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Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers 被引量:6
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作者 makoto arai Tomoaki Matsumura +8 位作者 Kenichiro Okimoto Arata Oyamada Keiko Saito Shoko Minemura Daisuke Maruoka Takeshi Tanaka Tomoo Nakagawa Tatsuro Katsuno Osamu Yokosuka 《World Journal of Gastroenterology》 SCIE CAS 2014年第43期16318-16322,共5页
AIM: To investigate the optimum period of treatment for post endoscopic submucosal dissection (ESD) ulcers.
关键词 Proton pump inhibitor Endoscopic submucosal dissection ESOMEPRAZOLE REBAMIPIDE Randomized control trial
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Efficacy of computed image modification of capsule endoscopy in patients with obscure gastrointestinal bleeding 被引量:4
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作者 Tomoaki Matsumura makoto arai +8 位作者 Toru Sato Tomoo Nakagawa Daisuke Maruoka Masaru Tsuboi Sachio Hata Eiji arai Tatsuro Katsuno Fumio Imazeki Osamu Yokosuka 《World Journal of Gastrointestinal Endoscopy》 CAS 2012年第9期421-428,共8页
AIM:To investigate whether flexible spectral color enhancement(FICE) improves diagnostic yields of capsule endoscopy(CE) for obscure gastro-intestinal bleeding(OGIB).METHODS:The study subjects consisted of 81 patients... AIM:To investigate whether flexible spectral color enhancement(FICE) improves diagnostic yields of capsule endoscopy(CE) for obscure gastro-intestinal bleeding(OGIB).METHODS:The study subjects consisted of 81 patients.Using FICE,there were three different sets with different wavelengths.Using randomly selected sets of FICE,images of CE were evaluated again by two individuals who were not shown the conventional CE reports and findings.The difference between FICE and conventional imaging was examined.RESULTS:The overall diagnostic yields in FICE sets 1,2,3 and conventional imaging(48.1%) were 51.9%,40.7%,51.9% and 48.1%,respectively,which showed no statistical difference compared to conventional imaging.The total numbers of detected lesions per examination in FICE imaging and conventional imaging were 2.5 ± 2.1 and 1.8 ± 1.7,respectively,which showed a significant difference(P = 0.01).CONCLUSION:The diagnostic yield for OGIB is not improved by FICE.However,FICE can detect significantly more small bowel lesions compared to conventional imaging. 展开更多
关键词 COMPUTED virtual CHROMOENDOSCOPY Flexible spectral color enhancement CAPSULE endoscopy Obscure gastro-intestinal BLEEDING Diagnostic yield
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Sofosbuvir treatment and hepatitis C virus infection 被引量:4
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作者 Masato Nakamura Tatsuo Kanda +7 位作者 Yuki Haga Reina Sasaki Shuang Wu Shingo Nakamoto Shin Yasui makoto arai Fumio Imazeki Osamu Yokosuka 《World Journal of Hepatology》 CAS 2016年第3期183-190,共8页
Hepatitis C virus(HCV) infection is a serious problem worldwide.The use of interferon-based therapy has made HCV eradication challenging.The recent appearance of direct-acting antiviral agents(DAAs) has changed HCV th... Hepatitis C virus(HCV) infection is a serious problem worldwide.The use of interferon-based therapy has made HCV eradication challenging.The recent appearance of direct-acting antiviral agents(DAAs) has changed HCV therapy.Combining the use of DAAs with peginterferon and ribavirin has improved treatment efficacy.Furthermore,the combination of different orally administered DAAs has enabled interferon-free therapy with much higher efficacy and safety.In particular,sofosbuvir,a nucleotide-based NS5 B inhibitor,prevents HCV RNA synthesis by acting as a "chain terminator".Treatment with sofosbuvir has attained an extremely high rate of sustained virologic response.The current review summarizes the efficacy and safety of sofosbuvir therapy. 展开更多
关键词 HEPATITIS C VIRUS INTERFERON Interferonfree GENOTYPE Sofosbuvir
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Polysomnographic assessment of respiratory disturbance during deep propofol sedation for endoscopic submucosal dissection of gastric tumors 被引量:3
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作者 Ryuma Urahama Masaya Uesato +7 位作者 Mizuho Aikawa Yukiko Yamaguchi Koichi Hayano Tomoaki Matsumura makoto arai Reiko Kunii Shiroh Isono Hisahiro Matsubara 《World Journal of Gastrointestinal Endoscopy》 CAS 2018年第11期340-347,共8页
AIM To investigate that polysomnographic monitoring can accurately evaluate respiratory disturbance incidence during sedation for gastrointestinal endoscopy compare to pulse oximetry alone.METHODS This prospective obs... AIM To investigate that polysomnographic monitoring can accurately evaluate respiratory disturbance incidence during sedation for gastrointestinal endoscopy compare to pulse oximetry alone.METHODS This prospective observational study included 10 elderly patients with early gastric cancer undergoing endoscopic submucosal dissection(ESD) under propofol sedation. Apart from routine cardiorespiratory monitoring, polysomnography measurements were acquired. The primary hypothesis was tested by comparing the apnea hypopnea index(AHI), defined as the number of apnea and hypopnea instances per hour during sedation, with and without hypoxemia; hypoxemia was defined as the reduction in oxygen saturation by ≥ 3% from baseline.RESULTS Polysomnography(PSG) detected 207 respiratory disturbances in the 10 patients. PSG yielded a significantly greater AHI(10.44 ± 5.68/h) compared with pulse oximetry(1.54 ± 1.81/h, P < 0.001), thus supporting our hypothesis. Obstructive AHI(9.26 ± 5.44/h) was significantly greater than central AHI(1.19 ± 0.90/h, P < 0.001). Compared with pulse oximetry, PSG detected the 25 instances of respiratory disturbances with hypoxemia 107.4 s earlier on average.CONCLUSION Compared with pulse oximetry, PSG can better detect respiratory irregularities and thus provide superior AHI values, leading to avoidance of fatal respiratory complications during ESD under propofol-induced sedation. 展开更多
关键词 POLYSOMNOGRAPHY HYPOXEMIA PROPOFOL Endoscopic SUBMUCOSAL dissection Pulse OXIMETRY SEDATION
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Platelet count and sustained virological response in hepatitis C treatment
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作者 Tatsuo Kanda Keizo Kato +11 位作者 Akihito Tsubota Nobuo Takada Takayoshi Nishino Shigeru Mikami Tatsuo Miyamura Daisuke Maruoka Shuang Wu Shingo Nakamoto makoto arai Keiichi Fujiwara Fumio Imazeki Osamu Yokosuka 《World Journal of Hepatology》 CAS 2013年第4期182-188,共7页
AIM:To examine the epidemiological data,hematological safety and treatment responses of peginterferonalpha 2a plus ribavirin therapy for hepatitis C.METHODS:Between March 2008 and February 2011,196 hepatitis C virus(H... AIM:To examine the epidemiological data,hematological safety and treatment responses of peginterferonalpha 2a plus ribavirin therapy for hepatitis C.METHODS:Between March 2008 and February 2011,196 hepatitis C virus(HCV)genotype 1 infected Japanese(127 treatment-naive and 69 treatment-experienced patients)patients treated with peginterferonalpha 2a plus ribavirin were enrolled.We examined the epidemiological data and treatment responses were retrospectively analyzed in terms of hematological safety.HCV RNA was measured by the COBAS TaqMan HCV test.RESULTS:Overall sustained virological response(SVR)rates of treatment-naive and treatment-experienced patients were 56% and 39%,respectively.Multivariate logistic regression analysis showed that SVR was attained independently of early virological response in both treatment-naive and treatment-experienced patients.SVR rates did not differ between the pretreatment hemoglobin < 13 g/dL and ≥ 13 g/dL groups.However,in treatment-naive patients,the SVR rate of the pretreatment platelet count < 130000/μL group was significantly lower than that of the pretreatment platelet count ≥ 130000/μL group.CONCLUSION:Attention should be paid to potential thrombocytopenia in the treatment of chronic hepatitis C patients. 展开更多
关键词 ANEMIA ANTIVIRAL TREATMENT Chronic hepatitis C PLATELET COUNT SUSTAINED virological response
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Natural interferon-beta treatment for patients with chronic hepatitis C in Japan
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作者 Reina Sasaki Tatsuo Kanda +7 位作者 Shingo Nakamoto Yuki Haga Masato Nakamura Shin Yasui Xia Jiang Shuang Wu makoto arai Osamu Yokosuka 《World Journal of Hepatology》 CAS 2015年第8期1125-1132,共8页
Chronic hepatitis C virus(HCV) infection can cause liver cirrhosis and hepatocellular carcinoma(HCC). Several studies have demonstrated that the eradication of HCV reduces the occurrence of HCC. In Japan, as many peop... Chronic hepatitis C virus(HCV) infection can cause liver cirrhosis and hepatocellular carcinoma(HCC). Several studies have demonstrated that the eradication of HCV reduces the occurrence of HCC. In Japan, as many people live to an advanced age, HCV-infected patients are also getting older, and the age at HCC diagnosis has also increased. Although older HCV-infected patients have a risk of developing HCC, the treatment response to peginterferon-alpha plus ribavirin therapy is relatively poor in these patients because of drop-out or discontinuation of this treatment due to adverse events. It is established that the mechanism of action between interferon-alpha and interferon-beta is slightly different. Short-term natural interferon-beta monotherapy is effective for patients with acute hepatitis C and patients infected with HCV genotype 2 and low viral loads. Natural interferon-beta plus ribavirin for 48 wk or for 24 wk are also effective for some patients with HCV genotype 1 or HCV genotype 2. Natural interferon-beta plus ribavirin has been used for certain "difficult-totreat" HCV-infected patients. In the era of direct-acting anti-virals, natural interferon-beta plus ribavirin may be one of the therapeutic options for special groups of HCV-infected patients. In the near future, signal transduction pathways of interferon-beta will inform further directions. 展开更多
关键词 HEPATOCELLULAR carcinoma HEPATITIS C VIRUS INTERFERON-BETA INTERFERON resistance RIBAVIRIN
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