the clinical role of 18F-fluorodeo-xyglucose positron emission and computed tomography (18F-FDG PET/CT) in detection of gastric cancer recurrence after initial surgical resection. METHODS: In the period from January 2007 to May 2008, 23 patients who had previous surgical resection of histopathologically diagnosed gastric cancer underwent a total of 25 18F-FDG PET/CT scans as follow-up visits in our center. The standard of reference for tumor recurrence consisted of histopathologic confirmation or clinical follow-up information for at least 5 mo after PET/CT examinations. RESULTS: PET/CT was positive in 14 patients (61%) and negative in 9 (39%). When correlated with final diagnosis, which was confirmed by histopathologic evidence of tumor recurrence in 8 of the 23 patients (35%) and by clinical follow-up in 15 (65%), PET/CT was true positive in 12 patients, false positive in 2, true negative in 8 and false negative in 2. Overall, the accuracy of PET/CT was 82.6%, the negative predictive value (NPV) was 77.7%, and the positive predictive value (PPV) was 85.7%. The 2 false positive PET/CT findings were actually chronic inflammatory tissue lesions. For the two patients with false negativePET/CT, the f inal diagnosis was recurrence of mucinous adenocarcinoma in the anastomosis in one patient and abdominal wall metastasis in the other. Importantly, PET/CT revealed true-positive findings in 11 (47.8%) patients who had negative or no definite findings by CT. PET/CT revealed extra-abdominal metastases in 7 patients and additional esophageal carcinoma in one patient. Clinical treatment decisions were changed in 7 (30.4%) patients after introducing PET/CT into their conventional post-operative follow-up program. CONCLUSION: Whole body 18F-FDG PET/CT was highly effective in discriminating true recurrence in post-operative patients with gastric cancer and had important impacts on clinical decisions in a considerable portion of patients. 展开更多
关键词 18F-FLUORODEOXYGLUCOSE Positron emissiontomography/computed tomography Gastric cancer FOLLOW-UP RECURRENCE
下载PDF
The effect of fire disturbance on short-term soil respiration in typical forest of Greater Xing'an Range, China 被引量:11
11
作者 long sun Tongxin Hu +4 位作者 Ji Hong Kim Futao Guo Hong Song Xinshuang Lv Haiqing Hu 《Journal of Forestry Research》 SCIE CAS CSCD 2014年第3期613-620,共8页
We investigated the effect of fire disturbance on short-term soil respiration in birch (Betula platyphylla Suk.) and larch (Larix gmelinii Rupr.) forests in Greater Xing’an range, northeastern China for further u... We investigated the effect of fire disturbance on short-term soil respiration in birch (Betula platyphylla Suk.) and larch (Larix gmelinii Rupr.) forests in Greater Xing’an range, northeastern China for further understanding of its effect on the carbon cycle in ecosystems. Our study show that post-fire soil respiration rates in B. platyphylla and L. gmelinii forests were reduced by 14%and 10%, respectively. In contrast, the soil heterotrophic respiration rates in the two types of forest were similar in post-fire and control plots. After fire, the contribution of root respiration to total soil respiration was dramatically reduced. Variation in soil respiration rates was explained by soil moisture (W) and soil tem-perature (T) at a depth of 5 cm. Exponential regression fitted T and W models explained Rs rates in B. platyphylla control and post-fire plots (83.1% and 86.2%) and L. gmelinii control and post-fire plots (83.7%and 88.7%). In addition, the short-term temperature coefficients in B. 展开更多
关键词 fire disturbance short-term soil respiration environmentfactors Q10
下载PDF
Positron emission tomography/computer tomography:Challenge to conventional imaging modalities in evaluating primary and metastatic liver malignancies 被引量:8
12
作者 long sun Hua Wu Yong-Song Guan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第20期2775-2783,共9页
Computer tomography (CT) and magnetic resonance imaging (MRI),as conventional imaging modalities,are the preferred methodology for tumor,nodal and systemic metastasis (TNM) staging. However,all the noninvasive techniq... Computer tomography (CT) and magnetic resonance imaging (MRI),as conventional imaging modalities,are the preferred methodology for tumor,nodal and systemic metastasis (TNM) staging. However,all the noninvasive techniques in current use are not sufficiently able to identify primary tumors and even unable to define the extent of metastatic spread. In addition,relying exclusively on macromorphological characteristics to make a conclusion runs the risk of misdiagnosis due mainly to the intrinsic limitations of the imaging modalities themselves. Solely based on the macromorphological characteristics of cancer,one cannot give an appropriate assessment of the biological characteristics of tumors. Currently,positron emission tomography/computer tomography (PET/CT) are more and more widely available and their application with 18F-fluorodeoxyglucose (18F-FDG) in oncology has become one of the standard imaging modalities in diagnosing and staging of tumors,and monitoring the therapeutic efficacy in hepatic malignancies. Recently,investigators have measured glucose utilization in liver tumors using 18F-FDG,PET and PET/CT in order to establish diagnosis of tumors,assess their biologic characteristics and predict therapeutic effects on hepatic malignancies. PET/ CT with 18F-FDG as a radiotracer may further enhance the hepatic malignancy diagnostic algorithm by accurate diagnosis,staging,restaging and evaluating its biological characteristics,which can benefit the patients suffering from hepatic metastases,hepatocellular carcinoma and cholangiocarcinoma. 展开更多
关键词 ^18F-fluorodeoxyglucose Positron emission tomography Positron emission tomography-computer tomography Hepatic metastases Hepatocellular carcinoma CHOLANGIOCARCINOMA
下载PDF
Positron emission tomography/computer tomography in guidance of extrahepatic hepatocellular carcinoma metastasis management 被引量:9
13
作者 long sun Yong-Song Guan +3 位作者 Wei-Ming Pan Gui-Bing Chen Zuo-Ming Luo Hua Wu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第40期5413-5415,共3页
Hepatocellular carcinoma (HCC) is one of the most common primary cancers in the world. Surgery is the gold standard for treatment of patients with HCC. Recurrence and metastasis are the major obstacles to further im... Hepatocellular carcinoma (HCC) is one of the most common primary cancers in the world. Surgery is the gold standard for treatment of patients with HCC. Recurrence and metastasis are the major obstacles to further improve the prognosis of HCC. Most recurrences are intrahepatic. However, 30% of the recurrences are extrahepatic. The role of resection in intrahepatic recurrences is widely accepted. The role of resection in extrahepatic HCC recurrence and metastasis is not well established. 18F fluorodeoxyglucose (18F-FDG) positron emission tomography/computer tomography (PET/CT) is useful in detecting distant metastasis from a variety of malignancies and shows superior accuracy to conventional imaging modalities in identification of intrahepatic and extrahepatic metastasis. We present one patient with one new isolated omental lymph node metastasis, who had a history of huge HCC resected six years ago. The metastatic focus was identified with 18 F-FDG PET/CT and resected. The follow-up revealed good prognosis with a long-term survival potential after resection of the omental lymphatic metastasis. 展开更多
关键词 FLUORODEOXYGLUCOSE Positron emissiontomography/computer tomography Huge hepatocellular carcinoma Omental node metastasis Extrahepatic metastasis
下载PDF
Clinical usefulness of ^(18) F-FDG PET/CT in the restaging of esophageal cancer after surgical resection and radiotherapy 被引量:7
14
作者 long sun Xin-Hui Su +5 位作者 Yong-Song Guan Wei-Ming Pan Zuo-Ming Luo Ji-Hong Wei long Zhao Hua Wu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第15期1836-1842,共7页
AIM: To evaluate the clinical usefulness of lSF-fluorodeoxyglucose positron emission and computed tomography QSF-FDG PET/CT) in restaging of esophageal cancer after surgical resection and radiotherapy. METHODS: Bet... AIM: To evaluate the clinical usefulness of lSF-fluorodeoxyglucose positron emission and computed tomography QSF-FDG PET/CT) in restaging of esophageal cancer after surgical resection and radiotherapy. METHODS: Between January 2007 and Aug 2008, twenty histopathologically diagnosed esophageal cancer patients underwent 25 PET/CT scans (three patients had two scans and one patient had three scans) for restaging after surgical resection and radiotherapy. The standard reference for tumor recurrence was histopathologic confirmation or clinical follow-up for at least ten months after ^18F-FDG PET/CT examinations. RESULTS: Tumor recurrence was confirmed histopathologically in seven of the 20 patients (35%) and by clinical and radiological follow-up in 13 (65%). ^18F-FDG PET/CT was positive in 14 patients (68.4%) and negative in six (31.6%). ^18F-FDG PET/CT was true positive in 11 patients, false positive in three and true negative in six. Overall, the accuracy of ^18F-FDG PET/CT was 85%, negative predictive value (NPV) was 100%, and positive predictive value (PPV) was 78.6%.The three false positive PET/CT findings comprised chronic inflammation of mediastinal lymph nodes (n = 2) and anastomosis inflammation (n = 1). PET/ CT demonstrated distant metastasis in 10 patients. ^18F-FDG PET/CT imaging-guided salvage treatment in nine patients was performed. Treatment regimens were changed in 12 (60%) patients after introducing ^18F-FDG PET/CT into their conventional post-treatment follow-up program. CONCLUSION: Whole body ^18F-FDG PET/CT is effective in detecting relapse of esophageal cancer after surgical resection and radiotherapy. It could also have important clinical impact on the management of esophageal cancer, influencing both clinical restaging and salvage treatment of patients. 展开更多
关键词 ^18F-fluorodeoxyglucose Positron emissiontomography/computed tomography Esophagealcancer Surgical resection Radiotherapy radiation RESTAGING
下载PDF
Spatial heterogeneity of soil respiration in a Larix gmelinii forest and the response to prescribed fire in the Greater Xing0an Mountains,China 被引量:12
15
作者 Haiqing Hu Tongxin Hu long sun 《Journal of Forestry Research》 SCIE CAS CSCD 2016年第5期1153-1162,共10页
This study was conducted in a fire-prone region in the Greater Xing'an Mountains, the primary forested area of northeastern China. We measured soil respiration and the affecting soil factors, i.e., soil microbial bio... This study was conducted in a fire-prone region in the Greater Xing'an Mountains, the primary forested area of northeastern China. We measured soil respiration and the affecting soil factors, i.e., soil microbial biomass and soil moisture, within an experimental plot of Larix gmelinii Rupr. A low-intensity, prescribed fire was applied as the treatment. Traditional descriptive statistics and geostatistics were used to analyze the spatial heterogeneity of soil respiration and the response of respiration to fire disturbance. Coefficients of variation (CVs) for pre-fire and post-fire soil respiration were 23.4 and 32.0 %, respec- tively. CVs for post-fire soil respiration increased signifi- cantly, with a moderate variation of all CVs. Soil respiration pre-fire was significantly correlated with soil microbial biomass carbon, biomass nitrogen, and soil moisture (W); post-fire soil respiration was not correlated with these factors. From the geostatistical analyses, the Co + C (sill) for post-fire soil respiration increased sig- nificantly, indicating that the post-fire spatial heterogeneity of soil respiration increased significantly. The nugget effect (nc) of soil respiration and the affecting factors pre-fire and post-fire disturbance were in the range of 12.5-50 %, with strong spatial autocorrelation. Fire disturbance changed the components of spatial heterogeneity, and the proportion of functional heterogeneity increased significantly post-fire. The ranges (a) for pre-fire and post-fire soil respiration were 81.0 and 68.2 m, respectively. The homogeneity of the distribution of post-fire soil respiration decreased and the spatial heterogeneity increased, thus the range for post- fire soil respiration decreased significantly. The fractal dimension (D) for soil respiration increased post-fire, the spatial heterogeneity of soil respiration affected by random components increased, indicating that the change in spatial heterogeneity of post-fire soil respiration should be con- sidered within the scale of the forest stand. Following Kriging interpolation, the increase in the patchiness of post-fire soil respiration was illustrated using a contour map. Based on these preliminary results, the change in the spatial heterogeneity of post-fire soil respiration was likely caused by changes in the distribution of soil moisture and microbial activity within the experimental plot at the scale of the forest stand. 展开更多
关键词 Prescribed fire - Soil respiration SPATIALHETEROGENEITY Larix gmelinii forest
下载PDF
Highly metabolic thrombus of the portal vein:^(18)F fluorodeoxyglucose positron emission tomography/computer tomography demonstration and clinical significance in hepatocellular carcinoma 被引量:7
16
作者 long sun Yong-Song Guan +4 位作者 Wei-Ming Pan Gui-Bing Chen Zuo-Ming Luo Ji-Hong Wei Hua Wu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第8期1212-1217,共6页
AIM: To assess the ability of ^18F-fluorodeoxyglucose positron emission tomography/computer tomography (^18F-FDG PET/CT) to differentiate between benign and malignant portal vein thrombosis in hepatocellular carcin... AIM: To assess the ability of ^18F-fluorodeoxyglucose positron emission tomography/computer tomography (^18F-FDG PET/CT) to differentiate between benign and malignant portal vein thrombosis in hepatocellular carcinoma (HCC) patients.METHODS: Five consecutive patients who had HBV cirrhosis, biopsy-proven HCC, and thrombosis of the main portal vein and/or left/right portal vein on ultrasound (US), computer tomography (CT) or magnetic resonance imaging (MRI) were studied with ^18F-FDG PET/CT. The presence or absence of a highly metabolic thrombus on ^18F-FDG PET/CT was considered diagnostic for malignant or benign portal vein thrombosis, respectively. All patients were followed-up monthly with US, CT or MRI. Shrinkage of the thrombus or recanalization of the vessels on US, CT or MRI during follow-up was considered to be definitive evidence of the benign nature of the thrombosis, whereas enlargement of the thrombus, disruption of the vessel wall, and parenchymal infiltration over follow-up were considered to be consistent with malignancy. ^18SF-FDG PET/CT, and US, CT or MRI results were compared.RESULTS: Follow-up (1 to 10 mo) showed signs of malignant thrombosis in 4 of the 5 patients. US, CT or MRI produced a true-positive result for malignancy in 4 of the patients, and a false-positive result in 1. ^18F-FDG PET/CT showed a highly metabolic thrombus in 4 of the 5 patients. ^18F-FDG PET/CT achieved a true-positive result in all 4 of these patients, and a true-negative result in the other patient. No false-positive result was observed using ^18F-FDG PET/CT.CONCLUSION: ^18F-FDG PET/CT may be helpful in discriminating between benign and malignant portal vein thrombi. Patients may benefit from ^18F-FDG PET/CT when portal vein thrombi can not be diagnosed exactly by US, CT or MRI. 展开更多
关键词 ^ 18F-fluorodeoxyglucose Positron emission tomography/computer tomography Hepatocellular carcinoma Portal vein tumor thrombus Portal vein blood thrombus
下载PDF
Fabricating covalent organic framework/CdS S-scheme heterojunctions for improved solar hydrogen generation 被引量:7
17
作者 long sun Lingling Li +2 位作者 Juan Yang Jiajie Fan Quanlong Xu 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2022年第2期350-358,共9页
The fabrication of S-scheme heterojunctions has received considerable attention as an effective approach to promote the separation and migration of photoexcited electron/hole pairs and retain strong redox abilities.He... The fabrication of S-scheme heterojunctions has received considerable attention as an effective approach to promote the separation and migration of photoexcited electron/hole pairs and retain strong redox abilities.Herein,an imine-based porous covalent organic framework(COF-LZU1)is integrated with controllably fabricated Cd S hollow cubes,resulting in the formation of an S-scheme heterojunction.When the COF content reaches 1.5 wt%,the COF/Cd S heterostructure(1.5%COF/Cd S)achieves the highest hydrogen generation rate of 8670μmol·h^(-1)·g^(-1),which is approximately 2.1 times higher than that of pure Cd S.The apparent quantum efficiency(AQE)of 1.5%COF/Cd S is approximately 8.9%at 420 nm.Further systematic analysis shows that the intimate contact interface and suitable energy band structures between Cd S and COF can induce the formation of an internal electric field at the heterojunction interface,which can effectively drive the spatial separation of photoexcited charge carriers and simultaneously maintain a strong redox ability,thus enhancing the photocatalytic H_(2) evolution performance. 展开更多
关键词 S-scheme Covalent organic framework CDS Photocatalytic H2 production
下载PDF
An Open IoT Framework Based on Microservices Architecture 被引量:7
18
作者 long sun Yan Li Raheel Ahmed Memon 《China Communications》 SCIE CSCD 2017年第2期154-162,共9页
With the continuous development and evolvement of Internet of Things (IoT), monolithic application becomes much larger in scale and even more complex in structure. This leads to poor scalability, extensibility and m... With the continuous development and evolvement of Internet of Things (IoT), monolithic application becomes much larger in scale and even more complex in structure. This leads to poor scalability, extensibility and maintainability. In response to those challenges, microservice architecture has been introduced in the field of IoT application, due to its flexibility, lightweight and loose coupling. However, the existing loT framework of microservice mainly focus on a specific domain, therefore, this greatly limits its application. In this paper, we propose a general microservice system framework for the loT application, which is a better scalable, extendable and maintainable architecture. We introduce its system design and related microservices, and emphasize on core service and device communication from service layer to physical layer. It has better capacity to support interoperability and accommodate heterogeneous objects. In addition, this framework can easily achieve more application integration such as automation, intelligence, Geo service and Big Data. 展开更多
关键词 Internet of things loT micro service software architecture
下载PDF
Lightweight Image Super-Resolution via Weighted Multi-Scale Residual Network 被引量:6
19
作者 long sun Zhenbing Liu +3 位作者 Xiyan sun Licheng Liu Rushi Lan Xiaonan Luo 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2021年第7期1271-1280,共10页
The tradeoff between efficiency and model size of the convolutional neural network(CNN)is an essential issue for applications of CNN-based algorithms to diverse real-world tasks.Although deep learning-based methods ha... The tradeoff between efficiency and model size of the convolutional neural network(CNN)is an essential issue for applications of CNN-based algorithms to diverse real-world tasks.Although deep learning-based methods have achieved significant improvements in image super-resolution(SR),current CNNbased techniques mainly contain massive parameters and a high computational complexity,limiting their practical applications.In this paper,we present a fast and lightweight framework,named weighted multi-scale residual network(WMRN),for a better tradeoff between SR performance and computational efficiency.With the modified residual structure,depthwise separable convolutions(DS Convs)are employed to improve convolutional operations’efficiency.Furthermore,several weighted multi-scale residual blocks(WMRBs)are stacked to enhance the multi-scale representation capability.In the reconstruction subnetwork,a group of Conv layers are introduced to filter feature maps to reconstruct the final high-quality image.Extensive experiments were conducted to evaluate the proposed model,and the comparative results with several state-of-the-art algorithms demonstrate the effectiveness of WMRN. 展开更多
关键词 Convolutional neural network(CNN) lightweight framework MULTI-SCALE SUPER-RESOLUTION
下载PDF
Prediction model of moisture content of dead fine fuel in forest plantations on Maoer Mountain,Northeast China 被引量:5
20
作者 Maombi Mbusa Masinda Fei Li +2 位作者 Qi Liu long sun Tongxin Hu 《Journal of Forestry Research》 SCIE CAS CSCD 2021年第5期2023-2035,共13页
Preventing and suppressing forest fires is one of the main tasks of forestry agencies to reduce resource loss and requires a thorough understanding of the importance of factors affecting their occurrence.This study wa... Preventing and suppressing forest fires is one of the main tasks of forestry agencies to reduce resource loss and requires a thorough understanding of the importance of factors affecting their occurrence.This study was carried out in forest plantations on Maoer Mountain in order to develop models for predicting the moisture content of dead fine fuel using meteorological and soil variables.Models by Nelson(Can J For Res 14:597-600,1984)and Van Wagner and Pickett(Can For Service 33,1985)describing the equilibrium moisture content as a function of relative humidity and temperature were evaluated.A random forest and generalized additive models were built to select the most important meteorological variables affecting fuel moisture content.Nelson’s(Can J For Res 14:597-600,1984)model was accurate for Pinus koraiensis,Pinus sylvestris,Larix gmelinii and mixed Larix gmelinii—Ulmus propinqua fuels.The random forest model showed that temperature and relative humidity were the most important factors affecting fuel moisture content.The generalized additive regression model showed that temperature,relative humidity and rain were the main drivers affecting fuel moisture content.In addition to the combined effects of temperature,rainfall and relative humidity,solar radiation or wind speed were also significant on some sites.In P.koraiensis and P.sylvestris plantations,where soil parameters were measured,rain,soil moisture and temperature were the main factors of fuel moisture content.The accuracies of the random forest model and generalized additive model were similar,however,the random forest model was more accurate but underestimated the effect of rain on fuel moisture. 展开更多
关键词 Forest plantations Fine fuel moisture content Weather factors Prediction models
下载PDF
上一页 1 2 3 下一页 到第
使用帮助 返回顶部