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Social skills and psychopathology are associated with autonomic function in children:a cross-sectional observational study
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作者 Elisa Cainelli luca vedovelli +2 位作者 Daniele Bottigliengo Dario Boschiero Agnese Suppiej 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第4期920-928,共9页
In recent years,the increase of psychopathological disorders in the population has become a health emergency,leading to a great effort to understand psychological vulnerability mechanisms.In this scenario,the role of ... In recent years,the increase of psychopathological disorders in the population has become a health emergency,leading to a great effort to understand psychological vulnerability mechanisms.In this scenario,the role of the autonomic nervous system(ANS)has become increasingly important.This study investigated the association between ANS,social skills,and psychopathological functioning in children.As an ANS status proxy,we measured heart rate variability(HRV).Infants admitted to the neonatal intensive care unit of the University Hospital of Padova because of preterm birth or neonatal hypoxic-ischemic encephalopathy were sequentially recruited from January 2011 to June 2013 and followed long-term up to school age in this cross-sectional observational study.We recorded 5 minutes of HRV immediately before measuring performance in social abilities tasks(affect recognition and theory of mind,NEPSY-II)in 50 children(mean age 7.4±1.4 years)with and without risk factors for developing neuropsychiatric disorders due to pre-/perinatal insults without major sequelae.Children also completed extensive cognitive,neuropsychological,and psychosocial assessment.Parents were assessed with psychopathological interviews and a questionnaire(CBCL 6-18).Analysis in a robust Bayesian framework was used to unearth dependencies between HRV,social skills,and psychopathological functioning.Social task scores were associated with HRV components,with high frequency the most consistent.HRV bands were also associated with the psychopathological questionnaire.Only normalized HRV high frequency was able to distinguish impaired children in the affect recognition task.Our data suggest that ANS may be implicated in social cognition both in typical and atypical developmental conditions and that HRV has cross-disease sensitivity.We suggest that HRV parameters may reflect a neurobiological vulnerability to psychopathology.The study was approved by the Ethics Committee of the University Hospital of Padova(Comitato Etico per la Sperimentazione,Azienda Opedaliera di Padova,approval No.1693 P). 展开更多
关键词 affect recognition autonomic nervous system CHILDREN hypoxic-ischemic encephalopathy IMPAIRMENT NEONATAL PREMATURITY PSYCHOPATHOLOGY recovery theory of mind
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Over-specialization versus synergy in neuroscience:professionals’integration is more than the sum of its parts
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作者 Elisa Cainelli luca vedovelli 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第11期2232-2233,共2页
Health care systems in industrialized countries are built around acute health problems(Etzwiler,1997).This approach is successful when the goal is to improve or overcome pathologies that result in severe health issues... Health care systems in industrialized countries are built around acute health problems(Etzwiler,1997).This approach is successful when the goal is to improve or overcome pathologies that result in severe health issues or death.With the recent tremendous improvement of the treatments of life-threatening conditions,the clinical focus has moved from short term results to the overall expected quality of life and longterm outcomes.Unfortunately,the new objectives imply to consider a multitude of interacting processes and variables.In fact,a complex interplay of biological systems(nervous,immune,and endocrine)works together in an integrated and synergistic way to deal with a constantly evolving environment,determining our physical,behavioral,and psychological/subjective conditions.This interplay is the mechanism that allows us to adapt promptly and appropriately to circumstances,the key feature for successful living. 展开更多
关键词 OVERCOME SYNERGISTIC determining
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Covalent functionalization of decellularized tissues accelerates endothelialization 被引量:1
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作者 Eleonora Dal Sasso Annj Zamuner +10 位作者 Andrea Filippi Filippo Romanato Tiziana Palmosi luca vedovelli Dario Gregori Jose Luís Gòmez Ribelles Teresa Russo Antonio Gloria Laura Iop Gino Gerosa Monica Dettin 《Bioactive Materials》 SCIE 2021年第11期3851-3864,共14页
In the field of tissue regeneration,the lack of a stable endothelial lining may affect the hemocompatibility of both synthetic and biological replacements.These drawbacks might be prevented by specific biomaterial fun... In the field of tissue regeneration,the lack of a stable endothelial lining may affect the hemocompatibility of both synthetic and biological replacements.These drawbacks might be prevented by specific biomaterial functionalization to induce selective endothelial cell(EC)adhesion.Decellularized bovine pericardia and porcine aortas were selectively functionalized with a REDV tetrapeptide at 10^(-5)M and 10^(-6)M working concentrations.The scaffold-bound peptide was quantified and REDV potential EC adhesion enhancement was evaluated in vitro by static seeding of human umbilical vein ECs.The viable cells and MTS production were statistically higher in functionalized tissues than in control.Scaffold histoarchitecture,geometrical features,and mechanical properties were unaffected by peptide anchoring.The selective immobilization of REDV was effective in accelerating ECs adhesion while promoting proliferation in functionalized decellularized tissues intended for blood-contacting applications. 展开更多
关键词 Decellularized pericardium Decellularized aorta Covalent functionalization ENDOTHELIALIZATION REDV Mechanical analysis
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