The emergence of SARS-CoV-2 variants threatens efforts to control the COVID-19 pandemic.At present,the global spread of the Delta(B.1.617.2)variant is responsible for a rapid increase in COVID-19 cases and hospitaliza...The emergence of SARS-CoV-2 variants threatens efforts to control the COVID-19 pandemic.At present,the global spread of the Delta(B.1.617.2)variant is responsible for a rapid increase in COVID-19 cases and hospitalizations in many countries.The variant evades neutralizing antibodies and is believed to be more transmissible and pathogenic[1,2,3,4].展开更多
The COVID-19 pandemic,caused by SARS-CoV-2,continues to rage in many countries,straining health systems and economies.Vaccines protect against severe disease and death and are considered central to ending the pandemic...The COVID-19 pandemic,caused by SARS-CoV-2,continues to rage in many countries,straining health systems and economies.Vaccines protect against severe disease and death and are considered central to ending the pandemic.COVID-19 vaccines(and SARS-CoV-2 infection)elicit antibodies that are directed against the viral spike(S)protein and neutralize the virus.However,the emergence of SARS-CoV-2 variants with S protein mutations that confer resistance to neutralization might compromise vaccine efficacy[1].展开更多
Since the beginning of the COVID-19 pandemic,multiple SARS-CoV-2 variants have emerged.While some variants spread only locally,others,referred to as variants of concern,disseminated globally and became drivers of the ...Since the beginning of the COVID-19 pandemic,multiple SARS-CoV-2 variants have emerged.While some variants spread only locally,others,referred to as variants of concern,disseminated globally and became drivers of the pandemic.All SARS-CoV-2 variants harbor mutations relative to the virus circulating early in the pandemic,and mutations in the viral spike(S)protein are considered of particular relevance since the S protein mediates host cell entry and constitutes the key target of the neutralizing antibody response.As a consequence,mutations in the S protein may increase SARS-CoV-2 infectivity and enable its evasion of neutralizing antibodies.Furthermore,mutations in the S protein can modulate viral transmissibility and pathogenicity.展开更多
The SARS-CoV-2 spike(S)protein engages ACE2 for cell entry,and the S protein/ACE2 interface is an important target for neutralizing antibodies.In the course of the COVID-19 pandemic,SARS-CoV-2 variants have emerged th...The SARS-CoV-2 spike(S)protein engages ACE2 for cell entry,and the S protein/ACE2 interface is an important target for neutralizing antibodies.In the course of the COVID-19 pandemic,SARS-CoV-2 variants have emerged that harbor mutations in the S protein,which confer neutralization resistance and allow viral spread in immunologically nonnaive populations.The most prominent example is the highly mutated Omicron variant,which infects convalescent or vaccinated individuals with unprecedented efficiency[1,2].展开更多
基金SP acknowledges funding by BMBF(01KI2006D,01KI20328A,01KI20396,and 01KX2021)the Ministry for Science and Culture of Lower Saxony(14-76103-184,MWK HZI COVID-19)and the German Research Foundation(DFG,PO 716/11-1,PO 716/14-1)+1 种基金MSW received unrestricted funding from Sartorius AG,Lung Research.HMJ received funding from BMBF(01KI2043,NaFoUniMedCovid19-COVIM:01KX2021)Bavarian State Ministry for Science and the Arts and Deutsche Forschungsgemeinschaft(DFG)through the research training groups RTG1660 and TRR130.G.B.acknowledges funding from the German Center for Infection Research(grant no 80018019238).
文摘The emergence of SARS-CoV-2 variants threatens efforts to control the COVID-19 pandemic.At present,the global spread of the Delta(B.1.617.2)variant is responsible for a rapid increase in COVID-19 cases and hospitalizations in many countries.The variant evades neutralizing antibodies and is believed to be more transmissible and pathogenic[1,2,3,4].
基金S.P.acknowledges funding by BMBF(01KI2006D,01KI20328A,01KI20396,01KX2021)the Ministry for Science and Culture of Lower Saxony(14-76103-184,MWK HZI COVID-19)+2 种基金the German Research Foundation(DFG,PO 716/11-1,PO 716/14-1)M.S.W.received unrestricted funding from Sartorius AG,Lung Research.H.-M.J.received funding from BMBF(01KI2043,NaFoUniMedCovid19-COVIM:01KX2021)Bavarian State Ministry for Science and the Arts and Deutsche Forschungsgemeinschaft(DFG)through the research training groups RTG1660 and TRR130.G.B.acknowledges funding from the German Center for Infection Research(grant no 80018019238).
文摘The COVID-19 pandemic,caused by SARS-CoV-2,continues to rage in many countries,straining health systems and economies.Vaccines protect against severe disease and death and are considered central to ending the pandemic.COVID-19 vaccines(and SARS-CoV-2 infection)elicit antibodies that are directed against the viral spike(S)protein and neutralize the virus.However,the emergence of SARS-CoV-2 variants with S protein mutations that confer resistance to neutralization might compromise vaccine efficacy[1].
基金SP acknowledges funding by BMBF(01KI2006D,01KI20328A,01KI20396,01KX2021)the Ministry for Science and Culture of Lower Saxony(14-76103-184,MWK HZI COVID-19)+3 种基金the German Research Foundation(DFGPO 716/11-1,PO 716/14-1)MSW received unrestricted funding from Sartorius AG,Lung Research.HMJ received funding from BMBF(01KI2043,NaFoUniMedCovid19-COVIM:01KX2021)Bavarian State Ministry for Science and the Arts and Deutsche Forschungsgemeinschaft(DFG)through the research training groups RTG1660 and TRR130.
文摘Since the beginning of the COVID-19 pandemic,multiple SARS-CoV-2 variants have emerged.While some variants spread only locally,others,referred to as variants of concern,disseminated globally and became drivers of the pandemic.All SARS-CoV-2 variants harbor mutations relative to the virus circulating early in the pandemic,and mutations in the viral spike(S)protein are considered of particular relevance since the S protein mediates host cell entry and constitutes the key target of the neutralizing antibody response.As a consequence,mutations in the S protein may increase SARS-CoV-2 infectivity and enable its evasion of neutralizing antibodies.Furthermore,mutations in the S protein can modulate viral transmissibility and pathogenicity.
基金SP acknowledges funding from BMBF(01KI2006D,01KI20328A,01KI20396,01KX2021)the Ministry for Science and Culture of Lower Saxony(14-76103-184,MWK HZI COVID-19)+2 种基金the German Research Foundation(DFG,PO 716/11-1,PO 716/14-1)MSW received unrestricted funding from Sartorius AG,Lung Research.H-MJ received funding from BMBF(01KI2043,NaFoUniMedCovid19-COVIM:01KX2021)Bavarian State Ministry for Science and the Arts and Deutsche Forschungsgemeinschaft(DFG)through the research training groups RTG1660 and TRR130.GMNB acknowledges funding from the German Center for Infection Research(grant no 80018019238).
文摘The SARS-CoV-2 spike(S)protein engages ACE2 for cell entry,and the S protein/ACE2 interface is an important target for neutralizing antibodies.In the course of the COVID-19 pandemic,SARS-CoV-2 variants have emerged that harbor mutations in the S protein,which confer neutralization resistance and allow viral spread in immunologically nonnaive populations.The most prominent example is the highly mutated Omicron variant,which infects convalescent or vaccinated individuals with unprecedented efficiency[1,2].
