At present,more and more diseases are associated with the lubrication dysfunction,which requires a systematic study of the complex lubrication behavior of tissues and organs in human body.Natural biomacromolecular lub...At present,more and more diseases are associated with the lubrication dysfunction,which requires a systematic study of the complex lubrication behavior of tissues and organs in human body.Natural biomacromolecular lubricants are essential for maintaining ultra-low coefficients of friction between sliding biological interfaces.However,when the surface lubrication performance of tissues or organs destroys heavily,it will bring friction/shear damage for sliding contact interfaces.Therefore,the application of exogenous biological lubricating materials to improve the lubrication situation of damaged tissue or organ interfaces has attracted extensive attention of researchers.In this review,based on a simple summary of lubrication mechanism at sliding biological interface,we systematically introduce the research progress of several kinds of representatively biolubrication materials,including eye drops,tissue anti-adhesion agents,joint lubricants,and medical device lubricants.Meanwhile,the lubrication mechanism and individual advantage and shortcoming for each of these synthetic exogenous lubricated materials are clarified.Correspondingly,the important lubrication application functionality of these biolubricant materials in typically medical surgery scenes,such as dry eye syndrome,tissue adhesion,arthritis,and interventional medical devices,is discussed.Finally,we look forward to the future development direction of artificial biolubricant materials.展开更多
基金We are grateful for the financial support from the National Natural Science Foundation of China(22032006 and 52075522)Key Research Project of Shandong Provincial Natural Science Foundation(ZR2021ZD27)+1 种基金Outstanding Youth Fund of Gansu Province(21JR7RA095)LICP Cooperation Foundation for Young Scholars(HZJ21-04).
文摘At present,more and more diseases are associated with the lubrication dysfunction,which requires a systematic study of the complex lubrication behavior of tissues and organs in human body.Natural biomacromolecular lubricants are essential for maintaining ultra-low coefficients of friction between sliding biological interfaces.However,when the surface lubrication performance of tissues or organs destroys heavily,it will bring friction/shear damage for sliding contact interfaces.Therefore,the application of exogenous biological lubricating materials to improve the lubrication situation of damaged tissue or organ interfaces has attracted extensive attention of researchers.In this review,based on a simple summary of lubrication mechanism at sliding biological interface,we systematically introduce the research progress of several kinds of representatively biolubrication materials,including eye drops,tissue anti-adhesion agents,joint lubricants,and medical device lubricants.Meanwhile,the lubrication mechanism and individual advantage and shortcoming for each of these synthetic exogenous lubricated materials are clarified.Correspondingly,the important lubrication application functionality of these biolubricant materials in typically medical surgery scenes,such as dry eye syndrome,tissue adhesion,arthritis,and interventional medical devices,is discussed.Finally,we look forward to the future development direction of artificial biolubricant materials.
