A calamitous landslide happened at 22:00 on September 1,2014 in the Yunyang area of Chongqing City,southwest China,enforcing the evacuation of 508 people and damaging 23 buildings.The landslide volume comprised 1.44 m...A calamitous landslide happened at 22:00 on September 1,2014 in the Yunyang area of Chongqing City,southwest China,enforcing the evacuation of 508 people and damaging 23 buildings.The landslide volume comprised 1.44 million m^(3) of material in the source area and 0.4 million m^(3) of shoveled material.The debris flow runout extended 400 m vertically and 1600 m horizontally.The Xianchi reservoir landslide event has been investigated as follows:(1)samples collected from the main body of landslide were carried out using GCTS ring shear apparatus;(2)the parameters of shear and pore water pressure have been measured;and(3)the post-failure characteristics of landslide have been analyzed using the numerical simulation method.The excess pore-water pressure and erosion in the motion path are considered to be the key reasons for the long-runout motion and the scale-up of landslides,such as that at Xianchi,were caused by the heavy rainfall.The aim of this paper is to acquired numerical parameters and the basic resistance model,which is beneficial to improve simulation accuracy for hazard assessment for similar to potentially dangerous hillslopes in China and elsewhere.展开更多
Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellu...Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellular pyroptosis-related proteins.Methods:Forty patients with granulomatous lobular mastitis were randomly divided into 20 cases in the observation group and 20 cases in the control group.Both groups were given dexamethasone ointment for treatment,and the observation group was treated with external application of Zi Cao Yang He Tang on the basis of the control group.Breast lump vol-ume changes,breast pain and pus symptoms,pathology and histology and immunohistochemistry,cellular death-related indicators expression were compared between the two groups.Results:After treatment,the difference in mass volume of the observation group was significantly greater than that of the control group(16.7±21.5 in the control group and 32.9±27.4 in the experimental group)and the difference between the two groups was statistically significant(P<0.05);the objective remission rate of the patients in the observation group(ORR=85%)was significantly higher than that of the treatment group(ORR=50%,P<0.05).In terms of pus formation rate and pain level,the breast pain score of the observation group was significantly lower than that of the control group after two weeks or three weeks of treatment(P<0.05);the pus formation rate of the observation group was 30%,and the pus formation rate of the control group was 20%,and the difference was not statistically significant(P>0.05).The immunohistochemical expression levels of caspase-1 and GSDMD in the observation group were significantly lower than those in the control group(P<0.05);and in terms of the expression of cellular pyroptosis-related indexes,the expression of GSDMD,cas-pase-1,and NLRP3 in the observation group was significantly lower compared with that in the control group(P<0.05).Conclusion:The efficacy of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in treating granulomatous lobular mastitis in the mass stage is remarkable,which can effectively reduce breast pain,reduce the size of the mass,de-crease the expression of cellular pyroptosisrelated indexes,and have a good anti-inflammatory effect.展开更多
Fluoride and nitrate enriched groundwater are potential threats to the safety of the groundwater supply that may cause significant effects on human health and public safety,especially in aggregated population areas an...Fluoride and nitrate enriched groundwater are potential threats to the safety of the groundwater supply that may cause significant effects on human health and public safety,especially in aggregated population areas and economic hubs.This study focuses on the high F^(−)and NO_(3)^(−)concentration groundwater in Tongzhou District,Beijing,North China.A total of 36 groundwater samples were collected to analyze the hydrochemical characteristics,elucidate genetic mechanisms and evaluate the potential human health risks.The results of the analysis indicate:Firstly,most of the groundwater samples are characterized by Mg-HCO_(3) and Na-HCO_(3) with the pH ranging from 7.19 to 8.28 and TDS with a large variation across the range 471-2337 mg/L.The NO_(3)^(−)concentration in 38.89%groundwater samples and the F^(−)concentration in 66.67%groundwater samples exceed the permissible limited value.Secondly,F^(−)in groundwater originates predominantly from water-rock interactions and the fluorite dissolution,which is also regulated by cation exchange,competitive adsorption of HCO_(3)−and an alkaline environment.Thirdly,the effect of sewage disposal and agricultural activities have a significant effect on high NO3-concentration,while the high F^(−)concentration is less influenced by anthropogenic activity.The alkaline environment favors nitrification,thus being conducive to the production of NO_(3)^(−).Finally,the health risk assessment is evaluated for different population groups.The results indicate that high NO_(3)^(−)and F^(−)concentration in groundwater would have the largest threat to children’s health.The findings of this study could contribute to the provision of a scientific basis for groundwater supply policy formulation relating to public health in Tongzhou District.展开更多
Geothermal resources are increasingly gaining attention as a competitive,clean energy source to address the energy crisis and mitigate climate change.The Wugongshan area,situated in the southeast coast geothermal belt...Geothermal resources are increasingly gaining attention as a competitive,clean energy source to address the energy crisis and mitigate climate change.The Wugongshan area,situated in the southeast coast geothermal belt of China,is a typical geothermal anomaly and contains abundant medium-and low-temperature geothermal resources.This study employed hydrogeochemical and isotopic techniques to explore the cyclic evolution of geothermal water in the western Wugongshan region,encompassing the recharge origin,water-rock interaction mechanisms,and residence time.The results show that the geothermal water in the western region of Wugongshan is weakly alkaline,with low enthalpy and mineralization levels.The hydrochemistry of geothermal waters is dominated by Na-HCO_(3)and Na-SO_(4),while the hydrochemistry types of cold springs are all Na-HCO_(3).The hydrochemistry types of surface waters and rain waters are NaHCO_(3)or Ca-HCO_(3).The δD and δ^(18)O values reveal that the geothermal waters are recharged by atmospheric precipitation at an altitude between 550.0 and 1218.6 m.Molar ratios of maj or solutes and isotopic compositions of^(87)Sr/^(86)Sr underscore the significant role of silicate weathering,dissolution,and cation exchange in controlling geothermal water chemistry.Additionally,geothermal waters experienced varying degrees of mixing with cold water during their ascent.Theδ^(13)C values suggest that the primary sources of carbon in the geothermal waters were biogenic and organic.Theδ^(34)S value suggests that the sulfates in geothermal water originate from sulfide minerals in the surrounding rock.Age dating using 3H and^(14)C isotopes suggests that geothermal waters have a residence time exceeding 1 kaBP and undergo a long-distance cycling process.展开更多
随着工业化进程的加快和城市化的发展,大量污染物排入黄河流域,并被频繁检出,威胁生态系统和人类健康。为获取潜在生态环境风险污染物,该研究通过调研2000年1月1日−2022年12月31日Web of Science(WoS)和中国知网(CNKI)数据库中黄河流域...随着工业化进程的加快和城市化的发展,大量污染物排入黄河流域,并被频繁检出,威胁生态系统和人类健康。为获取潜在生态环境风险污染物,该研究通过调研2000年1月1日−2022年12月31日Web of Science(WoS)和中国知网(CNKI)数据库中黄河流域已报道的288篇污染物相关文献,使用多指标综合评分法筛选黄河流域的特征污染物,采用风险商值法获取水样和沉积物中的风险污染物。结果表明:①黄河流域共检出10类144种污染物,采用9类共13个筛选指标构建多指标综合评分法,对污染物各项指标进行评分,然后进行K-means聚类分析,按得分高低分为Ⅰ~Ⅵ级,选取得分较高的33种Ⅰ级和Ⅱ级高分值污染物作为黄河流域特征污染物,包括12种有机氯农药、10种多环芳烃、10种多氯联苯和1种邻苯二甲酸酯。②水样污染物浓度和沉积物含量前5种都是重金属、有机氯农药、邻苯二甲酸酯、多环芳烃以及药品和个人护理产品,而且二者顺序完全一致,且多数污染物的浓度之间存在显著相关性。③根据风险最大化原则,使用风险商值法(RQ)分别对水样和沉积物进行风险评估,将RQ≥0.1的污染物列为风险污染物,水样中共筛选出21种风险污染物,其中RQ≥1的高风险污染物有5种,包括硒、铅、苯并[a,h]蒽、苯并[a]蒽和邻苯二甲酸二丁酯。④沉积物中共筛选出19种风险污染物,其中有13种高风险污染物,包括8种多环芳烃(芘、蒽、荧蒽、苊、萘、芴、苯并[a]蒽、苯并[a,h]蒽)、4种重金属(汞、铅、硒、砷)和1种邻苯二甲酸酯(邻苯二甲酸二丁酯)。该研究对相关部门拟定黄河流域污染物监测方案和管控措施有重要参考意义。展开更多
Objective To identify the representative attributes of the five elements of a person with a qualitative methodology and provide the basis for the clinical diagnosis and treatment of“people with the five elements in t...Objective To identify the representative attributes of the five elements of a person with a qualitative methodology and provide the basis for the clinical diagnosis and treatment of“people with the five elements in traditional Chinese medicine(TCM).”Methods Data collected from the literature review,two sessions of brainstorming of experts with related experience in“people with the five elements in TCM”from October 2020 to December 2020,and six rounds of in-depth interviews with 30 participants who had various attributes of the five elements from March 2021 to October 2021 were analyzed.Triangulation was used in this study,and theming and synthesizing were used to analyze the data.Results A total of 31 experts and 30 interviewees participated in this study.The median age of the experts and interviewees were 48.0 and 38.5 years,respectively;51.66%and 54.8%of experts and interviewees,respectively,were men.The descriptors of facial diagrams of“people with the five elements in TCM”were complexion,shape,distribution state of facial bones,convergence trend of facial muscles,and facial expression.A theoretical model of“people with the five elements in TCM”was shaped based on these findings.Conclusion The study suggests a possibility for bridging the gap between personality and bodily state,identifying an avenue for personality research from the perspective of TCM.展开更多
基金supported by the China Geological Survey Project(Grant No.DD20211314)the Fundamental Research Funds for Chinese Academy of Geological Science(No.JKY202122).
文摘A calamitous landslide happened at 22:00 on September 1,2014 in the Yunyang area of Chongqing City,southwest China,enforcing the evacuation of 508 people and damaging 23 buildings.The landslide volume comprised 1.44 million m^(3) of material in the source area and 0.4 million m^(3) of shoveled material.The debris flow runout extended 400 m vertically and 1600 m horizontally.The Xianchi reservoir landslide event has been investigated as follows:(1)samples collected from the main body of landslide were carried out using GCTS ring shear apparatus;(2)the parameters of shear and pore water pressure have been measured;and(3)the post-failure characteristics of landslide have been analyzed using the numerical simulation method.The excess pore-water pressure and erosion in the motion path are considered to be the key reasons for the long-runout motion and the scale-up of landslides,such as that at Xianchi,were caused by the heavy rainfall.The aim of this paper is to acquired numerical parameters and the basic resistance model,which is beneficial to improve simulation accuracy for hazard assessment for similar to potentially dangerous hillslopes in China and elsewhere.
基金Hubei Chen Xiaoping Science and Technology Development Foundation Special Fund Project (No.CXPJJH12000002-2020010)Education Science Research Project,Beijing University of Chinese Medicine (No.XJY21056)Beijing University of Chinese Medicine New Teachers Start-up Fund Project (No.2022-BUCMXJKY010)。
文摘Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellular pyroptosis-related proteins.Methods:Forty patients with granulomatous lobular mastitis were randomly divided into 20 cases in the observation group and 20 cases in the control group.Both groups were given dexamethasone ointment for treatment,and the observation group was treated with external application of Zi Cao Yang He Tang on the basis of the control group.Breast lump vol-ume changes,breast pain and pus symptoms,pathology and histology and immunohistochemistry,cellular death-related indicators expression were compared between the two groups.Results:After treatment,the difference in mass volume of the observation group was significantly greater than that of the control group(16.7±21.5 in the control group and 32.9±27.4 in the experimental group)and the difference between the two groups was statistically significant(P<0.05);the objective remission rate of the patients in the observation group(ORR=85%)was significantly higher than that of the treatment group(ORR=50%,P<0.05).In terms of pus formation rate and pain level,the breast pain score of the observation group was significantly lower than that of the control group after two weeks or three weeks of treatment(P<0.05);the pus formation rate of the observation group was 30%,and the pus formation rate of the control group was 20%,and the difference was not statistically significant(P>0.05).The immunohistochemical expression levels of caspase-1 and GSDMD in the observation group were significantly lower than those in the control group(P<0.05);and in terms of the expression of cellular pyroptosis-related indexes,the expression of GSDMD,cas-pase-1,and NLRP3 in the observation group was significantly lower compared with that in the control group(P<0.05).Conclusion:The efficacy of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in treating granulomatous lobular mastitis in the mass stage is remarkable,which can effectively reduce breast pain,reduce the size of the mass,de-crease the expression of cellular pyroptosisrelated indexes,and have a good anti-inflammatory effect.
基金supported by the project of China Geological Survey(Grant No.DD20221677-2)the fundamental research funds of Chinese Academy of Geological Sciences Basal Research Fund(Grant No.JKYQN202307).
文摘Fluoride and nitrate enriched groundwater are potential threats to the safety of the groundwater supply that may cause significant effects on human health and public safety,especially in aggregated population areas and economic hubs.This study focuses on the high F^(−)and NO_(3)^(−)concentration groundwater in Tongzhou District,Beijing,North China.A total of 36 groundwater samples were collected to analyze the hydrochemical characteristics,elucidate genetic mechanisms and evaluate the potential human health risks.The results of the analysis indicate:Firstly,most of the groundwater samples are characterized by Mg-HCO_(3) and Na-HCO_(3) with the pH ranging from 7.19 to 8.28 and TDS with a large variation across the range 471-2337 mg/L.The NO_(3)^(−)concentration in 38.89%groundwater samples and the F^(−)concentration in 66.67%groundwater samples exceed the permissible limited value.Secondly,F^(−)in groundwater originates predominantly from water-rock interactions and the fluorite dissolution,which is also regulated by cation exchange,competitive adsorption of HCO_(3)−and an alkaline environment.Thirdly,the effect of sewage disposal and agricultural activities have a significant effect on high NO3-concentration,while the high F^(−)concentration is less influenced by anthropogenic activity.The alkaline environment favors nitrification,thus being conducive to the production of NO_(3)^(−).Finally,the health risk assessment is evaluated for different population groups.The results indicate that high NO_(3)^(−)and F^(−)concentration in groundwater would have the largest threat to children’s health.The findings of this study could contribute to the provision of a scientific basis for groundwater supply policy formulation relating to public health in Tongzhou District.
基金funded by the project of China Geological Survey(Grant No.DD20221677-2)the Central Public-Interest Scientific Institution Basal Research Fund(Grant No.JKYQN202307)。
文摘Geothermal resources are increasingly gaining attention as a competitive,clean energy source to address the energy crisis and mitigate climate change.The Wugongshan area,situated in the southeast coast geothermal belt of China,is a typical geothermal anomaly and contains abundant medium-and low-temperature geothermal resources.This study employed hydrogeochemical and isotopic techniques to explore the cyclic evolution of geothermal water in the western Wugongshan region,encompassing the recharge origin,water-rock interaction mechanisms,and residence time.The results show that the geothermal water in the western region of Wugongshan is weakly alkaline,with low enthalpy and mineralization levels.The hydrochemistry of geothermal waters is dominated by Na-HCO_(3)and Na-SO_(4),while the hydrochemistry types of cold springs are all Na-HCO_(3).The hydrochemistry types of surface waters and rain waters are NaHCO_(3)or Ca-HCO_(3).The δD and δ^(18)O values reveal that the geothermal waters are recharged by atmospheric precipitation at an altitude between 550.0 and 1218.6 m.Molar ratios of maj or solutes and isotopic compositions of^(87)Sr/^(86)Sr underscore the significant role of silicate weathering,dissolution,and cation exchange in controlling geothermal water chemistry.Additionally,geothermal waters experienced varying degrees of mixing with cold water during their ascent.Theδ^(13)C values suggest that the primary sources of carbon in the geothermal waters were biogenic and organic.Theδ^(34)S value suggests that the sulfates in geothermal water originate from sulfide minerals in the surrounding rock.Age dating using 3H and^(14)C isotopes suggests that geothermal waters have a residence time exceeding 1 kaBP and undergo a long-distance cycling process.
文摘随着工业化进程的加快和城市化的发展,大量污染物排入黄河流域,并被频繁检出,威胁生态系统和人类健康。为获取潜在生态环境风险污染物,该研究通过调研2000年1月1日−2022年12月31日Web of Science(WoS)和中国知网(CNKI)数据库中黄河流域已报道的288篇污染物相关文献,使用多指标综合评分法筛选黄河流域的特征污染物,采用风险商值法获取水样和沉积物中的风险污染物。结果表明:①黄河流域共检出10类144种污染物,采用9类共13个筛选指标构建多指标综合评分法,对污染物各项指标进行评分,然后进行K-means聚类分析,按得分高低分为Ⅰ~Ⅵ级,选取得分较高的33种Ⅰ级和Ⅱ级高分值污染物作为黄河流域特征污染物,包括12种有机氯农药、10种多环芳烃、10种多氯联苯和1种邻苯二甲酸酯。②水样污染物浓度和沉积物含量前5种都是重金属、有机氯农药、邻苯二甲酸酯、多环芳烃以及药品和个人护理产品,而且二者顺序完全一致,且多数污染物的浓度之间存在显著相关性。③根据风险最大化原则,使用风险商值法(RQ)分别对水样和沉积物进行风险评估,将RQ≥0.1的污染物列为风险污染物,水样中共筛选出21种风险污染物,其中RQ≥1的高风险污染物有5种,包括硒、铅、苯并[a,h]蒽、苯并[a]蒽和邻苯二甲酸二丁酯。④沉积物中共筛选出19种风险污染物,其中有13种高风险污染物,包括8种多环芳烃(芘、蒽、荧蒽、苊、萘、芴、苯并[a]蒽、苯并[a,h]蒽)、4种重金属(汞、铅、硒、砷)和1种邻苯二甲酸酯(邻苯二甲酸二丁酯)。该研究对相关部门拟定黄河流域污染物监测方案和管控措施有重要参考意义。
基金financially supported by the Beijing Hospital Management Center“Dengfeng”plan[DFL20191901]。
文摘Objective To identify the representative attributes of the five elements of a person with a qualitative methodology and provide the basis for the clinical diagnosis and treatment of“people with the five elements in traditional Chinese medicine(TCM).”Methods Data collected from the literature review,two sessions of brainstorming of experts with related experience in“people with the five elements in TCM”from October 2020 to December 2020,and six rounds of in-depth interviews with 30 participants who had various attributes of the five elements from March 2021 to October 2021 were analyzed.Triangulation was used in this study,and theming and synthesizing were used to analyze the data.Results A total of 31 experts and 30 interviewees participated in this study.The median age of the experts and interviewees were 48.0 and 38.5 years,respectively;51.66%and 54.8%of experts and interviewees,respectively,were men.The descriptors of facial diagrams of“people with the five elements in TCM”were complexion,shape,distribution state of facial bones,convergence trend of facial muscles,and facial expression.A theoretical model of“people with the five elements in TCM”was shaped based on these findings.Conclusion The study suggests a possibility for bridging the gap between personality and bodily state,identifying an avenue for personality research from the perspective of TCM.
