Objective Colorectal cancer(CRC) is a heterogeneous disease in which both epigenetic alterations and gene mutations transform normal cells into cancer cells. Apart from a variety of standard treatments, there are few ...Objective Colorectal cancer(CRC) is a heterogeneous disease in which both epigenetic alterations and gene mutations transform normal cells into cancer cells. Apart from a variety of standard treatments, there are few options available to improve a CRC patient's overall survival(OS) and quality of a life. The objective of the present retrospective study was to analyze the response and toxicity associated with apatinib in patients with metastatic CRC(m CRC).Method Data on the use of apatinib as salvage therapy were collected from patients diagnosed with m CRC, Eastern Cooperative Oncology Group(ECOG) performance status ≤ 3, from the Luhe Hospital. A total of 17 patients with stage IV unresectable m CRC, who received at least one cycle of apatinib, between October 2015 and February 2017, were involved in this study. Our primary endpoints were the overall response rate(ORR) and disease control rate(DCR), and the secondary objectives were progression-free survival(PFS), OS and safety.Result Seventeen patients with a median age of 62 years(34–83 years) were enrolled. Twelve patients were male, and the location of the primary tumor was in the colon and the rectum in 9 and 8 patients, respectively. Liver metastasis was observed in 9 patients and lung metastasis in 5. The ECOG performance status was 0 to 2 in 13 patients. The ORR at the first evaluation was 17.6 %(3/17). The DCR was 82.4%(14/17). The median PFS was 3.0 months(95% confidence interval(CI): 1.924–4.076 months) and the median OS was 5.4 months(95% CI: 3.383–7.417 months). Grade 1–2 adverse events included hypertension(52.9%), fatigue(64.7%), anorexia(29.4%), hoarseness(23.5%), proteinuria(23.5%), and development of rashes(17.6%). Grade 3 adverse events included thrombocytopenia(5.9%) and proteinuria(5.9%). There were no Grade 4 adverse events in our analysis.Conclusions Apatinib was found to be both safe and effective in the treatment of advanced m CRC, and its associated toxicities were acceptable and manageable. However, further studies are required to validate these findings.展开更多
Microbial trdrisformation of taxoids was inveStigared: taxoid 2 was transformed into 1β and 14β hydroxylated derivahves 3 and 4, unnatural taxoid 6 was transformed into 1β-hydroxy derivative 7 and 11(15-1) abeotaxa...Microbial trdrisformation of taxoids was inveStigared: taxoid 2 was transformed into 1β and 14β hydroxylated derivahves 3 and 4, unnatural taxoid 6 was transformed into 1β-hydroxy derivative 7 and 11(15-1) abeotaxane 8. Taxoids with an oxetane ring, 11-13 were synthesized from 1 via chemical reachons.展开更多
Treatment of 1.4-diary1 -2. 3 -dimethy1-2, 3-epoxide of butane(1) with 2. 3-dichloro-5.6 6dicyano-1.4-benzoquinone(DDQ) in trifluoroacetic acid (TFA)furnishes a new benzofuran typeIignan (2) The structure of (2) was e...Treatment of 1.4-diary1 -2. 3 -dimethy1-2, 3-epoxide of butane(1) with 2. 3-dichloro-5.6 6dicyano-1.4-benzoquinone(DDQ) in trifluoroacetic acid (TFA)furnishes a new benzofuran typeIignan (2) The structure of (2) was esbolished by MS,IR,UV and NMR spectra.and X-ravcrystallographic analysis.展开更多
KLEIN-64 is a lightweight block cipher designed for resource-constrained environment,and it has advantages in software performance and hardware implementation.Recent investigation shows that KLEIN-64 is vulnerable to ...KLEIN-64 is a lightweight block cipher designed for resource-constrained environment,and it has advantages in software performance and hardware implementation.Recent investigation shows that KLEIN-64 is vulnerable to differential fault attack(DFA).In this paper,an improved DFA is performed to KLEIN-64.It is found that the differential propagation path and the distribution of the S-box can be fully utilized to distinguish the correct and wrong keys when a half-byte fault is injected in the 10th round.By analyzing the difference matrix before the last round of S-box,the location of fault injection can be limited to a small range.Thus,this improved analysis can greatly improve the attack efficiency.For the best case,the scale of brute-force attack is only 256.While for the worst case,the scale of brute-force attack is far less than 232 with another half byte fault injection,and the probability for this case is 1/64.Furthermore,the measures for KLEIN-64 in resisting the improved DFA are proposed.展开更多
文摘Objective Colorectal cancer(CRC) is a heterogeneous disease in which both epigenetic alterations and gene mutations transform normal cells into cancer cells. Apart from a variety of standard treatments, there are few options available to improve a CRC patient's overall survival(OS) and quality of a life. The objective of the present retrospective study was to analyze the response and toxicity associated with apatinib in patients with metastatic CRC(m CRC).Method Data on the use of apatinib as salvage therapy were collected from patients diagnosed with m CRC, Eastern Cooperative Oncology Group(ECOG) performance status ≤ 3, from the Luhe Hospital. A total of 17 patients with stage IV unresectable m CRC, who received at least one cycle of apatinib, between October 2015 and February 2017, were involved in this study. Our primary endpoints were the overall response rate(ORR) and disease control rate(DCR), and the secondary objectives were progression-free survival(PFS), OS and safety.Result Seventeen patients with a median age of 62 years(34–83 years) were enrolled. Twelve patients were male, and the location of the primary tumor was in the colon and the rectum in 9 and 8 patients, respectively. Liver metastasis was observed in 9 patients and lung metastasis in 5. The ECOG performance status was 0 to 2 in 13 patients. The ORR at the first evaluation was 17.6 %(3/17). The DCR was 82.4%(14/17). The median PFS was 3.0 months(95% confidence interval(CI): 1.924–4.076 months) and the median OS was 5.4 months(95% CI: 3.383–7.417 months). Grade 1–2 adverse events included hypertension(52.9%), fatigue(64.7%), anorexia(29.4%), hoarseness(23.5%), proteinuria(23.5%), and development of rashes(17.6%). Grade 3 adverse events included thrombocytopenia(5.9%) and proteinuria(5.9%). There were no Grade 4 adverse events in our analysis.Conclusions Apatinib was found to be both safe and effective in the treatment of advanced m CRC, and its associated toxicities were acceptable and manageable. However, further studies are required to validate these findings.
文摘Microbial trdrisformation of taxoids was inveStigared: taxoid 2 was transformed into 1β and 14β hydroxylated derivahves 3 and 4, unnatural taxoid 6 was transformed into 1β-hydroxy derivative 7 and 11(15-1) abeotaxane 8. Taxoids with an oxetane ring, 11-13 were synthesized from 1 via chemical reachons.
文摘Treatment of 1.4-diary1 -2. 3 -dimethy1-2, 3-epoxide of butane(1) with 2. 3-dichloro-5.6 6dicyano-1.4-benzoquinone(DDQ) in trifluoroacetic acid (TFA)furnishes a new benzofuran typeIignan (2) The structure of (2) was esbolished by MS,IR,UV and NMR spectra.and X-ravcrystallographic analysis.
基金This work was supported in part by project supported by National Natural Science Foundation of China(Grant Nos.U1936115,61572182).
文摘KLEIN-64 is a lightweight block cipher designed for resource-constrained environment,and it has advantages in software performance and hardware implementation.Recent investigation shows that KLEIN-64 is vulnerable to differential fault attack(DFA).In this paper,an improved DFA is performed to KLEIN-64.It is found that the differential propagation path and the distribution of the S-box can be fully utilized to distinguish the correct and wrong keys when a half-byte fault is injected in the 10th round.By analyzing the difference matrix before the last round of S-box,the location of fault injection can be limited to a small range.Thus,this improved analysis can greatly improve the attack efficiency.For the best case,the scale of brute-force attack is only 256.While for the worst case,the scale of brute-force attack is far less than 232 with another half byte fault injection,and the probability for this case is 1/64.Furthermore,the measures for KLEIN-64 in resisting the improved DFA are proposed.
