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Hepatitis C and double-hit B cell lymphoma successfully treated by antiviral therapy 被引量:2
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作者 Giovanni Galati lorenzo rampa +5 位作者 Umberto Vespasiani-Gentilucci Mirella Marino Francesco Pisani Carlo Cota Alessandro Guidi Antonio Picardi 《World Journal of Hepatology》 CAS 2016年第29期1244-1250,共7页
B cells lymphoma is one of the most challenging extrahepatic manifestations of hepatitis C virus(HCV). Recently, a new kind of B-cell lymphoma, named doublehit B(DHL), was characterized with an aggressive clinical cou... B cells lymphoma is one of the most challenging extrahepatic manifestations of hepatitis C virus(HCV). Recently, a new kind of B-cell lymphoma, named doublehit B(DHL), was characterized with an aggressive clinical course whereas a potential association with HCV was not investigated. The new antiviral direct agents(DAAs) against HCV are effective and curative in the majority of HCV infections. We report the first case, to our knowledge, of DHL and HCV-infection successfully treated by new DAAs. According to our experience, a DHL must be suspected in case of HCV-related lymphoma, and an early diagnosis could direct towards a different hematological management because a worse prognosis might be expected. A possible effect of DAAs on DHL regression should be investigated, but eradicating HCV would avoid life-threatening reactivation of viral hepatitis during pharmacological immunosuppression in oncohaematological diseases. 展开更多
关键词 Hepatitis C LYMPHOMA Direct antiviral agents Double hit lymphoma Chronic hepatitis C
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