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T细胞亚群水平可预测主动脉夹层患者入院30天生存状态
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作者 吴文飞 龙雄 赖智权 《内科急危重症杂志》 2024年第5期425-428,共4页
目的:探究主动脉夹层患者T细胞亚群水平与30 d生存状态的关系。方法:收集184例接受手术治疗的主动脉夹层患者的临床资料,根据入院30 d生存状态分为生存组(149例)和死亡组(35例),比较2组T细胞亚群(CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(... 目的:探究主动脉夹层患者T细胞亚群水平与30 d生存状态的关系。方法:收集184例接受手术治疗的主动脉夹层患者的临床资料,根据入院30 d生存状态分为生存组(149例)和死亡组(35例),比较2组T细胞亚群(CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(+))水平。采用多元Logistic回归分析患者入院30 d死亡的影响因素,受试者工作特征曲线分析CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(+)T细胞的预测价值。结果:184例主动脉夹层患者入院30 d内全因死亡35例(19.02%)。死亡组Stanford A型、低氧血症、高血压患者占比、入院收缩压及舒张压、CD3^(+)CD8^(+)T细胞水平高于生存组,CD3^(+)与CD3^(+)CD4^(+)T细胞水平低于生存组(P均<0.05)。Logistic回归分析结果显示,CD3^(+)CD8^(+)T细胞、Stanford A型、低氧血症、高血压是主动脉夹层患者入院30 d死亡的危险因素,CD3^(+)、CD3^(+)CD4^(+)T细胞是其保护性因素(P均<0.05)。CD3^(+)与CD3^(+)CD4^(+)、CD3^(+)CD8^(+)T细胞预测主动脉夹层患者入院30 d死亡的曲线下面积分别为0.731(95%CI 0.644~0.819)、0.801(95%CI 0.726~0.875)、0.824(95%CI 0.731~0.918)。结论:主动脉夹层患者T细胞亚群CD3^(+)、CD3^(+)CD4^(+)、CD3^(+)CD8^(+)水平与入院30 d生存状态相关,三者与Stanford A型、低氧血症、高血压共同影响患者入院30 d生存状态。 展开更多
关键词 主动脉夹层 T细胞亚群 生存状态 影响因素
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On the Preparation of Low-Temperature-Rise and Low-Shrinkage Concrete Based on Phosphorus Slag
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作者 Jianlong Jin Jingjing Ding +2 位作者 long xiong Ming Bao Peng Zeng 《Fluid Dynamics & Materials Processing》 EI 2024年第4期803-814,共12页
The effects of different contents of a MgO expansive agent and phosphorus slag on the mechanical properties,shrinkage behavior,and the heat of hydration of concrete were studied.The slump flow,setting time,dry shrinka... The effects of different contents of a MgO expansive agent and phosphorus slag on the mechanical properties,shrinkage behavior,and the heat of hydration of concrete were studied.The slump flow,setting time,dry shrinkage,and hydration heat were used as sensitive parameters to assess the response of the considered specimens.As shown by the results,in general,with an increase in the phosphorus slag content,the hydration heat of concrete decreases for all ages,but the early strength displays a downward trend and the dry shrinkage rate increases.The 90-d strength and dry shrinkage of concrete could be improved with a phosphorus residue content between 0%-20%,with the best performances in terms of mechanical properties and shrinkage characteristics being achieved for a content of 20 kg/m^(3).On the basis of these results,it can be concluded that appropriate amounts of phosphorus slag and MgO expansive agent can be used to improve the compressive strength of concrete in the later stage by reducing the hydration heat and dry shrinkage rate,respectively. 展开更多
关键词 Phosphorus slag MgO expansion agent mass concrete hydration heat
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Mechanism of Polygoni Cuspidati Rhizoma in treating atherosclerosis based on network pharmacology and molecular docking
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作者 long xiong Ting-Ting Liao Qian Zhou 《Integrative Medicine Discovery》 2024年第26期1-11,共11页
Background:The incidence and prevalence of atherosclerosis(AS)is increasing every year and has becoming a major health issue of global concern.Polygoni Cuspidati Rhizoma(PCR)is a Chinese herb that is widely used clini... Background:The incidence and prevalence of atherosclerosis(AS)is increasing every year and has becoming a major health issue of global concern.Polygoni Cuspidati Rhizoma(PCR)is a Chinese herb that is widely used clinically for the treating of AS.However,its pertinent targets and probable mechanisms,still need to be completely explored.Methods:Active compounds and targets for PCR and AS targets were screened using public databases.A“drug-component-disease target”network map was created and analyzed after using the Venn online tool to identify common targets and Cytoscape software to screen drug-disease core targets.Critical targets pathway enrichment analyses are conducted using the Metascape database.Using AutoDock Vina and Pymol software,docking validation and visualization of active components and core targets were carried out.Results:PCR was obtained for ten compounds with 105 AS-related targets.Rhein,quercetin,beta-sitosterol,and luteolin may be drug candidates,and the genes for AKT1,TNF,IL-6,EGFR,TP53,IL-1,RELA,and VEGFA are potential therapeutic targets,according to network analysis.PCR might modulate the AGE/RAGE,PI3K/Akt,IL-17 and NF-ᴋB signaling pathways against the development of AS.Molecular docking indicated that quercetin has high affinity for AKT1 and TNF gene targets.Conclusion:This study provides rare information and scientific basis for further exploration of PC in the treatment of AS. 展开更多
关键词 Polygoni Cuspidati Rhizoma ATHEROSCLEROSIS network pharmacology molecular docking
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渗透结晶型防水剂对PE-ECC力学和自愈合性能影响 被引量:1
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作者 谭燕 赵犇 +2 位作者 肖衡林 龙雄 万祥淼 《人民长江》 北大核心 2023年第9期206-215,共10页
为设计力学和自愈合性能优良的高延性水泥基复合材料(Engineered Cementitious Composite,ECC),以掺超高分子量聚乙烯短切纤维(UHMWPEF,文后简写PE)的ECC(PE-ECC)为基准组,掺入不同类型和掺量的水泥基渗透结晶型防水材料(Cementitious C... 为设计力学和自愈合性能优良的高延性水泥基复合材料(Engineered Cementitious Composite,ECC),以掺超高分子量聚乙烯短切纤维(UHMWPEF,文后简写PE)的ECC(PE-ECC)为基准组,掺入不同类型和掺量的水泥基渗透结晶型防水材料(Cementitious Capillary Crystalline Waterproofing Materials,CCCW),通过抗压、抗折、抗拉试验及预制裂缝法分别分析其力学和自愈合性能,并通过压汞法(MIP)、X射线衍射仪(XRD)和扫描电子显微镜(SEM)对其孔隙结构、物相组成和微观形貌进行分析。结果表明:随着CCCW掺量的增加,PE-ECC力学性能呈先增后减趋势,当掺量为1.0%时,其力学性能最佳,且掺XYPEX型CCCW对PE-ECC力学性能的提升更为明显,此时抗压强度为53.8 MPa,提升了37.95%;抗折强度为11.8 MPa,提升了53.25%;极限拉应力为5.56 N/mm^(2),提升了14.17%;极限拉应变为7.53%,提升了21.65%。通过对共振频率和裂缝宽度的变化情况分析可知,CCCW对PE-ECC的自愈合性能有明显提升效果,能有效修复宽度小于0.5 mm的裂缝。MIP测试表明CCCW能有效改善PE-ECC孔隙结构;XRD和SEM显示掺入CCCW后PE-ECC自愈合产物种类不变,但Ca^(2+)络合剂种类增加,提供Ca^(2+)能力变强;裂缝处自愈合产物分布更为密集,愈合程度更高。 展开更多
关键词 水泥基渗透结晶型防水材料(CCCW) 高延性水泥基复合材料(ECC) 力学性能 自愈合性能 孔隙结构 物相组成 微观形貌
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Analysis of a Composite Admixture Based on Ready-Mixed Concrete Waste Residuals
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作者 Jinfa Jiang long xiong +1 位作者 Ming Bao Zihan Zhou 《Fluid Dynamics & Materials Processing》 EI 2023年第8期1983-1995,共13页
Reasonable treatment and utilization of waste residuals discharged during the production of ready-mixed concrete is an important problem in the cement industry.In this study,a composite admixture was prepared by using... Reasonable treatment and utilization of waste residuals discharged during the production of ready-mixed concrete is an important problem in the cement industry.In this study,a composite admixture was prepared by using ready-mixed concrete waste residuals,furnace slag,and water granulated slag.The grinding characteristics of such material were investigated.Moreover,the effect of such admixture on cement hydration and pore structure was analyzed by X-ray diffraction,thermogravimetric-differential scanning calorimetry,scanning electron microcopy and mercury intrusion porosimetry.As shown by the results:The grinding characteristics of the waste residuals can be improved significantly by mixing them with furnace slag and water granulated slag.Furthermore,the composite admixture does not change the composition of hydration products;rather it contributes to refine the pore structure of the matrix,thus improving the mechanical properties of these cement-based materials. 展开更多
关键词 Waste residue of ready-mixed concrete station ready mixed concrete composite admixture ACTIVITY MICROSTRUCTURE
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Ground State and Its Topological Properties of Three-Dimensional Spin-Orbit Coupled Degenerate Fermi Gases
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作者 long xiong Ming Gong +1 位作者 Zhao-Xiang Fang Rui Sun 《Chinese Physics Letters》 SCIE EI CAS CSCD 2023年第12期143-148,共6页
Three-dimensional(3D)degenerate Fermi gases in the presence of spin-orbit coupling,inducing various kinds of physical findings and phenomena,have attracted tremendous attention in these years.We investigate the 3D spi... Three-dimensional(3D)degenerate Fermi gases in the presence of spin-orbit coupling,inducing various kinds of physical findings and phenomena,have attracted tremendous attention in these years.We investigate the 3D spin-orbit coupled degenerate Fermi gases in theory and first present the analytic expression of their ground state.Our study provides an innovative perspective into understanding of the topological properties of 3D unconventional superconductors,and describes the topological phase transitions in trivial and topological phase areas.Further,such a system is provided with a richer set of Cooper pairings than traditional superconductors.The dual Cooper pairs with same spin directions emerge and exhibit peculiar behaviors,leading to topological phase transitions.Our study and discussion can be generalized to some other types of unconventional superconductors and areas of optical lattices. 展开更多
关键词 FERMI TOPOLOGICAL DEGENERATE
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广东省中山市小榄镇急诊心血管风险评估 被引量:1
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作者 单立兵 张建东 +1 位作者 龙雄 耿文静 《现代医药卫生》 2022年第17期2919-2923,共5页
目的了解广东省中山市小榄镇居民心血管病危险因素暴露情况,评估未来10年缺血性心血管病(ICVD)发病危险度,为不同心血管风险类型实施不同的健康管理策略提供科学依据。方法收集2020年2-12月该院急诊门诊收治的1640例20~79岁患者的临床资... 目的了解广东省中山市小榄镇居民心血管病危险因素暴露情况,评估未来10年缺血性心血管病(ICVD)发病危险度,为不同心血管风险类型实施不同的健康管理策略提供科学依据。方法收集2020年2-12月该院急诊门诊收治的1640例20~79岁患者的临床资料,分析心血管疾病相关危险因素(血压、血脂、血糖、吸烟等)暴露情况,并应用Framingham危险评估模型评估未来10年ICVD的发病危险性。结果1640例患者高血压、高血脂、高血糖、吸烟暴露率分别为32.4%(531/1640)、33.9%(556/1640)、33.1%(543/1640)、10.2%(167/1640),10年ICVD绝对危险值大于或等于10%者312例;男性ICVD相关危险因素检出率明显高于女性,差异有统计学意义(P<0.05);男、女性不同年龄患者10年ICVD发病危险度比较,差异均有统计学意义(P<0.05);随年龄增长男,女性10年ICVD发病中、高危险度均逐渐升高;10年ICVD发病绝对危险值大于或等于10%者各项ICVD危险因素检出率均明显高于小于10%者,差异均有统计学意义(P<0.05);年龄增长者在未来10年发生ICVD的危险性最大。结论广东省中山市小榄镇急诊门诊患者ICVD危险因素水平较高,55~79岁患者10年ICVD发病风险较大,应积极加强对ICVD危险因素的干预。 展开更多
关键词 急诊处理 心血管疾病 危险因素 Framingham危险评估模型 风险评估
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纤支镜和DNA倍体分析系统在细菌性肺炎诊治中的临床应用 被引量:1
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作者 单立兵 张建东 +1 位作者 龙雄 耿文静 《分子影像学杂志》 2019年第3期336-339,共4页
目的探讨纤支镜和DNA倍体分析系统在细菌性肺炎诊治中的临床应用价值。方法收集整理2017年10月~2018年3月南方医科大学附属小榄医院在局麻下行纤支镜诊治的96例细菌性肺炎患者的临床资料,从性别、发病年龄、临床表现、实验室检查结果、... 目的探讨纤支镜和DNA倍体分析系统在细菌性肺炎诊治中的临床应用价值。方法收集整理2017年10月~2018年3月南方医科大学附属小榄医院在局麻下行纤支镜诊治的96例细菌性肺炎患者的临床资料,从性别、发病年龄、临床表现、实验室检查结果、影像学检查结果、治疗方法、治疗效果等方面进行系统回顾性分析。结果96例细菌性肺炎患者在局麻下行纤维支气管镜检查及肺泡灌洗治疗,肺泡灌洗液进行DNA倍体分析。其中男39例,女57例,年龄17~92岁。胸部CT表现:双肺病变58例,左肺23例,右肺15例;渗出63例,实变54例;支气管扩张13例,胸腔积液7例。实验室检查:血沉异常64例;感染性标志物:白介素升高42例,降钙素升高78例,免疫球蛋白升高55例;外周血白细胞数目:16例<4×109,(4~10)×109的共68例,(10~20)×109的共12例。纤支镜检查结果:支气管内膜炎96例。灌洗液细菌培养及痰培养阳性0例,均为正常菌群未见致病菌。96例肺炎患者经纤支镜灌洗后87例症状迅速改善,治愈率达90.6%。本研究共23例行支气管灌洗液DNA倍体分析检查,均未见DNA倍体异常细胞。结论局麻下应用纤维支气管镜肺泡灌洗术治疗成人细菌性肺炎方法简单,安全有效。纤支镜检查和DNA倍体分析对成人细菌性肺炎的诊治有一定的价值。 展开更多
关键词 纤维支气管镜 肺泡灌洗术 细菌性肺炎 DNA倍体分析
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Dynamics of Quantum State and Effective Hamiltonian with Vector Differential Form of Motion Method
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作者 long xiong Wei-Feng Zhuang Ming Gong 《Chinese Physics Letters》 SCIE EI CAS CSCD 2022年第7期36-40,共5页
Effective Hamiltonians in periodically driven systems have received widespread attention for realization of novel quantum phases, non-equilibrium phase transition, and Majorana mode. Recently, the study of effective H... Effective Hamiltonians in periodically driven systems have received widespread attention for realization of novel quantum phases, non-equilibrium phase transition, and Majorana mode. Recently, the study of effective Hamiltonian using various methods has gained great interest. We consider a vector differential equation of motion to derive the effective Hamiltonian for any periodically driven two-level system, and the dynamics of the spin vector are an evolution under the Bloch sphere. Here, we investigate the properties of this equation and show that a sudden change of the effective Hamiltonian is expected. Furthermore, we present several exact relations, whose expressions are independent of the different starting points. Moreover, we deduce the effective Hamiltonian from the high-frequency limit, which approximately equals the results in previous studies. Our results show that the vector differential equation of motion is not affected by a convergence problem, and thus, can be used to numerically investigate the effective models in any periodic modulating system. Finally, we anticipate that the proposed method can be applied to experimental platforms that require time-periodic modulation, such as ultracold atoms and optical lattices. 展开更多
关键词 Dynamics of Quantum State and Effective Hamiltonian with Vector Differential Form of Motion Method HAMILTONIAN VECTOR QUANTUM
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浅谈SPC的应用
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作者 龙雄 袁万达 +1 位作者 闫翔 王瑞平 《汽车实用技术》 2019年第4期198-200,203,共4页
20世纪50年代,二战后的日本将SPC运用于生产,经过将近30年的努力,日本跃居世界质量与生产率的领先地位。20世纪90年代,美国汽车工业大规模推行SPC,如福特、通用,经过发展成为了世界著名的汽车制造商。^([2])为了对标前进汽车企业,SPC的... 20世纪50年代,二战后的日本将SPC运用于生产,经过将近30年的努力,日本跃居世界质量与生产率的领先地位。20世纪90年代,美国汽车工业大规模推行SPC,如福特、通用,经过发展成为了世界著名的汽车制造商。^([2])为了对标前进汽车企业,SPC的应用愈来愈多地被广大的汽车制造厂所接受并运用。有的推行成果显著,但是也有的造成资源巨大浪费,归咎其原因还是在于对SPC认识不足,对SPC运用存在一定的误区。文章对SPC的定义,实施过程存在的误区及具体的实施步骤作出了阐述。 展开更多
关键词 SPC 制造过程 控制图 品质管控
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无机增殖剂对PE/ECC力学、抗氯离子渗透及自愈合性能的影响
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作者 谭燕 龙雄 +1 位作者 余江滔 赵犇 《复合材料学报》 EI CAS CSCD 北大核心 2024年第2期937-951,共15页
为研究无机增殖剂(CCCA)对聚乙烯(PE)纤维增强高延性水泥基复合材料(ECC)力学、抗氯离子渗透及自愈合性能的影响,以PE/ECC为对照组,分别掺入不同质量分数的CCCA(2wt%、4wt%、6wt%、8wt%、10wt%),通过抗压、抗折、抗拉、电通量法及预加... 为研究无机增殖剂(CCCA)对聚乙烯(PE)纤维增强高延性水泥基复合材料(ECC)力学、抗氯离子渗透及自愈合性能的影响,以PE/ECC为对照组,分别掺入不同质量分数的CCCA(2wt%、4wt%、6wt%、8wt%、10wt%),通过抗压、抗折、抗拉、电通量法及预加应变损伤法对PE/ECC力学、抗氯离子渗透及自愈合性能进行研究,并利用XRD、SEM-EDS对其自愈合产物进行物相成分、微观形貌及元素组成分析。结果表明:随着CCCA掺量的增加,PE/ECC力学和抗氯离子渗透性能呈先增后减趋势,当CCCA掺量为4wt%时,CCCA对PE/ECC力学和抗氯离子渗透性能整体提升最为明显,抗压、抗折、极限抗拉强度分别提升了55.5%、10.8%、79.4%,极限拉应变变化不大,电通量下降了38.6%。自愈合试验表明,掺入CCCA后,PE/ECC抗拉强度和应变能的恢复率有明显提升,自愈合性能得到了增强。当预损伤应变为0.5%时,掺CCCA的PE/ECC试件抗拉强度和应变能在养护84天后均高于原始基体,较原始基体分别提高10.41%和2.83%。未掺CCCA的PE/ECC试件在3种应变损伤下的抗拉强度和应变能均低于原始基体。XRD和SEMEDS结果显示,掺CCCA的PE/ECC水化产物中CaCO_(3)、水化硅酸钙(C-S-H)、钙矾石(AFt)衍射峰值强度有所增长,自愈合产物主要是C-S-H晶体,且掺CCCA的PE/ECC中分布更密集。 展开更多
关键词 无机增殖剂 水泥基复合材料 抗氯离子渗透性能 自愈合 微观形貌
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