Several epidemiological,cellular,and molecular studies demonstrate the role of environmental chemicals with endocrine disrupting activities,typical of Westernized societies,in the pathogenesis of numerous diseases inc...Several epidemiological,cellular,and molecular studies demonstrate the role of environmental chemicals with endocrine disrupting activities,typical of Westernized societies,in the pathogenesis of numerous diseases including cancer.Nonetheless this information,the design and execution of studies on endocrine disruptors are not yet cognizant that the specific actions of individual hormones often change with development and ageing,they may be different in males and females and may be mediated by different receptors isoforms expressed in different tissues or at different life stages.These statements are particularly true when assessing the hazard of endocrine disruptors against 17β-estradiol(E2)actions in that this hormone is crucial determinant of sexrelated differences in anatomical,physiological,and behavioral traits which characterize male and female physiology.Moreover,E2 is also involved in carcinogenesis.The oncogenic effects of E2 have been investigated extensively in breast and ovarian cancers where hormone-receptor modulators are now an integral part of targeted treatment.Little is known about the E2preventive signalling in colorectal cancer,although this disease is more common in men than women,the difference being more striking amongst pre-menopausal women and age-matched men.This review aims to dissect the role and action mechanisms of E2 in colorectal cancer evaluating the ability of estrogen disruptors(i.e.,xenoestrogens)in impair these E2 actions.Data discussed here lead to define the possible role of xenoestrogens in the impairment and/or activation of E2signals important for colorectal cancer prevention.展开更多
The need to standardise stratigraphical subdivisions of continuous marine sedimentary successions that outcrop for hundreds metres, using clearly defined points fixed in the field is strongly felt. A proposal is prese...The need to standardise stratigraphical subdivisions of continuous marine sedimentary successions that outcrop for hundreds metres, using clearly defined points fixed in the field is strongly felt. A proposal is presented here to formalize regional stages for the Lower Pleistocene （Calabrian） and for the Middle Pleistocene （Ionian） in Italy. The sections are well exposed, carefully investigated using multiple criteria （an integrated stratigraphical approach） and located in the central part of the Mediterranean. This area is recognized worldwide as a classical region for the Neogene and the Pleistocene sequences. The terrestrial record is directly correlated with the deep-sea record, as determined from ODP Sites 653 （Tyrrhenian Sea）, 963 （Sicily Channel） and 964 （Ionian Sea）from the central Mediterranean. The present formal proposal is consistent with the INQUA and ICS decision to define and correlate the Plio/Pleistocene boundary （GSSP at Vrica） within the Olduvai Subchron, at 1.81 My, the Lower/Middle Pleistocene boundary at the Matuyama/Brunhes reversal at 0. 78 My and the Middle/ Upper Pleistocene boundary with the base of MIS 5, approximately 0. 13My. The present proposal also is consistent with the call for stage unit stratotypes that emphasize both the physical content of a stage and its boundaries （Hilgen et al., 2006）.展开更多
The name Calabrian was introduced in the geological literature by the French stratigrapher Maurice Gignoux in 1910, and later described in his important monograph （633 pages） ＂Les formations marines pliocknes et qu...The name Calabrian was introduced in the geological literature by the French stratigrapher Maurice Gignoux in 1910, and later described in his important monograph （633 pages） ＂Les formations marines pliocknes et quaternaires de l＇ltalie du sud et de la Sicile ＂published in 1913. Detailed data were provided on several sections （Santa Maria di Catanzaro, Caraffa, Monasterace, Palermo） and on their fossil content. The Calabrian Stage has commonly been used for over fifty years as the oldest subdivision of the Qua- ternary, notably in the time scales of Berggren ＆ van Cou- vering （1974） and Haq ＆ Eysinga （1987）. However, after the GSSP for the Pliocene/Pleistocene boundary （P/P） was approved by INQUA in 1982 and ratified by lUGS in 1984 at the Vrica section of Calabria, there was a decline in the usage of the stage name, and an increasing tendency by many Quaternary workers to question the boundary stratotype. This was because there was increasing evidence that it did not correspond to the beginning of the ＂ice age＂. In doing so, they were not complying with the recommendations presented at the 18th International Geological Congress （IGC） in London, 1948 （Oakley, 1950）.展开更多
Neurodegenerative diseases（NDs）include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cogniti...Neurodegenerative diseases（NDs）include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cognitive deficits.The pathogenesis of NDs involves mitochondrial dysfunction/oxidative stress,programmed cell death or abnormal protein aggregation,trafficking,and/or degradation.In most cases,展开更多
文摘Several epidemiological,cellular,and molecular studies demonstrate the role of environmental chemicals with endocrine disrupting activities,typical of Westernized societies,in the pathogenesis of numerous diseases including cancer.Nonetheless this information,the design and execution of studies on endocrine disruptors are not yet cognizant that the specific actions of individual hormones often change with development and ageing,they may be different in males and females and may be mediated by different receptors isoforms expressed in different tissues or at different life stages.These statements are particularly true when assessing the hazard of endocrine disruptors against 17β-estradiol(E2)actions in that this hormone is crucial determinant of sexrelated differences in anatomical,physiological,and behavioral traits which characterize male and female physiology.Moreover,E2 is also involved in carcinogenesis.The oncogenic effects of E2 have been investigated extensively in breast and ovarian cancers where hormone-receptor modulators are now an integral part of targeted treatment.Little is known about the E2preventive signalling in colorectal cancer,although this disease is more common in men than women,the difference being more striking amongst pre-menopausal women and age-matched men.This review aims to dissect the role and action mechanisms of E2 in colorectal cancer evaluating the ability of estrogen disruptors(i.e.,xenoestrogens)in impair these E2 actions.Data discussed here lead to define the possible role of xenoestrogens in the impairment and/or activation of E2signals important for colorectal cancer prevention.
文摘The need to standardise stratigraphical subdivisions of continuous marine sedimentary successions that outcrop for hundreds metres, using clearly defined points fixed in the field is strongly felt. A proposal is presented here to formalize regional stages for the Lower Pleistocene （Calabrian） and for the Middle Pleistocene （Ionian） in Italy. The sections are well exposed, carefully investigated using multiple criteria （an integrated stratigraphical approach） and located in the central part of the Mediterranean. This area is recognized worldwide as a classical region for the Neogene and the Pleistocene sequences. The terrestrial record is directly correlated with the deep-sea record, as determined from ODP Sites 653 （Tyrrhenian Sea）, 963 （Sicily Channel） and 964 （Ionian Sea）from the central Mediterranean. The present formal proposal is consistent with the INQUA and ICS decision to define and correlate the Plio/Pleistocene boundary （GSSP at Vrica） within the Olduvai Subchron, at 1.81 My, the Lower/Middle Pleistocene boundary at the Matuyama/Brunhes reversal at 0. 78 My and the Middle/ Upper Pleistocene boundary with the base of MIS 5, approximately 0. 13My. The present proposal also is consistent with the call for stage unit stratotypes that emphasize both the physical content of a stage and its boundaries （Hilgen et al., 2006）.
文摘The name Calabrian was introduced in the geological literature by the French stratigrapher Maurice Gignoux in 1910, and later described in his important monograph （633 pages） ＂Les formations marines pliocknes et quaternaires de l＇ltalie du sud et de la Sicile ＂published in 1913. Detailed data were provided on several sections （Santa Maria di Catanzaro, Caraffa, Monasterace, Palermo） and on their fossil content. The Calabrian Stage has commonly been used for over fifty years as the oldest subdivision of the Qua- ternary, notably in the time scales of Berggren ＆ van Cou- vering （1974） and Haq ＆ Eysinga （1987）. However, after the GSSP for the Pliocene/Pleistocene boundary （P/P） was approved by INQUA in 1982 and ratified by lUGS in 1984 at the Vrica section of Calabria, there was a decline in the usage of the stage name, and an increasing tendency by many Quaternary workers to question the boundary stratotype. This was because there was increasing evidence that it did not correspond to the beginning of the ＂ice age＂. In doing so, they were not complying with the recommendations presented at the 18th International Geological Congress （IGC） in London, 1948 （Oakley, 1950）.
基金supported by Ministero dell’Istruzione,dell’Università e della Ricerca of Italy (PRIN 20109MXHMR_001)Associazione Italiana Ricerca sul Cancro (AIRC,IG#15221)
文摘Neurodegenerative diseases（NDs）include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cognitive deficits.The pathogenesis of NDs involves mitochondrial dysfunction/oxidative stress,programmed cell death or abnormal protein aggregation,trafficking,and/or degradation.In most cases,
