为了解正念在儿童群体中的研究热点和前沿动态,研究者以ISI Web of Science数据库中2007—2021年的1900篇文献为原始数据,应用CiteSpace知识图谱软件,绘制与儿童正念研究相关的知识图谱,挖掘国外儿童正念的发表文献时间分布、研究热点...为了解正念在儿童群体中的研究热点和前沿动态,研究者以ISI Web of Science数据库中2007—2021年的1900篇文献为原始数据,应用CiteSpace知识图谱软件,绘制与儿童正念研究相关的知识图谱,挖掘国外儿童正念的发表文献时间分布、研究热点与研究前沿。研究结果发现:国外儿童正念研究发文量近五年呈明显上升趋势,研究热点涉及正念疗法及其效果、儿童心理问题与行为问题、正念干预使用率、正念教养等领域,研究前沿主要包括正念干预的科学性、儿童社会情绪能力培养以及师生关系等研究主题。展开更多
目的探讨卵巢-附件超声报告和数据风险分层系统(O-RADS US)结合卵巢恶性肿瘤风险算法(ROMA)鉴别卵巢-附件肿瘤良恶性的价值。方法回顾性分析2021年6月至2023年5月于青岛市市立医院妇产科住院治疗的卵巢-附件肿瘤患者89例的临床资料。采...目的探讨卵巢-附件超声报告和数据风险分层系统(O-RADS US)结合卵巢恶性肿瘤风险算法(ROMA)鉴别卵巢-附件肿瘤良恶性的价值。方法回顾性分析2021年6月至2023年5月于青岛市市立医院妇产科住院治疗的卵巢-附件肿瘤患者89例的临床资料。采用经阴道超声观察病灶的大小、回声、形态、内部分隔及血流分布等超声特征,按照O-RADS US对病灶进行分类,并通过糖类抗原125(CA125)和人附睾蛋白4(HE4)表达水平计算ROMA值。采用受试者操作特征(ROC)曲线分析O-RADS US、ROMA及其联合诊断卵巢癌的效能。结果本研究共收集到93个病灶,卵巢癌病灶的最大径及ROMA值均高于良性病灶,差异有统计学意义(P<0.05)。O-RADS US分类为2、3、4、5类的病灶分别占21.5%(20/93)、26.9%(25/93)、33.3%(31/93)和18.3%(17/93);联合ROMA对O-RADS US分类进行校正,则O-RADS US分类为2、3、4、5类的病灶分别占34.4%(32/93)、29.0%(27/93)、14.0%(13/93)、22.6%(21/93)。联合ROMA后,O-RADS US 2、3、4类卵巢-附件病灶分别有4、6、9个升级为O-RADS US 3、4、5类;同样,O-RADS US 5、4、3类卵巢-附件病灶分别有5、20、16个降级为O-RADS US 4、3、2类。O-RADS US诊断卵巢癌的敏感度、特异度、准确度、曲线下面积分别为80.0%、75.3%、76.3%、0.861。ROMA诊断绝经前和绝经后患者卵巢癌的敏感度、特异度、准确度及曲线下面积分别为85.0%、82.2%、82.8%、0.876及90.0%、89.0%、89.2%、0.904。O-RADS US联合ROMA诊断卵巢癌的敏感度、特异度、准确度及曲线下面积分别为95.0%、91.8%、92.5%、0.926。以O-RADS US联合ROMA诊断卵巢癌的曲线下面积最大,其次是ROMA,差异有统计学意义(P<0.05)。结论O-RADS US分类系统可以有效识别卵巢癌,与ROMA联合应用,能够克服单独应用的不足,提高卵巢癌诊断的性能,减少不必要的穿刺活检。展开更多
In this paper,we propose a novel approach to visualizing global geographical information:a panoramic sphere in an immersive environment.The whole geographical surface can be observed through the rotating of heads as t...In this paper,we propose a novel approach to visualizing global geographical information:a panoramic sphere in an immersive environment.The whole geographical surface can be observed through the rotating of heads as the viewpoint of the panoramic sphere is inside the sphere.We compared three approaches to visualizing the earth for rendering the geographical information in a virtual reality environment.On the tasks of terrestrial and marine geographical information,we compare the visualization effects on a)a globe,b)a flat map and c)a panoramic sphere.Terrestrial geographical information tasks include the area comparison and direction determination.Marine geographical information tasks contain the visualization of sea surface temperature and sea surface currents.For terrestrial geographical information tasks,the experimental results show that the panoramic sphere outperforms the globe and the flat map,with a higher average accuracy and a shorter time.On marine geographical information task,the panoramic sphere visualization is also superior to the flat map and the globe in an immersive environment for the sea surface temperature data and the sea surface current fields.In all three visualization experiments,the panoramic sphere is most preferred by the participants,particularly for global,transcontinental and transoceanic needs.展开更多
Objective:A chiral resolution method for enantiomers of two chiral nitrogen-containing metabolites R-gentiandiol and S-gentiandiol of swertiamarin in plasma was developed,and the pharmacokinetics of the metabolites we...Objective:A chiral resolution method for enantiomers of two chiral nitrogen-containing metabolites R-gentiandiol and S-gentiandiol of swertiamarin in plasma was developed,and the pharmacokinetics of the metabolites were studied.Methods:The metabolites of swertiamarin in vivo were detected by LC-MS/MS using Astec CyclobondⅡCyclodextrin column(4.6 mm×100 mm,5μm),gradient elution with acetonitrile-water as mobile phase,and monitored by multiple reaction monitoring(MRM)method in positive mode.The ion pairs for quantitative analysis are R-gentiandiol(m/z 210.04→192.06),S-gentiandiol(m/z 210.04→192.06)and gentianone(m/z 192.02→162.08).Results:The linear correlation coefficients of the method developed were greater than 0.999,the precision was less than 7.00%,the recovery was 99.57%-102.65%,and the matrix effect was 90.94%-91.34%.The peak t_(max)of R-gentiandiol and S-gentiandiol in rat plasma after oral administration of swertiamarin were(1.63±0.23)h and(1.58±0.21)h,t_(1/2)was(6.23±0.52)h and(5.46±0.38)h,C_(max)was(86.79±20.81)ng/mL and(60.72±18.95)ng/mL,and the AUC_(0-24)were(1094.58±86.37))(ng·h)/mL and(724.67±58.38)(ng·h)/mL,respectively.Conclusion:The method was highly sensitive with good accuracy and precision,and it was successfully applied for chiral resolution and pharmacokinetics study of R-gentiandiol and S-gentiandiol in plasma.The method developed and experimental results will provide scientific basis for the study of pharmacodynamics and pharmacodynamic material basis of swertiamarin,and lay a foundation for clinical application and resource development of TCM monomer.展开更多
文摘为了解正念在儿童群体中的研究热点和前沿动态,研究者以ISI Web of Science数据库中2007—2021年的1900篇文献为原始数据,应用CiteSpace知识图谱软件,绘制与儿童正念研究相关的知识图谱,挖掘国外儿童正念的发表文献时间分布、研究热点与研究前沿。研究结果发现:国外儿童正念研究发文量近五年呈明显上升趋势,研究热点涉及正念疗法及其效果、儿童心理问题与行为问题、正念干预使用率、正念教养等领域,研究前沿主要包括正念干预的科学性、儿童社会情绪能力培养以及师生关系等研究主题。
文摘目的探讨卵巢-附件超声报告和数据风险分层系统(O-RADS US)结合卵巢恶性肿瘤风险算法(ROMA)鉴别卵巢-附件肿瘤良恶性的价值。方法回顾性分析2021年6月至2023年5月于青岛市市立医院妇产科住院治疗的卵巢-附件肿瘤患者89例的临床资料。采用经阴道超声观察病灶的大小、回声、形态、内部分隔及血流分布等超声特征,按照O-RADS US对病灶进行分类,并通过糖类抗原125(CA125)和人附睾蛋白4(HE4)表达水平计算ROMA值。采用受试者操作特征(ROC)曲线分析O-RADS US、ROMA及其联合诊断卵巢癌的效能。结果本研究共收集到93个病灶,卵巢癌病灶的最大径及ROMA值均高于良性病灶,差异有统计学意义(P<0.05)。O-RADS US分类为2、3、4、5类的病灶分别占21.5%(20/93)、26.9%(25/93)、33.3%(31/93)和18.3%(17/93);联合ROMA对O-RADS US分类进行校正,则O-RADS US分类为2、3、4、5类的病灶分别占34.4%(32/93)、29.0%(27/93)、14.0%(13/93)、22.6%(21/93)。联合ROMA后,O-RADS US 2、3、4类卵巢-附件病灶分别有4、6、9个升级为O-RADS US 3、4、5类;同样,O-RADS US 5、4、3类卵巢-附件病灶分别有5、20、16个降级为O-RADS US 4、3、2类。O-RADS US诊断卵巢癌的敏感度、特异度、准确度、曲线下面积分别为80.0%、75.3%、76.3%、0.861。ROMA诊断绝经前和绝经后患者卵巢癌的敏感度、特异度、准确度及曲线下面积分别为85.0%、82.2%、82.8%、0.876及90.0%、89.0%、89.2%、0.904。O-RADS US联合ROMA诊断卵巢癌的敏感度、特异度、准确度及曲线下面积分别为95.0%、91.8%、92.5%、0.926。以O-RADS US联合ROMA诊断卵巢癌的曲线下面积最大,其次是ROMA,差异有统计学意义(P<0.05)。结论O-RADS US分类系统可以有效识别卵巢癌,与ROMA联合应用,能够克服单独应用的不足,提高卵巢癌诊断的性能,减少不必要的穿刺活检。
基金This research was funded by the Science and Technology Innovation Project for Laoshan Laboratory(No.LSKJ202204303)the National Natural Science Foundation of China(No.42030406)+1 种基金the Fundamental Research Funds for the Central Universities(No.202261006)the ESANRSCC Scientific Cooperation Project on Earth Observation Science and Applications:Dragon 5(No.58393).
文摘In this paper,we propose a novel approach to visualizing global geographical information:a panoramic sphere in an immersive environment.The whole geographical surface can be observed through the rotating of heads as the viewpoint of the panoramic sphere is inside the sphere.We compared three approaches to visualizing the earth for rendering the geographical information in a virtual reality environment.On the tasks of terrestrial and marine geographical information,we compare the visualization effects on a)a globe,b)a flat map and c)a panoramic sphere.Terrestrial geographical information tasks include the area comparison and direction determination.Marine geographical information tasks contain the visualization of sea surface temperature and sea surface currents.For terrestrial geographical information tasks,the experimental results show that the panoramic sphere outperforms the globe and the flat map,with a higher average accuracy and a shorter time.On marine geographical information task,the panoramic sphere visualization is also superior to the flat map and the globe in an immersive environment for the sea surface temperature data and the sea surface current fields.In all three visualization experiments,the panoramic sphere is most preferred by the participants,particularly for global,transcontinental and transoceanic needs.
基金This study was supported by Key Research and Development Guidance Program of Heilongjiang Province(GZ20210125)。
文摘Objective:A chiral resolution method for enantiomers of two chiral nitrogen-containing metabolites R-gentiandiol and S-gentiandiol of swertiamarin in plasma was developed,and the pharmacokinetics of the metabolites were studied.Methods:The metabolites of swertiamarin in vivo were detected by LC-MS/MS using Astec CyclobondⅡCyclodextrin column(4.6 mm×100 mm,5μm),gradient elution with acetonitrile-water as mobile phase,and monitored by multiple reaction monitoring(MRM)method in positive mode.The ion pairs for quantitative analysis are R-gentiandiol(m/z 210.04→192.06),S-gentiandiol(m/z 210.04→192.06)and gentianone(m/z 192.02→162.08).Results:The linear correlation coefficients of the method developed were greater than 0.999,the precision was less than 7.00%,the recovery was 99.57%-102.65%,and the matrix effect was 90.94%-91.34%.The peak t_(max)of R-gentiandiol and S-gentiandiol in rat plasma after oral administration of swertiamarin were(1.63±0.23)h and(1.58±0.21)h,t_(1/2)was(6.23±0.52)h and(5.46±0.38)h,C_(max)was(86.79±20.81)ng/mL and(60.72±18.95)ng/mL,and the AUC_(0-24)were(1094.58±86.37))(ng·h)/mL and(724.67±58.38)(ng·h)/mL,respectively.Conclusion:The method was highly sensitive with good accuracy and precision,and it was successfully applied for chiral resolution and pharmacokinetics study of R-gentiandiol and S-gentiandiol in plasma.The method developed and experimental results will provide scientific basis for the study of pharmacodynamics and pharmacodynamic material basis of swertiamarin,and lay a foundation for clinical application and resource development of TCM monomer.
